Artificial Substitutes Research Articles

The Impact of Job Anxiety Caused by Artificial Intelligence Substitution on Organizational Members’Turnover Intention : The Mediating Role of Job Insecurity and the Moderating Effect of Job Uncertainty

The Impact of Job Anxiety Caused by Artificial Intelligence Substitution on Organizational Members’Turnover Intention : The Mediating Role of Job Insecurity and the Moderating Effect of Job Uncertainty

3D Bioprinting of Artificial Skin Substitute with Improved Mechanical Property and Regulated Cell Behavior through Integrating Patterned Nanofibrous Films.

Three-dimensional (3D) bioprinting has advantages for constructing artificial skin tissues in replicating the structures and functions of native skin. Although many studies have presented improved effect of printing skin substitutes in wound healing, using hydrogel inks to fabricate 3D bioprinting architectures with complicated structures, mimicking mechanical properties, and appropriate cellular environments is still challenging. Inspired by collagen nanofibers withstanding stress and regulating cell behavior, a patterned nanofibrous film was introduced to the printed hydrogel scaffold to fabricate a composite artificial skin substitute (CASS). The artificial dermis was printed using gelatin-hyaluronan hybrid hydrogels containing human dermal fibroblasts with gradient porosity and integrated with patterned nanofibrous films simultaneously, while the artificial epidermis was formed by seeding human keratinocytes upon the dermis. The collagen-mimicking nanofibrous film effectively improved the tensile strength and fracture resistance of the CASS, making it sewable for firm implantation into skin defects. Meanwhile, the patterned nanofibrous film also provided the biological cues to guide cell behavior. Consequently, CASS could effectively accelerate the regeneration of large-area skin defects in mouse and pig models by promoting re-epithelialization and collagen deposition. This research developed an effective strategy to prepare composite bioprinting architectures for enhancing mechanical property and regulating cell behavior, and CASS could be a promising skin substitute for treating large-area skin defects.

Mini review on Artificial Blood Substitutes: Future perspective of Perfluorocarbon based oxygen carriers

The primary cause of death in the battle field and in civilian trauma is haemorrhagic shock. Around 50% combat deaths occur due to haemorrhage, depending on the severity of bleeding medical supervision can be provided like in catastrophic haemorrhage individual death occurs before providing the medical care and it is not a prehospital combat medical management problem during warfare scenario, even to transport wounded personnel to causality centre often takes 45 minutes to one hours. The hazardous nature of the forward combat areas and hostile operational environment frequently prevents medical personnel from quickly reaching the wounded even if the transport distances are small. Moreover, injuries with penetrating battlefield trauma often have only a "platinum 5 minutes." It is very important for military medical personnel to understand their options for treating haemorrhage quickly and efficiently during combat. Early intervention and definitive treatment could save up to 30% of soldier’s who die of action or of wounds. In view of this there is a requirement for the development of synthetic blood substitutes or oxygen therapeutic agents (OTA) in order to maintain the tissue oxygenation. Blood substitutes are the substances which mimic one of the physiological functions of the blood that is transportation of oxygen and carbon dioxide throughout the body. Blood substitutes or OTAs are being clinically tested as artificial oxygen carriers to improve tissue oxygenation and also to reduce allogenic blood transfusions. Two types of blood substitutes are reported so far: 1. Haemoglobin based oxygen carriers (HBOCs) and 2. Perfluorocarbon based oxygen carriers (PFOCs). PFOCs has huge advantages like universal compatibility, no requirement of cold storage, longer shelf life and no risk of infection transmission. These products have their own limitations and they have been withdrawn from international market for clinical use because of their side effects. It is a challenging task to the scientists to develop a safe, stable and biocompatible blood substitute for combat scenarios and also for civilian applications.

