Correlation Of Aspiration Cytology Research Articles

Ultrasonography and Fine Needle Aspiration Cytology Correlation of Thyroid Lesions

Ultrasonography and Fine Needle Aspiration Cytology Correlation of Thyroid Lesions

Efficacy of Ultrasound Intrinsic Compression Strain Elastography in Prediction of Malignancy in Thyroid Nodules with Fine Needle Aspiration Cytology Correlation

Background: Different diagnostic modalities are used to evaluate and diagnose efficiently thyroid nodules. These include Clinical Examinations, Thyroid Function Test (TFT), Scintiscan, Ultrasonography (USG), Fine Needle Aspiration Cytology (FNAC), and Histopathological examination. However, clinical assessment, TFT and USG have been poor parameters for assessing thyroid nodules. The objective is to this study was aimed to evaluate the efficacy of Ultrasound Elastography for the prediction of malignancy in thyroid nodule. Subjects and Methods:After obtaining written informed consent, demographic data such as age, sex and clinical features like, swelling, mode of onset, difficulty in swallowing, difficulty in breathing, hoarseness of voice obtained through an interview and recorded on predesigned and pretested proforma (Annexure II). Further these patients were subjected Grayscale Ultrasound, Ultrasound Elastography and FNAC. Results: Malignant lesions were noted in 19 patients on FNAC. Among them, 16 (84.21%) patients had malignant lesions while 3 (15.79%) patients had benign lesions based on combined USE and ECI criteria. This difference was statistically significant (p<0.001). The sensitivity of combined USE and ECI criteria in the diagnosis of malignant lesions was 84.21% with Specificity of 81.69%, PPV 55.17% and NPV 95.08%. Conclusion: Based on the findings of this study it may be concluded that, USE as determined by the Ragos criteria, TI RADS score are highly associated with malignant thyroid lesions and useful in differentiating the malignant thyroid lesions from benign ones.

Ultrasonographic and fine needle aspiration cytology correlation of thyroid gland lesions: a study of 100 cases

<p class="abstract"><strong>Background:</strong> Thyroid gland is unique among endocrine organs as it is the largest endocrine gland in the body and the first to develop in the fetal life. There is approximately 4-5% incidence of clinically apparent thyroid lesions in general population. The goal of USG and FNAC diagnosis work up now is to select those patients for surgery who have a high likelihood of harboring malignancy in the nodule. Ultrasonography is the single most valuable imaging modality in the evaluation of the thyroid gland. Indications for thyroid USG include evaluation for palpable thyroid lesion or suspected thyroid enlargement and workup of thyroid lesions discovered incidentally.The present study is undertaken to evaluate the utility of FNAC in preoperative diagnosis of various thyroid lesions and to evaluate the efficacy of in USG and FNAC differentiating between benign and malignant lesions.</p><p class="abstract"><strong>Methods:</strong> A retrospective clinical study, 100patients, in the age group of equal to or above 18 years, with thyroid swellings, referred to the department of ENT, sent for USG and FNAC at radiology and pathology department during the period from July 2014 to July 2016. </p><p class="abstract"><strong>Results:</strong> Out of 100 cases, 6% were malignant, 94% were benign on grey scale ultrasound. Out of 6 malignant cases 2 cases were confirmed malignant by FNAC.</p><p class="abstract"><strong>Conclusions:</strong> High resolution grey scale ultrasound has emerged as initial imaging modality of choice for the evaluation of patients with thyroid enlargement. Ultrasound can detect solitary nodule, multiple nodules and diffuse thyroid enlargement. It can also differentiate solid and cystic lesions.</p>

Clinico-Radiological and Pathological Correlation of Breast Lesions in Patients Presenting to a Tertiary Hospital in Western Nepal

INTRODUCTION: Breast masses are frequently encountered problem, especially in females. Mammography and ultrasound are considered the standard imaging techniques for detection and evaluation of breast disease. The study was done to discuss the role of mammography and ultrasound in evaluation of breast mases with cytological correlation and to compare the sensitivity, specificity, positive predictive value and negative predictive value of ultrasonography6 with mammography in breast masses in different age groups and in patients with different breast density.MATERIALS AND METHODS: It was a non randomized prospective study carried out in Manipal teaching hospital Pokhara. The data for study was collected from patients with breast lump who attended the department of Radiology during the period from October 2013 to October 2014. Mammography and ultrasonography were performed on all cases presented with breast lump. A Fine needle aspiration cytology correlation was then performed with formed the basis for definitive judgement.RESULTS: The study analyzed 50 total numbers of patients presented to Radiology department who had breast lumps. Patients were aged between 20 and 75 years. Maximum numbe3r of patients were between 40 and 49 yrs constituting 40%. The mean age was 39.8 years ± 12.85 yrs. Ultrasound was significantly more sensitive than mammography in age less than 40 years. Mammogram had a significantly higher sensitivity than ultrasound in age group of more than 40 yrs. By using combined modalities (ultrasonography combined with mammogram), all benign cases were diagnosed correctly. For malignant breast masses, 10% were diagnosed as false negative but no cases were diagnosed false positive by combined modalities. Ultrasound was more sensitive than mammography in dense and heterogeneously dense breast whereas mammography was more sensitive than ultrasound in predominantly fatty breast.CONCLUSION: Combination of ultrasound and mammogram is more sensitive than other modality alone.Journal of Universal College of Medical Sciences, Vol. 5, No. 2, 2017, Page: 40-44

