Association Of ABO Blood Groups Research Articles

The ABO blood group antigens in patients with oral lichenoid reaction.

Evaluating the association of ABO blood group with different delayed hypersensitivity reactions, such as oral lichenoid reaction (OLR), can provide a new perspective for clinical practice. Therefore, this study designed to investigate ABO blood group antigens in OLR patients. In this case-control study, the ABO blood group of 112 OLR patients and 117 individuals without oral lesions were included. Gender, age, characteristics of the lesions, medications and restorative materials recorded. Chi-square test used to compare the frequency of ABO blood groups in OLR patients with controls. The O blood group was significantly higher in OLR patients and all its subtypes. Also, there were significant relation between O blood group, and severity of lesions. The frequency of dysplasia was non-statistically significant higher in OLR patients with O blood group than other blood group. Based on the results of the present study, O blood group was significantly more in patients with lichenoid reaction than control group, and AB blood group was the lowest. Also, O blood group showed a positive association with the more severe form of OLR lesions and frequency of dysplasia.

Association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19.

Previous studies have reported that the susceptibility to coronavirus disease 2019 (COVID-19) is related to ABO blood group, but the relationship with Rh phenotype and MN blood group is unknown. China had adopted a strict control policy on COVID-19 until December 5, 2022, when local communities were liberalized. Therefore, we aimed to explore the correlation between ABO blood group, Rh phenotype, MN blood group and susceptibility to COVID-19 based on the time sequence of infection during the pandemic. A total of 870 patients who were routinely hospitalized in Ningbo Medical Center Lihuili Hospital from March 1, 2023 to March 31, 2023 were randomly selected to enroll in this study. Patients were divided into susceptible group and non-susceptible group, according to the time of their previous infection. The demographics and clinical information of the enrolled participants were collected from electronic medical records. The association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19 was analyzed. A total of 650 cases (74.7%) had been infected with COVID-19, with 157 cases (18.0%) in the second week and 252 cases (29.0%) in the third week, reaching the peak of infection. Compared with the non-susceptible group, the susceptible group had no statistically significant differences in ABO blood group and Rh phenotype, but the proportion of N+ was higher (75.6% vs 68.9%, P = 0.030) and the proportion of MM was lower (24.4% vs 31.1%, P = 0.030). Consistent with this, ABO blood group and Rh phenotype were not significantly associated with susceptibility to COVID-19 (P>0.05), while N+ and MM were associated with susceptibility to COVID-19 (OR: 1.432, 95% confidence interval [CI]: 1.049, 1.954, P = 0.024; OR: 0.698, 95% CI: 0.512, 0.953, P = 0.024, respectively), after adjusting for age, sex, BMI, basic disease, and vaccination status in multivariate logistic regression analysis. Our study showed that ABO blood group and Rh phenotype may not be related to the susceptibility to COVID-19, but MN blood group may be associated with the susceptibility to COVID-19.

Association of ABO Blood Groups and Obesity in Patients With Diabetes Mellitus in King Abdulaziz University Hospital.

Differences in the blood, resulting from the presence or absence of antigens corresponding to specific blood types, have indirect implications for susceptibility to diseases. The aim of this study was to examine the association between the ABO type and obesity in patients with diabetes mellitus. This is a cross-sectional observational study that was conducted at King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia. Data were collected using a simple random method through hospital records during the period between August and September 2022. Patients with type 1 diabetes mellitus (T1DM) and T2DM were included in this study. Binary logistic regression analysis was used to identify the association between blood group and obesity. A total of 411 patients were involved in this study. More than half of the patients (54.3%; n= 223) are diagnosed with T1DM. O-positive was the most common blood group type among the patients, accounting for 38.6% (n= 161). Only 23.6% (n= 97) of the patients were classified as having normal weight. Around 32.6% (n= 134) of the patients were classified as having the pre-obesity stage. More than one-third of the patients (35.1%; n= 145) were classified as being obese. There was no statistically significant difference between the patients in terms of their blood type group and its association with obesity (p>0.05). Many diabetics are overweight or obese, according to thisstudy. This shows the importance of weight management for diabetes treatment. Many patients were overweight, emphasizing the importance of obesity prevention and diabetes care. Most patients were O-positive, according to blood type tests. Previous research suggests that blood types may be linked to diabetes. However, this study found no significant relationships. More research is needed to understand the complex link between blood types, weight, and diabetes.

