Assessment Of Valvular Heart Disease Research Articles

Role of Cardiovascular Magnetic Resonance in the Assessment of Native Aortic Regurgitation With Insights on Mixed and Multiple Valvular Heart Disease: A Narrative Review.

Cardiovascular magnetic resonance imaging (CMR) has received extensive validation for the assessment of valvular heart disease (VHD) and offers an accurate and direct method for the quantification of aortic regurgitation (AR). According to the current guidelines, CMR represents a useful second-line investigation in patients with poor acoustic windows or when echocardiography is inconclusive, for example, in cases of multiple or eccentric aortic jets. Without ionizing radiation exposure, CMR provides in-depth information not only on the severity degree of AR, providing a precise quantification of regurgitant volume and fraction, but also on cardiac structure and function, being recognized as the gold standard for the assessment of heart chamber size and systolic function. CMR allows a free choice of cardiac imaging planes and provides further information on the myocardium, thanks to the tissue characterization ability offered by several sequences, such as the late gadolinium enhancement technique. The possibilities offered by CMR become even more interesting in the context of mixed and multiple VHD, where the echocardiographic assessments often encounter difficulties in the quantification of each single valve lesion. The current scientific data support a greater expansion of CMR in this field, thanks to its additional advantages for the diagnosis, risk stratification, and to guide treatment. This review investigates the current CMR techniques and protocols in AR, with special insights into the evaluation of mixed aortic valve disease and multiple VHD including AR.

Good agreement between cardiac magnetic imaging protocols using free-breathing and breath-holding techniques for flow quantification in valvular heart disease

Abstract Background Cardiac magnetic resonance (CMR) evaluation of valvular heart disease is an important diagnostic tool when echocardiography is inconclusive. Flow quantification is usually performed during breath hold, which can be challenging in valvular heart disease patients often suffering from dyspnea and heart failure. Purpose The purpose of the present study is to evaluate a free-breathing protocol of flow measurement in the aortic, pulmonary and tricuspid valves in healthy subjects (HS) and patients with tricuspid regurgitation (TR). Methods Phase contrast flow volume measurements were performed in 20 HS and 25 patients with TR using standard breath-holding (BH) and a free-breathing (FB) technique. Two venc-adjusted volume acquisition were acquired in the aortic, pulmonary and tricuspid valve during BH and one during FB. Mean, standard deviation (SD) and limits of agreement (LoA) for aortic forward flow volume (AoFF), pulmonary forward flow volume (PuFF) and tricuspid inflow volume (TrIF) were evaluated. Results Figure 1 presents flow volume (ml) of AoFF, PuFF and TrIF during BH (mean of 2 measurements) and FB. Conclusions The present study demonstrated good agreements between phase contrast flow measurements using FB and BH techniques. These parameters are used in the evaluation of aortic, mitral, pulmonary and tricuspid regurgitations using CMR imaging. Thus, free-breathing CMR acquisition can be an important complement in the assessment of valvular heart disease and may be applied in patients with difficulty to hold their breath.

Unlocking the Secrets of Valvular Heart Disease: A Journey through the World of Imaging Modalities

Valvular heart disease is a prevalent and clinically significant condition with potential complications and adverse outcomes if left untreated or poorly managed. Accurate assessment of valve structure, function and hemodynamics is crucial for effective evaluation and management of valvular heart disease. In this systematic review, we provide a comprehensive overview and comparison of imaging modalities used in the assessment of valvular heart disease. The introduction highlights the background and significance of valvular heart disease, emphasizing its impact on cardiovascular health, global prevalence, and associated complications. Furthermore, it emphasizes the importance of imaging modalities in the evaluation and management of valvular heart disease, discussing their role in providing crucial information for accurate diagnosis, risk stratification, treatment planning, and monitoring. The objective of this review article is to summarize the strengths, limitations and diagnostic accuracy of different imaging modalities in valvular heart disease assessment. We present detailed discussions on echocardiography, computed tomography (CT) imaging, nuclear imaging techniques and emerging imaging modalities, such as 3D echocardiography, strain imaging and fusion imaging. Each section explores the specific role of the imaging modality, its advantages, limitations and diagnostic accuracy in the evaluation of valvular heart disease. Additionally, we provide a comparative analysis of these imaging modalities, highlighting their strengths, weaknesses and specific indications. The integration of multiple imaging modalities for a comprehensive evaluation in specific scenarios is also discussed, emphasizing the complementary roles of different modalities in optimizing diagnostic accuracy and treatment planning. The review concludes with implications for clinical practice and future research directions. It underscores the importance of selecting the appropriate imaging modality or combination of modalities based on individual patient characteristics and clinical needs. Furthermore, it highlights the potential clinical impact of emerging imaging techniques and the need for standardization, cost-effectiveness studies, and further research to optimize the utilization of imaging modalities in valvular heart disease management. Bangladesh Heart Journal 2023; 39(1): 49–56

