Association Annual Congress Research Articles

Treatment with IMR-687, a Highly Selective PDE9 Inhibitor, Increases HbF and Reduces VOCs in Adults with Sickle Cell Disease in a Long-Term, Phase 2a, Open-Label Extension Study

IntroductionIMR-687 (tovinontrine) is a highly selective phosphodiesterase 9 (PDE9) inhibitor being developed as an orally administered therapy for patients with sickle cell disease (SCD) and beta-thalassemia. IMR-687 increases intracellular cGMP levels and has been shown in preclinical studies to increase fetal hemoglobin (HbF) expression and reduce hemolysis and sickling of RBCs, which can lead to painful vaso-occlusive crisis (VOC). In a Phase 2a, randomized, double-blind, placebo-controlled study of adult patients with SCD (N=93) (NCT03401112), IMR-687 was generally well-tolerated as a monotherapy and in combination with hydroxyurea (HU) (European Hematology Association Annual Congress 2021, Abstract S263). IMR-687 treatment with 50-200 mg once daily (N=63) for up to 6 months, as compared with placebo (N=30), resulted in a 40% lower mean annualized rate of VOCs, 38% lower mean annualized rate of VOC-related hospitalizations, and increased median time to first VOC (169 days vs 87 days, respectively, p=0.029). Improvements were also observed in patient-reported outcomes regarding pain episode severity (ASCQ-Me) and percentage of RBCs containing HbF (F-cells).MethodsA Phase 2a open-label extension (OLE) study (NCT04053803) is ongoing to assess the long-term safety and benefit of IMR-687 administered to adult subjects with SCD for up to 4 years. Secondary long-term pharmacokinetic (PK) and pharmacodynamic (PD) parameters are also being examined. The use of background HU is permitted. The Safety Review Committee meets regularly and ad hoc as necessary.Subjects were eligible upon completion of the Phase 2a parent study (16 or 24 weeks depending on the assigned treatment arm and without early withdrawal) and if they met all inclusion and exclusion criteria. For subjects without treatment interruption, baseline values from the parent study were used, as appropriate. The dose of IMR-687 initially administered in the OLE study was 200 mg as a once daily oral dose. The dose of IMR-687 is planned to be increased to 300 or 400 mg daily, depending on the subject's weight.Subjects are evaluated every 4-6 months for safety, PK and PD parameters (including HbF, F-cells, hemoglobin [Hb] and other biomarkers) as well as incidence of VOCs.ResultsAs of a data cut-off of 12-May-2021, 24 subjects were enrolled in the OLE study, 17 of which had a treatment interruption between the parent and OLE studies, and 7 subjects had direct roll-over to the OLE study. Seventeen of the OLE subjects were treated with IMR-687 monotherapy and 7 subjects were treated with combination IMR-687 + HU.IMR-687 continued to be well-tolerated in the OLE study (N=24). There were no treatment-related serious adverse events (SAEs), and the most common (≥10%) AEs were headache (21% of subjects), back pain (17%) and nausea (13%). There were 3 (13%) subjects with VOC-related hospitalizations.Annualized VOC rate was analyzed for 18 subjects treated for at least 200 days in the OLE study. Subjects who were previously in the active treatment arm in the parent study (N=13) maintained a low mean annualized VOC rate while continuing IMR-687 in the OLE study (1.35/yr [parent] and 1.85/yr [OLE]); subjects previously treated with placebo (N=5) had a 39% reduction in VOC rate when switched to IMR-687 (4.71/yr [parent] vs 2.89/yr [OLE]) (Figure 1). Of 15 subjects with evaluable PD data at 8 months, 7 (47%) subjects had a ≥ 6% absolute increase in F-cells, and 4 of 11 (36%) subjects had a ≥ 3% absolute increase in HbF (Figure 2). Updated data for subjects completing 12 months in the OLE study will be presented.ConclusionsConsistent with the parent study, preliminary results from the ongoing Phase 2a OLE study demonstrate that daily dosing of 200 mg IMR-687 was well-tolerated with longer-term treatment as a monotherapy or in combination with HU. IMR-687 treatment reduced the annualized rate of VOCs and increased HbF (%) and F-cells (%). Based on these encouraging data, a Phase 2b study (NCT04474314) is ongoing to further explore IMR-687 at doses up to 400 mg daily as a disease-modifying therapy for SCD. [Display omitted] DisclosuresBarysauskas: Imara Inc.: Current Employment, Current equity holder in publicly-traded company. Yen: Imara Inc.: Current Employment, Current equity holder in publicly-traded company. Tang: Imara Inc.: Current Employment, Current equity holder in publicly-traded company. Ballal: Imara Inc.: Current Employment, Current equity holder in publicly-traded company. Attie: Imara Inc.: Current Employment, Current equity holder in publicly-traded company.

