Over the last two decades, scientific studies have increasingly highlighted the vulnerability of cities to global changes, especially in sub-Saharan Africa, where climate phenomena and urbanization are intensifying. These realities necessitate a reassessment of current urban management models in order to reaffirm the central role of cities in promoting sustainability. In this context, establishing a robust scientific foundation for evaluating the transition processes of cities towards sustainability is essential. This article presents a methodology developed to select and validate indicators, taking into account local issues and the needs expressed by stakeholders. The research was conducted using a mixed-methods approach, which included a literature review, consultations with populations from five study districts, analysis of the indicator needs of development stakeholders, adoption of two methods, and validation of the indicators by a group of experts. The outcome of this research is a set of 20 indicators organized into five dimensions: environmental, social, economic, built environment, and cultural. The analysis of the proportional distribution of these indicators across dimensions reveals a notable predominance of the social dimension, which accounts for 35% of the indicators, including key indicators such as access to potable water, electricity, education, and healthcare services, inter alia. The environmental and built environment dimensions each comprise 20% of the indicators, encompassing indicators such as the preservation of natural resources, waste management, land use management, and flood management, among others. The economic and cultural dimensions represent 15% and 10% of the selected indicators, respectively. These data indicate that achieving sustainable urban development within the context of this study requires a focused effort on enhancing the performance of these indicators, with substantial efforts needed in the social domain. It is of paramount importance to incorporate these indicators into the decision-making processes related to urban development planning in Moundou and other cities in the region, as they provide valuable scientific insights crucial to the pursuit of sustainability.