Assessment Of Clinical Features Research Articles

Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography.

A few studies have reported the medium-sized and small airway morphological abnormalities of bronchiolitis. Whether spirometry or impulse oscillometry (IOS) is correlated with airway remodeling of bronchiolitis remains unclear. Aiming to demonstrate the airway morphological abnormalities of bronchiolitis obliterans (BO) and diffuse panbronchiolitis (DPB) assessed by endobronchial optical coherence tomography (EB-OCT), and elucidate whether spirometric and IOS parameters have correlation with the airway remodeling of bronchiolitis. We recruited 18 patients with bronchiolitis (BO, n = 9; DPB, n = 9) and 17 control subjects. Assessments of clinical features, St. George's respiratory questionnaire (SGRQ), chest computed tomography (CT), spirometry, IOS, and EB-OCT were performed in all enrolled subjects. The correlation between EB-OCT and lung function parameters was studied and analyzed. The magnitude of abnormalities of spirometric and IOS parameters was significantly greater in patients with bronchiolitis than that in control subjects (p < 0.05). Patients with BO had notably lower forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, maximal mid-expiratory flow (MMEF)% pred and higher resonant frequency (Fres), and area of reactance (AX) than those with DPB (p < 0.05). The EB-OCT measurement among patients with bronchiolitis and between the bronchus in the left and the right lung demonstrated a heterogeneous distribution of airway calibers, presenting a high intra- and inter-individual variability. Patients with bronchiolitis had notably greater airway wall area (p < 0.05) compared with control, while BO presented greater magnitude of airway abnormalities than DPB. Fres and the difference in airway resistance at 5 and 20 Hz (R5-R20) correlated negatively with medium-sized and small airway inner area, and correlated positively with airway wall area (p < 0.05), whose correlation coefficients were higher than those of spirometric parameters. Bronchiolitis, BO and DPB, manifested a heterogeneous distribution of airway calibers with significant intra- and inter-individual variability. IOS parameters, rather than spirometry, correlated better with medium-sized and small airway remodeling in bronchiolitis assessed by EB-OCT measurement.

Assessment of clinical features and coexisting geriatric syndromes in newly diagnosed dementia with Lewy bodies: a retrospective study in a tertiary geriatrics setting in Turkey.

Identifying the associated clinical conditions in patients with newly diagnosed dementia with Lewy bodies (DLB) may contribute to the disease management. This study aimed to examine the clinical features and coexisting geriatric syndromes of patients with newly diagnosed DLB. This cross-sectional study included newly diagnosed DLB participants who were admitted to a tertiary geriatric outpatient clinic. Of the 857 patients with dementia, 116 DLB diagnoses were eligible for analysis. The core and supportive clinical features of DLB were recorded. Geriatric syndromes including polypharmacy, depression, insomnia, dependency, a history of delirium, falls, malnutrition, urinary incontinence, functional impairment, and living alone, were assessed and recorded at baseline. The mean age was 79.0 ± 6.9years, and 50.9% of the participants were female. The majority (63.8%) had mild dementia, 31.9% had moderate, and 4.3% had severe disease. Cognitive fluctuations (78.4%), visual hallucinations (77.6%), and Parkinsonism (73.3%) were the most common clinical features. Functional impairment (59.5%) and urinary incontinence (59.5%) were the leading geriatric syndromes, followed by polypharmacy (56.9%), depressive symptoms (54.7%), falls (52.6%), insomnia (49.1%), malnutrition (24.3%), and delirium (6.0%). Women had more functional impairment and depressive symptoms than men. Although most patients had mild dementia, three-quarters of the DLB cohort had hallucinations, and nearly two-thirds were functionally impaired. The proportion of other serious health conditions also increased, indicating a high comorbidity and geriatric syndrome burden. Comprehensive geriatric assessment is strongly recommended for DLB patients from the time of diagnosis until death to reduce disability and comorbidities. NCT05052450.

Assessment of Clinical Features in HIV-Infected Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention in China.