Management of patients with difficult-to-treat multiple myeloma.

Newer treatments for multiple myeloma (MM) have improved response rates and survival for many patients. However, MM remains challenging to treat due to the propensity for multiple relapses, cumulative and emergent toxicities from prior therapies and increasing genomic complexity that arises due to clonal evolution. In particular, patients with relapsed/refractory MM often require increased complexity of treatment, yet still experience poorer outcomes compared with patients who are newly diagnosed. Additionally, several patient subgroups, including those with extramedullary disease and patients who are frail and/or have multiple comorbidities, have an unfavorable prognosis and remain undertreated. This review (based on an Updates-in-Hematology session at the 25th European Hematology Association Annual Congress2020) discusses the management of these difficult-to-treat patients with MM.

Introduction

ABSTRACTIn Donald Davidson's Triangulation Argument: A Philosophical Inquiry, Robert H. Myers and Claudine Verheggen spell out, and extensively build on, the triangulation argument advanced by Donald Davidson. This paper is an introduction to a symposium devoted to their development of that argument. The symposium began in 2018 as an authors-meet-critics session at the Canadian Philosophical Association Annual Congress, and consists in the responses of three critics, Kirk Ludwig, Alexander Miller, and Paul Hurley, followed by Verheggen's and Myers's replies. I offer a brief sketch of each of the two parts of the book, and an overview of the questions raised by the critics.

25th European Hematology Association Annual Congress (EHA25). Virtual Meeting - June 11-21, 2020

The ongoing COVID-19 pandemic has to date led to many conferences opting for a virtual experience, and, as such, the European Hematology Association (EHA)'s 25th Annual Congress, due to be held in Frankfurt, Germany, became EHA25 Virtual The virtual congress continued the EHA Congress goal of bringing together hematologists worldwide to present and discuss new and ongoing developments in the field and provide online networking opportunities Presentations were given in the usual settings of poster and oral sessions, including both live and recorded sessions, with the platform allowing for questions to be asked and responded to throughout the congress Live Theme-of-the-Day sessions allowed Q&A opportunities via online chat Additionally, a virtual exhibit hall was also created allowing online content from industry members, giving EHA25 Virtual a true congress feel This report covers the highlights from poster and oral sessions on the latest developments in treatments of hematological diseases

21st Turkish Surgical Association Annual Congress Abstract Supplement.

21st Turkish Surgical Association Annual Congress Abstract Supplement.

WSAVA award winners announced

Delegates visiting the World Small Animal Veterinary Association (WSAVA) annual congress in Singapore from 25–28 September can attend ‘Award Lectures’ given by this year’s WSAVA Award Winners. The work of these inspirational individuals has benefited companion animals and people around the world. The WSAVA Awards are one of the few opportunities for truly global recognition in our sector with this year’s recipients drawn from the USA, Australia and Sri Lanka.

Influence of social networks on congresses of urological societies and associations: Results of the 81st National Congress of the Spanish Urological Association

ObjectiveTo measure social network activity during the 81st National Congress of the Spanish Urological Association (AEU) and to compare it with the activity during other congresses of national and international urological associations. Material and methodsWe designed and registered the official hashtag #AEU16 for the 81st National Congress of the AEU on the Symplur website. The following measurements were recorded: number of participants, number of tweets, tweets by participant, tweets per hour and views. ResultsThe number of participants in the social network activity during the congress was 207. The measurements of activity in Twitter consisted of a total of 1866 tweets, a mean rate of 16 tweets/h, 9 tweets per participant and 1,511,142 views. The activity during the international congresses is as follows: 2016 American Urological Association annual congress (views: 28,052,558), 2016 European Association of Urology annual congress (views: 13,915,994), 2016 Urological Society of Australia and New Zealand (views: 4,757,453), 2015 Société Internationale d’Urologie annual congress (views: 1,023,038). The activity during the national congresses was recorded as follows: 2016 Annual Conference of The British Association of Urological Surgeons (views: 2,518,880), 81st National Congress of the AEU (views: 1,511,142), 109th Congress of l’Association Française d’Urologie (views: 662,828), 67th German Congress of Urology (views: 167,347). We found 10 posts in Facebook and 2 communications via Periscope TV related to #AEU16. ConclusionsThe social network activity during the 81st National Congress of the AEU was notable given the results of this study. The use of social networks has expanded among urological associations, congresses and meetings, giving them a global character.