Associations Between Blood Group and COVID-19 Mortality, Severity, and Length of Hospitalization

Objectives: This study aimed to investigate the relationship between ABO blood groups and the mortality rate, disease severity, and length of hospitalization (LOH) in patients with COVID-19. Methods: A hospital-based cross-sectional study was conducted from March 1 to June 1, 2020. Demographics, comorbidities, and biochemical data were gathered, and the association of ABO blood groups with mortality rate, disease severity (hospitalization in general ward or ICU), and LOH was investigated using standard univariate analysis and logistic regression. Results: Out of 398 patients who were positive for COVID-19, 65 (16.3%), 71 (17.8%), 9 (2.3%), and 252 (63.3%) had blood groups of A, B, AB, and O, respectively. Multivariate analysis showed that for each day of hospitalization, the odds of death increased by 4% (OR = 1.04, P = 0.004). Also, the chance of death was 43% lower in patients with blood group O than those with other blood groups (OR = 0.574, P = 0.032). In patients with blood group A, the chance of hospitalization at the ICU was five times higher compared to patients with other blood groups (OR = 5.038, P = 0.002). The LOH was 5.437 and 2.6 days shorter in Rh-positive patients and those with blood group B, while patients with blood group A were hospitalized 3.7 days longer than individuals with other blood groups. Conclusions: The present study showed that COVID-19 mortality was lower in patients with blood group O compared to individuals with other blood groups. Also, blood group A was associated with more severe COVID-19 disease and longer LOH.

The relationship between ABO blood group and blood transfusion in upper gastrointestinal bleeding

Introduction: ABO blood group (BG) antigens found in many cells and tissues, especially in erythrocytes, have been associated with many diseases including cardiovascular diseases, infections, and malignancies. The association of ABO BG with duodenal and gastric ulcers and upper gastrointestinal bleeding (UGB) has been investigated in few studies and the information on this subject is limited. The primary objective of our study is to examine whether there is an association between ABO BG and UGB, and the secondary objective is to examine whether there is an association between ABO BG and UGB in patients who received blood transfusions after bleeding. Methods: The prevalence values of A, B, AB, 0 BG and Rh antigens, endoscopic procedure, and blood transfusion information of patients who were diagnosed with UGB by endoscopic examination and hospitalized were recorded. Healthy individuals without UGB in the same period were included as the control group (CG). Those who had UGB by endoscopic examination constituted the study group (SG) while those who received at least 2 units of blood transfusion formed the transfusion group (TG). Results: SG consisted of 423 patients, TG included 383 patients, and CG had 1650 individuals. While the risk of bleeding was higher in SG patients with BG 0 (OR 1.33 1.07-1.66 P=0.009), the bleeding risk was lower in SG patients with BG B (OR 0.77 0.63-0.95 P=0.014). In addition, while the risk of bleeding was higher in TG patients with BG 0 (OR 1.35 1.08-1.70 P=0.009), the bleeding risk was lower in TG patients with BG B (OR 0.55 0.38-0.79 P=0.001). There was no statistically significant difference in SG, and TG in other BG A and AB and no significant difference in Rh. Conclusion: While UGB is more common in individuals with BG 0, it is less common in individuals with BG B. The risk of need for blood transfusion during the follow-up period of these patients in the ward is higher in patients with BG 0 but lower in patients with BG B. Keywords: Blood group, bleeding, transfusion

Association of ABO blood groups and Diabetes Mellitus in King Abdulaziz University Hospital: A case-control study

Association of ABO blood groups and Diabetes Mellitus in King Abdulaziz University Hospital: A case-control study

