Purpose: We report a case of bilateral neovascular glaucoma developing secondary to a parotid pleomorphic adenoma of the parapharyngeal space.Case summary: A 60-year-old female was referred to us with bilateral neovascular glaucoma, no diabetic indication in any blood test, no retinal vascular abnormality apparent in fundus examination, and no abnormal Doppler ultrasound parameter. As the intraocular pressures of both eyes remained uncontrolled despite maximal medical treatment, Ahmed valve implantation was planned. When preparing for surgery, we found a palpable mass in front of the right ear that extended to the angle of the right jaw. Computed tomography of the salivary gland revealed tumors compressing both carotid arteries; we thus diagnosed a pleomorphic adenoma of the parotid gland.Conclusions: Ocular ischemia syndrome attributable to external compression of the carotid artery is very rare but may in fact be the cause of neovascular glaucoma if no other cause is apparent.