Aspects Of Cognitive Function Research Articles

Boosting decision-making in rat models of early-life adversity with environmental enrichment and intranasal oxytocin

Impaired decision-making constitutes a fundamental issue in numerous psychiatric disorders. Extensive research has established that early life adversity (ELA) increases vulnerability to psychiatric disorders later in life. ELA in human neonates is associated with changes in cognitive, emotional, as well as reward-related processing. Maternal separation (MS) is an established animal model of ELA and has been shown to be associated with decision-making deficits. On the other hand, enriched environment (EE) and intranasal oxytocin (OT) administration have been demonstrated to have beneficial effects on decision-making in humans or animals. Given these considerations, our investigation sought to explore the impact of brief exposure to EE and intranasal OT administration on the decision-making abilities of adolescent rats that had experienced MS during infancy.The experimental protocol involved subjecting rat pups to the MS regimen for 180 min per day from postnatal day (PND) 1 to PND 21. Then, from PND 22 to PND 34, the rats were exposed to EE and/or received intranasal OT (2 μg/μl) for seven days. The assessment of decision-making abilities, using a rat gambling task (RGT), commenced during adolescence. Our findings revealed that MS led to impaired decision-making and a decreased percentage of advantageous choices. However, exposure to brief EE or intranasal OT administration mitigated the deficits induced by MS and improved the decision-making skills of maternally-separated rats. Furthermore, combination of these treatments did not yield additional benefits. These results suggest that EE and OT may hold promise as therapeutic interventions to enhance certain aspects of cognitive performance.

Effects of Various Caffeine Doses on Cognitive Abilities in Female Athletes with Low Caffeine Consumption.

Caffeine (CAF), a prevalent psychoactive stimulant, is believed to potentially enhance cognitive ability. However, studies on the effects of various doses are limited and yield inconsistent results, particularly in female athletes. Therefore, we aimed to assess the association between three different dosages of CAF intake (low, moderate, and high) and cognitive skills in female athletes with low CAF consumption. This study had a randomized, crossover, double-blind design in which each athlete performed four experimental sessions after ingesting either a placebo (PLAC), 3 mg·kg-1 of CAF (3 mg of CAF), 6 mg·kg-1 of CAF (6 mg of CAF), or 9 mg·kg-1 of CAF (9 mg of CAF) with an in-between washout period of at least 72 h. Following a 60 min window post-capsule consumption, fourteen female athletes (age: 17.4 ± 0.8 years) were assessed through various cognitive tests, namely, simple reaction time (SRT), choice reaction time (CRT), and attentional task (AT) tests, along with the mental rotation test (MRT). Additionally, they were required to complete a questionnaire about the undesirable side effects of CAF. Our results indicated that, compared to those of PLAC, the SRT, CRT, and AT performance were significantly improved following the administration of both 3 mg of CAF and 6 mg of CAF. While the greatest enhancement was observed after consuming 3 mg of CAF, no significant differences were found between the effects of 3 mg and 6 mg of CAF. Interestingly, MRT performance did not improve with any of the CAF dosages. Moreover, the ingestion of 9 mg of CAF did not enhance cognitive skills and was linked to the highest occurrence of CAF-related side effects. In conclusion, our results highlight the recommendation for a low CAF dosage of 3 mg·kg-1, in contrast to a higher dose of 6 mg·kg-1 or 9 mg·kg-1 of CAF, to enhance various aspects of cognitive performance in female athletes with low CAF consumption without adverse side effects.

Relationship Between Mental Workload and Cognitive Function in the Academic Staff of Shahid Sadoughi University of Medical Sciences, Yazd, Iran, 2022

