Look at this month’s cover, the leftmost image in Figure 1Figure 1. Can you figure out what it means? Five months ago, the Cell Systems editorial team revised our guidelines for authors who are interested in submitting cover images. Now, with a full hand of covers to reflect on, I’d like to highlight these new guidelines and their broader significance.Figure 1Left to Right: Volume 5 Issue 5, November 22, 2017; Volume 5 Issue 4, October 25, 2017; Volume 5 Issue 3, September 27, 2017; Volume 5 Issue 1, July 26, 2017; Volume 2 Issue 1, January 27, 2016 (copyright William Rainey).View Large Image | View Hi-Res Image | Download PowerPoint SlideThe inset white diamond on the November cover is a radar chart. The purple and grey quadrilaterals drawn on the chart each plot four parameters of an oscillating waveform: its period (top vertex), amplitude (bottom vertex), rise time (left vertex), and decay time (right vertex). The purple shape is squashed on the bottom because that waveform oscillates with a much shorter amplitude. The gray shape doesn’t extend as high as the purple because it has a shorter period.Now, let’s layer on more information. The gray quadrilateral represents the behavior of a synthetic gene circuit containing a single branch of negative feedback. The purple quadrilateral represents the circuit with two parallel feedback branches. So the differences in shapes tell us that the oscillatory behavior of the circuit changes—predictably, as it turns out—when the circuit’s components are modified. This captures the essence of the work by Ping Wei, Wendell Lim, and Chao Tang on page 445 of this issue.Our new cover guidelines request images based on data and photos instead of original artwork. The previous guidelines specified, “Although submissions featuring original artwork will be considered, editors will look more favorably toward submissions that feature actual scientific data.” The new guidelines read, “The ideal cover image will either feature actual scientific data from the paper or high-quality photographs that convey the paper’s message.”So why the shift? Simply put, we believe in powerful stories told through data, clearly presented and set center stage. The use of visual design principles and an artistic touch can enhance the visual appeal of a piece of data. But beneath this surface appeal, we are looking for images that shine a spotlight on a crucial idea or piece of data central to a paper.Three recent covers provide examples of different approaches to featuring data. In some cases, a single figure panel showing a central result of the paper is visually striking and can be used on its own, as in the case of our October 2017 cover (second image from left; dark brown lines show the accumulation of metabolites secreted by yeast and then consumed by lactic acid bacteria). In other cases, an image can be rearranged, rotated, or repositioned to create an attractive composition (middle image; an initial oval-shaped group of cells was shifted down and left, and some cells were “wrapped around” to the top right corner). Alternatively, the strong use of color and background can accentuate an interesting shape (the silhouette of a tomato plant on the July 2017 cover; second image from right). For the inspiration behind this cover, see Henri Matisse's “Algue blanche sur fond orange et rouge.”Photos can also often be used to effectively create an enticing visual puzzle, and it is relatively easy to achieve polished results using them. For instance, for the cover of our January 2016 issue, which highlights engineering in biology, we chose a cover of a beaver—nature’s engineer—drinking at water’s edge.In contrast to photos, it can be more challenging to generate a scientifically meaningful and aesthetically appealing cover in which original artwork is used. We have used original artwork in the past, but going forward, we now request that authors use either original data or photos, which provide, in our experience, the most straightforward route to produce a compelling cover.To facilitate the creation of a cover image, we provide a template that shows the placement of the journal title and that indicates what parts of the image will be lost when the cover is trimmed to generate an online image (hint: make sure the important parts of the image are contained within the box labeled “trim”).I hope that exposing our approach to thinking about cover images will help those of you creating your own image for our covers. Going forward, we aim to further expose how we think about other aspects of running the journal, ranging from nuts-and-bolts decisions (such as how we choose the cover) to deeper issues (such as editorial decision-making criteria). Please write with any comments or suggestions for other aspects of our thinking that you would like to hear about (systems@cell.com).