Artificial Intelligence Analysis Research Articles

The Role of Artificial Intelligence in Literary Analysis: A Computational Approach to Understand Literary Styles

This research explores the evolving landscape of literary analysis through the integration of Artificial Intelligence (AI) and traditional human scholarship. The primary objective is to assess the extent to which AI can enhance the analysis of literary texts by examining its performance in uncovering thematic and stylistic elements within William Shakespeare's "Hamlet." This study employs a mixedmethods research approach, combining qualitative and quantitative techniques to provide a comprehensive evaluation. In the digital age, AI has emerged as a promising tool for text analysis, offering efficiency and scalability. However, it raises fundamental questions about its ability to grasp the profound nuances, cultural contexts, and thematic richness inherent in literary works. Through meticulous comparative and thematic analyses, this research investigates the strengths and limitations of AI in literary analysis, juxtaposing its findings with traditional human interpretations. The results of our study reveal that AI excels in identifying patterns, themes, and stylistic markers within "Hamlet." It effectively recognizes key themes such as revenge, madness, and moral corruption. However, AI's analysis often lacks the depth and contextual understanding present in traditional critiques, particularly in interpreting abstract motifs and cultural references. Our findings underscore the complementary nature of AI and human scholarship in literary analysis. While AI offers quantitative efficiency and objectivity, human interpretation provides the depth, cultural insights, and emotional resonance necessary for a comprehensive understanding of literary works. We argue for a harmonious future where AI augments human expertise, leading to more profound insights and a richer literary scholarship. This research not only contributes to the field of literary analysis but also offers a broader perspective on the evolving relationship between technology and human creativity. As AI technologies advance, the collaborative synergy between AI's quantitative efficiency and human interpretation's qualitative depth promises to reshape the landscape of literary studies, enriching our understanding of literature across diverse genres, time periods, and cultural contexts.

Implementing AI in Hospitals to Achieve a Learning Health System: Systematic Review of Current Enablers and Barriers.

Efforts are underway to capitalize on the computational power of the data collected in electronic medical records (EMRs) to achieve a learning health system (LHS). Artificial intelligence (AI) in health care has promised to improve clinical outcomes, and many researchers are developing AI algorithms on retrospective data sets. Integrating these algorithms with real-time EMR data is rare. There is a poor understanding of the current enablers and barriers to empower this shift from data set-based use to real-time implementation of AI in health systems. Exploring these factors holds promise for uncovering actionable insights toward the successful integration of AI into clinical workflows. The first objective was to conduct a systematic literature review to identify the evidence of enablers and barriers regarding the real-world implementation of AI in hospital settings. The second objective was to map the identified enablers and barriers to a 3-horizon framework to enable the successful digital health transformation of hospitals to achieve an LHS. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were adhered to. PubMed, Scopus, Web of Science, and IEEE Xplore were searched for studies published between January 2010 and January 2022. Articles with case studies and guidelines on the implementation of AI analytics in hospital settings using EMR data were included. We excluded studies conducted in primary and community care settings. Quality assessment of the identified papers was conducted using the Mixed Methods Appraisal Tool and ADAPTE frameworks. We coded evidence from the included studies that related to enablers of and barriers to AI implementation. The findings were mapped to the 3-horizon framework to provide a road map for hospitals to integrate AI analytics. Of the 1247 studies screened, 26 (2.09%) met the inclusion criteria. In total, 65% (17/26) of the studies implemented AI analytics for enhancing the care of hospitalized patients, whereas the remaining 35% (9/26) provided implementation guidelines. Of the final 26 papers, the quality of 21 (81%) was assessed as poor. A total of 28 enablers was identified; 8 (29%) were new in this study. A total of 18 barriers was identified; 5 (28%) were newly found. Most of these newly identified factors were related to information and technology. Actionable recommendations for the implementation of AI toward achieving an LHS were provided by mapping the findings to a 3-horizon framework. Significant issues exist in implementing AI in health care. Shifting from validating data sets to working with live data is challenging. This review incorporated the identified enablers and barriers into a 3-horizon framework, offering actionable recommendations for implementing AI analytics to achieve an LHS. The findings of this study can assist hospitals in steering their strategic planning toward successful adoption of AI.