Background: Academic staff have different roles which may impose a high mental workolad on them and affect their cognitive function. This study was designed to assess different subscales of mental worklaod and cognitive function in university academic staff.
 Methods: This was a cross-sectional study on 86 faculty members of Shahid Sadoughi University of Medical Sciences. Stratified sampling was used to select participants from different schools. The participants were divided into basic sciences and clinical faculty members. Mental workload was assessed by National Aeronautics and Space Administration-Task Load Index (NASA-TLX). Cognitive function was assessed by Stroop test. Data were analyzed by SPSS 26 using Shapiro-Wilks test, Student’s T-test, Mann Whitney U test, univariate ANOVA, and Kruskal-Wallis test. The level of significance was 0.05.
 Results: Mean age and work history of the participants was 43.6±8.6 yr. and 11.7±9.1 yr., respectively. Mental workload, especially two aspects of mental demand and performance, was high and it was significantly higher in the participants from school of medicine and among those with executive/administrative responsibilities. From subscales of mental workload, physical demand was significantly higher among clinical than basic sciences faculty members (p<0.05). Among different aspects of cognitive function, only numbers of congruent errors were significantly higher among clinical faculties. Mental workload and cognitive function were not significantly correlated.
 Conclusion: This study showed a high level of mental workload in university academic staff, especially in clinical faculty members, but this high mental workload did not affect their cognitive function.

Influence of Sleep Deprivation on Cognitive Performance

Sleep deprivation is a pervasive phenomenon affecting millions worldwide, with profound implications for cognitive performance. This article explores the intricate interplay between sleep and cognition, examining the multifaceted effects of sleep deprivation on various aspects of cognitive function. Drawing upon neuro scientific research and clinical studies, we delve into the biological mechanisms underlying the impact of sleep loss on memory, attention, executive function, and emotional regulation. Additionally, we explore the implications of sleep deprivation for academic and occupational performance, as well as its potential long-term consequences for cognitive health. This article aims to provide a comprehensive understanding of the influence of sleep deprivation on cognitive performance, highlighting the importance of prioritizing sleep for optimal cognitive function and overall well-being.

3D convolutional neural networks uncover modality-specific brain-imaging predictors for Alzheimer’s disease sub-scores

Different aspects of cognitive functions are affected in patients with Alzheimer’s disease. To date, little is known about the associations between features from brain-imaging and individual Alzheimer’s disease (AD)-related cognitive functional changes. In addition, how these associations differ among different imaging modalities is unclear. Here, we trained and investigated 3D convolutional neural network (CNN) models that predicted sub-scores of the 13-item Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS–Cog13) based on MRI and FDG–PET brain-imaging data. Analysis of the trained network showed that each key ADAS–Cog13 sub-score was associated with a specific set of brain features within an imaging modality. Furthermore, different association patterns were observed in MRI and FDG–PET modalities. According to MRI, cognitive sub-scores were typically associated with structural changes of subcortical regions, including amygdala, hippocampus, and putamen. Comparatively, according to FDG–PET, cognitive functions were typically associated with metabolic changes of cortical regions, including the cingulated gyrus, occipital cortex, middle front gyrus, precuneus cortex, and the cerebellum. These findings brought insights into complex AD etiology and emphasized the importance of investigating different brain-imaging modalities.

Brain stimulation for patients with multiple sclerosis: an umbrella review of therapeutic efficacy.

Multiple sclerosis patients often experience various symptoms that can greatly impact their quality of life. There are various brain stimulation techniques that have been evaluated for their ability to reduce the symptoms of multiple sclerosis. However, there is inconsistency in the specific stimulation methods used and the symptoms targeted in the existing research. This umbrella review conducted in order to evaluate the effectiveness of brain stimulation and identify limitations and gaps for further research. In this umbrella review, we conducted a searched on Web of Knowledge, PubMed, and Scopus database. We specifically looked for reviews, with or without meta-analyses, that have investigated the effects of brain stimulation methods on symptoms of multiple sclerosis. All articles were examined by AMSTAR 2 (A Measure Tool to Assess Systematic Review 2). We identified 155 articles, of which 14 were eligible for inclusion. Of those, five were qualitative studies and nine were meta-analyses. Among the included studies, four examined the use of deep brain stimulation, while ten investigated the therapeutic potential of noninvasive brain stimulation. Considering the heterogeneity of studies, the current evidence suggests that repetitive transcranial magnetic stimulation may be effective in treating pain and improving motor function, while transcranial direct current stimulation may be useful in alleviating fatigue and enhancing certain aspects of cognitive performance. Deep brain stimulation, on the other hand, appears to be effective in reducing tremors. However, further research is warranted to validate these findings and address the existing limitations in the field.