Use of a novel handheld ultrasound device with continuous-wave doppler capability for the assessment of valvular heart disease

Abstract Background/Introduction Echocardiography is the primary non-invasive imaging method for the diagnosis and evaluation of valvular heart disease. Doppler echocardiography provides accurate non-invasive evaluation of valve hemodynamics. Recent technological advancements have enabled the acquisition of echocardiographic images at the point-of-care by using small handheld ultrasound devices (HUDs); their availability and relatively low cost compared to the high-end systems have made these devices attractive to use for rapid medical decision making. However, the inability to quantify flow velocity has been a major limitation for HUDs; the lack of spectral Doppler capability has so far hindered the comprehensive assessment of haemodynamic data and valve function. Purpose To evaluate for the first time the accuracy of a novel HUD with continuous-wave (CW) Doppler capability to measure flow velocity in valvular heart disease. Methods We prospectively included 56 consecutive patients who were referred to the echocardiography laboratory of a tertiary hospital. All patients were scanned with both the Kosmos HUD and the standard echocardiography cart-based system (reference standard) in a randomized order. CW Doppler measurements of maximum velocities (Vmax) were obtained from the apical five-chamber view for the aortic ejection and regurgitation and from the apical four-chamber view for the mitral and tricuspid regurgitation (presence assessed by colour Doppler), maintaining a parallel orientation between the ultrasound beam and the blood flow. All measurements were compared to assess inter-method agreement using linear regression and Bland-Altman analysis. Results The acquisition of CW Doppler signal using the HUD was feasible in 55 out of 56 patients (mean age 66±16 years old, 40% female). Among them, there were 31 cases of (at least mild) aortic stenosis and 23 cases of valvular regurgitation (4 aortic, 6 mitral and 13 tricuspid regurgitations). There was excellent correlation between the HUD and the cart-based system CW Doppler for the aortic Vmax measurements (r=0.99, p<0.001) and for the valvular regurgitation Vmax measurements (r=0.98, p<0.001). The corresponding Bland-Altman plots showed a small underestimation bias of −0.13 m/sec (p<0.001), with limits of agreement ±0.41 m/sec for the aortic Vmax and −0.21 m/sec (p=0.003), with limits of agreement ±0.57 m/sec for the valvular regurgitation Vmax measurements. Conclusion A novel HUD with CW Doppler spectral analysis was able to provide peak jet velocity measurements comparable to the standard cart-based echocardiography systems, in patients with valvular stenosis and regurgitation. Such expanded capabilities of HUDs show clinical potential and may lead to the improvement of the assessment of valvular pathology at the point-of-care. Funding Acknowledgement Type of funding sources: None.