Mempersiapkan Sumber Daya Manusia (SDM) dalam Menghadapi Tantangan Artifical Intelligence Pada Sektor Publik

Artificial Intelligence (AI) is one area of technology that plays a major role in digital transformation. Human Resource Management (HRM) has an unlimited role to play in creating a fair work environment throughout the world and ensuring fairness in the company. AI analytics can be used in the human resources sector to generate strategies and solutions quickly and enable employees to align processes efficiently. The method used in this research is literature study by collecting information through articles and scientific journals. The research results show that public sector workers must acquire new skills and knowledge necessary to interact with and manage AI systems. In facing advances in AI, companies/agencies need to pay attention to HR career development through training and improving new skills and knowledge needed to interact and manage AI systems. In facing global challenges, AI must be seen as a tool, not a substitute for human resource management.

The Applications of Artificial Intelligence (AI)-Driven Tools in Virus-Like Particles (VLPs) Research.

Viral-like particles (VLPs) represent versatile nanoscale structures mimicking the morphology and antigenic characteristics of viruses, devoid of genetic material, making them promising candidates for various biomedical applications. The integration of artificial intelligence (AI) into VLP research has catalyzed significant advancements in understanding, production, and therapeutic applications of these nanostructures. This comprehensive review explores the collaborative utilization of AI tools, computational methodologies, and state-of-the-art technologies within the VLP domain. AI's involvement in bioinformatics facilitates sequencing and structure prediction, unraveling genetic intricacies and three-dimensional configurations of VLPs. Furthermore, AI-enabled drug discovery enables virtual screening, demonstrating promise in identifying compounds to inhibit VLP activity. In VLP production, AI optimizes processes by providing strategies for culture conditions, nutrient concentrations, and growth kinetics. AI's utilization in image analysis and electron microscopy expedites VLP recognition and quantification. Moreover, network analysis of protein-protein interactions through AI tools offers an understanding of VLP interactions. The integration of multi-omics data via AI analytics provides a comprehensive view of VLP behavior. Predictive modeling utilizing machine learning algorithms aids in forecasting VLP stability, guiding optimization efforts. Literature mining facilitated by text mining algorithms assists in summarizing information from the VLP knowledge corpus. Additionally, AI's role in laboratory automation enhances experimental efficiency. Addressing data security concerns, AI ensures the protection of sensitive information in the digital era of VLP research. This review serves as a roadmap, providing insights into AI's current and future applications in VLP research, thereby guiding innovative directions in medicine and beyond.

Potentials and challenges of artificial intelligence-supported greenwashing detection in the energy sector

Fossil fuel actors have been using greenwashing strategies to enhance their public image by making ‘green’ and ‘sustainable’ claims, which can be misleading for the investing public. This is particularly concerning as it can lead to the unwitting investment in carbon-intensive businesses and investments. The challenge lies in verifying the accuracy of environmental practices due to the vague language used in environmental reporting and disclosures. This Perspective proposes the use of Artificial Intelligence (AI)-supported greenwashing detection tools to help identify and scrutinise greenwashing practices, especially through web scraping, natural language processing, and life cycle assessments to assess the claims made in environmental reports and disclosures using examples from three cases to detect deceptive practices and promote transparency in the industry. However, for AI to be effective in detecting greenwashing practices, it is essential to have trustworthy and readily available databases, as well as human expert involvement to check for any biases in the AI's analysis.