CORRELATION BETWEEN BLOOD GROUP, AGE & GENDER WITH COVID-19 INFECTION

Background. Covid-19, conjointly referred to as severe acute metabolism syndrome appeared in December 2019 by a new Corona virus. The virus originated from Wuhan, the capital of China’s Hubei Province and unfold everywhere the globe and have become a worldwide pandemic due to lack of cure.
 Aim:To study the association of ABO Blood Group, Rh, Age and gender with and COVID-19 infection.
 Material and methods. This retrospective study was conducted after the approval college research committee of Teerthanker Mahaveer medical college and research center. The study period of this study is from 12 March 2021 to 12 March 2022. The current research included 3000 Covid-19 patients confirmed by RTPCR test and admitted in the Teerthanker Mahaveer University Hospital, Moradabad. Covid -19 positive patient’s age, gender, ABO blood group, Rh factor and personal data was collected from the medical record department.
 Results. The most common blood group affected was B+ (1,119, 37.3%) followed by O+ (729, 24.3%), A+ (653, 21.8%), AB+ (330, 11.0%), B- (77, 2.6%), O- (36, 1.2%), A-(36, 1.2%) and AB- (20, 0.7%). Among study population, 69 (2.3%) belonged to 1-10 years, 157 (5.2%) belonged to 11-20 years, 727 (24.2%) belonged to 21-30 years, 479 (16.0%) belonged to 31-40 years, 455 (15.2%) belonged to 41-50 years, 584 (19.5%) belonged to 51-60 years, 377 (12.6%) belonged to 61-70 years, 114 (3.8%) belonged to 71-80 years and 38 (1.3%) belonged to above 80 years. The study population consisted of 1,811 (60.4%) males and 1,189 (39.6%) females.
 Conclusions. The findings of this study are In our study we found that age group that was most vulnerable was 21-30 years. We also observed that Males were affected more as compared to females and the blood group that was affected most was B positive and least numbers of patients affected are of AB negative blood group.

Association of ABO blood groups with the severity of coronary artery disease in southern India population: A prospective cross-sectional study

This study aimed to find an association between ABO blood groups with presence and severity of Coronary artery disease (CAD) among Indian population. 1500 patients undergoing elective coronary angiogram (CAG) at a tertiary care hospital in Karnataka were enrolled in the study. Baseline demographic data and the presence of cardiac comorbidities were documented. Data from baseline echocardiography and angiographic studies were compiled. The incidence of CAD was higher among patients with blood group A. Blood group A also showed a higher incidence of acute coronary syndrome (ACS), left ventricular dysfunction, triple vessel disease, and severe CAD among the patients who underwent CAG.

Association of ABO blood groups with diabetic microvascular complications

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Association Of ABO Blood Groups with Malocclusion: A Narrative Review

Association Of ABO Blood Groups with Malocclusion: A Narrative Review

Association of ABO blood groups with venous thrombosis recurrence in middle-aged patients: insights from a weighted Cox analysis dedicated to ambispective design

BackgroundIn studies of time-to-events, it is common to collect information about events that occurred before the inclusion in a prospective cohort. When the studied risk factors are independent of time, including both pre- and post-inclusion events in the analyses, generally referred to as relying on an ambispective design, increases the statistical power but may lead to a selection bias. In the field of venous thromboembolism (VT), ABO blood groups have been the subject of extensive research due to their substantial effect on VT risk. However, few studies have investigated their effect on the risk of VT recurrence. Motivated by the study of the association of genetically determined ABO blood groups with VT recurrence, we propose a methodology to include pre-inclusion events in the analysis of ambispective studies while avoiding the selection bias due to mortality.MethodsThis work relies on two independent cohorts of VT patients, the French MARTHA study built on an ambispective design and the Dutch MEGA study built on a standard prospective design. For the analysis of the MARTHA study, a weighted Cox model was developed where weights were defined by the inverse of the survival probability at the time of data collection about the events. Thanks to the collection of information on the vital status of patients, we could estimate the survival probabilities using a delayed-entry Cox model on the death risk. Finally, results obtained in both studies were then meta-analysed.ResultsIn the combined sample totalling 2,752 patients including 993 recurrences, the A1 blood group has an increased risk (Hazard Ratio (HR) of 1.18, p = 4.2 × 10–3) compared with the O1 group, homogeneously in MARTHA and in MEGA. The same trend (HR = 1.19, p = 0.06) was observed for the less frequent A2 group.ConclusionThe proposed methodology increases the power of studies relying on an ambispective design which is frequent in epidemiologic studies about recurrent events. This approach allowed to clarify the association of ABO blood groups with the risk of VT recurrence. Besides, this methodology has an immediate field of application in the context of genome wide association studies.

Association of ABO Blood Group with Delayed Cerebral Ischemia and Clinical Outcomes Following Aneurysmal Subarachnoid Hemorrhage in Pakistan.