Prognostic value of cardiopulmonary exercise testing in valvular heart disease

Abstract Introduction Cardiopulmonary exercise testing (CEPT) is not routinely used for the assessment of valvular heart disease (VHD) patients. The cutoff values of percentage of predicted peak VO2 and ventilatory efficiency parameters that carry out a bad prognosis have been predominantly validated in heart failure. The aim of this study was to analyze the prognostic value of CPET parameters in a broad population of VHD patients. Methods 163 patients (51% female) with moderate or severe VHD who underwent a CEPT (n=197) at their physician's discretion from 2017 until 2019 were included. We calculated the net reclassification index of CPET, compared to the classical clinical or echocardiographic parameters, regarding the need for surgical indication. Also, the predictive value of CPET for death and symptom development during follow-up was estimated using regression analysis. Results At inclusion, all patients were asymptomatic or with minimal equivocal symptoms. Aortic valvular lesions were the most common (47%), followed by mitral valvular disease (44%). There was a predominance of severe valvular heart disease (71%) and most of the CEPTs were performed on a treadmill (74%). The percentage of predicted peak VO2 was 76±18% and at anaerobic threshold was 61±18%. The mean follow-up time was 15±10 months. There were 5 deaths (3%) and 24 patients became symptomatic. The net reclassification index of CPET over either clinical or echocardiographic parameters was 46%. The CEPT parameters that predicted increased risk of death were VE/VCO2 slope (p=0.009), % of predicted peak VO2 (p=0.049) and Eq CO2 at anaerobic threshold (p=0.047). None of the CEPT parameters was predictive of symptom development during follow-up, however, in the subgroup of patients who became clearly symptomatic, the ventilatory efficiency parameters were similar to the cut off values that confer bad prognosis (see Table in Figure). Conclusion In our series, CPET added prognostic mortality value to patients with VHD. The cut off values used for patients with HF can also be applied in a VHD population. In addition, CEPT clearly improved the clinical decision for surgical referral. Nevertheless, these results need to be validated in a broader population. Funding Acknowledgement Type of funding sources: None.

Cardiac Magnetic Resonance in Valvular Heart Disease: Assessment of Severity and Myocardial Remodeling.

Cardiac magnetic resonance (CMR) has emerged as the gold standard in assessing ventricular mass, volume, and systolic function. Due to these and other strengths, CMR has increasingly been used to study valvular heart disease (VHD) and resultant cardiac remodeling. By using CMR to assess flow, limitations in echocardiographic assessment of VHD can be overcome, particularly in regurgitant lesions. The following article reviews the current role of CMR imaging in studying disease severity and myocardial remodeling in patients with VHD.

Comparative Imaging Assessment of Valvular Heart Disease

Comparative Imaging Assessment of Valvular Heart Disease

Von Willebrand factor multimer quantitation for assessment of cardiac lesion severity and bleeding risk

Unlabelled Box Backgroundvon Willebrand factor (VWF) multimer quantitation has been utilized in the assessment of valvular heart disease, however, there is no standardized method for quantitation. We compared three methods of assessment which utilized a normal plasma control. MethodsWe analyzed 476 samples and their control plasma from 368 patients with valvular heart disease, hypertrophic cardiomyopathy, or LVAD therapy, and 27 normal subjects. VWF multimers were assessed as normalized VWF multimer ratios (NMR) of gel bands >15/2‐15 (NMR15) or gel bands >10/2‐10 (NMR10). Associations of VWF laboratory and multimeric assessments with cardiac lesion severity and acquired bleeding were investigated. ResultsAbnormal multimers were present in 78% of patients with moderate to severe hemodynamic abnormalities compared to 19% of patients with normal or mildly abnormal hemodynamics. NMR showed strong association with severe cardiac lesions (NMR15: OR 15.29, CI 9.04‐27.18; NMR10: OR 14.18, CI 8.88‐23.21). PFA‐CADP was strongly associated with moderate to severe cardiac lesions (OR 14.91, CI 9.08‐24.50). PFA‐CADP and NMR15 showed excellent ability to discriminate ≥moderate (AUC 0.86, CI 0.83‐0.89 and 0.83, CI 0.79‐0.87 respectively) and severe cardiac lesions (AUC 0.84, CI 0.81‐0.88 and 0.85, CI 0.81‐0.88 respectively). NMR was less strongly associated with bleeding (OR 4.01 for NMR10, CI 2.49‐6.58). ConclusionQuantification of VWF multimers may provide clinical utility in circumstances where clinical estimation of cardiac lesion severity is challenging, such as with dysfunctional prosthetic valves. The presence of abnormal VWF multimers is associated with bleeding, however further quantitation provided only modest improvement in risk stratification.

Utility of Echocardiogram in the Evaluation of Heart Murmurs.

