Artery Doppler In Prediction Research Articles

Role of PAPP-A (Pregnancy Associated Plasma Protein-A), PlGF (Placental Growth Factor) and uterine artery doppler in prediction of preeclampsia

Role of PAPP-A (Pregnancy Associated Plasma Protein-A), PlGF (Placental Growth Factor) and uterine artery doppler in prediction of preeclampsia

Role of uterine artery Doppler in prediction of preeclampsia and associated adverse outcomes between 12-20 weeks in low risk pregnancies

Role of uterine artery Doppler in prediction of preeclampsia and associated adverse outcomes between 12-20 weeks in low risk pregnancies

Performance of HDP-Gestosis Score and Ophthalmic Artery Doppler in Prediction of Pre-eclampsia.

To study the predictive accuracy of maternal characteristics, mean arterial pressure, uterine artery doppler and maternal ophthalmic artery doppler in second trimester for subsequent development of pre-eclampsia. Aprospective cohort study of 440 women at 19-24weeks' gestation. It included recording of maternal demographic characteristics and calculation of HDP Gestosis Score, measurement of MAP and ultrasound evaluation for fetal anatomy, Uterine artery doppler and maternal ophthalmic artery doppler. The mean Peak Systolic Velocity ratio was obtained by taking two sets of reading from both eyes. The statistical analysis was done using independent t-test for quantitative variables and chi-square test, Fisher's exact test for qualitative variables and Area Under Curve was obtained at 10% False Positive Rate. Among 440 pregnant women, 43(10.8%) developed Hypertensive Disorder of Pregnancy (8 early onset PE, 16 late onset PE and 19 GHTN) and 42 were lost to follow up, withan incidence rate of 10.8%. Combination of Gestosis Score + OAD PSV Ratio had highest AUC of 0.73. Whereas combination of Gestosis Score + MAP + UtAPI + OAD-PSV Ratio had highest sensitivity of 97.67%. The OAD PSV ratio improved detection rate of Gestosis Score (from 90 to 100%) for prediction of development of PE, especially Preterm PE at 10% FPR. Maternal Ophthalmic artery doppler study significantly improved prediction of development of PE at 19-24weeks' gestation, both independently as well as in combination with HDP-Gestosis Score, MAP and uterine artery doppler.

PREDICTION OF PREECLAMPSIA BY UTERINE ARTERY DOPPLER

Objective: To evaluate the role of mean pulsatility index by rst trimester uterine artery doppler in prediction of preeclampsia. A prospective observational study was conducted in a tertiary c Methodology: are center. Of 200 women screened, 136 women met eligible criteria and 130 consented for participation in the study. In addition to nuchal translucency and crown-rump length, mean uterine artery pulsatility index (PI) was measured at 11–13+6 weeks, and women were followed up till delivery to observe the development of gestational hypertension, preeclampsia and fetal growth restriction (FGR). Categorical variables were analyzed using ROC curve, and P≤0.05 (5%) was used to calculate signicance. Among 130 women followed t Results: ill delivery, 9 (6.92%) had mean PI >95% and 121 (93.08%) had normal Doppler. A signicantly higher number of women with PI ≥95% had preeclampsia (55.55%) (p < 0.001), and the sensitivity of PI in prediction of preeclampsia was 55.55% with specicity of 98.80%. No association was found between PI and FGR (p = 0.228). Conclusion: This study showed a positive association with the development of preeclampsia . The predictive accuracy of rst trimester uterine artery Doppler using PI with cutoff of >95% has low sensitivity in prediction of preeclampsia (55.55%) but it has high specicity(98.80%) for prediction of PE(Preeclampsia).