Evaluation of breast lesions by digital mammography and ultrasound along with fine-needle aspiration cytology correlation.

Screening and diagnostic efforts for breast cancer are critical because the disease has a high rate of successful outcomes with early identification and treatment. The mammography (MG) and Ultrasonography/ ultrasound (USG) are individually effective diagnostic modalities for detection of breast pathologies. This cross-sectional, prospective, hospital-based study was carried out with an aim to evaluate breast lesions using digital MG and ultrasonography (USG) independently and in combination with fine-needle aspiration cytology (FNAC) correlation. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MG in detecting carcinoma breast were 77.77%, 97.72%, 87.5%, and 95.55%, respectively. The sensitivity, specificity, PPV, and NPV of USG in detecting carcinoma breast were 55.55%, 97.72%, 83.33%, and 91.48%, respectively. In our study population, 83.01% of breast lesions were benign, and of them, 77.27% were diagnosed by MG alone and 72.72% were diagnosed by USG alone. When these modalities were combined, 97.72% of the lesions were diagnosed. The correlation coefficients of MG alone (0.792), USG alone (0.631), and MG and USG combination (0.884) with FNAC are all positive, and P values are significant of all the modalities. This study confirms that the MG and ultrasound (USG) when combined have significantly higher sensitivity and NPV than observed for a single modality in detecting the both benign and malignant lesions of the breast.

“Ultrasongraphic And Colour Doppler Evaluation of Cervical Lymphadenopathy with fine Needle Aspiration Cytology Correlation.”

“Ultrasongraphic And Colour Doppler Evaluation of Cervical Lymphadenopathy with fine Needle Aspiration Cytology Correlation.”

Preoperative fine needle cytology and imaging facilitates the management of submandibular salivary gland lesions

Lesions of the submandibular gland represent a pleomorphically diverse group in which benign and malignant pathologies are difficult to differentiate from each other. Accurate diagnosis and surgical intervention relies upon clinical presentation, examination and investigations to guide appropriate management. The current series aimed to identify the roles of preoperative cytology and imaging with subsequent histopathology in the management of these lesions. Between 1998 and 2008, 54 patients of median age 54 years (range 25-94), with a male : female ratio of 1:3.5 were identified, of which, 50 patients underwent 52 excisions of the submandibular gland. Demographic data were recorded. The utility of imaging and cytology were analysed, and the accuracy of cytology correlated with histology. Pathologies of resected specimens were sialadenitis 17 (32%), pleomorphic adenomas nine (17%), calculi eight (15%), lymphoma five (10%), squamous cell carcinoma two (4%), adenoid cystic carcinoma one (2%) and other 10 (20%). Twenty-eight patients (52%) underwent fine-needle aspiration cytology/core biopsies, of which 25 (89%) were correlated with histology. The accuracy, sensitivity and specificity of the fine-needle aspiration cytology correlation with histology were 88.0%, 71.4% and 94.4%, respectively. Overall, the complication rate was 9.6%; involving five temporary nerve palsies of the marginal mandibular branch of the facial nerve, including one temporary lingual nerve palsy. This series demonstrates histological outcomes in patients specific to the submandibular salivary gland. The malignancy rate was low compared to current published literature. The transcervical surgical approach to submandibular gland pathology is a safe and effective method with minimal morbidity when performed by experienced surgeons. No single investigative modality can be solely aligned with diagnosing a specific lesion of the submandibular gland.