Background The ABO blood type, due to its various hemostaseologic properties, has been associated with several vascular diseases, including aneurysmal subarachnoid hemorrhage (aSAH). However, the role of ABO blood type in delayed cerebral ischemia (DCI) onset and other clinical outcomes after aSAH is largely unexplored. This study aimed to investigate the association between ABO blood type and outcomes after aSAH, primarily DCI. Methods A retrospective analysis was made on the data collected from 175 aSAH patients at a tertiary supraregional neurosurgery department over 5 years. Socio-demographic factors, clinical variables (DCI, mFG, WFNS grade, and Glasgow Outcome Scale at discharge), EVD placement, and aneurysm size were analyzed for their association with ABO blood type. Results DCI was reported in 25% of patients with 'O' blood type and 9.6% with 'non-O' blood type. A stepwise logistic regression model showed that after adjusting for BMI, mFG, WFNS grade, and EVD placement, 'O' type blood group was an independent risk factor for DCI, greatly increasing the risk of DCI as compared to 'non-O' type groups (OR = 3.27, 95% CI: 1.21-8.82). Conclusion This study provides evidence that individuals with 'O' blood type may have a higher risk of DCI onset after aSAH. However, further studies are essential to address the limitations of our work and confirm our findings.

ABO Blood Group and the Risk and Prognosis of Lymphoma.

ABO blood group antigens exhibit alternative phenotypes and genetically derived structures that are located on the red cell surface. The role of ABO blood group in cancer biology has been intensely reported by several studies, and it is now widely recognized that ABO antigens are associated with the risk and prognosis of several types of tumors, namely gastric cancer and pancreatic cancer. However, there have been contentious limited issues with the association between the ABO blood group and lymphoma. In this narrative review, based on literature data, we discuss the role of ABO blood group in the risk and prognosis of lymphoma and summarize the current knowledge of the underlying pathogenic mechanisms of the association. The possible association of ABO blood group with racial disparities and pathological classification in lymphoma patients is also discussed.

Association between ABO blood group and COVID-19-positive patients in institutional-based hospital, Coimbatore – A cross-sectional study

Objective: The novel coronavirus disease (COVID-19) has spread globally and caused 6.5 million death as of October 2022. Risk factors for COVID-19 morbidity and mortality include age, sex, smoking, hypertension, cardiovascular disorders, respiratory disease, and diabetes mellitus. Association between ABO blood groups and number of other infections or disease severity following infections such as SARS-COV-1 and hepatitis B virus has been reported. Rh(D) phenotype (positive and negative Rh blood types) is associated with very few diseases compared to ABO blood group. Various articles have reported the association of ABO blood group and COVID-19. Our aim was to investigate if any association exists in between ABO blood group with Rh phenotype and COVID-19 infection in Coimbatore and with the result an awareness among the public should be created to hasten the preventive measure from further encounter of the infection and help the government in taking a proactive approach to fight COVID-19 in the area. Thus, we conducted a study to find out the association between ABO blood group and COVID-19-positive (SARS-COV-2) patients in institutional-based hospital – Coimbatore which was one of the most affected districts in Tamil Nadu. Materials and Methods: This is a single-center, retrospective, observational, and cross-sectional study conducted in a private institutional-based hospital in Coimbatore. The data were collected from around 437 patients’ medical records, who were tested COVID-19-positive between October 2020 and November 2021 whose blood grouping was available as part of investigation. Data were analyzed statistically to correlate the association of ABO blood group, Rh phenotype, and COVID-19 infection. Results: In 437 COVID-19-infected patients, the ABO blood group displayed a percentage distribution for A, B, AB, and O at 19% (83), 35% (153), 8.5% (37), and 37.5% (164), respectively and 409 (93.6%) were Rh +ve. Among the patients, blood group O 164 (37.5%), followed by blood group B153 (35%) is observed to be significantly associated with COVID-19 susceptibility, whereas blood group A83 (19%) and AB 37(8.5%) showed lower susceptibility for COVID-19 infection. Conclusion: This study did not show any statistically significant association of ABO blood group and Rh phenotype seen in relation to COVID-19 infection.