Cervical length Measurements and Uterine Artery Doppler in Prediction of Preterm Labour of High-Risk Women

Cervical length Measurements and Uterine Artery Doppler in Prediction of Preterm Labour of High-Risk Women

Role of Ophthalmic Artery Doppler in Prediction of Preeclampsia

Role of Ophthalmic Artery Doppler in Prediction of Preeclampsia

The Role of Fetal Pulmonary Artery Doppler in Prediction of Fetal Lung Maturity

The Role of Fetal Pulmonary Artery Doppler in Prediction of Fetal Lung Maturity

Role of Uterine Artery Doppler in Prediction of Preeclampsia: A Prospective Analytical Study

Introduction: Preeclampsia is pregnancy specific hypertensive disorder of pregnancy which is associated with both high maternal and perinatal morbidity and mortality. Timely prediction and management in time, are the two key factors for prevention of these morbidities and mortalities. The aim of present study was to evaluate role of uterine artery doppler in prediction of preeclampsia in second and third trimester of pregnancy in Indian setting. Materials and Methods: This was a prospective analytical study done at department of Obstetrics and Gynaecology, King George Medical university, Lucknow over a period of one year. After ethical approval (Institutional Ethics Committee, KGMU, Lucknow, Ref. Code: 92nd ECM II B- thesis P/29.) and informed consent from every patient, recruitment was done. Group I had 120 normotensive patients and Group 2 had 100 preeclampsia patients at time of enrollment. Bilateral uterine artery doppler was done for every patient and patient were further followed for maternal and perinatal outcome. Results: Total 220 patients were studied. In Group 1, 15 patients developed preeclampsia. Both groups were comparable for maternal age and parity. However, BMI was found to be significantly higher in the patients of Preeclampsia group. Uterine artery doppler, showed statistically significant difference and it was high in preeclampsia group. It had high negative predictive value. Gestation of termination was significantly lower in preeclampsia group. Fetal birth weight was significantly lower in preeclampsia group. Conclusion: Uterine artery doppler is a non-invasive test with high negative predictive value which should be utilized for prediction of preeclampsia for all pregnant patients.

Ophthalmic artery Doppler in prediction of pre‐eclampsia: insights from hemodynamic considerations

Linked article: This Correspondence comments on Sapantzoglou et al. and Sarno et al.

Ophthalmic artery Doppler in prediction of pre-eclampsia at 35-37 weeks' gestation.

First, to examine the potential value of maternal ophthalmic artery Doppler at 35-37 weeks' gestation in the prediction of subsequent development of pre-eclampsia (PE), and, second, to examine the variability between repeat measurements in the same eye and variability in measurements between the two eyes. This was a prospective observational study in women attending for a routine hospital visit at 35 + 0 to 36 + 6 weeks' gestation. The visit included recording of maternal demographic characteristics and medical history and assessment of flow velocity waveforms from the maternal ophthalmic artery. Waveforms were obtained in sequence from the right eye, left eye and again from the right and then left eye. We recorded the average of the four measurements, two from each eye, for the following four indices: first peak of systolic velocity; second peak of systolic velocity; pulsatility index; and the ratio of the second to first peak of systolic velocity (PSV ratio). The measurements of the four indices were standardized to remove the effects of maternal characteristics and elements from the medical history. The competing-risks model was used to determine the detection rate (DR) of delivery with PE at any time and at < 3 weeks after assessment, at a 10% false-positive rate (FPR), in screening by maternal factors alone and a combination of maternal factors and the adjusted value of each of the four ophthalmic artery indices. The study population of 2287 pregnancies contained 60 (2.6%) that developed PE, including 19 (0.8%) that delivered with PE at < 3 weeks after assessment. The DR, at 10% FPR, of delivery with PE at any time after assessment by maternal factors was 25.0% (95% CI, 14.7-37.9%), and this increased by 25 percentage points to 50.0% (95% CI, 36.8-63.2%) with the addition of the adjusted PSV ratio (P = 0.005); the respective values for delivery with PE at < 3 weeks after assessment were 31.6% (95% CI, 12.6-56.6%) and 57.9% (95% CI, 33.5-79.8%). The other ophthalmic artery indices did not improve the prediction provided by maternal factors alone. There was good correlation between the first and second measurements of PSV ratio from the same eye (right eye r = 0.823, left eye r = 0.840), but poorer correlation in the first and second measurements between the two eyes (first measurement r = 0.690, second measurement r = 0.682). In screening by maternal factors and PSV ratio for PE with delivery at any stage after assessment, the estimated DR, at 10% FPR, was 50.0% when the average of four measurements was used (two from each eye), 49.1% when the average of one measurement from each eye was used, 47.3% when the average of two measurements from the same eye was used, and 45.8% when only one measurement was used. Ophthalmic artery PSV ratio at 35-37 weeks' gestation can predict subsequent delivery with PE, especially if this occurs within 3 weeks after assessment. In the assessment of ophthalmic artery Doppler, it is necessary to use the average of one measurement from each eye to minimize variability of measurements. © 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Role of uterine and umbilical artery doppler in prediction of developing pre- eclampsia in pregnancy