Valvular heart disease is a common condition in today's patient population. Accurate characterization of vital cardiac structures has become crucial to early diagnosis and varied treatment options. The advent of ultrasound technology has had a large impact in cardiovascular medicine, particularly in the assessment of valvular heart disease. Today its versatility and availability have allowed it to become one of the most frequently ordered imaging tests for cardiovascular indications. Despite the tremendous evidence that suggests that clinical examinations are still standard of care, a large volume of referrals for echocardiograms suggests differently.

Normal Reference Values for Doppler Echocardiography: Influences of Ageing, Gender and Ethnicity.

Normal Reference Values for Doppler Echocardiography: Influences of Ageing, Gender and Ethnicity.

0180: Dynamic assessment of valvular heart disease by stress echocardiography

Stress echocardiography (SEC) is emerging as an important component of stress testing in patients with valvular heart disease (VHD). The aim of this study is to determinate the indications, proven prognostic values and potential influence on clinical decisions of SEC in left VHD Retrospective study conducted between January 2008 and December 2013. SEC was performed in 12 patients having left VHD. The mean age was 50 years [41; 60]. There were 9 women and 3 men. SEC was realized to study the contractile reserve in 3 patients having severe aortic stenosis with left ventricular systolic dysfunction (LVSD) and in 2 patients of aortic regurgitation with LVSD and to assess the severity of mitral stenosis in 7 very symptomatic patients having moderate mitral stenosis (mean mitral area =1,6 cm 2 ). It was a dobutamine SEC in 9 patients and exercise SEC in 3 patients. We objectified a contractile reserve in the 3 patients with aortic stenosis; subaortic ITV had increased by more than 20%. The mean LV–aortic gradient had increased in 2 patients and decreased in one patient. The 3 patients underwent aortic valve replacement and 2 of them died 2 days after surgery. For the 2 patients presenting aortic regurgitation, we found a contractile reserve in only one patient. The 2 patients were operated with favourable outcome. Concerning patients with mitral stenosis, SEC showed an increase in transmitral mean gradient in 2 patients (from 7 to 12 mmHg and 15 mmHg respectively) with increase of systolic PAP (45 and 46 mmHg to 65 mmHg respectively). Hence, the 2 patients underwent a percutaneous mitral commissurotomy (PMC) which was done with good results. For the other cases, PMC was recused by the lack of significant change in the hemodynamic profile (moderate increase of transmitral mean gradient and systolic PAP). Dynamic evaluation of the severity and hemodynamic effects of VHD can provide the clinician with additional diagnostic and prognostic information that can contribute to subsequent clinical decisions.

Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients scheduled for heart valve surgery

Coronary angiography (CA), an invasive and expensive procedure, is still recommended in most patients referred for elective valve surgery. Multislice computed tomography (MSCT) is a promising alternative technique to rule out significant coronary artery lesions. To evaluate MSCT in detecting significant coronary artery lesions in patients referred for elective valve surgery. Between August 2007 and December 2010, patients referred for elective valve surgery were identified prospectively and underwent 64-slice MSCT and CA. We compared significant coronary stenoses, defined as a reduction of luminal diameter ≥ 50%, to establish the diagnostic accuracy of MSCT. All coronary segments were analysed and uninterpretable lesions were scored positive. Forty-eight patients were included (62.5% male; mean age 65 ± 12 years), the majority had aortic insufficiency (37.7%) or aortic stenosis (32.0%). The prevalence of significant coronary artery stenoses was 27.1%. The sensitivity, specificity, positive and negative predictive values of MSCT were 77%, 89%, 71% and 91%, respectively, in a patient-based analysis; 82%, 86%, 64% and 94% in a revascularization-based analysis; 67%, 94%, 52% and 97% in a vessel-based analysis; and 65%, 98%, 52% and 99% in a segment-based analysis. Overall, CA could have been avoided in 65% of patients. In patients referred for elective valve surgery, MSCT had a high diagnostic accuracy to rule out significant coronary stenoses. However, larger multicenter studies in an unselected population of patients are needed to determine its place within the range of diagnostic tool in the preoperative assessment of valvular heart disease.