Objectives We aimed to compare coronary risk factors, burden of coronary artery disease (CAD), and 1-year prognosis of people living with HIV (PLWH) and HIV-negative controls who underwent percutaneous coronary intervention (PCI) for acute coronary syndromes (ACSs). Background Cardiovascular disease is drawing more and more attention in PLWH since effective antiretroviral therapy (ART) has been available. Clinical characteristics and outcomes of PLWH undergoing PCI for ACS in China remain unknown. Methods We compared demographic characteristics, angiographic features, and 1-year outcomes of 48 PLWH versus 48 HIV-negative controls matched for age (±2 years), sex, diabetes mellitus, and year of PCI (±2 years) in Beijing Ditan Hospital, Capital Medical University from January 2008 to November 2020. Results In PLWH (mean age: 53.6 ± 10.6 years, 95.8% male, and 79.2% on ART), high-density lipoprotein cholesterol was lower than in HIV-negative controls; however, the statin use was more common, the incidence of hypertension was lower, and low-density lipoprotein cholesterol, and the body mass index were significantly lower than in controls. Two groups had a similar extent of coronary atherosclerosis as measured by the presence of multivessel diseases and the median Gensini score; however, lesions of PLWH were longer and were more likely to locate at the proximal segment of the coronary artery. In addition, the risk of major adverse cardiac and cerebrovascular events at 1 year was similar in both groups. Conclusion PLWH undergoing PCI displayed similar CAD burden and 1-year prognosis compared with HIV-negative patients. Early detection of cardiovascular risk factors and appropriate secondary prevention of CAD in PLWH might alleviate the risk of severe adverse cardiovascular events.

Onychomycosis: Recommendations for Diagnosis, Assessment of Treatment Efficacy, and Specialist Referral. The CONSONANCE Consensus Project.

IntroductionOnychomycosis is the most common nail disorder in adults, with high recurrence and relapse rates. Its diagnosis may be difficult by non-experts because the clinical signs may overlap with other dermatoses. The treatment may be challenging, as it should be patient-tailored.MethodsAn online survey was conducted among European Nail Society (ENS) members to provide recommendations on the diagnosis and assessment of distal lateral subungual onychomycosis (DLSO) in non-specialized clinical environments, as well as recommendations for patient referral.ResultsDLSO diagnosis is predominantly based on clinical aspects, and microscopy and fungal culture are commonly employed to establish the diagnosis. Assessment of clinical features is the main method for DLSO follow-up, and the main criterion to define cure is a combination of mycologic cure and clinical cure. The most commonly selected treatments for onychomycosis include oral antifungals, topical antifungals, and nail debridement. According to the nail experts, predisposing factors of DLSO to be evaluated include concurrent tinea pedis diagnosis, immunocompromised status, and diabetes. The minimum clinical aspects to be evaluated for DLSO diagnosis should include subungual hyperkeratosis, white-yellow-orange subungual scales, and absence of salmon-pink coloration. Recommendations for clinical signs that should be evaluated to confirm treatment effectiveness include normal appearance and color of the nail, reduction or absence of scales under the nail, and absence of onycholysis. Recommendations for specialist referral include lack of treatment effectiveness, need of additional therapies, concurrent presence of other diseases or comorbidities, severe DLSO, and presence of a dermatophytoma or involvement of the nail matrix.ConclusionsAccording to the surveyed nail experts, after evaluating clinical signs and predisposing factors for DLSO, the diagnosis should include subungual hyperkeratosis, nail color (yellow-orange), and onycholysis and thickening. In cases of severe DLSO, when there is treatment failure, concomitant diseases/comorbidities, presence of a dermatophytoma or involvement of the nail matrix, or involvement of several/all nails, referral should be considered.Supplementary InformationThe online version contains supplementary material available at 10.1007/s13555-022-00698-x.

Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark

BackgroundHypophosphatasia (HPP) is an inborn disease caused by pathogenic variants in ALPL. Low levels of alkaline phosphatase (ALP) are a biochemical hallmark of the disease. Scarce knowledge about the prevalence of HPP in Scandinavia exists, and the variable clinical presentations make diagnostics challenging. The aim of this study was to investigate the prevalence of ALPL variants as well as the clinical and biochemical features among adults with endocrinological diagnoses and persistent hypophosphatasaemia. MethodsA biochemical database containing ALP measurements of 26,121 individuals was reviewed to identify adults above 18 years of age with persistently low levels of ALP beneath range (≤ 35 ± 2.7 U/L). ALPL genetic testing, biochemical evaluations and assessment of clinical features by a systematic questionnaire among included patients, were performed. ResultsAmong 24 participants, thirteen subjects (54.2%) revealed a disease-causing variant in ALPL and reported mild clinical features of HPP, of which musculoskeletal pain was the most frequently reported (n = 9). The variant c. 571G > A; p.(Glu191Lys) was identified in six subjects, and an unreported missense variant (c.1019A > C; p.(His340Pro)) as well as a deletion of exon 2 were detected by genetic screening. Biochemical analyses showed no significant differences in ALP (p = 0.059), the bone specific alkaline phosphatase (BALP) (p = 0.056) and pyridoxal-5′-phosphate (PLP) (p = 0.085) between patients with an ALPL variant and negative genetic screening. Patients with a variant in ALPL had significantly higher PLP levels than healthy controls (p = 0.002). We observed normal ALP activity in some patients classified as mild HPP, and slightly increased levels of PLP in two subjects with normal genetic screening and four healthy controls. Among 51 patients with persistent hypophosphatasaemia, fifteen subjects (29.4%) received antiresorptive treatment. Two patients with unrecognized HPP were treated with bisphosphonates and did not show complications due to the treatment. ConclusionsPathogenic variants in ALPL are common among patients with endocrinological diagnoses and low ALP. Regarding diagnostics, genetic testing is necessary to identify mild HPP due to fluctuating biochemical findings. Antiresorptive treatment is a frequent reason for hypophosphatasaemia and effects of these agents in adults with a variant in ALPL and osteoporosis remain unclear and require further studies.

Assessment of clinical profile of multi drug resistant tuberculosis patients

Background: Drug-resistant tuberculosis (DR-TB) has become a significant public health problem in number of countries and one of the major obstacles in effective tuberculosis control programme. The present study was conducted to assess clinical profile of multi drug resistant tuberculosis patients.Materials & Methods: 82 patients of drug resistant TB of both genders were included and all were subjected to chest X-ray and mantoux test. Assessment of clinical features, type and treatment outcome was recorded.Results: Out of 82 patients, males were 52 and females were 30. Clinical features were fever in 69, cough in 56, loss of appetite in 28, loss of weight in 14 and past history in 6. Type of drug resistance was contact with partial XDR in 10, MDR in 6, MDR with contact in 30 and partial XDR in 36 patients. Type of tuberculosis was pulmonary TB in 40, disseminated TB in 26, TB lymphadenopathy in 9 and abdominal TB in 7 cases. The difference was significant (P

Assessment of clinical features and determinants of mortality among cancer patients with septic shock of pulmonary origin: A prospective analysis

Assessment of clinical features and determinants of mortality among cancer patients with septic shock of pulmonary origin: A prospective analysis

Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients.

The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in Covid-19 disease. In this retrospective study, we analysed the clinical features of patients diagnosed with Covid-19 and investigated the effect of Covid-19 on kidney function. Ninety-six patients diagnosed with Covid-19 were included in our study. Demographic features (Age, gender, co-morbidities), symptoms, thorax CT findings, Covid-19 PCR results and laboratory findings were recorded. The clinical features of the patients were analysed and kidney function values before Covid-19 diagnosis were compared with kidney function values after Covid-19 diagnosis. Most presenting symptom was fever (51%). Most accompanying co-morbidity was hypertension (56%). According to laboratory findings; ferritin, D-dimer and C-reactive protein levels were statistically significantly higher in ARDS group than severe pneumonia and pneumonia group (P=.002, P=.001 and P<.001, respectively). Also lymphocyte levels were statistically significantly lower in ARDS group than severe pneumonia and pneumonia group (P=.042). According to KDIGO criteria 3 (3.1%) patients had AKI during the hospital stay. For all patients, there was statistically significant difference between basal, 1st, 5th and 10th day BUN and SCr levels (P=.024 and P=.018, respectively). For severe pneumonia group there was statistically significant difference between basal, 1st, 5th and 10th day SCr levels (P=.045). Our study demonstrated that Covid-19 can cause renal impairment both with pneumonia and ARDS. A large-scale prospective randomised studies are needed to reach final judgement about this topic.

Diagnosis of obstructive sleep apnoea-A review

Obstructive sleep apnoea (OSA) is a breathing disorder that takes place during sleep and it involves a decreased or complete cessation in airflow despite the effort to breathe. The diagnosis of obstructive sleep apnoea syndrome (OSAS) requires the combined assessment of clinical features and the assessment of abnormal breathing during sleep. Current evidence indicates that attempts to base the diagnosis of the clinical syndrome on either aspect alone are unreliable. In this review article, we will discuss various modalities to make diagnosis of obstructive sleep apnoea by various ways. Keywords: Sleep Apnoea, Diagnosis, Hypopnoea, OSA, OSAS.