Myxoid liposarcoma: A case report of a sentinel metastasis to the parotid gland with molecular confirmation

Myxoid liposarcoma is a subtype of liposarcoma with a predilection for the deep soft tissues of the extremities that accounts approximately for 10% of all adult soft tissue sarcomas. We report a case of a metastatic myxoid liposarcoma to the parotid gland, with fine-needle aspiration cytology correlation and molecular characterization. The lesion was diagnosed in a 53-year-old Hispanic male who presented with a left posterior thigh mass. A core needle biopsy established the diagnosis of myxoid liposarcoma. The patient underwent limb-sparing, wide local excision of the malignancy and later presented with an initial metastatic lesion to the parotid gland. The diagnosis of metastatic myxoid liposarcoma was rendered by fine-needle aspiration cytology with cell block preparation, and molecular confirmation. Although myxoid/round cell liposarcomas are classically described as having minimal pleomorphism on cytologic material, we encountered significant pleomorphism in our case. Therefore, a diagnosis of myxoid/round cell liposarcoma should still be a diagnostic consideration even if markedly pleomorphic cells are seen in fine-needle aspiration biopsies.

GS36P PREOPERATIVE FINE NEEDLE CYTOLOGY AND IMAGING FACILITATES THE MANAGEMENT OF SUBMANDIBULAR SALIVARY GLAND LESIONS

Purpose: Lesions of the submandibular gland represent a pleomorphically diverse group making benign and malignant lesions difficult to differentiate from each other. The current series aims to identify the roles of pre‐operative cytology and imaging with subsequent histopathology in the management of these lesions.Methods: Between 1998 and 2008 fifty‐four patients, of median age 54 years (range 25–94), were retrospectively identified. Fifty patients underwent fifty‐two surgical procedures involving the submandibular gland. The utility of imaging and cytology was analysed, and the accuracy of cytology correlated with histopathology.Results: Pathologies of resected specimens included: sialadenitis; 17 (32%), pleomorphic adenoma; 9 (17%), calculi; 8 (15%), lymphoma; 5 (10%) squamous cell carcinoma; 2 (4%), adenoid cystic carcinoma; 1 (2%) and other; 10 (20%). Twenty‐eight patients (52%) underwent fine needle aspiration cytology/core biopsies; of these 25 proceeded to surgery. Accuracy, sensitivity, and specificity of fine needle aspiration cytology correlation with histology were 88.0%, 71.4%, and 94.4% respectively. Overall, the complication rate was 9.6%.Conclusion: This series demonstrates histological outcomes in patients specific to the submandibular salivary gland for which there are few comparative series in the literature. The trans‐cervical surgical approach to submandibular gland pathology is a safe and effective method with minimal morbidity. Combining investigative modalities and cytology optimises the diagnosis and management of submandibular salivary gland lesions.

Secretory carcinoma of the male breast: Correlation of aspiration cytology and pathology

Secretory carcinoma (SC) is a rare variant of breast carcinoma, which was first described in children and adolescents but it can occur at all ages. Very few cases have been reported in male patients. We describe the cytological and histopathological features of SC in a 79-yr-old man. Cytological findings demonstrated cohesive sheets of monotonous cells with round nuclei and small nucleoli. Most cells contained intracytoplasmic vacuoles, which are the key feature of an accurate diagnosis. Differential diagnosis with other tumors is discussed briefly.

1012 - Correlation of Aspiration Cytology of the Prostate in Tissue Prostate Biopsy

No AccessJournal of Urology1 Jun 1987Correlation of Aspiration Cytology of the Prostate in Tissue Prostate Biopsy Joseph R. Drago, Pete Acetta, James Simon, Evangelos Geraniotis, and Sedigheh Keyhani-Rofagha Joseph R. DragoJoseph R. Drago More articles by this author , Pete AcettaPete Acetta More articles by this author , James SimonJames Simon More articles by this author , Evangelos GeraniotisEvangelos Geraniotis More articles by this author , and Sedigheh Keyhani-RofaghaSedigheh Keyhani-Rofagha More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)76160-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Correlation of Aspiration Cytology of the Prostate in Tissue Prostate Biopsy." The Journal of Urology, 137(6), p. 356A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 356A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Joseph R. Drago More articles by this author Pete Acetta More articles by this author James Simon More articles by this author Evangelos Geraniotis More articles by this author Sedigheh Keyhani-Rofagha More articles by this author Expand All Advertisement PDF downloadLoading ...

Prostatic biopsy. A morphologic correlation of aspiration cytology with needle biopsy histology.

One hundred and eighteen aspiration biopsies of the prostate are correlated with needle biopsies. The overall accuracy of the needle biospy is 85.6% and that of the aspirates is 86.6%. The author recommends that both techniques should be used simultaneously in the diagnosis of carcinoma of the prostate. Descriptions are given of benign and malignant cell types in prostatic aspirates, with special emphasis on the features differentiating benign atypia of prostatic cells from well-differentiated adenocarcinoma, as this is potentially an important source of false-positive reports in aspiration smears.