Leadership training and development in the age of artificial intelligence

PurposeThe purpose of this study is to examine the multifaceted implications of AI on leadership dynamics and organizational practices. By synthesizing insights from behavioral theory, AI analytics, and ethical considerations, the study aims to equip leaders with the requisite knowledge, skills, and mindset to foster adaptive leadership, anticipate change, and cultivate innovation amidst AI-driven disruptions.Design/methodology/approachThis article employs a qualitative research approach, integrating literature review and conceptual analysis to explore the intersection of leadership development and Artificial Intelligence (AI). Drawing insights from scholarly articles, theoretical frameworks and practice, the study elucidates the evolving landscape of leadership in the context of AI adoption. Practical action points are derived to guide organizational leaders and educators in navigating AI-induced transformations effectively.FindingsThe integration of AI into leadership dynamics necessitates a paradigm shift in leadership paradigms, emphasizing the fusion of technical proficiency with emotional intelligence. Behavioral theory coupled with AI analytics offers valuable insights into effective leadership behaviors, facilitating the design of tailored leadership development programs. Proactive leadership strategies, ethical considerations, and talent management emerge as pivotal factors in navigating AI-induced transformations and fostering organizational resilience.Originality/valueThis article contributes to the literature by synthesizing diverse perspectives on AI leadership and offering practical action points for organizational leaders and educators. By highlighting the integration of behavioral theory, AI analytics, and ethical considerations, the study underscores the importance of interdisciplinary approaches in leadership research and education. The insights derived from this study inform organizational practices, curriculum development in higher education, and future research agendas, fostering ethical AI adoption and cultivating adaptive leadership cultures in the age of Artificial Intelligence.

Artificial Intelligence in Next-Generation Networking: Energy Efficiency Optimization in IoT Networks Using Hybrid LEACH Protocol

The convergence of the Internet of Things (IoT) and Artificial Intelligence (AI) is significantly transforming the landscape of future networking. The Internet of Things (IoT) is a technological paradigm that encompasses embedded systems, wireless sensors, and automation, facilitating the integration of various applications ranging from smart homes to wearable devices. In addition, the advent of artificial intelligence (AI) amplifies this influence by providing data-driven analytics, optimising processes, and presenting novel opportunities for growth. Nevertheless, the widespread adoption of devices within Internet of Things (IoT) networks gives rise to apprehensions regarding increased energy consumption. In order to ensure the longevity of network operations, it is imperative to employ energy-efficient protocols for sensor nodes that possess limited power resources. One example of a protocol that demonstrates this concept is the Low Energy Adaptive Clustering Hierarchy (LEACH) protocol. This protocol effectively divides networks into clusters and dynamically adjusts the cluster heads to optimise the transmission of data to the base stations. Our study enhances the LEACH protocol by incorporating digital twin simulation, thereby enhancing the efficiency of IoT systems. Virtual network models and AI analytics are employed to assess energy consumption and performance. Cache nodes play a crucial role within this framework as they collect data from cluster heads in order to transmit it to the base station. By leveraging artificial intelligence (AI) and simulation techniques, we are able to improve the energy efficiency and reliability of the Internet of Things (IoT) systems. The findings indicate a significant reduction of 83% in non-functioning nodes and a notable increase of 1.66 times in energy levels of nodes compared to conventional approaches. This study highlights a potential direction for energy-efficient, AI-enhanced Internet of Things (IoT) networking through the utilisation of the Low-Energy Adaptive Clustering Hierarchy (LEACH) protocol.

AI analytics can be used as imaging biomarkers for predicting invasive upgrade of ductal carcinoma in situ