Typical agramaticalized constructions as actualized mono- and polysynonymic transforms of virtual primary syntagmata and propositions (on the material of modern french fiction)

In this article, mono- and polysynonymic typical agrammaticalized constructions are defined as virtual transforms of primary syntagmata and propositions, actualized in the form of reduced, extended, and quantitatively equacomponential preferential options, in which expressivity prevails over expression. The aim of this research was to suggest a typology and to determine the degree of co(n)textual pertinence of typical agrammaticalized mono- and polysynonymic transforms in modern French fiction. To reach this aim I used the procedure of inverse reconstruction (discourse → language) of the primary structure of the analyzed types of mono- and polysynonymic agrammaticalized discourse innovations. The method of systematization made it possible to build a typology of common agrammaticalized synonymic preferential options. An “alternative” linguistic experiment, i.e., an artificial substitution by the recipient of a certain syntagm or proposition of the analyzed discourse fragment by a synonymic syntagm or proposition, helped to determine the degree of co(n)textual pertinence of the primary structure and secondary synonymic transforms. As a result, the types of mono- and polysynonymic typical agrammaticalized constructions were distinguished, the primary structure and members of virtual synonymic series were inversely reconstructed, and the co(n)textual pertinence of the constructions under analysis was justified by means of the “alternative” linguistic experiment. I claim, that in the French fiction of the 20th ‒ 21st centuries, the most frequent elements are mono- and polysynonymic typical agrammaticalized mono- and polypredicative utterances, extended by the interrogative or relative pronoun que, the personal pronoun il (and its colloquial analogues), quantitatively equacomponential preferential options containing the pronominal component que, and elliptical constructions with final suppression of complement after prepositions avec, sans, pour, contre, parmi, comme. I also claim, that the main reason for actualizing typical agrammaticalized constructions is to emphatically focalize new co(n)textual referents, stylistically nuance the intra- and / or interphrasal co(n)text, syntactically simplify complex structures, or prevent the re-actualization of referents previously introduced to the pre- or post-text.

Class-specific recognition and monitoring of environmental steroid estrogens in real water systems utilizing aptamer base substitution mutagenesis approach

The same class of environmental steroid estrogens (SEs) with the highest estrogenic activity share the same chemical core structure and are often found together in the environment, posing significant risks to organismal health and environmental safety due to toxicity accumulation. In this study, a novel method for constructing the group-targeting aptasensor was developed to comprehensively analyze SEs. Through artificial intervention base substitution mutagenesis of adjacent bases T13 and C20 of the aptamer-binding domain recognizing 17β-estradiol, combined with docking calculations, the group-targeting SEs-aptamer for class-specific recognition SEs, such as estrone, estradiol, estriol, and ethinylestradiol were obtained. The binding constant of the SEs-aptamer to the SEs was 108 M−1. The established group-targeting SEs aptasensor exhibited high sensitivity within a concentration range from 0.1 to 10 nM and demonstrated strong interference resistance, as well as high stability and wide pH water applicability. It was further applied to analyze real water samples and monitor changes in SEs concentrations during the removal process by Chlorella pyrenoidosa. These successful applications have demonstrated the excellent ability of this aptasensor to monitor SE in the environment. The method offered a new approach and idea for recognizing and detecting the same class of environmental pollutants in complex systems.

PbrChiA: a key chitinase of pear in response to Botryosphaeria dothidea infection by interacting with PbrLYK1b2 and down-regulating ROS accumulation.

Pear ring rot, caused by the pathogenic fungi Botryosphaeria dothidea, seriously affects pear production. While the infection-induced reactive oxygen species (ROS) burst of infected plants limits the proliferation of B. dothidea during the early infection stage, high ROS levels can also contribute to their growth during the later necrotrophic infection stage. Therefore, it is important to understand how plants balance ROS levels and resistance to pathogenic B. dothidea during the later stage. In this study, we identified PbrChiA, a glycosyl hydrolases 18 (GH18) chitinase-encoding gene with high infection-induced expression, through a comparative transcriptome analysis. Artificial substitution, stable overexpression, and virus induced gene silencing (VIGS) experiments demonstrated that PbrChiA can positively regulate pear resistance as a secreted chitinase to break down B. dothidea mycelium in vitro and that overexpression of PbrChiA suppressed infection-induced ROS accumulation. Further analysis revealed that PbrChiA can bind to the ectodomain of PbrLYK1b2, and this interaction suppressed PbrLYK1b2-mediated chitin-induced ROS accumulation. Collectively, we propose that the combination of higher antifungal activity from abundant PbrChiA and lower ROS levels during later necrotrophic infection stage confer resistance of pear against B. dothidea.