Three-dimensional Echocardiography in Valvular Heart Disease

Recent technologic advances in 3-dimensional (3D) echocardiography, using parallel processing to scan a pyramidal volume, have allowed for a superior ability to describe valvular anatomy using both transthoracic and transesophageal echocardiography. Although still in evolution and at an early phase of adaptation with respect to its clinical application, 3D echocardiography has emerged as an important clinical tool in the assessment of valvular heart disease. Three-dimensional echocardiography provides unique perspectives of valvular structures by presenting "en face" views of valvular structures, allowing for a better understanding of the topographical aspects of pathology, and a refined definition of the spatial relationships of intracardiac structures. Three-dimensional echocardiography makes available indices not described by 2D echocardiography and has been demonstrated to be superior to 2D echocardiography in a variety of valvular disease scenarios. The information gained from 3D echocardiography has especially made an impact in guiding clinical decisions in the evaluation of mitral valve (MV) disease. The decision of early surgery in degenerative MV disease is based on the suitability of repair, and the suitability of repair is generally based on echocardiography. The superior understanding of MV anatomy afforded by 3D echocardiography has been shown to be quite valuable in this setting. This review will describe the contemporary use of 3D echocardiography in the assessment of valvular heart disease, including MV, aortic, tricuspid, and prosthetic valve abnormalities. This article illustrates how 3D echocardiography can complement current echocardiography techniques in the management of valvular heart disease.

Three‐Dimensional Echocardiography in Valvular Heart Disease

Two-dimensional echocardiography (2DE) with color Doppler has been the standard tool for assessing valvular heart disease. However, this requires conceptualizing three-dimensional (3D) valvular anatomy from individual 2D slices, which is inadequate for complex valvular abnormalities. Similarly, Doppler-based methods are inherently limited by several assumptions and are influenced by hemodynamics and concomitant valvular disease. 3DE has improved both morphological and functional assessment of valvular heart disease. It provides additional morphological information, which leads to better understanding of the mechanism of valvular dysfunction and surgical planning. 3D planimetry has proven to be accurate in the evaluation of valvular stenosis. This direct assessment eliminates measurement errors and could potentially serve as new gold standard. The continuity equation for aortic stenosis can be simplified by directly measuring left ventricular outflow tract area and stroke volume. In patients with valvular regurgitation, vena contracta area can be directly measured by using 3D color Doppler which is more accurate than the standard 2D methods. By applying hemi-elliptical formula or directly measuring isovelocity surface area, 3DE has significantly improved the accuracy in regurgitant severity assessment. This is particularly useful in patients with eccentric jets. 3DE has an advantage over 2DE in assessment of tricuspid valve due to its complex geometry. Direct planimetry of orifice area in tricuspid stenosis, or vena contracta area in tricuspid regurgitation are promising although validation studies are needed before they can be applied for clinical decision making. 3DE has not been widely studied in pulmonic valve disease but preliminary data indicate that it is feasible.

Diagnostic approach to assessment of valvular heart disease using MRI—Part I: a practical approach for valvular regurgitation

Valvular heart diseases from any cause are divided into two categories: stenosis and regurgitation. Acquired knowledge of the pathological aetiology and disease severity are the important clues for optimal treatment,...

Assessment of Valvular Heart Disease by Cardiovascular Magnetic Resonance Imaging: A Review

CMR is a comprehensive non-invasive tool capable of evaluating all aspects of valvular heart disease. It has advantages over echo including direct quantification of regurgitant lesions, highly accurate assessment of ventricular size and function, visualisation myocardial scar, and interrogation of extracardiac abnormalities. Although these gains can be realised with current scanning techniques, CMR's full potential has yet to be realised, and further studies of clinical outcomes are needed before CMR data can be integrated into the management algorithms for patients with significant valvular lesions.

Mitral Valve Regurgitation and 3D Echocardiography

The mitral valve is a complex, dynamic and functional apparatus that can be altered by a wide range of disorders leading to stenosis or regurgitation. Surgical management of mitral valve disease may be difficult. Planned intervention may not always be feasible when the surgeon is faced with complex pathology that cannot be assessed fully by conventional 2D echocardiography. Transthoracic and transesophageal 3D echocardiography can provide a more reliable functional and anatomical assessment of the different valve components and evaluation of its geometry, which can aid the surgeon in planning a more suitable surgical intervention and improve outcomes. Although 3D echocardiography is a new technology, it has proven to be an important modality for the accurate assessment of valvular heart disease and in the future, it promises to be an essential part in the routine assessment of cardiovascular patients.