ObjectivesTo evaluate whether the quantitative abnormality scores provided by artificial intelligence (AI)-based computer-aided detection/diagnosis (CAD) for mammography interpretation can be used to predict invasive upgrade in ductal carcinoma in situ (DCIS) diagnosed on percutaneous biopsy.MethodsFour hundred forty DCIS in 420 women (mean age, 52.8 years) diagnosed via percutaneous biopsy from January 2015 to December 2019 were included. Mammographic characteristics were assessed based on imaging features (mammographically occult, mass/asymmetry/distortion, calcifications only, and combined mass/asymmetry/distortion with calcifications) and BI-RADS assessments. Routine pre-biopsy 4-view digital mammograms were analyzed using AI-CAD to obtain abnormality scores (AI-CAD score, ranging 0–100%). Multivariable logistic regression was performed to identify independent predictive mammographic variables after adjusting for clinicopathological variables. A subgroup analysis was performed with mammographically detected DCIS.ResultsOf the 440 DCIS, 117 (26.6%) were upgraded to invasive cancer. Three hundred forty-one (77.5%) DCIS were detected on mammography. The multivariable analysis showed that combined features (odds ratio (OR): 2.225, p = 0.033), BI-RADS 4c or 5 assessments (OR: 2.473, p = 0.023 and OR: 5.190, p < 0.001, respectively), higher AI-CAD score (OR: 1.009, p = 0.007), AI-CAD score ≥ 50% (OR: 1.960, p = 0.017), and AI-CAD score ≥ 75% (OR: 2.306, p = 0.009) were independent predictors of invasive upgrade. In mammographically detected DCIS, combined features (OR: 2.194, p = 0.035), and higher AI-CAD score (OR: 1.008, p = 0.047) were significant predictors of invasive upgrade.ConclusionThe AI-CAD score was an independent predictor of invasive upgrade for DCIS. Higher AI-CAD scores, especially in the highest quartile of ≥ 75%, can be used as an objective imaging biomarker to predict invasive upgrade in DCIS diagnosed with percutaneous biopsy.Critical relevance statementNoninvasive imaging features including the quantitative results of AI-CAD for mammography interpretation were independent predictors of invasive upgrade in lesions initially diagnosed as ductal carcinoma in situ via percutaneous biopsy and therefore may help decide the direction of surgery before treatment.Key points• Predicting ductal carcinoma in situ upgrade is important, yet there is a lack of conclusive non-invasive biomarkers.• AI-CAD scores—raw numbers, ≥ 50%, and ≥ 75%—predicted ductal carcinoma in situ upgrade independently.• Quantitative AI-CAD results may help predict ductal carcinoma in situ upgrade and guide patient management.Graphical

The Use of Uroflowmetry as a Diagnostic Test.

Uroflowmetry is widely used for initial non-invasive evaluation of lower urinary tract disorders. Current clinical use is mostly restricted to a scrutiny of the maximum flow rate and uroflow pattern recorded by a conventional flowmeter in a health care facility. There are several advancements in our understanding and in available technologies that promise to transform clinical utilization of this simple test. Several aspects of the uroflow test in addition to maximum flow rate and uroflow pattern show potential diagnostic utility. This includes flow acceleration, uroflow indices, uroflow-electromyography including lag time, stop uroflow test, and uroflow-based nomograms. There are initial attempts to use artificial intelligence in analysis. There is also new data with regard to factors influencing variability of uroflow testing that might influence the diagnostic value in as yet uncertain ways including diurnal variability, postural variability, locational variability, and operator variability. There are new technologies for uroflow testing in a home environment allowing for easy repetition. However, there are several challenges owing to a paucity of clinical data and standardization. There are also critical lacunae in terminology that need to be addressed. There are exciting new advancements in the field of uroflowmetry. However, there is need to standardize and validate the newer uroflow tracing analyses and technologies.

Applied AI for finance and accounting: Alternative data and opportunities

Big data and artificial intelligence (AI) have transformed the finance industry by altering the way data and information are generated, processed, and incorporated into decision-making processes. Data and information have emerged as a new class of assets, facilitating efficient contracting and risk-sharing among corporate stakeholders. Researchers have also increasingly embraced machine learning and AI analytics tools, which enable them to exploit empirical evidence to an extent that far surpasses traditional methodologies. In this review article, prepared for a special issue on Artificial Intelligence (AI) and Finance in the Pacific-Basin Finance Journal, we aim to provide a summary of the evolving landscape of AI applications in finance and accounting research and project future avenues of exploration. Given the burgeoning mass of literature in this field, it would be unproductive to attempt an exhaustive catalogue of these studies. Instead, our goal is to offer a structured framework for categorizing current research and guiding future studies. We stress the importance of blending financial domain expertise with state-of-the-art data analytics skills. This fusion is essential for researchers and professionals to harness the opportunities offered by data and analytical tools to better comprehend and influence our financial system.

