Aspects Of Toxins Research Articles

Which snake venom would be the deadliest?

Snakebites constitutes a public health problem worldwide and is a neglected tropical disease. It causes at least 120000 death each year and amputations account for about three times as many deaths. This paper explores the toxicity of three types of snake venom including hemotoxic venom, neurotoxic venom, and cytotoxic venom in the aspects of toxins contained, mechanism consequents as well as their future prospect as anticancer agents.

Toxins by first-principles: Electronic structure mapping structural changes

In this work, we apply first-principles calculations combined with model potential dynamics simulations to investigate structural and electronic aspects of toxins. The dynamics were carried out for ω-conotoxins MVIIA and MVIIC as well as for mutated structures in which tyrosine at position 13, a key residue for the toxin function, was replaced by alanine. An analysis of the electronic structure of specific snapshots shows that structural changes may be mapped in the local electronic behavior of carbonyl groups.