Background: The aesthetic and functional aspects of artificial tooth selection are pivotal for an individual's quality of life, a skill paramount to every prosthodontist. It gives a pleasing, expressive and confident life to the patient. Aim: This study aimed to juxtapose the dimensions of natural maxillary and mandibular anterior and posterior teeth with those of three commercially available denture teeth brands: Acryrock, Biorock, and Ivoclar Vivadent, taking into account gender variations Materials and Methods: Dentate casts from 23 males and 77 females were scrutinized for length and width of the natural anterior and posterior teeth dimensions. These measurements, collected by a single examiner employing a digital vernier calliper and flexible ruler, were subsequently compared to the specifications provided in the respective denture teeth mold charts. like Acryrock, Biorock, Ivoclar vivadent. The dimensions thus obtained are compared between the three systems of artificial teeth and natural teeth for selecting the best system of artificial teeth for complete denture prosthesis. Results : The study revealed that all three artificial teeth systems matched the width of natural maxillary anterior teeth. However, only the Ivoclar Vivadent teeth set closely resembled the dimensions of mandibular anterior and posterior teeth, as well as maxillary posterior teeth, across both genders. Conclusion: The findings confirm the feasibility of employing natural teeth dimensions to determine the size of anterior and posterior artificial teeth for complete denture prosthesis fabrication, providing a statistically and mathematically supported approach. keywords: artificial teeth, aesthetics, complete denture, dentulous subjects, mesiodistal width, prosthesis.