Explainable artificial intelligence in deep learning neural nets-based digital images analysis

This review shows the capabilities of artificial intelligence in the analysis of digital images in the field of medicine using convolutional neural networks of deep learning. A new generation of artificial intelligence systems is described with an explanation of decision-making algorithms to the user — explainable artificial intelligence (XAI). The taxonomy of the methods of explanation and the description of the methods themselves are given. The substantiation of the need to use explainable artificial intelligence in classification tasks is given on the example of ophthalmic diseases. The study of the components of deep learning methods used in the reviewed works (neural network architecture, accuracy, characteristics of data sets) and explainable artificial intelligence (methods of explanation, criteria for the accuracy of explanation). As an example, the problem of recognizing two of the most commonly diagnosed eye diseases: diabetic retinopathy and glaucoma by artificial neural networks is considered.

Artificial intelligence predictive analytics in heart failure: results of the pilot phase of a pragmatic randomized clinical trial.

We conducted an implementation planning process during the pilot phase of a pragmatic trial, which tests an intervention guided by artificial intelligence (AI) analytics sourced from noninvasive monitoring data in heart failure patients (LINK-HF2). A mixed-method analysis was conducted at 2 pilot sites. Interviews were conducted with 12 of 27 enrolled patients and with 13 participating clinicians. iPARIHS constructs were used for interview construction to identify workflow, communication patterns, and clinician's beliefs. Interviews were transcribed and analyzed using inductive coding protocols to identify key themes. Behavioral response data from the AI-generated notifications were collected. Clinicians responded to notifications within 24 hours in 95% of instances, with 26.7% resulting in clinical action. Four implementation themes emerged: (1) High anticipatory expectations for reliable patient communications, reduced patient burden, and less proactive provider monitoring. (2) The AI notifications required a differential and tailored balance of trust and action advice related to role. (3) Clinic experience with other home-based programs influenced utilization. (4) Responding to notifications involved significant effort, including electronic health record (EHR) review, patient contact, and consultation with other clinicians. Clinician's use of AI data is a function of beliefs regarding the trustworthiness and usefulness of the data, the degree of autonomy in professional roles, and the cognitive effort involved. The implementation planning analysis guided development of strategies that addressed communication technology, patient education, and EHR integration to reduce clinician and patient burden in the subsequent main randomized phase of the trial. Our results provide important insights into the unique implications of implementing AI analytics into clinical workflow.

The Role of Artificial Intelligence in Plastic Surgery: Review, Applications, and Future Prospects to Revolutionize Patients Outcomes, Safety and Satisfaction

The integration of artificial intelligence (AI) in plastic surgery holds immense potential for transforming the field, improving outcomes, and enhancing patient satisfaction. This article examines the application of AI in pre-operative planning, intra-operative decision making, and post-operative monitoring. AI tools leverage patient images to provide valuable insights into surgical outcomes, aiding in visualization and communication. Real-time guidance during surgery is facilitated by AI's analysis of intra-operative images, ensuring accurate execution and enhancing safety. In post-operative monitoring, AI analyzes patient data to predict outcomes, detect complications, and optimize wound healing assessment. Despite challenges, the future of AI in plastic surgery looks promising, with advancements in augmented reality, mobile applications, computer vision, and robotically assisted treatments driving progress and strengthening patient-physician relationships.

Operando Electron Microscopy of Catalysts: The Missing Cornerstone in Heterogeneous Catalysis Research?

