Assessment Of Parathyroid Function Research Articles

Modern Surgical Techniques of Thyroidectomy and Advances in the Prevention and Treatment of Perioperative Complications.

Thyroid cancer is the most common cancer of the endocrine system, and, in recent years, there has been a phenomenon of overdiagnosis followed by subsequent overtreatment. This results in an increasing number of thyroidectomy complications being faced in clinical practice. In this paper, we present the current state of knowledge and the latest findings in the fields of modern surgical techniques, thermal ablation, the identification and assessment of parathyroid function, recurrent laryngeal nerve monitoring and treatment and perioperative bleeding. We reviewed 485 papers, from which we selected 125 papers that are the most relevant. The main merit of this article is its comprehensive view of the subject under discussion-both general, concerning the selection of the appropriate method of surgery, and particular, concerning the selection of the appropriate method of prevention or treatment of selected perioperative complications.

Significance of a new PTH assay (the comparison between whole-PTH and intact-PTH assay)

It has been shown that intact-PTH assay measures not only full-length biologically active PTH with 84 amino acids, but also some PTH fragments such as (7-84) PTH. Whole-PTH assay is a new method believed to react only with (1-84) PTH. Because circulatory concentrations of various fragments of PTH are very high especially in patients with secondary hyperparathyroidism associated with renal failure, evaluation of PTH levels by whole-PTH assay seems to be useful for accurate assessment of parathyroid function in these patients.

Rapid Radioimmunoassay for Parathyroid Hormone: Its Use in Hypercalcemic Crisis

Patients with severe hypercalcemia often require intensive medical therapy to avoid a fatal outcome. When therapy with saline and loop diuretics cannot control the hypercalcemia, use of the toxic drug mithramycin is most appropriate for malignancy-associated hypercalcemia, but parathyroidectomy is indicated for parathyroid crisis. Although differentiation of these two syndromes is possible in many cases on clinical grounds, the determination of immunoreactive parathyroid hormone values provides a direct assessment of parathyroid function. Radioimmunoassay for parathyroid hormone has traditionally required four to seven days, but more rapid results would be desirable in this medical emergency. We report a modification of a previously published midregion-specific PTH assay that provides accurate results within 24 hours and describe its use in six patients with life-threatening hypercalcemia.

An Approach to the Pre- and Post-Operative Assessment of Parathyroid Function in Primary Hyperparathyroidism (HPT).

Excerpt Three major clinical problems relating to primary hyperparathyroidism (HPT) have been under investigation in our institution for several years. [1] Which patient with borderline or definite...