Artemisia Herba-alba Research Articles

Medicinal plants used in the treatment of urogenital disorders in the Drâa-Tafilalet region of Southeastern Morocco: An ethnobotanical survey

This study presents an ethnobotanical survey of medicinal plants used in the treatment of urogenital disorders in the Drâa-Tafilalet region, located in southeastern Morocco. The survey involved 200 herbalists and medicinal plant vendors across three provinces: Errachidia, Tinghir, and Zagora. Ethnobotanical data were analyzed using metrics such as use value (UV), frequency of citation (FC), relative frequency of citation (RFC), and family importance value (FIV). The study identified 80 species belonging to 44 plant families. The most represented families were Asteraceae (8 species), Lamiaceae (7 species), Apiaceae (7 species), and Fabaceae (6 species). The species most frequently cited treating urogenital disorders included Petroselinum sativum Hoff. (RFC = 0.018), Arenaria rubra L. (RFC = 0.016), Ziziphus lotus (L.) Lank. (RFC = 0.016), Zea mays (RFC = 0.013), Artemisia herba-alba (RFC = 0.013), and Ammi visnaga (RFC = 0.011). Leaves were the most commonly used plant part (35 %). The primary preparation methods of these remedies were decoction (53.75 %) and infusion (30 %), with oral administration being the preferred route (95 %). The findings of this study provide a valuable resource for researchers and practioners of traditional medicine, highlighting the importance of Morocco's medicinal flora. This ethnobotanical knowledge not only supports the conservation of national pharmacopoeia but also offers a promising foundation for the discovery of new therapeutic agents, particularly for the treatment of urogenital disorders. Future research could further investigate the bioactive compounds present in the identified species, potentially leading to innovative treatments for urogenital health issues.

A Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management.

Moroccan flora, renowned for its diverse medicinal plant species, has long been used in traditional medicine to manage diabetes. This review synthesizes ethnobotanical surveys conducted during the last two decades. Among these plants, 10 prominent Moroccan medicinal plants are evaluated for their phytochemical composition and antidiabetic properties through both in vitro and in vivo studies. The review encompasses a comprehensive analysis of the bioactive compounds identified in these plants, including flavonoids, phenolic acids, terpenoids, and alkaloids. Phytochemical investigations revealed a broad spectrum of secondary metabolites contributing to their therapeutic efficacy. In vitro assays demonstrated the significant inhibition of key enzymes α-amylase and α-glucosidase, while in vivo studies highlighted their potential in reducing blood glucose levels and enhancing insulin secretion. Among the ten plants, notable examples include Trigonella foenum-graecum, Nigella Sativa, and Artemisia herba-alba, each showcasing distinct mechanisms of action, such as enzymatic inhibition and the modulation of glucose metabolism pathways. This review underscores the necessity for further chemical, pharmacological, and clinical research to validate the antidiabetic efficacy of these plants and their active compounds, with a view toward their potential integration into therapeutic practices.

The Therapeutic and Toxic Effects of Artemisia herba alba Extract on the Reproductive System and Fertility of Male Rabbits Oryctolagus cuniculus

The Therapeutic and Toxic Effects of Artemisia herba alba Extract on the Reproductive System and Fertility of Male Rabbits Oryctolagus cuniculus

Toxicity of Essential Oil from Artemisia herba-alba (Asso.) against Two Insect Pests of Stored Products

This study aimed to examine the insecticide properties of Artemisia herba-alba essential oil (EO) against two main insect pests of stored products Tribolium castaneum and Sitophilus zeamais. The toxicity of EO was tested using contact and fumigant bioassays. Repellent activity was also studied using the preference zone method on filter paper. Using GC/MS analysis, the major compounds were, respectively, camphor (23.61%), α-thujone (13.67%), chrysanthenone (11.21%), 1,8-cineole (10%) and β-thujone (7.65%). In both insects, the toxicity tests applied showed a significant increase in the percentage of mortality according to the doses tested (p ≤ 0.05). Moreover, the probit analysis exposed lower values of doses and lethal concentrations (LD50, LD90, LC50, and LC90), which justified the toxic effect of EO on the two insects. In addition, EO caused a significant repulsion after 1 h and 2 h of exposure. The results obtained suggest that A. herba-alba EO can be an excellent alternative to chemical insecticides in the conservation of stored products.