Results: The pregnant women were grouped into two groups: 65 women who developed PE with or without other pregnancy complications and 30 pregnant women who did not develop PE. Among the pregnant women that developed PE, 20 had mild PE and 45 had severe PE. The mean age of pregnant women who developed PE was 31.03 ± 3.11 years with a range of 22–39 years, while the mean age of pregnant women who did not develop PE was 30.65 ± 5.20 years with a range of 15–48. Conclusion: The findings of our study show that the PSV and EDV were significantly lower, whereas the RI, PI and S/D were significantly higher in cases that developed PE. The uterine artery PI is the best predictor of PE. A combination of the uterine artery PSV and the umbilical artery PSV best predict severity of PE among pregnant women.

Role of First and Second Trimester Uterine Artery Doppler in Prediction of Pre-Eclampsia

Role of First and Second Trimester Uterine Artery Doppler in Prediction of Pre-Eclampsia

Uterine Artery Doppler for Prediction of Amenorrhea in Women Desiring to use the Lactational menorrhea Method for Contraception

Uterine Artery Doppler for Prediction of Amenorrhea in Women Desiring to use the Lactational menorrhea Method for Contraception

Serum biomarkers combined with uterine artery Doppler in prediction of preeclampsia

Preeclampsia is a multi-systemic disease which affects 4-5% of pregnancies, being one of the main causes often leading to death for both the mother and the baby, the death rate going up to 50,000-60,000 cases on an annual basis, which occurs in countries where the income is low or average. Although preeclampsia is considered one of the medical disorders that are still uncertain, recent research raises the question of the endothelial dysfunction, thus the imbalance between pro-angiogenic and anti-angiogenic factors is taken into consideration both as a means to diagnose and prognosticate it. Furthermore, the biomarkers play a key role regarding the disease, being subject to accurate interpretation. Measurements of the IP of the uterine blood vessels through Doppler interpretation during the second term of the pregnancy might bring further evidence in support of identifying preeclampsia features, which emphasize the role of the biomarkers in predicting the development of the disease.

OP12.10: Added value of second‐trimester uterine artery Doppler in predicting pre‐eclampsia and small‐for‐gestational age neonates in the general population

OP12.10: Added value of second‐trimester uterine artery Doppler in predicting pre‐eclampsia and small‐for‐gestational age neonates in the general population

Serum biomarkers combined with uterine artery Doppler in prediction of preeclampsia.

First-trimester screening may be a major advantage over a second-trimester approach since it opens prospects for early and more efficient interventions. The aim of the current study was to evaluate whether the measurement of maternal serum inhibin A, activin A and placental growth factor (PlGF) at three to four months gestation with the second-trimester uterine artery pulsatility index (PI) are useful in predicting preeclampsia in a group of nulliparous women. All the patients also underwent uterine artery Doppler examination to measure the PI at 22–24 weeks gestation. Inhibin A, activin A and PlGF were measured using an ELISA by an examiner who was blinded to the pregnancy outcome. Thirty-eight cases with preeclampsia and 100 controls were analyzed. Second-trimester uterine artery PI and marker levels were expressed as multiples of the median (MoM). The uterine artery PI was increased in pregnancies with preeclampsia compared with controls. In pregnancies that developed preeclampsia, the uterine artery PI was increased (1.61±0.047 vs. 1.02±0.049, P<0.001), as was the level of inhibin A (1.72±0.023 vs. 1.03±0.063, P<0.001) and the level of activin A (1.68±0.38 vs. 1.06±0.42, P<0.001) compared with the controls. In contrast, the level of PlGF was decreased in pregnancies that developed preeclampsia compared with the controls (0.69±0.23 vs. 1.00±0.26, P<0.001). A combination of activin A, PlGF and uterine artery PI gave an AUC of 0.915 (95% CI, 0.812–0.928; P<0.001) with a sensitivity of 91% at a specificity of 82%. In our study, we demonstrated that both serum inhibin A and activin A levels were increased, while the PlGF level was decreased in the early second-trimester in women who developed preeclampsia.