Addition of Slowly Repeated Evoked Pain Responses to Clinical Symptoms Enhances Fibromyalgia Diagnostic Accuracy.

Fibromyalgia is a chronic pain syndrome characterized by central sensitization. A novel protocol based on slowly repeated evoked pain (SREP) appears to be a useful marker of pain sensitization in fibromyalgia patients. Whether SREP enhances diagnostic accuracy beyond key clinical symptoms that characterize fibromyalgia has not been examined. Fifty fibromyalgia patients, 30 rheumatoid arthritis patients, and 50 healthy individuals were evaluated to assess clinical pain, as well as fatigue, insomnia, pain catastrophizing, and negative mood. The SREP protocol consisted of a series of nine low-intensity painful pressure stimuli of five seconds' duration with 30-second interstimulus intervals. SREP sensitization was indexed by increases in pain intensity ratings across stimuli. SREP sensitization was observed in fibromyalgia but not in rheumatoid arthritis or healthy individuals. As expected, fibromyalgia patients exhibited a more negative psychosocial profile than did rheumatoid arthritis patients and healthy individuals. SREP was positively associated with clinical pain, fatigue, insomnia, and catastrophizing, but not with negative mood. SREP discriminated fibromyalgia cases from rheumatoid arthritis and healthy individuals even when current clinical pain was included in the analysis. Combining fatigue, insomnia, and SREP led to near perfect diagnostic accuracy (99%) in differentiating fibromyalgia from healthy individuals and 86.3% accuracy in discriminating fibromyalgia from rheumatoid arthritis. These results provide further evidence of SREP as a marker of pain sensitization in fibromyalgia and suggest that it captures aspects of fibromyalgia not fully captured by clinical features. Combining SREP with assessment of clinical features could potentially improve fibromyalgia diagnosis.

Role of Percutaneous Computed Tomography-guided Lung Biopsy in Non-resolving Consolidation and Identification of Clinical and High-resolution Computed Tomography Characteristics Predicting Outcome.

Objective:Non-resolving consolidation (NRC) with inconclusive sputum, bronchoscopy, and bronchoalveolar lavage results poses a diagnostic dilemma. This retrospective analytical study was conducted to evaluate diagnostic yield and complications of percutaneous computed tomography (CT)-guided lung biopsy (PCLB) in NRC. Assessment of clinical features and high-resolution CT (HRCT) characteristics was also done which may predict outcome.Materials and Methods:Data of PCLB performed for lung consolidation from January 2010 to January 2019 were retrospectively evaluated. For the determination of diagnostic yield, a positive result from any one specimen obtained by PCLB (tissue core, aspiration cytology, or microbiology) was sufficient to considered procedure diagnostic if it was concordant with clinical features, imaging findings, response to treatment, and subsequent follow-up. Student’s t-test and Fisher’s exact test were used for statistical analysis.Results:Out of total 56 patients, final diagnosis was achieved in 48 (19 malignant and 29 benign). Diagnostic yield was 69.6%. Complications were noted in 10 patients including mild hemoptysis and pneumothorax, which were managed conservatively. No clinical feature was having statistically significant association with final diagnosis. HRCT findings significantly associated with malignant outcome were larger size of consolidation, multiple contiguous lobe involvement, multiple air-filled cysts inside consolidation, and associated ground-glass areas or multiple ground-glass nodules. The absence of air bronchogram was more common in benign cases.Conclusion:PCLB is a safe and useful method for obtaining specimen in NRC. Differentiation of benign from malignant outcome is not possible based on clinical findings; however, certain HRCT findings raise suspicion of malignancy.

Assessment of clinical features and determinants of mortality among cancer patients with septic shock of pulmonary origin: a prospective analysis

BackgroundPneumonia-associated septic shock (PASS) in patients with cancer inflicts healthcare burden attributed to high morbidity and mortality. Current study was aimed to evaluate the clinical outcomes, microbiological characteristics, risk factors...