Long-Term Safety of Dasatinib in Chinese Chronic Phase Chronic Myeloid Leukemia Patients with Imatinib-Resistance or -Intolerance: Results from a 6-Year Follow-up of a Multicenter Phase II Study

Background:The development of BCR/ABL1 tyrosine kinase inhibitors (TKIs) has turned chronic myeloid leukemia (CML) from a fatal disease into a controllable chronic condition. Most CML patients, especially those who were in chronic phase (CP), now may require life-long TKIs therapy. Thus, the long-term safety of TKIs is of great importance. Dasatinib is a second-generation TKI that has been approved in China in 2011 as a treatment for imatinib-resistant or -intolerant CML. Previously we have reported safety findings from the Chinese dasatinib registration study after 4 years of follow-up. The results showed that dasatinib was well tolerated, with a low rate of discontinuation and a safety profile that supported previous data from large Phase 3 clinical trials (CA180-034)[1]. Here we present the safety results from the 6-year follow-up of 59 CML-CP patients in this pivotal Chinese studyAims:To evaluate the long-term safety of dasatinib in Chinese CML-CP patients who were resistant to or intolerant of imatinib after 6 years of follow-up. Important endpoints included the incidence and severity of adverse events (AEs) and treatment discontinuation due to drug-related AEs.Methods:This was an open-label, single-arm phase 2 clinical study conducted at 10 centers in China. Adult, Chinese CML patients with imatinib-resistant or -intolerant were recruited. CML-CP patients received oral dasatinib of 100mg/d, until disease progression or intolerable toxicity. Follow-up visits were scheduled at least every 4 weeks until all study-related toxicities returned to baseline or ≤ National Cancer Institute - Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 3.0 Grade 1, stabilized or were irreversible.Results:A total of 140 patients were enrolled, 59 of whom had CML-CP. After 6 years of follow-up, 61% (36/59) of patients with CML-CP remained on treatment. Between the 4- and 6-year follow-up, there were no further deaths on the study and no more patients with CML-CP discontinued treatment due to drug-related AEs.Overall, drug-related AEs of any grade were experienced by 74.6% (44/59) of patients with CML-CP, of which 3 patients experienced drug-related AEs after 4-year follow-up (Table). 20.3% (12/59) of patients with CML-CP experienced drug-related, Grade 3-4 AEs and 16.9% (10/59) experienced drug-related serious AEs (Table). 16.9% (10/59) of patients experienced haematological AEs (Grade 3-4, 11.9%, 7/59) and none of the 10 cases happened after 4-year follow-up. The most frequently reported drug-related AEs for CML-CP patients remained pleural effusion (25.4%, 15/59; Grade 3-4, 3.4%, 2/59) and 1.7% (1/59) of the patients discontinued dasatinib treatment due to pleural effusion. Only 1 new case of pleural effusion occurred between 4-year and 6-year follow-up and no more Grade 3-4 pleural effusion has been observed after 4-year follow-up. Pulmonary hypertension were experienced by 8.5% (5/59) patients. Only 1 new case of pulmonary hypertension happened between 4-year and 6-year follow-up and no more Grade 3-4 pulmonary hypertension occurred after 4-year follow-up. Between 4-year and 6-year follow-up, 1 patient (1.7%) experienced Grade 1-2 pulmonary arterial hypertension and this was the only case of pulmonary arterial hypertension observed in the study. Deep vein thrombosis (1.7%, 1/59) occurred to 1 patient in 4-year follow-up and no more cases of deep vein thrombosis occurred between 4-year and 6-year follow-up.Conclusion:The safety profile of dasatinib after 6-year follow-up was consistent with the results from 4-year follow-up, which confirmed the long-term safety of dasatinib in the treatment for Chinese CML-CP patients with imatinib-resistance or -intolerance. Pleural effusion remained the most common adverse event during long-term follow up. As TKI-associated vascular AEs (VAEs) is drawing more and more attention in recent years, we have evaluated their incidence in our study and the results showed that the risk of VAEs remained low with long-term dasatinib treatment.Acknowledgment: BMS funded this research and medical writing support.Reference[1] Huang XJ, Hu JD, Li JY, et al. Four-year follow-up of patients with imatinib-resistant or -intolerant chronic-phase chronic myeloid leukaemia receiving dasatinib: efficacy and safety. Poster (#54229) presented at the 19th European Haematology Association Annual Congress; 12-15 June 2014; Milan, Italy DisclosuresNo relevant conflicts of interest to declare.