Evaluating the efficacy of a modified mindfulness program in enhancing psychosocial wellbeing and cognitive functions of community dwelling older adults

Objective To assess the effects of a modified Mindfulness for Senior Wellbeing (MSW) program on older adults’ psychosocial wellbeing (flourishing, sleep quality, self-transcendence, purpose and meaning) and cognitive functions (working memory, episodic memory, speed of processing, cognitive flexibility). Methods Twenty-eight community dwelling older adults were recruited to participate in the 5-week mindfulness training out of which nineteen (mean age = 69.7 years) who met the training requirements were included in the data analysis. Due to practical limitations, a single-group pre–post study design was adopted. Participants completed the outcome measures before and after the training program. Results Participants experienced significant improvements in their levels of mindfulness, sleep quality, and some aspects of cognitive functions (working memory, episodic memory, cognitive flexibility), and reduced worrying thoughts related to a financial subscale of flourishing. Other outcome measures showed slight improvements albeit not statistically significant. Conclusion Taken together, these preliminary findings shed light on the feasibility and potential of the locally tailored mindfulness program to bring about positive benefits to the older adults.

PREVALENCE AND PATTERN OF COGNITIVE IMPAIRMENT IN PATIENTS ON MAINTENANCE HEMODIALYSIS

Background: Cognitive impairment is defined as a deficit in at least two aspects of cognitive function. The important aspects of cognition are attention, memory, language, visuo-spatial skills, and frontal/executive functions. Different pattern of cognitive impairment are seen in patients with CKD not on hemodialysis and those on hemodialysis. This study was conducted to know the prevalence and pattern of cognitive impairment in patients on chronic hemodialysis. Methods: This was a cross sectional study and was conducted at hemodialysis unit of Shifa International Hospitals, Islamabad. The study was performed over a period of six months and 250 hemodialysis patients were recruited through consecutive non probability sampling technique and were looked for cognitive impairment by using minimental state examination questionnaire translated in Urdu. Results: Out of 250 patients, mean age was 49 + 8.4 years. 92 (37%) were females and 158 (63%) were male patients. Education level of 133 (53%) patients were up to secondary school, 99 (40%) patients were higher secondary and 18 (7%) patients were masters. 43(17%) of patients were on hemodialysis for 4-6 months, 95(38%) of patients for 7-12 months, 78(31%) of patients for 13-24 months and 34(13%) of patients for> 24 months. The minimum MMSE score of patients were minimum of 26 and maximum of 30 with mean score of 28.5+0.811. Out of 250, 230(92%) patients had cognitive impairment. Mean scores in different MMSE domains like for orientation score was 9.5+0.497, for registration 2.9 +0.289, attention and calculation score was 4.738+ 0.5000, recall score was 2.8+0.352, language score was 8.5 +0.538. Conclusion: The study concluded that patients on hemodialysis have cognitive impairment and there is no relation of cognitive impairment with duration and frequency of hemodialysis, age , gender, level of education of patients. P value was insignificant.

Cognitive inflexibility and heightened error monitoring are related to lower sexual functioning

Sexual functioning is an important predictor of well-being and relationship satisfaction. Previous research indicates that several aspects of cognitive function are related to sex-related behaviors and functioning among individuals with sex-related disorders, neurological disorders, and in older adults; however, this has been relatively underexamined in younger populations. To examine this, the present study assessed whether behavioral and/or neurophysiological measures of cognitive function are associated with sexual functioning in a community sample of young 489 adults (64 % female) ages 18–30. Cognitive flexibility (n = 460) and inhibition (n = 466) were measured using neuropsychological assessment (D-KEFS), and conflict monitoring and error monitoring were measured by event-related potentials (conflict N2: n = 394; error-related negativity: n = 389). After separately testing relations between the different measures of cognitive function and sexual functioning, we assessed whether results (1) remained after covarying for externalizing and internalizing dimensions (PID-5; n = 489) or (2) varied by gender. Finally, we tested whether any aspects of cognitive function were unique predictors of sexual functioning. Cognitive flexibility and error monitoring (i.e., error-related negativity) were both significantly related to sexual functioning among males and females, such that poorer cognitive flexibility and heightened error monitoring were related to lower sexual functioning. No significant effects emerged for inhibition or conflict monitoring. In a multiple regression model, cognitive flexibility and error monitoring each accounted for a unique portion of variance in sexual functioning beyond other aspects of cognitive function and psychopathology-related traits. Results suggest that cognitive function is a meaningful correlate of sexual functioning in young adulthood, which should be considered further in future research.