Artificial Bone Graft Substitutes for Curettage of Benign and Low-Grade Malignant Bone Tumors: Clinical and Radiological Experience with Cerasorb

BackgroundArtificial bone graft substitutes (ABGS) for curettage of bone tumors are becoming increasingly popular. The aim of this retrospective analysis was to determine the efficacy of the ABGS Cerasorb (Curasan-AG, Kleinostheim, Germany), a beta-tricalcium phosphate (beta-TCP), concerning resorption profile, bone healing, and remodeling after surgery and to evaluate potential complications.MethodsForty-three patients suffering from benign and low-grade malignant bone tumors were treated with curettage and refilling of the bony cavity using the ABGS Cerasorb between 2018 and 2021 and included in the final analysis. Clinical follow-up exams with X-rays in two planes were performed 6 weeks, 3 months, 6 months, and 1 year after surgery.ResultsAfter a mean follow-up period of 14.6 months, radiological consolidation following curettage was observed in all patients. Total resorption was observed in 16.3% of patients; in the other 83.7%, resorption was partial. In four patients, of whom two had a tumor in the distal femur and two in the humeral diaphysis, fractures occurred within 6 weeks after primary surgery.ConclusionIn conclusion, the beta-TCP Cerasorb seems to be a reliable bone graft substitute with low complication rates and is a suitable alternative to autologous bone grafts or allografts. Nonetheless, it shows a tendency of delayed resorption.Level of EvidenceIII; retrospective cohort study.

Synonymic monopredicative utterances with the interjectional head lexeme (based on French fiction of the 20th – the 21st centuries)

In this article interjectional monopredicative utterances (MPU) of modern French fiction are defined as compressed one-basis (with one transformational terminal chain) synonymic transforms of virtual (linguistic) primary proposition actualized in the form of mono- and polysynonymic (with the intra-, interphrastic and intra-interphrastic bi- and polysynonymy) elliptic complex lingua-discursive signs‑preferential options with the interjectional head lexeme.
 The goal of this research is to identify the structural and semantic types and to reveal the co(n)textual (linguistic and / or situational) functions of the interjectional MPU of French fiction of the 20th – the 21st centuries and to determine the degree of their co(n)textual pertinence.
 In this article they use the procedure of the inverse reconstruction (discourse → language) of virtual transformational processes with the aim to identify the primary proposition of each synonymic transform; and the «alternative» linguistic experiment consisting in the artificial substitution by the addresser of some utterance of the analyzed discursive fragment with the synonymic utterance that allows to determine the degree of co(n)textual pertinence of all the members of virtual synonymic chains.
 It is revealed that in the synonymic interjectional MPU with non-derivative (primary) interjections of modern French fiction the author doesn’t exteriorize the structure subject + personal performative predicate with the referentially determined or non-determined actant, explicated in the contact, interphrastic or distant co(n)text (+ circumstance) and the existential structure c’est with the demiactive (active and passive simultaneously) actant referentially non-determined or determined in the intra- or interphrastic co(n)text. The structural and semantic (qualificative, processual, emotional-specificative, volitional-specificative) types of interjectional elliptic structures are distinguished, their co(n)textual functions are revealed and the degree of their co(n)textual pertinence, according to the pragmatic planification of the narration or to the author’s idiostylistic peculiarities, is justified.