Influencia de las redes sociales en congresos de sociedades y asociaciones urológicas: Resultados del 81.° Congreso Nacional de la Asociación Española de Urología

ObjectiveTo measure social network activity during the 81th National Congress of the Spanish Urological Association (AEU) and to compare it with the activity during other congresses of national and international urological associations. Material and methodsWe designed and registered the official hashtag #AEU16 for the 81th National Congress of the AEU on the Symplur website. The following measurements were recorded: number of participants, number of tweets, tweets by participant, tweets per hour and views. ResultsThe number of participants in the social network activity during the congress was 207. The measurements of activity in Twitter consisted of a total of 1866 tweets, a mean rate of 16 tweets/h, 9 tweets per participant and 1,511,142 views. The activity during the international congresses is as follows: 2016 American Urological Association annual congress (views: 28,052,558), 2016 European Association of Urology annual congress (views: 13,915,994), 2016 Urological Society of Australia and New Zealand (views: 4,757,453), 2015 Société Internationale d’Urologie annual congress (views: 1,023,038). The activity during the national congresses was recorded as follows: 2016 Annual Conference of The British Association of Urological Surgeons (views: 2,518,880), 81th National Congress of the AEU (views: 1,511,142), 109th Congress of l’Association Française d’Urologie (views: 662,828), 67th German Congress of Urology (views: 167,347). We found 10 posts in Facebook and 2 communications via Periscope TV related to #AEU16. ConclusionsThe social network activity during the 81th National Congress of the AEU was notable given the results of this study. The use of social networks has expanded among urological associations, congresses and meetings, giving them a global character.

Pharmacy students’ rural career intentions: Perspectives on rural background and placements

ObjectiveTo describe the effect of rural placements and rural background on pharmacy students’ intention to practice rurally. MethodsThis cross-sectional study invited 250 pharmacy students to participate in the mixed-methods survey. Pharmacy students were invited to participate at the National Australian Pharmacy Student Association (NAPSA) annual congress held in Bendigo, Victoria in January 2014. This study aimed to investigate the pharmacy students’ intention to pursue a rural career. ResultsA total of 156 participants responded to the survey. Participants were mostly female (68%), and were aged under 30 years with the majority aged 20–24 years (116, 74%). A third of the respondents were (32%) identified with having a rural background, and about half of all the participants (53%) had undertaken a clinical placement. Students who came from a rural background were more likely to work in rural areas than urban after graduation (p < 0.001). However, when both rural and urban background students undertook a rural placement there was no difference in their rural career intentions. Additionally, the majority of students (93%) considered rural placements as beneficial to their training. Standards of health care and social isolation features are major barriers to rural practice and facilitators included increased patient interaction and community engagement. ConclusionThis study shows that rural exposure (rural background or rural placement) can positively affect students’ intentions to participate in the rural workforce regardless of their background. Students have a desire to understand rural health and are likely to consider a rural career.

Estimating greenhouse gas emissions from travel – a GIS-based study

Abstract. Conferences, meetings and congresses are an important part of today's economic and scientific world. But the environmental impact, especially from greenhouse gas emissions associated with travel, can be extensive. Anthropogenic greenhouse gas (GHG) emissions account for the warming of the atmosphere and oceans. This study draws on the need to quantify and reduce greenhouse gas emissions associated with travel activities and aims to give suggestions for organizers and participants on possible ways to reduce greenhouse gas emissions, demonstrated on the example of the European Geography Association (EGEA) Annual Congress 2013 in Wasilkow, Poland. The lack of a comprehensive methodology for the estimation of greenhouse gas emissions from travel led to an outline of a methodology that uses geographic information systems (GIS) to calculate travel distances. The calculation of travel distances in GIS is adapted from actual transportation infrastructure, derived from the open-source platform OpenStreetMap. The methodology also aims to assess the possibilities to reduce GHG emissions by choosing different means of transportation and a more central conference location. The results of the participants of the EGEA congress, who shared their travel data for this study, show that the total travel distance adds up to 238 000 km, with average travel distance of 2429 km per participant. The travel activities of the participants in the study result in total GHG emissions of 39 300 kg CO2-eq including both outward and return trip. On average a participant caused GHG emissions of 401 kg CO2-eq. In addition, the analysis of the travel data showed differences in travel behaviour depending on the distance between conference site and point of origin. The findings on travel behaviour have then been used to give an estimation of total greenhouse gas emissions from travel for all participants of the conference, which result in a total amount of 79 711 kg CO2-eq. The potential for reducing greenhouse gas emissions by substituting short flights with train rides and car rides with bus and train rides is limited. Only 6 % of greenhouse gas emissions could be saved by applying these measures. Further considerable savings could only be made by substituting longer flights (32.6 %) or choosing a more central conference location (26.3 %).