Some new approaches for prevention of schizophrenia spectrum disorders in patients exposed to exogenous stressors

Background Environment factors affects to the clinical phenotype of schizophrenia spectrum disorders. Aim To develop recommendations for the prevention schizophrenia spectrum disorders considering the influence of environment factors on the clinical pathomorphosis of the disease. Methods It was conducted the psychopathological and psychodiagnostic survey of 186 patients with schizophrenia spectrum disorders with an assessment of clinical features and level of social functioning. It was identified factors that have the most significant pathological effects on the course of disorders on the basis of the received data: the using of a cannabinoid in a family history, mother`s infectious and somatic diseases during pregnancy, mother's using alcohol during pregnancy, consumption of alcohol in adolescent patients, fetal hypoxia or perinatal trauma of the patient at birth, problems with the group of primary support in the family of a child in childhood, maternal toxicosis, crisis relationships in the family, migration to different cultural environment. Results Clinical pathomorphism of disorders of the spectrum of schizophrenia under the influence of environment factors determines the features of psychotherapeutic interventions. In people with cannabinoids, it is important to eliminate the symptoms of anxiety through emotion-supportive measures, as well as to create a motivation to ask help in case of symptoms of schizophrenia spectrum disorders. In a group with perinatal complications, the emphasis should be put on cognitive methods in order to correct mental disorders and overcome hypochondria. Early measures to form a positive attitude towards themselves and the environment, supporting family relationships, overcoming depressive symptoms, and developing social activity are targets of psychotherapeutic interventions in people with schizophrenic spectrum disorders and psychological traumatic events. Conclusion Minimization of environmental factors influence in high risk individuals would postpone early manifestation, reduce disability in patients with schizophrenia spectrum disorders, as evidenced by the statement of leading health experts.

Assessment of Clinical Features and Presentation of Breast Diseases at a Tertiary Care Hospital of Telangana

Assessment of Clinical Features and Presentation of Breast Diseases at a Tertiary Care Hospital of Telangana

Accidental poisoning its magnitude and implications in children

incidence, and mortality in pediatric population.Objective: Estimating the magnitude and assessing the pattern of AP in children was the primary objective. Describing the affected age group, common agents, and assessment of clinical features were the secondary objectives.Materials & Methods: Children aged 1month- 12years with history of AP were included; those with allergic reactions to plant products, food and idiosyncratic reactions to drugs were excluded.Result: 101 children accounted for 1.7% of total pediatric admission. Accidental ingestion of poisons (90.09%) and poisoning due to insect and snake bites (9.90%) were reported. Males (n=62) outnumbered females. Patients from urban area (68.2 %), children aged1-3 years (56.43%) wereaffected the most. All incidents were unintentional and occured in the home surroundings.April (n=21), March (n=20) recorded higher number followed by December (n=14). Hydrocarbon poisoning (43.56%) was most common followed by poisoning due to medicaments (18.8 %,), chemicals (12.87%), and food poisoning (9.90%). Insect bites & stings were seen in 9.90%. Supportive treatment was given to 49.5%, further gastric absorption prevented in 24.45 % and specific antidote to 7.9% patients.Three patients died due to scorpion bite, Phenytoin and kerosene ingestion.Conclusion: AP is a preventable emergency. Incidence, agents, clinical features, treatment administered and therapeutic outcome of AP in children are comparable to the available national data. Preventive measures, strict legislative actions and restriction of availability of hazardous chemicals will reduce the incidence.

Age-related clinical features of chronic heart failure and structural-functional changes in the heart on the background of overweight and obesity

The results of epidemiologic researches in European countries and USA demonstrated that the prevalence of chronic heart failure (CHF) varies within 0,4-2,5 %. The aim of research –an assessment of clinical features of CHF and structural-functional changes in the heart on the background of overweight and obesity in patients of the different age groups. Methods . It was examined 300 patients of the different age groups with CHF of 1-111 functional class (FC) on the background of overweight and abdominal obesity of 1-111 degree. Depending on division of indicators there was used an unpaired Student t-criterion or Mann-Whitney U-criterion. Results . In examined patients with overweight and obesity CHF progress with age that declares itself by FC increase and of body mass index (BMI) decrease. The clinical course of CHF in elder age is characterized by the spread of the permanent form of atrial fibrillation. With age CHF of combined etiology is more often. The structural changes in the heart at CHF in elder patients are characterized by the more significant dilatation of the left atrial and hypertrophy of the left ventricle of concentric type. The clinical course of CHF in elder age is characterized by an increase of frequency of systolic dysfunction of the left ventricle and formation of the lung hypertension. Conclusions : It was established that in examined patients with CHF on the background of an overweight and obesity with age took place an increase of FC of disease, the prevalence of CHF of combined etiology and decrease of BMI. In elder patients with CHF it were observed the more apparent spread of the permanent form of atrial fibrillation and the dilatation of the left atrial and hypertrophy of myocardium of concentric type. Functional changes in the heart in examined patients of an elder age group are characterized by the more frequent systolic dysfunctio ns of the left ventricle and formation of the lung hypertension.