АВТОРСЬКА ІНТУЇЦІЯ ТА ІНТРОСПЕКЦІЯ В ПРОЦЕСІ ФОРМУВАННЯ ТА РЕАЛІЗАЦІЇ СИНОНІМІЧНИХ СТРУКТУР (на матеріалі сучасної французької художньої прози)

The article studies intuitive mechanisms of sublinguistic schemes, primary structures and synonymic transforms formation in modern French fiction and mechanisms of synonymic preferential options actualization in correlation with the (auto)observation. This led to the use of the introspection method, the procedure of inverse reconstruction (discourse → language) of virtual (linguistic) transformational processes and the “alternative” linguistic experiment consisting in the artificial substitution of some utterance by a synonymic one. The goal of the article is to study intuitive mechanisms of synonymic constructions creation and realization in correlation with the observation of the facts and events of the real world and the introspection, alongside with the inverse reconstruction of the virtual transformational processes as an “alternative” linguistic experiment strategy. In the course of analysis we have found that the prearranged situation correlates with the addresser’s observation of the facts of reality, and that the mechanisms of prelinguistic, linguistic and discourse intuitions work at the level of three components of G. Guillaume’s speech act causation – mental operations → language → discourse, that is in the process of unconscious, subconscious and conscious activity of psychomechanisms (cognitive polyoperations) – and correlate with the introspection. It was proved that formation, exteriorization and interiorization of synonymic discourse innovations is the bidirectional process. The addressee reveals the author’s communicative intention to simplify or to complicate the information and the peculiarities of his/her idiostyle through two stages of the “alternative” linguistic experiment. First stage is an inverse reconstruction of the primary structure and extended, reduced and equal by quantity ludic and non-ludic synonymic transformants (microfields) of the functional-semantic macrofield virtual synonymic series by means of exteriorized synonymic discourse innovations observation and interiorization as a result of the author’s observation of facts of objective reality – introspection which cover the prelinguistic, linguistic and discursive intuitions. Second stage is to determine the degree of co(n)textual (linguistic and / or situational) pertinence of each member in synonymic series and to justify preferential option co(n)textual adequation. It was revealed that the inverse reconstruction is possible to realize only up to the primary structure which is formed in the process of the conscious activity of psychomechanisms because the pre-linguistic cognitive polyoperations and subconscious sublinguistic schemes aren’t available for the analysis of information recipient.

Comparison of Milk Odd- and Branched-Chain Fatty Acids among Human, Dairy Species and Artificial Substitutes.

The aim of the study was to compare odd and branched-chain fatty acids (OBCFA) of milk from sheep, goat, cow, buffalo, donkey, human, and formula milk. Ruminant, monogastric, and human milks have different concentrations of these fatty acids (FA). To highlight the differences on OBCFA, a total of 282 individual milk samples were analyzed by gas chromatography. The OBCFA were found higher in ruminant than non-ruminant milks (p < 0.05). Among ruminants, sheep milk had the highest OBCFA (4.5 g/100 g of total FAME), whereases the lowest values were found in formula milk (0.18 g/100 g of total FAME). Regarding individual linear odd-chain FA (linear-OCFA), C11:0 was found higher in donkey milk than others, while sheep and buffalo milks had the greatest concentration of C15:0. Among BCFA, the iso-BCFA were higher than anteiso-BCFA in all considered milks. The isoC17:0 showed the highest concentration in all milks except for donkey and buffalo, which showed higher concentration of isoC16:0 than others. In conclusion, ruminant milks are different in terms of these FA compared to human milk and its substitutes. However, the greatest differences were found with formula milk, suggesting that this product needs the implementation of these FA to be more similar to human milk composition.

Effect of Carbonate Contents on the Thermal Stability and Mechanical Properties of Carbonated Apatite Artificial Bone Substitute

Effect of Carbonate Contents on the Thermal Stability and Mechanical Properties of Carbonated Apatite Artificial Bone Substitute

Electrical Signal Initiates Kinetic Assembly of Collagen to Construct Optically Transparent and Geometry Customized Artificial Cornea Substitutes.