British Orthopaedic Association Annual Congress – October 2013

Last year’s annual congress of the British Orthopaedic Association took place at the ICC in Birmingham and, judging by the number of delegates who attended, there was a tangible difference to previous annual meetings. There were just under 2000 delegates present and the sheer number provided a new and much needed impetus to the congress which was a tremendous success. A clear victory for the BOA’s policy of including the congress registration in the membership fees. The theme of last year’s congress was ‘Putting Evidence Into Action’, a response to a period of tremendous and unprecedented change within the NHS, and the need for the orthopaedic profession to use evidence to support and underpin best practice. The four-day event included an increase in revalidation/instructional symposia and the addition of new sessions including GPs and Commissioning of health care, Good Clinical Practice training and the spectacularly popular Trauma Boot Camp sessions with overflowing auditoriums for many of the sessions. An Update on Infection in Orthopaedics instructional session provided a topical and comprehensive overview on an extensive and hugely important issue from a multi-disciplinary panel of experts. Opinions were put forward from orthopaedic and plastic surgeons and microbiologists. Some points of interest raised in preventing infection were the avoidance of use of forced air warming which increases air contamination in laminar flow theatres. Questions were asked as to …

Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation – (Engage Af – Timi 48 Trial): Primary Results

The following is an executive summary of the abstract presentation by Prof Robert Giugliano on the ENGAGE AF – TIMI 48 trial primary results. It was presented on 19th November 2013 at the American Heart Association (AHA) annual congress, held in Dallas, Texas.

Macdonald Roundtable

Abstract: The CHR is publishing the papers presented at the Sir John A. Macdonald Prize roundtable which took place during the 2012 Canadian Historical Association's annual congress. This is the most prestigious prize awarded each year by the Association for the best scholarly book in Canadian history. The roundtable provides the opportunity for historians in the field to discuss the winning study's contribution from multiple perspectives. The 2011 winner was Michel Ducharme's Le concept de liberté au Canada à l'époque des Révolutions atlantiques (1776–1838), published by McGill-Queen's University Press (2010).

Management of cranial cruciate ligament rupture in small dogs: A questionnaire study

To survey the current management of cranial cruciate ligament rupture in small dogs (<15 kg) by veterinarians. A questionnaire was distributed to veterinarians attending the British Veterinary Orthopaedic Association Spring meeting and British Small Animal Veterinary Association Annual Congress which took place in April 2010. Respondents were surveyed on their management of small dogs with cranial cruciate ligament rupture. Immediate surgical management was chosen by 15.5% of the respondents. Following that, 77.6% of respondents suggested that case management would depend on severity of lameness (81%), age (72.6%), bodyweight (70.4%), degree of instability (64.8%), and duration of lameness (64.0%). Conservative management included non-steroidal anti-inflammatory drugs (91.1%), short leash walks (91.1%), weight loss (89.0%), hydrotherapy (53.6%), physiotherapy (41.9%), and cage rest (24.2%). Where surgical management was chosen, 71.4% would perform the procedure rather than refer it to another practice. Surgical techniques included extra-capsular stabilisation (63.4%), corrective osteotomies (32.9%), and intra-articular stabilisation (6.8%). The demographic characteristics of the responding veterinarians had no effect on their initial management of the case. General practice veterinarians were less likely to perform a corrective osteotomy than to refer the case, but were no less likely to perform an extracapsular technique. Conservative management is still widely used for treatment of cranial cruciate ligament rupture in dogs weighing less than 15 kg; this is in agreement with previous publications on the management of this condition in small dogs.

