BACKGROUND AND AIM: Environmental noise is a growing public health problem. International studies agree that exposure to high noise concentrations causes health damages, this kind of environmental noise exposition decreases quality of life, increases the risk of premature death or disability, increases inequity, and generates economic losses. In 2017, Mexico City was the seventh city with the highest noise pollution worldwide, however, there are no studies that show the effects on health, so it is relevant to generate national information to support decision-making about environmental noise policies. The aim of this study was to evaluate the association between complaints about environmental noise and admissions to emergency rooms in Mexico City during 2012-2017. METHODS: Case-crossover study, bidirectional and symmetric. The exposure variable corresponds to noise complaints and the response variable is admissions to the emergency room for conditions previously related to the exposure. RESULTS:A positive association was found between the number of complaints and admission to the emergency services for all the causes studied (OR 1.027 95% CI 0.99-1.06). After adjusting for meteorological covariates and air pollutants (OR 1.063 95% CI 1.00-1.12), the results remained with a positive and significant association. Similarly, this association was obtained when performing the stratified analysis between the number of complaints made for noise and admissions to the emergency room for the 50-59-year-old group (OR = 1.129 95% CI 1.00-1.26) and the Arterial Hypertension condition (OR = 1.088 95% CI 1.00-1.17), adjusted for meteorological covariates and air pollutants. CONCLUSIONS:Even using proxy variables to measure the exposure to environmental noise in the general population, a positive and significant relationship is evidenced between it and the presence of acute health events in Mexico City during 2012-2017. KEYWORDS: Noise, Methodological study design, Environmental epidemiology