The accuracy of transvaginal ultrasound and uterine artery Doppler in the prediction of adenomyosis

Abstract Objective To measure the accuracy of the ultrasonographic features in predicting adenomyosis and to determine if there is a role for uterine artery Doppler in adenomyosis prediction. Study design A prospective comparative study. Setting Cairo University hospital. Materials and methods Three hundred and fifty-two women who were scheduled for hysterectomy for various indications underwent preoperative transvaginal ultrasound scan (TVS) and uterine artery Doppler velocimetry in an attempt to diagnose adenomyosis. All the results were then correlated with histopathological results after hysterectomy. Results Forty-eight participants were ultrasonographically diagnosed as having adenomyosis from which 37 patients were histologically confirmed. Both groups were comparable in age, but adenomyosis tend to occur in multiparas. We found that subendometrial linear striations, myometrial cysts’ number and poor endometrial delineation were significantly associated with adenomyosis. Sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of TVS for diagnosing adenomyosis were: 75.68%, 90.79%, 49.12%, 96.95% and 89.20%, respectively. Heterogenous myometrial echotexture was the most common ultrasonographic feature in adenomyotic cases. Neither uterine artery resistance index nor pulsatility index showed significant association with adenomyosis. Conclusion TVS is a potentially valuable tool in predicting adenomyosis especially when subendometrial linear echogenic striations, myometrial cysts, and poor endometrial delineations were found. However, uterine artery Doppler has no diagnostic values.

Role of genome damage and Uterine Artery Doppler in prediction of uteroplacental insufficiency

Role of genome damage and Uterine Artery Doppler in prediction of uteroplacental insufficiency

The clinical value of combining maternal serum screening and uterine artery Doppler in prediction of adverse pregnancy outcome

SummaryUterine artery Doppler waveform analysis is not offered in routine antenatal care in the UK. The aim of this study is to evaluate a policy of offering uterine artery Doppler ultrasound, in the setting of a District General Hospital, to women who are judged to be at high risk of adverse pregnancy outcome, based on their mid-trimester biochemical serum screening. Data from 73 cases with abnormal serum screening were collected and analysed. Abnormal outcome occurred in 11 cases (16%) including two perinatal deaths. The positive predictive value of adverse outcome was 13% for abnormal serum screening, 26% for human chorionic gonadotropin (hCG) >3 multiples of the median (MOM) and 8% for alfa-fetoprotein (AFP) >2.5 MOM. A total of 56 cases of the study group had uterine artery Doppler at 22 weeks' gestation. Evaluation of the performance of uterine artery Doppler in prediction of adverse pregnancy outcome revealed a sensitivity of 43%, specificity of 70%, a positive predictive value (PPV) of 18% and a negative predictive value (NPV) of 89%. When the presence of diastolic notch was taken to define a positive result the sensitivity remained unchanged, however the specificity, PPV and NPV improved to 91%, 43% and 91%, respectively. In conclusion, the combination of serum markers and abnormal uterine artery Doppler ultrasound improves the identification of women at risk of subsequent pregnancy complications. Raised serum hCG has a better predictive value for adverse pregnancy outcome as opposed to raised serum AFP. In the absence of diastolic notch, the accuracy of abnormal uterine artery Doppler ultrasound is markedly reduced.