Percutaneous Drainage may not be Necessary in a Significant Subset of Patients with Complicated Liver Abscess

Background and Aims: Clinical outcomes of liver abscess are changing, even in South Asia, where parasitic infections are common. We wanted to capture this emerging spectrum in ‘‘real life’’ through assessment of clinical features, management strategies, and outcomes of a cohort of treated liver abscess patients at a single center. Methods: In this retrospective study of patients admitted to a referral institution between February 2010 and June 2014, patients with liver abscess, who had received prior treatment in another hospital and then been referred for complicated illness, were studied; their demographics, presentations, evolution, and outcomes were analyzed. Results: A total of 154 patients [males 109, 70.78%), mean age 43.71 16.49 years] were included in this study. Alcohol was the commonest (n = 36, 23.38%) predisposing factor, followed by biliary obstruction (n = 32, 20.78%) and diabetes (n = 17, 11.04%). The most common presenting features were fever, pain abdomen, and jaundice [143 (92.86%), 133 (86.36%) and 32 (20.78%) respectively]. Majority of patients (90, 58.44%) had solitary liver abscess, right lobe being commonest location (94, 61.04%). Median abscess volume was 180 mL (7–1524 mL); abscess rupture occurred in 21 (13.64%) cases, most commonly to subdiaphragmatic location (12/21). Overall, 97 (63%) patients required abscess drainage [single time aspiration 15 (15.46%), percutaneous indwelling catheter in 80 (82.47%), and surgical drainage in 2 (2.06%)]. Patients who required percutaneous drainage were mostly males, had higher abscess volumes, and were more frequently alcohol users and diabetics (data provided in table). Six (3.9%) of the patients died during study period. Higher bilirubin level, shortness of breath, higher volume of abscess, and requirement of surgery were more frequent in non-survivors. Conclusion: While large abscess, alcoholism, and diabetes were associated with increased need for catheter drainage; 37% can be treated by drug therapy alone. Careful selection of subjects for drainagemight avoid premature mortality in this benign condition.

Elevated percentage of HLA-DR+ and ICAM-1+ conjunctival epithelial cells in active Graves’ orbitopathy

BackgroundTo evaluate if conjunctival epithelial cells’ expression of HLA-DR and ICAM-1 could be helpful as early topical markers of inflammation in Graves’ orbitopathy (GO).MethodsThe ocular examination evaluated a clinical activity score (CAS) by assessment of clinical features, (e.g., eyelid or conjunctival inflammation, lid width, lid closure, proptosis, ocular motility). Conjunctival epithelial cell specimens for flow-cytometric evaluations of ICAM-I and HLADR expression were collected by impression cytology from ten eyes with active GO (CAS ≥ 4 and duration ≤ 12 months), from 15 eyes with Graves’ disease (GD) without active GO (CAS 0–2) and from 15 normal specimens without any ocular disorders.ResultsThe percentage of HLA-DR + conjunctival epithelial cells was significantly elevated in patients with active GO comparing to GD without active GO and healthy controls, 10.7 % (8.5–17.7) and 7.78 % (3.92–10.1) (p < 0.05) vs. control 4.89 % (3.5–5.5) (p < 0.005), respectively. The expression of ICAM − 1+ conjunctival epithelial cells was greater only in patients with GO vs. controls, 5.5 % (4.8–7.03) and 1.46 % (0.69–2.51) (p < 0.005), respectively.ConclusionThe percentage of HLA-DR+ and ICAM-1+ conjunctival epithelial cells in patients with the active GO may serve as a topical inflammation marker in Graves’ orbitopathy.

An assessment of clinical features and operative treatment in non-infiltrating and infiltrating angiolipoma

An assessment of clinical features and operative treatment in non-infiltrating and infiltrating angiolipoma

Assessment of Clinical Features and Pulmonary Functions Associated With Frequent Acute Exacerbations in COPD Patients

Assessment of Clinical Features and Pulmonary Functions Associated With Frequent Acute Exacerbations in COPD Patients