Corneal transplantation is an effective treatment for reconstructing injured corneas but is very limited due to insufficient donors, which has led to a growing demand for development of artificial corneal substitutes (ACSs). Collagen is a potential building block for ACS fabrication, whereas technically there are limited capabilities to control the collagen assembly for creating highly transparent collagen ACSs. Here, we report an electro-assembly technique to kinetically control collagen assembly on the nanoscale that allows the yielding collagen ACSs with structure determined superior optics. Structurally, the kinetically electro-assembled collagen (KEA-Col) is composed of partially aligned microfibrils (∼10 nm in diameter) with compacted lamellar organization. Optical analysis reveals that such microstructure is directly responsible for its optimal light transmittance by reducing light scattering. Moreover, this method allows the creation of complex three-dimensional geometries and thus is convenient to customize collagen ACSs with specific curvatures to meet refractive power requirements. Available properties (e.g., optics and mechanics) of cross-linked KEA-Cols were studied to meet the clinical requirement as ACSs, and in vitro tests further proved their beneficial characteristics of cell growth and migration. An in vivo study established a rabbit lamellar keratectomy corneal wound model and demonstrated the customized collagen ACSs can adapt to the defective cornea and support epithelial healing as well as stroma integration and reconstruction with lower immunoreaction compared with commercial xenografts, which suggests its promising application prospects. More broadly, this work illustrates the potential for enlisting electrical signals to mediate collagen's assembly and microstructure organization for specific structural functionalization for regenerative medicine.

АПОЗИТИВНІ СТРУКТУРИ ЯК СИНОНІМІЧНІ МОВЛЕННЄВІ ІННОВАЦІЇ У ФРАНЦУЗЬКІЙ ХУДОЖНІЙ ПРОЗІ ХХ – ПОЧАТКУ ХХІ СТОЛІТЬ

In this article the appositive structures of modern French fiction are studied in the continuum language → discourse and defined as two-basis (with several transformational terminal chains) synonymic transforms of the virtual (linguistic) primary subordinate proposition which are formed in the space of the operating time of a thought movement and actualized in the form of compressed discourse innovations with the implicit predication. The goal of this research is the establishment of the structural-semantic typology of mono- and polypredicative utterances with the appositive synonymic transforms of French fiction of the XXth – the beginning of the XXIst centuries, the inverse reconstruction (discourse → language) of the virtual transformational processes and of the primary proposition within the functional‑semantic macrofield of the analyzed appositive constructions and the justification of the co(n)textual pertinence of the actualized appositive preferential options. In the article the method of the inverse reconstruction of the systemic (linguistic) transformational operations is used with the aim to reveal all the members of synonymic chains. The “alternative” linguistic experiment, that consists on the artificial substitution by the recipient of some utterance of the analyzed discursive fragment with the synonymic utterance, allows to determine the degree of the co(n)textual pertinence of the primary proposition and of each synonymic transform. The immediately and distantly pre-, inter- and postpositive mono- and polysynonymic (with the polysynonymy in the level of a syntagm and the utterance) appositive preferential options with explicative, concessive, conditional and causal semantic values are distinguished. They revealed the mono- and polypredicative utterances: a) with explicit actant-referent point of the appositive segment; b) with implicit actant and indirect designation of the appositive referent by the immediate actant markers in the form of possessive, demonstrative et al. adjectives that introduce the substantive which marks the part of body, the human condition, the feeling etc.; c) with implicit actant and indirect designation of the appositive referent by the distant actant markers (most often by the personal pronouns direct and indirect complements). The virtual transformational processes are inversely reconstructed and the degree of the co(n)textual pertinence of each member of the synonymic chain of analyzed appositive constructions conditioned by the author’s intention to avoid the reactualization of the exteriorized referents, the overload of the co(n)text with complex predicative constructions or by his idiostylistic peculiarities, is determined.

Academy of Breastfeeding Medicine Recommendations During Shortage of Artificial Breast Milk Substitutes.

Academy of Breastfeeding Medicine Recommendations During Shortage of Artificial Breast Milk Substitutes.