Heterogeneous catalysis in thermal gas-phase and electrochemical liquid-phase chemical conversion plays an important role in our modern energy landscape. However, many of the structural features that drive efficient chemical energy conversion are still unknown. These features are, in general, highly distinct on the local scale and lack translational symmetry, and thus, they are difficult to capture without the required spatial and temporal resolution. Correlating these structures to their function will, conversely, allow us to disentangle irrelevant and relevant features, explore the entanglement of different local structures, and provide us with the necessary understanding to tailor novel catalyst systems with improved productivity. This critical review provides a summary of the still immature field of operando electron microscopy for thermal gas-phase and electrochemical liquid-phase reactions. It focuses on the complexity of investigating catalytic reactions and catalysts, progress in the field, and analysis. The forthcoming advances are discussed in view of correlative techniques, artificial intelligence in analysis, and novel reactor designs.

Intelligent Decision Support for Energy Management: A Methodology for Tailored Explainability of Artificial Intelligence Analytics

This paper presents a novel development methodology for artificial intelligence (AI) analytics in energy management that focuses on tailored explainability to overcome the “black box” issue associated with AI analytics. Our approach addresses the fact that any given analytic service is to be used by different stakeholders, with different backgrounds, preferences, abilities, skills, and goals. Our methodology is aligned with the explainable artificial intelligence (XAI) paradigm and aims to enhance the interpretability of AI-empowered decision support systems (DSSs). Specifically, a clustering-based approach is adopted to customize the depth of explainability based on the specific needs of different user groups. This approach improves the accuracy and effectiveness of energy management analytics while promoting transparency and trust in the decision-making process. The methodology is structured around an iterative development lifecycle for an intelligent decision support system and includes several steps, such as stakeholder identification, an empirical study on usability and explainability, user clustering analysis, and the implementation of an XAI framework. The XAI framework comprises XAI clusters and local and global XAI, which facilitate higher adoption rates of the AI system and ensure responsible and safe deployment. The methodology is tested on a stacked neural network for an analytics service, which estimates energy savings from renovations, and aims to increase adoption rates and benefit the circular economy.

Applications of artificial intelligence in the analysis of dental panoramic radiographs: an overview of systematic reviews.

This overview of systematic reviews aimed to establish the current state of knowledge on the suitability of artificial intelligence (AI) in dental panoramic radiograph analysis and illustrate its changes over time. Medical databases covered by the Association for Computing Machinery, Bielefeld Academic Search Engine, Google Scholar, and PubMed engines were searched. The risk of bias was assessed using ROBIS tool. Ultimately, 12 articles were qualified for the qualitative synthesis. The results were visualized with timelines, tables, and charts. In the years 1988-2023, a significant development of information technologies for the analysis of DPRs was observed. The latest analyzed AI models achieve high accuracy in detecting caries (91.5%), osteoporosis (89.29%), maxillary sinusitis (87.5%), periodontal bone loss (93.09%), and teeth identification and numbering (93.67%). The detection of periapical lesions is also characterized by high sensitivity (99.95%) and specificity (92%). However, due to the small number of heterogeneous source studies synthesized in systematic reviews, the results of this overview should be interpreted with caution. Currently, AI applications can significantly support dentists in dental panoramic radiograph analysis. As systematic reviews on AI become outdated quickly, their regular updating is recommended. PROSPERO registration number: CRD42023416048.

The Role of Artificial Intelligence in Deciphering Diet-Disease Relationships: Case Studies.

Modernization of society from a rural, hunter-gatherer setting into an urban and industrial one, with the associated dietary changes, has led to an increased prevalence of cardiometabolic and additional noncommunicable diseases, such as cancer, inflammatory bowel disease, and neurodegenerative and autoimmune disorders. However, while dietary sciences have been rapidly evolving to meet these challenges, validation and translation of experimental results into clinical practice remain limited for multiple reasons, including inherent ethnic, gender, and cultural interindividual variability, among other methodological, dietary reporting-related, and analytical issues. Recently, large clinical cohorts with artificial intelligence analytics have introduced new precision and personalized nutrition concepts that enable one to successfully bridge these gaps in a real-life setting. In this review, we highlight selected examples of case studies at the intersection between diet-disease research and artificial intelligence. We discuss their potential and challenges and offer an outlook toward the transformation of dietary sciences into individualized clinical translation. Expected final online publication date for the Annual Review of Nutrition, Volume 43 is August 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Definition drives design: Disability models and mechanisms of bias in AI technologies