Risk of COVID-19 infection and severity of clinical outcomes and its association with ABO blood groups

Objective: To determine association of ABO blood groups with severity of COVID-19 symptoms among covid recovered patients of different blood type. Methodology: An observational/experimental study was conducted at department of physiology, Sindh university Jamshoro from April 2021 to December 2021.The sample size (n) was 732, data consist of male and female covid recovered participants of age group 18-30yrs. Self -structured questionnaire was used to evaluate intensity of symptoms of COVID 19 and for other characteristics such as gender and age. Blood was drawn for ABO blood typing. Statistical analysis was performed on SPSS- 21.Results: Seven hundred thirty two was the total study population of COVID-19 recovered patients, out of which male population was 489 (66.9%) and female population was 243 (33.1%).The results reports that there is statistically significant association present between the A +ve blood type and susceptibility of COVID-19 infection, whereas AB +ve and A +ve shown higher percentage of severe infection. Blood group B +ve with (48%) with less severe symptoms. O +ve people shown mild symptoms that is 60% of entire O+ve population and 30% are presented with severe symptoms.Conclusion: This study suggests that A +ve blood group is susceptible blood type with high chances to get infection. People having A +ve and AB +ve blood types are more susceptible towards severe COVID 19 infection in comparison to other blood types, O +ve blood shown rather protective effect.

Association of ABO blood groups with ovarian reserve: a retrospective cohort study in Chinese Han women younger than 40 years with infertility

BackgroundOvarian reserve reflects both the quantity and quality of oocytes available for procreation and is affected by many known and unknown factors. ABO blood type is related to several infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve.ObjectiveThe purpose of the study was to explore the correlation between ABO blood types and ovarian reserve in infertile Chinese Han women under 40 years of age undergoing the in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI)-embryo transfer (IVF/ICSI-ET) treatment.MethodsWomen aged < 40 years who underwent IVF/ICSI-ET at our institution and had a documented ABO blood type were eligible for this study. In this study, patients were divided into two groups according to the diminished ovarian reserve (DOR) group (AMH < 1.1 ng/mL, AFC < 6) and the non-diminished ovarian reserve (non-DOR) group (AMH ≥ 1.1 ng/mL, AFC ≥ 6). The relationship between ovarian reserve and ABO blood group was determined by correlation analysis.ResultsIn this retrospective cohort study, clinical data were collected from 1690 Chinese Han women treated with IVF/ ICSI-ET in hospital records between April 2019 and March 2020 in the affiliated hospital of Southwest Medical University, located in Luzhou, China. The differences in age, duration of infertility, BMI, FSH, FSH / LH, and p (DOR vs non-DOR) for each parameter (DOR vs non-DOR) were statistically significant, and the differences in LH and E2 were not statistically significant. ABO blood groups were most prevalent in the DOR group with O (143, 34.8%) and A (122, 29.7%) and in the non-DOR group with A (428, 33.5%) and O (419, 32.8%). ABO blood groups were most prevalent in the DOR group with O (n = 57, 30.5%) and A (n = 54, 28.9%) and in the non-DOR group with A (n = 335, 34.0%) and O (n = 323, 32.8%) were the most frequent in the non-DOR group.ConclusionsIn this retrospective cohort study, we confirmed the lack of a significant association between ABO blood type and ovarian reserve. Further studies are needed to clarify whether there is any prognostic correlation between ABO blood group and ovarian reserve in women undergoing IVF/ICSI-ET.

Immunoglobulin Class Profiles of ABO Antibodies in Saliva and Serum of Healthy Individuals

Introduction: The coronavirus disease (COVID-19) pandemic gave rise to studies investigating the association of ABO blood group with COVID-19 susceptibility. It is hypothesized that ABO antibodies might play a role in neutralizing SARS-CoV-2. However, ABO antibodies were exclusively analyzed in blood samples. Investigation of ABO antibodies in saliva, an easy-to-obtain surrogate for respiratory secretions, may provide novel insights into mucosal immunity crucial in early defense against respiratory pathogens. Methods: In this study, saliva and serum samples from healthy individuals with known blood groups were investigated using a flow cytometric method for separate anti-A/anti-B IgA, IgM, and IgG class antibody detection. Saliva samples were additionally tested using hemagglutination-based neutral and indirect anti-human globulin test gel cards. This method comparison was complemented by dilution experiments with a high-titer anti-A/anti-B WHO standard. Results: In saliva, IgA was the most abundant ABO antibody class, followed by IgM; IgG was detected only in low levels in all non-AB blood types. In serum, IgM was the predominant ABO antibody class in all non-AB blood types, followed by IgA and IgG, the latter mainly detected in group O individuals. Saliva and serum samples of group O individuals yielded the highest variability of ABO-specific antibody levels. Regardless of sample material and blood type, major interindividual differences in ABO antibody reactivities were recorded. Antibody levels correlated moderately between these two body fluids. There were no significant sex and age-group differences in ABO antibody levels in both serum and saliva. WHO standard dilution experiments yielded technique-specific limits of detection, illustrating the inherent differences of immunofluorescence versus agglutination. Conclusion: For the first time, salivary ABO antibodies were investigated by separate detection of the three most relevant antibody classes IgA, IgM, and IgG in a healthy cohort. This study opens new perspectives regarding mucosal ABO antibody class profiles and their potential influence on respiratory infections.