24‐hour rest‐activity rhythms and light exposure patterns in relation to cognitive function in a nationally representative U.S. sample

AbstractBackgroundHuman diurnal behaviors are orchestrated by the internal circadian clock and influenced by external stimuli such as light. Aging is associated with declined circadian output and shifted circadian phase, leading to weakened rest‐activity rhythms and altered light exposure patterns, which may in turn further exacerbate circadian impairment. Limited but growing research reported that characteristics of rest‐activity rhythms were associated with risk of dementia and cognitive decline in older populations. However, there are several gaps in the literature: 1) most previous studies included predominantly white participants with relatively high socioeconomic status, limiting the generalizability of study findings to more diverse populations; 2) few studies examined the 24‐hour light exposure pattern, an environmental cue essential to healthy circadian function, in relation to cognitive function.MethodsWe applied the extended cosine model, nonparametric algorithms, and functional principal component analysis (fPCA), to characterize rest‐activity rhythms and light exposure patterns in the National Health and Nutrition Examination Survey (2011‐2014). Cognitive function was measured by word learning and recall modules from the Consortium to Establish a Registry for Alzheimer’s disease (CERAD), the Animal Fluency test, and the Digit Symbol Substitution test.ResultsMultiple rest‐activity characteristics were associated with different aspects of cognitive function, generally supporting a relationship between weakened circadian rhythms and poorer cognitive performance. For example, when compared to the highest quintile, the lowest quintile of F statistic, a measure of overall rhythmicity, was associated with a significantly lower score on the CERAD delay recall test (beta (95% confidence interval (CI)), ‐0.61 (‐0.77, ‐0.18)) and an increase in the odds of having a performance score in the lowest quartile of the study sample (odds ratio (95% CI), 1.55 (1.05, 2.29)). Moreover, measures of amplitude and rhythm fragmentation derived from nonparametric algorithms and fPCA were also associated with cognitive function. Findings were generally consistent across subgroups with different gender, age, race/ethnicity and education levels, but subgroup differences were also observed. Moreover, preliminary findings suggested a relationship between light exposure patterns and cognitive function.Conclusions24‐hour rest‐activity and light exposure patterns are associated with cognitive function in a diverse and nationally representative sample.

The Mobile Toolbox for assessing cognition in older adults: associations with standardized cognitive testing and amyloid and tau PET

AbstractBackgroundRemote, smartphone‐based cognitive assessments such as the Mobile Toolbox (MTB) can improve our ability to detect subtle, yet meaningful cognitive changes that are affected early on by Alzheimer’s disease (AD) pathology. The goal of our study was to investigate which MTB tests are sensitive to subtle cognitive deficits due to early amyloid and tau deposition.MethodThe MTB will be administered to N = 100 clinically normal (CN) older adults who have retrospective and prospective clinical, cognitive and AD biomarker data from three well‐characterized prospective cohort‐studies of CN older adults: the Harvard Aging Brain Study and the affiliated Subjective Cognitive Decline and Instrumental Activities of Daily Living cohorts. The MTB includes six measures of fluid cognition, including episodic memory (Picture Sequence Memory and Face‐Name Associations), executive functions (Dimensional Change Card Sort, Flanker), working memory (Memory for Sequence), processing speed (Number‐Symbol Match), and two measures of crystallized cognition (Spelling and Vocabulary). Using confirmatory factor analysis, MTB baseline data will be used to determine which MTB tests are most strongly associated with established clinical assessments (i.e., measures included in the Preclinical Alzheimer’s Cognitive Composite‐5 [PACC5]) as well as amyloid and tau biomarkers on positron emission tomography (PET) imaging.ResultPreliminary MTB data was available on 15 participants (age 74.3±8.2, 63% female, 16.6±2.9 years of education, MMSE 29±1.5). Table 1 shows exploratory correlation analyses, revealing that both MTB crystallized measures were associated with education but not age or sex. As expected, worse performance on MTB memory measures were associated with lower PACC5 scores, and greater amyloid and tau burden, albeit at trend‐level. Executive function and processing speed measures were not related to amyloid but did show associations with entorhinal tau.ConclusionWhile preliminary, these findings suggest that the MTB may help elucidate the subtle cognitive deficits that are associated with early AD pathology. In addition to memory measures, the MTB fluid measures capture various aspects of cognitive function that are also relevant to preclinical AD. Data collection is ongoing, and next steps include examining which (combination of) MTB measures are most sensitive for detecting emerging AD pathology and to track cognitive change over time.