HLA in Las Alpujarras Mts., South-East Spain: A Renaissance process of population artificial substitution

Spain was invaded in 711 CE by mostly Berber North Africans carrying Muslim religion to a mostly Christian/Catholic Kingdom. A fight to expel Muslims soon started and were apparently driven out of Iberia (Spain) starting in 1492 CE. However, many of these expelled people were of Iberian old ancestry that had become Muslims at Las Alpujarras Mts. (South-East Spain). Also, Muslim North Africans converted to Christianity either remained there or came back after they more definetively were expelled by 1609 CE. Las Alpujarras region was also repopulated by northern Spaniards mostly from Galicia. Our HLA study of present day Alpujarrans shows that typical North Spain and European Atlantic façade HLA extended haplotypes are very frequent in nowadays Las Alpujarras region, i. e.: HLA-(A*29-B*44)-DRB1*07:01-DQA1*02:01-DQB1*02:01 and (A*02-B*27)-DRB1*15:01-DQA1*01:02-DQB1*06:02. It is concluded that repopulation had a noticeable success even in today Alpujarran population.

Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms.

The existence of orderly structures, such as tissues and organs is made possible by cell adhesion, i.e., the process by which cells attach to neighbouring cells and a supporting substance in the form of the extracellular matrix. The extracellular matrix is a three-dimensional structure composed of collagens, elastin, and various proteoglycans and glycoproteins. It is a storehouse for multiple signalling factors. Cells are informed of their correct connection to the matrix via receptors. Tissue disruption often prevents the natural reconstitution of the matrix. The use of appropriate implants is then required. This review is a compilation of crucial information on the structural and functional features of the extracellular matrix and the complex mechanisms of cell–cell connectivity. The possibilities of regenerating damaged tissues using an artificial matrix substitute are described, detailing the host response to the implant. An important issue is the surface properties of such an implant and the possibilities of their modification.

Utilization of Artificial Coarse Aggregate from Polyethylene Terephthalate Plastic Waste in Concret

Plastic waste production is increasing in tandem with increased plastic consumption. Plastic waste used in construction is one of the most environmentally friendly options available for reducing environmental impact. This research is an experiment on the petrography, the porosity, and the mechanical characteristics of concrete using PET (Polyethylene Terephthalate) plastic aggregates to replace natural aggregates. Artificial aggregate by heating PET plastic waste until it reaches a melting point of about 250 °C to- 260 °C, produces concrete with four percentage levels of artificial aggregate substitution, namely 25%, 50%, 75%, and 100%. The mechanical testing of the sample is done after 28 days. The compressive strength of plastic concrete used as a substitute for artificial aggregate in concrete mixtures has been reduced as a result of this research. The replacement of 25% of PET plastic-made aggregates has significantly increased tensile and flexural strength, and PET petrography has revealed cement-filled pores and cracks. The PET artificial aggregate and the cement matrix have adhered perfectly and have formed an impenetrable bond. The exponential power equation may be used to estimate the connection between porosity and compressive strength in concrete using PET plastic artificial aggregates.

Molecular and kinetic characterization of two acetylcholinesterases with particular focus on the roles of two amino acid substitutions (Y390N and F392W) in Bemisia tabaci

Two acetylcholinesterases (AChEs) are present in Bemisia tabaci (BtAChE1 and BtAChE2). A conserved AChE mutation conferring organophosphate (OP) resistance (F392W in BtAChE1) is saturated in field populations despite its potential fitness cost, and a highly conserved amino acid residue forming the backdoor of AChE is substituted with a unique amino acid (Y390N in BtAChE1) in B. tabaci. Thus, the roles and relationships of the two amino acid substitutions in the evolutionary adaptation of B. tabaci remain to be elucidated, and little information is available on the catalytic and molecular properties of BtAChE1 and BtAChE2. To determine which AChE is a more relevant target of OPs and carbamates, the molecular and kinetic properties of BtAChE1 and BtAChE2 were investigated. Both BtAChE1 and BtAChE2 were exclusively expressed in head and thorax but not in abdomen, bound to the membrane via GPI anchoring, and present as dimeric forms. Soluble monomeric form was detected only in BtAChE2. The catalytic activity of baculovirus-expressed BtAChE1 was 19.5-fold higher than that of BtAChE2. The inhibition assay revealed that the F392W mutation in BtAChE1 enhanced resistance to OPs. The artificial substitution of N390 (wild form) to Y (putative ancient form) led to reduced catalytic efficiency and increased inhibition by glycoalkaloids, suggesting that the Y390N substitution in BtAChE1 may have been required for Solanaceae host adaptation. BtAChE1 was proven to function as a main catalytic enzyme for ACh hydrolysis, thus being the main target of OPs and carbamates.

