AbstractA method for preparation of alkyl 3‐aryl‐(1,2,4‐oxadiazol‐5‐yl)propanoates by base‐catalyzed domino reaction of an aryl aldoxime with N‐chlorosuccinimide in alcohol is described. In this reaction, initially aldoxime and N‐chlorosuccinimide react to produce hydroximidoyl chloride and succinimide. The hydroximidoyl chloride and base produces nitrile oxide which undergoes [3+2] annulation with succinimide followed by ring opening reaction with the assistance of alcohol to give alkyl 3‐aryl‐(1,2,4‐oxadiazol‐5‐yl)propanoates in 65–95% yield.magnified image