Within-person changes in reproductive hormones and cognition in the menopause transition.

Most women complain of cognitive deficits in the menopause transition, though the cause is unclear. The current study investigated the role that within-person changes in reproductive hormones, particularly estradiol, may play in triggering such perimenopausal cognitive difficulties. Participants were 43 women aged 45-55years and currently in the menopause transition. Once a week for 12weeks, participants provided a urine sample for the measurement of estrone glucuronide (E1G), a urinary metabolite of estradiol. Every three weeks across the 12-week period, participants also underwent cognitive testing, including assessments of immediate and delayed memory, attention, and executive function, and completed questionnaires assessing subjective cognitive performance. Potential confounding variables including sleep quality, vasomotor symptoms, and depressive symptoms were also assessed. Within-person E1G was positively associated with objective measures of attention, particularly the ability to passively register auditory information on the first pass, as well as subjective measures of memory, specifically relating to a lower frequency of forgetting things in everyday life. Perimenopausal women with lower estimated levels of intellectual functioning furthermore exhibited a stronger relationship between E1G changes and objective cognitive performance. While depressive mood, poor sleep, and vasomotor symptoms were all negatively associated with at least one aspect of cognitive function, the E1G-cognition relationship was not explained by these factors. This study provides evidence that validates perimenopausal women's cognitive complaints but also suggests that cognitive deficits are generally mild and transient.

68 The Impact of Pain Catastrophizing on Neuropsychological Performance in Youth with Persistent Post Concussive Symptoms

Objective:Patients with persistent post-concussion symptoms (PPCS) experience prolonged recovery (e.g., headache, fatigue, or dizziness) lasting >2 months post injury. These symptoms are thought to be maintained by several biopsychosocial factors including dysregulated stress responses, such as pain catastrophizing, that may drive behavioral avoidance and contribute to mood symptoms and cognitive difficulties. Conditions with similar symptomatology to PPCS (e.g., anxiety disorders, somatosensory disorders, chronic pain, etc.) also exhibit maladaptive thought patterns like pain catastrophizing as well as decrements in certain aspects of cognitive performance; however little is known about how pain catastrophizing might relate to neuropsychological performance in youth with PPCS. Therefore, the purpose of this study was to examine the relationship between pain catastrophizing and neuropsychological performance in youth participants with PPCS.Participants and Methods:A prospective case-control study design was used to examine 29 participants between the ages of 13 to 23. Participants were divided into two groups: 1) patients with PPCS (2-16 months post-injury; n = 15) and 2) age-matched, non-injured controls (n = 14). Participants completed the Pain Catastrophizing Scale (PCS) to determine degree of catastrophic thinking related to pain experience and the Beck Depression Inventory (BDI). Neuropsychological performance was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and a modified version of the Paced Auditory Serial Addition Test (PASAT) where performance was evaluated by total correct and error type (i.e., commission and omission) across 5 trials. ANCOVA was used to compare group differences in pain catastrophizing and neuropsychological tests scores while controlling for age and linear regressions examined the relationship between PCS total score and each neuropsychological test score while controlling for level of depression.Results:Overall, the PPCS group reported significantly higher levels of pain catastrophizing on the PCS compared to the control group (p < 0.01). For neuropsychological performance, the PPCS group scored significantly lower than the control group on List Learning (p < 0.01), Semantic Fluency (p < 0.05), and List Recall (p < 0.01) on the RBANS and made significantly higher omission errors (but not commission) on the PASAT(p <.01). Higher pain catastrophizing was also associated with poorer neuropsychological performance on the exact same tasks the PPCS group performed worse than controls. There was no significant interaction by group in the impact of PCS scores on neurocognitive performance.Conclusions:Compared to controls, youth PPCS patients reported higher levels of pain catastrophizing. Additionally, pain catastrophizing was associated with poorer neuropsychological performance. These findings suggest that increased pain catastrophizing after head injury could contribute to poorer cognitive performance in youth. As such, interventions that target maladaptive cognitive coping styles like pain catastrophizing may be especially helpful for patients with PPCS.

Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial

BackgroundDietary nitrate (NO3−) has been shown to be useful as an ergogenic aid with potential applications in health and disease (e.g., blood pressure control). However, there is no consensus about the effects of dietary NO3− or beetroot (BR) juice supplementation on cognitive function.ObjectiveThe aim of this study was to evaluate the effects of a single dose of a chewable BR-based supplement on cognitive performance.MethodsA double-blind randomized placebo-controlled two-period crossover clinical trial was carried out based on the extension of the CONSORT guidelines for randomized crossover trials. A total of 44 participants (24 F; 20 M; 32.7 [12.5] years; 66.3 [9.0] kg; 170 [9.2] cm; 22.8 [1.4] kg/m2) were randomly allocated to receive first either four BR-based chewable tablets (BR-CT) containing 3 g of a Beta vulgaris extract (RedNite®) or four tablets of a placebo (maltodextrin). A 4-day washout period was used before crossover. Ninety minutes after ingestion of the treatments, a neuropsychological testing battery was administered in each period. The trial was registered at clinicaltrials.gov NCT05509075.ResultsSignificant improvements with moderate effect size were found on memory consolidation at the short and long term only after BR-CT supplementation via the Rey Auditory Verbal Learning Test immediate (+ 20.69%) and delayed (+ 12.34%) recalls. Likewise, enhancement on both frontal lobe functions (+ 2.57%) and cognitive flexibility (+ 11.16%) were detected after BR-CT. There was no significant change (p < 0.05) on verbal memory of short-term digits, working memory and information processing speed. Mixed results were found on mood and anxiety through the Beck Depression Inventory-II (BDI-II) and the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2); however, sequence and period effects were seen on STAI-Y2.ConclusionsThe acute administration of a chewable BR-based supplement improves certain aspects of cognitive function in healthy females and males, particularly memory capacity and frontal skills.

Carbon is to life as g is to _____: A review of the contributions to the special issue on specific abilities in intelligence

Just as carbon infuses all life forms, g infuses almost all aspects of cognitive performance. This Special Issue focuses on specific abilities, defined as distinct abilities (e.g., verbal, math, spatial) that differ conceptually and empirically from g, which refers to variance common to tests. The nine contributions examine different specific abilities (e.g., spatial, academic, executive), involve different samples (e.g., humans, animals, countries), and compare different groups (e.g., males and females; gifted and nongifted). The contributions are discussed in terms of their support for a “primacy of g hypothesis,” which assumes that the validity of tests is largely attributable to g, or a “more than g hypothesis,” which assumes that specific abilities contribute to the validity of tests beyond g. The article summarizes each contribution and discusses models and theories of g and specific abilities (e.g., Cattell-Horn-Carroll and Verbal-Perceptual-Image Rotation models; investment and differentiation theories), with a focus on future research on specific abilities. Taken together, the contributions show that specific abilities are a meaningful addition to g but that their validity depends on the particular abilities, models, and theories being examined.

Does the Brain Drain Effect Really Exist? A Meta-Analysis.

Smartphones have become an indispensable part of everyday life. Given the current debate about the use of smartphones in classrooms and schools, it seems appropriate to examine their effects on aspects of cognitive performance in more detail. Ward and colleagues not only demonstrated the negative effect of smartphones on cognitive performance but also showed that the mere presence of these devices can have this effect-this is known as the Brain Drain effect. In the present article, a meta-analytic approach was adopted in order to verify these findings. Here we show a significant overall negative effect of smartphone use and presence. In a database search we identified 22 studies with a total of 43 relevant effects that could be assigned to the categories "memory", "attention", and "general cognitive performance". A subgroup analysis suggests that not all cognitive domains are equally affected by the negative effect of smartphones. The heterogeneity of the effects reinforces this finding. The nationality of the test subjects or the origin of the studies was identified as a further key variable. Our findings also indicate that the distracting effect of smartphones varies on the area studies and further research is necessary. In view of the present research results, it seems important that people in general, and especially children and adolescents in schools and classrooms, learn how to deal with the distracting potential of smartphones.

Alpha wave asymmetry is associated with only one component of melancholia, and in different directions across brain regions.