Hemoglobin-Inorganic Hybrid Nanoflowers with Different Metal Ions as Potential Oxygen Carrying Systems.

Protein-inorganic hybrid nanoflowers have tremendous potential in bionanotechnology due to their simple method of preparation, high stability and superior properties. Considering these features, the present study was designed to investigate the artificial blood substitution potentials of hemoglobin-inorganic hybrid nanoflowers. In this context, hemoglobin-inorganic hybrid nanoflowers (Cu-NF, Co-NF and Zn-NF) were synthesized using with different metal ions (copper, cobalt and zinc), then their oxygen carrying capacity, the hemolytic studies, in vitro oxidant/antioxidant capacity levels and oxidative stress index were reported for the first time. The present findings have revealed that Zn-NF had significant oxygen content and artificial oxygen carriers (AOC), as well as a significantly low percent hemolysis rate and a safe standard value. Also, hemolysis rate decreased along with the increases in hemoglobin content coupled with increments in nanoflower concentrations. The percentage hemolysis rate was lower than all nanoflowers at low free hemoglobin concentration, but hemolysis rates also increased with increments in concentration. The results showed that in general, Zn-NF stands out with its high total antioxidant capacity and low total oxidant capacity and oxidative stress index. The obtained results showed that Cu-NF and Co-NF, especially Zn-NF might be considered as a potential superior artificial oxygen carrier. Therefore, this nanoflower system might be act as an efficient material as a blood substitute in the near future.

Аналіз статистичних показників дисперсії, асиметрії та ексцесу при визначенні порушень інформаційної безпеки кіберфізичних систем вітрових генераторів

The active introduction of intelligent systems that closely interact with physical processes to solve a wide range of different tasks of human life increases the relevance of risk analysis associated with the functioning of such systems. Such hybrid complex intelligent systems belong to the class of cyberphysical systems (CPS). Violations of CPS security caused by outside interference in the information flow can lead to economic losses, environmental threats, and threats to human life and health. A significant increase in incidents of violation of the safety of CPS wind turbines determines the relevance of research on methods for protecting such systems. The subject matter of the study in the article is the process of determining violations of the information security of the CPS of a wind generator based on the analysis of statistical indicators of variance, asymmetry, and kurtosis of the input parameter "Power" collected by CPS sensors. The goal is to develop an algorithm for determining violations of the information security of the CPS using methods for analyzing statistical indicators of variance, asymmetry, and kurtosis. The tasks to be solved are: to formalize the process of identifying falsified data in the information flow of the CPS; to determine the advantages and disadvantages of existing methods for ensuring the information security of the CPS; to determine the degree of changes in statistical indicators of variance, asymmetry, and kurtosis of the sample of the "Power" parameter of the wind generator in the presence of misinformation in the information flow; to analyze the possibility of supplementing and further improving the proposed algorithm. The methods used are analysis of statistical indicators of variance, asymmetry, and kurtosis of the sample of the parameter "Power" of the wind generator. The following results are obtained: the general characteristics of the CPS and features of the functioning of the CPS of the wind turbine as the object of research of this work are considered; an initial algorithm for determining violations of the information security of the CPS of wind turbine based on the use of statistical indicators of variance, asymmetry, and excess is developed; the fact of artificial substitution of data for the parameter "power" of the information flow of the CPS of a wind turbine is determined; ways to improve the developed algorithm using one-factor variance analysis, bootstrap methods are proposed. Conclusions. The scientific novelty of the results obtained consists of the development of an improved algorithm for determining the fact of data falsification in the CPS information flow based on the analysis of variance, asymmetry, and kurtosis indicators; the use of a statistical method for determining CPS security violations, analyzing the shortcomings of existing methods for determining CPS security violations and the possibility of their comprehensive improvement. The issues of the possibility of improving the developed method and testing the method in the future are also considered.