Abstract Introduction Parkinson’s disease (PD) is a neurodegenerative disorder with increasing prevalence into older age. Aerobic exercise (AE) is the most commonly prescribed exercise for PD, although an optimal protocol is undefined. This umbrella review aimed to summarise and synthesize existent evidence regarding the effectiveness of AE on balance, gait, functional mobility, and QoL in people with PD. Content Six databases were searched for systematic reviews reporting the effects of AE on balance, gait, functional mobility, and QoL in people with PD from inception to June 2024. Quality of evidence was assessed using the AMSTAR-2 tool. From 4182 records, 17 systematic reviews were included for qualitative analysis. Most (n=12) were rated as critically low for methodological quality, with four rated low and one high. Moderate intensity was the most commonly investigated AE intensity (n=4), although almost half of the reviews (n=8) did not report intensity. AE protocols lasted from 1 to 64 weeks and 1 to 7 days per week. Session length was between 20 and 120 minutes. Reported outcomes included gait (n=15), QoL (n=14), balance (n=12), and functional mobility (n=7). AE does improve aspects of gait, balance, and functional mobility in PD; however it does not appear to improve QoL. Summary and Outlook AE is recommended as part of rehabilitation for people with PD. However, research exploring the efficacy of AE assesses multiple modalities with varied protocols. Further research is needed to identify AE protocols that will best alleviate the symptoms of PD, providing an evidence base for effective clinical translation.
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