The increasing deployment of artificial intelligence (AI) tools to inform decision-making across diverse areas including healthcare, employment, social benefits, and government policy, presents a serious risk for disabled people, who have been shown to face bias in AI implementations. While there has been significant work on analysing and mitigating algorithmic bias, the broader mechanisms of how bias emerges in AI applications are not well understood, hampering efforts to address bias where it begins. In this article, we illustrate how bias in AI-assisted decision-making can arise from a range of specific design decisions, each of which may seem self-contained and non-biasing when considered separately. These design decisions include basic problem formulation, the data chosen for analysis, the use the AI technology is put to, and operational design elements in addition to the core algorithmic design. We draw on three historical models of disability common to different decision-making settings to demonstrate how differences in the definition of disability can lead to highly distinct decisions on each of these aspects of design, leading in turn to AI technologies with a variety of biases and downstream effects. We further show that the potential harms arising from inappropriate definitions of disability in fundamental design stages are further amplified by a lack of transparency and disabled participation throughout the AI design process. Our analysis provides a framework for critically examining AI technologies in decision-making contexts and guiding the development of a design praxis for disability-related AI analytics. We put forth this article to provide key questions to facilitate disability-led design and participatory development to produce more fair and equitable AI technologies in disability-related contexts.

Artificial intelligence underpins urban water infrastructure of the future: A holistic perspective

Abstract The potential of artificial intelligence (AI) in water management is widely recognised by research and practice communities alike, with an increasing number of applications showed tackling water supply, stormwater and wastewater management challenges. However, there is a critical knowledge gap in understanding the fundamental role of AI in the development of urban water infrastructure (UWI). This review aimed to provide an analysis of how AI could be aligned to support the future development of UWI systems. Four types of AI analytics – descriptive, diagnostic, predictive and prescriptive – are discussed and linked to the improvement in the performance of UWI systems from three categories: reliability, resilience and sustainability. It is envisioned that AI technology will play a pivotal role in UWI transitioning to the future through underpinning the five development pathways: decentralisation, circular economy, greening, decarbonisation and automation. The barriers in improving AI adoption in the real world are also highlighted from four dimensions: cyber-physical infrastructure, institutional governance, social-economic systems and technological development in wider society. Embedding AI in the development pathways and tackling the barriers can ensure that AI-empowered systems are deployed in an equitable and responsible way to improve the resilience and sustainability of future UWI systems.

The role of artificial intelligence in analysis of biofluid markers for diagnosis and management of glaucoma: A systematic review.

This review focuses on utility of artificial intelligence (AI) in analysis of biofluid markers in glaucoma. We detail the accuracy and validity of AI in the exploration of biomarkers to provide insight into glaucoma pathogenesis. A comprehensive search was conducted across five electronic databases including Embase, Medline, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Web of Science. Studies pertaining to biofluid marker analysis using AI or bioinformatics in glaucoma were included. Identified studies were critically appraised and assessed for risk of bias using the Joanna Briggs Institute Critical Appraisal tools. A total of 10,258 studies were screened and 39 studies met the inclusion criteria, including 23 cross-sectional studies (59%), nine prospective cohort studies (23%), six retrospective cohort studies (15%), and one case-control study (3%). Primary open angle glaucoma (POAG) was the most commonly studied subtype (55% of included studies). Twenty-four studies examined disease characteristics, 10 explored treatment decisions, and 5 provided diagnostic clarification. While studies examined at entire metabolomic or proteomic profiles to determine changes in POAG, there was heterogeneity in the data with over 175 unique, differentially expressed biomarkers reported. Discriminant analysis and artificial neural network predictive models displayed strong differentiating ability between glaucoma patients and controls, although these tools were untested in a clinical context. The use of AI models could inform glaucoma diagnosis with high sensitivity and specificity. While insight into differentially expressed biomarkers is valuable in pathogenic exploration, no clear pathogenic mechanism in glaucoma has emerged.