Features of Carcinoid Heart Disease Identified by 2- and 3-Dimensional Echocardiography and Cardiac MRI

Background— Carcinoid heart disease is a rare form of valvular heart disease. We sought describe the spectrum of carcinoid heart disease identified by echocardiography and cardiac MRI. Method and Results— Two hundred fifty-two patients with carcinoid syndrome underwent a range of investigations including 2D transthoracic echocardiography, 3D transthoracic echocardiography and transesophageal echocardiography, and cardiac MRI. Fifty-two patients had evidence of carcinoid heart disease. Involvement of the tricuspid, pulmonary, mitral, and aortic valves were found in 47 (90%), 36 (69%), 15 (29%), and 14 (27%), respectively. Myocardial metastases were found in 2 (3.8%) patients. Several patterns of disease were identified depending on the extent and severity to which each leaflet and its associated subvavlular apparatus was affected. Thirteen of 15 (87%) patients with left-sided carcinoid involvement had a patent foramen ovale. Three patients with severe degree of shunting had severe valvular regurgitation. Patients with mild/moderate degree of shunting had mild or moderate valvular regurgitation. Three-dimensional transthoracic echocardiography/transesophageal echocardiography provided detailed anatomic information particularly for the tricuspid and pulmonary valves. Cardiac MRI allowed complementary assessment of valvular heart disease and delineation of myocardial metastases. Gallium-68 octreotide positron emission tomography identified neuroendocrine metastases. Conclusions— Carcinoid heart disease is a heterogeneous disease with a wide spectrum of echocardiographic findings. A multimodality approach is needed in patients with this complex pathology.

Cardiovascular magnetic resonance imaging for valvular heart disease

Valvular heart disease (VHD) is a clinically important diagnosis, with significant associated morbidity and mortality. Multiple imaging modalities exist to characterize valvular and associated cardiac anatomy. Cardiovascular magnetic resonance (CMR) has emerged as a comprehensive noninvasive imaging modality for VHD. With use of well-established, standardized imaging sequences, CMR can accurately and precisely diagnose valvular structural abnormalities, assess severity of regurgitant and stenotic lesions, and potentially define patient prognosis. This article reviews the clinical applications of CMR in assessment of VHD.

Hand-carried Ultrasound Performed by Hospitalists: Does It Improve the Cardiac Physical Examination?

Objective The traditional physical examination of the heart is relatively inaccurate. There is little information regarding whether cardiac hand-carried ultrasound performed by noncardiologists adds to the accuracy of physical examinations. The purpose of this study was to determine whether hand-carried ultrasound can add to the accuracy of hospitalists' cardiac physical examinations. Methods During a focused training program in hand-carried echocardiography, 10 hospitalists performed cardiac examinations of 354 general medical inpatients first by physical examination and then by hand-carried ultrasound. Eligible inpatients included those for whom a conventional hospital echocardiogram was ordered. We measured how frequently the hospitalists' cardiac examination with or without hand-carried ultrasound matched or came within 1 scale level of an expert cardiologist's interpretation of the hospital echocardiogram. Results Adding hand-carried ultrasound to the physical examination improved hospitalists' assessment of left ventricular function, cardiomegaly, and pericardial effusion. For left ventricular function, using hand-carried ultrasound increased the percentage of exact matches with the expert cardiologist's assessment from 46% to 59% ( P = .005) and improved the percentage of within 1-level matches from 67% to 88% ( P = .0001). The addition of hand-carried ultrasound failed to improve the assessments of aortic stenosis, aortic regurgitation, and mitral regurgitation. Conclusion Adding hand-carried ultrasound to physical examination increases the accuracy of hospitalists' assessment of left ventricular dysfunction, cardiomegaly, and pericardial effusion, and fails to improve assessment of valvular heart disease. The clinical benefit achieved by improved immediacy of this information has not been determined. An important limitation is that the study assessed only 1 level of training in hand-carried ultrasound.