British Veterinary Association annual general meeting, 2012

The 2012 annual general meeting of the British Veterinary Association was held at the Merseyside Maritime Museum, Liverpool, on September 29, at the end of the Association's annual congress

Reflections on The Great Land Rush : Snapshots from British North America

The CHR is publishing the papers presented at the François-Xavier Garneau Prize roundtable, which takes place during the Canadian Historical Association's annual congress. The François-Xavier Garneau Medal, awarded every five years, is the most prestigious of the CHA prizes, honouring an outstanding Canadian contribution to historical research. The roundtable provides the opportunity for historians in the field to discuss the winning study's contribution from multiple perspectives. The 2010 winner was John C. Weaver's The Great Land Rush and the Making of the Modern World, 1650-1900 , published by McGill-Queen's University Press, 2003. La CHR publie les interventions faites lors d'une table ronde organisée pour la remise de la médaille François-Xavier-Garneau, qui s'est tenue lors de la rencontre annuelle de la Société historique du Canada. Attribuée tous les cinq ans, la médaille François-Xavier-Garneau est le plus prestigieux prix de la SHC . Elle honore une contribution canadienne remarquable à la recherche en histoire. La table ronde donne aux historiens spécialistes l'occasion de discuter de la contribution du livre gagnant selon plusieurs perspectives. En 2010, le gagnant fut The Great Land Rush and the Making of the Modern World, 1650-1900 , de John C. Weaver, paru chez McGill-Queen's University Press en 2003.

A Historical Panorama

The CHR is publishing the papers presented at the François-Xavier Garneau Prize roundtable, which takes place during the Canadian Historical Association's annual congress. The François-Xavier Garneau Medal, awarded every five years, is the most prestigious of the CHA prizes, honouring an outstanding Canadian contribution to historical research. The roundtable provides the opportunity for historians in the field to discuss the winning study's contribution from multiple perspectives. The 2010 winner was John C. Weaver's The Great Land Rush and the Making of the Modern World, 1650-1900 , published by McGill-Queen's University Press, 2003. La CHR publie les interventions faites lors d'une table ronde organisée pour la remise de la médaille François-Xavier-Garneau, qui s'est tenue lors de la rencontre annuelle de la Société historique du Canada. Attribuée tous les cinq ans, la médaille François-Xavier-Garneau est le plus prestigieux prix de la SHC . Elle honore une contribution canadienne remarquable à la recherche en histoire. La table ronde donne aux historiens spécialistes l'occasion de discuter de la contribution du livre gagnant selon plusieurs perspectives. En 2010, le gagnant fut The Great Land Rush and the Making of the Modern World, 1650-1900 , de John C. Weaver, paru chez McGill-Queen's University Press en 2003.

Garneau Roundtable

Abstract: The chr is publishing the papers presented at the François-Xavier Garneau Prize roundtable, which takes place during the Canadian Historical Association's annual congress. The François-Xavier Garneau Medal, awarded every five years, is the most prestigious of the cha prizes, honouring an outstanding Canadian contribution to historical research. The roundtable provides the opportunity for historians in the field to discuss the winning study's contribution from multiple perspectives. The 2010 winner was John C. Weaver's The Great Land Rush and the Making of the Modern World, 1650–1900, published by McGill-Queen's University Press, 2003.

Material Processes and Moral Values: A Meditation on the Work of John C. Weaver

The CHR is publishing the papers presented at the François-Xavier Garneau Prize roundtable, which takes place during the Canadian Historical Association's annual congress. The François-Xavier Garneau Medal, awarded every five years, is the most prestigious of the CHA prizes, honouring an outstanding Canadian contribution to historical research. The roundtable provides the opportunity for historians in the field to discuss the winning study's contribution from multiple perspectives. The 2010 winner was John C. Weaver's The Great Land Rush and the Making of the Modern World, 1650-1900 , published by McGill-Queen's University Press, 2003. La CHR publie les interventions faites lors d'une table ronde organisée pour la remise de la médaille François-Xavier-Garneau, qui s'est tenue lors de la rencontre annuelle de la Société historique du Canada. Attribuée tous les cinq ans, la médaille François-Xavier-Garneau est le plus prestigieux prix de la SHC . Elle honore une contribution canadienne remarquable à la recherche en histoire. La table ronde donne aux historiens spécialistes l'occasion de discuter de la contribution du livre gagnant selon plusieurs perspectives. En 2010, le gagnant fut The Great Land Rush and the Making of the Modern World, 1650-1900 , de John C. Weaver, paru chez McGill-Queen's University Press en 2003.