While there is an emerging and always-growing interest for novel paradigms appeared recently (e.g., social networks,Cloud computing,NoSQL databases, Big Data, and so forth), Artificial Intelligence (AI) always plays a critical role in next-generation Information Systems. Indeed, as technology and paradigms pervade our life, there is a challenging need for smarter and more sophisticated Information Systems, for instance using innovative methodologies like crowdsourcing. As a consequence, it is natural to foresee the advancement of a novel class of Information Systems, which we call as AI-Inspired Information Systems. Basically, these are Information Systems which incorporate in their critical layers (i.e., design, implementation, validation) AI methodologies, yet extending their roots to classical foundations, with, indeed, exciting innovations. From this main evidence, there emerges a great interest in methodologies that can improve the variegate aspects of Information Systems life-cycle, with special emphasis on the modeling, representation, querying, retrieval, reasoning, mining and end-user phases. On the other hand, AI-inspired approaches tend to be computationally expensive, so that complexity analysis of proposed solutions must be rigorously evaluated and reasonable execution bounds should be derived. As a consequence, it naturally follows that designing, implementing and validating AI-Inspired Information Systems not only conveys in the need for elegant and scalable approaches, but also these approaches need to be theoretically-sound and exposing bounded complexities. Along this line, this special issue on “Design, Implementation and Validation of AIInspired Information Systems” of Journal of Intelligent Information Systems focuses on latest research results and open research challenges on the problem of designing, implementing and validating Information Systems, based on AI paradigms, according to principles and guidelines provided above. With the aim of adequately fulfilling both theoretical and practical issues of the investigated research context, this special issue contains five papers, which have gone through two rigorous review rounds before being accepted for the final inclu-