Association Between ABO Blood Group and Gestational Diabetes Mellitus in Pregnant Women at King Abdulaziz University Hospital: A Retrospective Study.

Objective Gestational diabetes mellitus (GDM) can occur during pregnancy. One of the leading causes of it is a hormone produced by the placenta that interferes with glucose absorption and causes glucose buildup in the bloodstream. Genetic variations between ethnicities are believed to be associated with GDM, and there has been some research on the association of ABO blood group with GDM in different populations. However, the results so far are inconsistent, and there is no conclusive evidence on how ABO blood group affects the occurrence of GDM. This study aims to examine the link between ABO blood group and GDM in pregnant women at King Abdulaziz University Hospital. Methodology A retrospective cohort study was conducted on a group of GDM patients between 2019 and 2022 using data collected from the patients' medical records at King Abdulaziz University Hospital. Results The overall prevalence of GDM was high at 74.7%, and the percentage of patients with A, O, B, and AB blood group who had GDM was 42.9%, 41.41%, 12.1%, and 3.59%, respectively. However, there was no significant difference in Rh status or any other clinical characteristic between the participants who had GDM and those who did not have GDM. Conclusion The present findings indicate that blood group is not associated with the development of GDM in this cohort from Saudi Arabia. However, more studies are required in the future to corroborate these findings.

Blood group B and decreased risk of coronary artery disease in hypertensive elderly.

Although ABO blood groups have been associated with cardio-vascular disease, little is known about whether ABO blood groups contribute to the risk of the presence and severity of coronary artery disease (CAD) in elderly individuals with hypertension. This study was aimed to explore this as-sociation. A total of 793 hypertensive patients aged ≥60 years out of 2095 patients who underwent primary coronary angiography were retrospectively included. They were divided into CAD and non-CAD groups. Demographic and clinical characteristics, ABO blood groups and other biochemical parameters were compared. Further evaluation was performed to determine the impact of ABO blood groups on CAD severity using the Gensini score and the number of significantly diseased vessels. A logistic regression model was constructed to identify the association of ABO blood groups with CAD. There was a substantial difference in the distribution of ABO blood groups in elderly and hypertensive adults with and without CAD (p=0.022). Hypertensive patients with CAD had a significantly lower proportion of the blood group B than those without CAD (p=0.008). Compared to those with non-Blood group B, hypertensive elderly with a blood group B tended to have significantly lower concentrations of TC, LDL -C and Apo B, and a lower number of significantly stenosed vessels. The blood group B was found to be an independent protective factor for CAD in elderly with hypertension. The blood group B is significantly associated with a decreased risk of CAD and is inversely correlated with the severity of coronary stenosis in the elderly with hypertension.

Analysis of pattern of ABO Blood groups in pediatric diabetic patients – An observational study

Diabetes Mellitus (DM) is the most frequently occurring metabolic disorder, caused by inadequacy in secretion of insulin or malfunction leading to chronic hyperglycemia. Well-established corroborations have been reported in the literature suggesting association of ABO blood group with DM. The available literature focuses on adult population, with limited information of said association in children. Thus this study was aimed to determine the association of ABO blood group with Diabetes in pediatric patients having confirmed diagnosis. This was a comparative cross sectional study conducted from October 2021-January 2022 at Endocrinology Ward, Children Hospital Lahore (CHL), Pakistan. The study was approved by the local research ethics committee of CHL and conducted according to the declaration of Helsinki 2000. Blood grouping was done by forward and reverse methods. A total of 25 patients, including 18 males and 7 females were included. Frequency of blood group B (n=10;40%) was highest followed by blood group O (n=4;16%), A blood group (n=3;12%), and AB (n=1;4%) in males. In females, the blood group AB (n=3;12%) has the highest frequency followed by O (n=2;8%). Blood group A (n=1;4%) and B (n=1;4%) had the same frequency among female diabetic patients