Alpha wave asymmetry inconsistently correlates with Major Depressive Disorder (MDD). One possible reason for this inconsistency is the heterogeneity of MDD, leading to study of depressive 'subtypes', one of which is Melancholia. To investigate the correlation between Melancholia and alpha-wave asymmetry, 100 community participants (44 males, 56 females; aged at least 18yr) completed the Zung self-rated Depression Scale, and underwent 3min of eyes closed EEG recording from 24 scalp sites. There was no significant correlation between EEG data and Melancholia total score for the entire sample, but there was for those participants who had clinically significant depression (n=33). When examined at the level of individual Melancholia scale items, significant EEG data correlations were found for some of the items but not for others. Factor analysis revealed a two-factor structure for the Melancholia scale, only one of which exhibited significant correlations with EEG AA data. Further exploration of those data identified two subcomponents of that Melancholia factor, one which was inversely correlated with frontal alpha asymmetry, and another which was directly correlated with parietal-occipital alpha wave asymmetry. These findings suggest that Melancholia may itself be heterogeneous, similarly to MDD, and rely upon different aspects of cognitive function.

Chronotype and Time of Day Effects on a Famous Face Recognition Task with Dynamic Stimuli.

Chronotype and Time of Day (ToD) can modulate several aspects of cognitive performance. However, there is limited evidence about the effect of these variables on face recognition performance, so the aim of the present study is to investigate this influence. For this, 274 participants (82.5% females; age 18-49 years old, mean = 27.2, SD = 1.82) were shown 20 short videoclips, each gradually morphing from a general identity unfamiliar face to a famous face. Participants should press the spacebar to stop each video as soon as they could identify the famous face, and then provide the name or an unequivocal description of the person. Analysis of response times (RT) showed that evening-types recognised the faces faster than morning-types. Considering different ToD windows, the effect of chronotype was only significant in the 13h-17h and in the 21h-6h time-windows. Altogether, results suggest an advantage of evening-types on famous face recognition using dynamic stimuli with morning-types, being particularly slower during their non-optimal period.

Longitudinal Examination of Potential Bilingual Advantage Effects for Selective Attention and Cognitive Functioning in Young Children

ABSTRACT A good deal of research purports that bilingualism has a positive effect on some aspects of cognitive functioning. However, this effect is not consistent, and little research examines trajectories of cognitive skill development in bilingual children. Moreover, it remains unclear whether different types of bilingualism impact how cognitive abilities unfold. The reported study investigates children’s data from three linguistic groups (179 sequential bilingual, 96 simultaneous bilingual and 57 monolingual German-speaking children) and examines differences (1) regarding cognitive outcome measures pertaining to selective attention, visuospatial thinking and abstract thinking and (2) searches for substantial developmental trajectory differences regarding said measures. Children were tested at 3 points in time; at age 4;10, 6;2 and 7;4. Results indicate no significant linguistic group differences in selective attention, visuospatial thinking and abstract thinking when controlling for gender, language comprehension of the child, and families’ socioeconomic status. Moreover, the three linguistic groups did not differ in developmental trajectories. Theoretical and practical implications are discussed.

Mental fatigue, cognitive performance and autonomic response following sustained mental activity in clinical burnout

ObjectiveTo investigate the effects of sustained mental activity on perceptions of mental fatigue, cognitive performance, and autonomic response in patients with clinical burnout as compared to a healthy control group. MethodsPatients with clinical burnout (n = 30) and healthy control participants (n = 30) completed a 3-hour test session, in which they were administered a set of cognitive tests before and after an effortful cognitive task with concurrent sound exposure. Perceptions of mental fatigue and task demands (mental effort and concentration difficulties) were assessed repeatedly over the course of the test session. Heart rate variability was recorded to index autonomic response. ResultsIn comparison with controls, perceived mental fatigue increased earlier in the session for the clinical burnout group and did not recover following a short rest period. Throughout the session, patients rated the tasks as more demanding and showed less improvement on measures of attention and processing speed, inhibition and working memory. While autonomic responses were initially comparable, there was a unique decrease in high-frequency heart rate variability in the clinical burnout group after extended testing and exposure. ConclusionPatients with clinical burnout are affected differently than healthy controls by sustained mental activity, as reflected by ratings of perceived mental fatigue, aspects of cognitive performance and autonomic response. Further investigation into the role of autonomic regulation in relation to cognitive symptoms in clinical burnout is warranted.