In vitro anthelmintic activity of hydroethanolic extract of Artemisia herba aba and Juniperus phoenicea on abomasal Teladorsagia circumcincta of sheep.

The present study aimed to evaluate the in vitro anthelmintic activity of Juniperus phoenicea and Artemisia herba-alba against abomasal nematodes collected from naturally infected sheep. The anthelmintic activities of the extracts were assessed using egg hatch inhibition (EHIA) and adult motility assays (AMA) against Teladorsagia circumcincta. The parasites were stored in phosphate-buffered saline (PBS) until the in vitro assessment began. The leaf powders of J. phoenicea and A. herba-alba were extracted using the maceration procedure. Briefly, the leaf powders were mixed with a sufficient quantity of 99% ethanol and distilled water (80%/20%). The extracts were dissolved in a 3% dimethyl sulfoxide (DMSO) solution to improve water solubility. The hydroethanolic extracts were tested at concentrations of 1.562, 3.125, 6.25, 12.5, and 25 mg/ml. Adult motile worms were individually subjected to each treatment at laboratory temperature. The PBS and albendazole (25 mg/ml) were prepared and used as negative and positive controls, respectively. The test was repeated five times for each concentration. The results showed that both plant extracts exhibited anthelmintic effects. A. herba-alba extract at 25 mg/ml inhibited the motility of all T. circumcincta adult worms within 1 hour of administration, while J. phoenicea extract caused 100% mortality of adult worms after 4 hours at the same concentration. Neither of the extracts, at 1.562 mg/ml, had any inhibitory effect on motility. At 25 mg/ml, the A. herba-alba (98.67%) and J. phoenicea (96.24%) showed high activity with an inhibitory effect on hatchability compared to the other tested concentrations. The findings of the present study showed that hydroethanolic extracts of A. herba-alba and J. phoenicea leaves had in vitro anthelmintic activity on eggs and adult T. circumcincta of sheep.

Heavy metal contents in water extracts of selected medicinal plants used in the folk medicine of Jordan

BackgroundContamination of medicinal plants with heavy metals from environmental sources may severely impact the quality and safety of botanical products. The consumption of botanicals that are contaminated with heavy metals represents a severe health-threatening danger. Study designThe present toxicological study was conducted to determine the heavy metal concentrations of Cd, Pb, Ni, Cr, Hg, As, and Cu in selected medicinal plants and their water extracts (infusions) of Achillea santolina L., Amygdalus communis L., Artemisia herba-alba Asso., Crataegus aronia L., Viscum cruciatum Sieb., and Nepeta involucrata (Bunge) Bornm. collected from different regions in the south of Jordan, including Birkhdad (site 1), Al-Rashadihya (site 2), and Ain-Lahda (sites 3 and 4). MethodsHeavy metal concentrations in the medicinal herbs and their infusions were determined by Inductively Coupled Plasma Optical Emission Spectrometric Analysis (ICP-OES). The correlation between the content of heavy metals in the studied plants, their water extracts, and the surrounding soil environment was also studied. ResultsHigh concentrations of Ni, Cr, and Cu were detected at all investigated sites of soil. They were in the ranges of 8.46 ± 0.02 to 18.36 ± 0.02 ppm (for Ni), 9.47 ± 0.02 to 24.97 ± 0.06 ppm (for Cr), and 9.53 ± 0.01 to 17.05 ± 1.32 ppm (for Cu), respectively. The high levels of Ni, Cr, and Cu are mainly due to the presence of a highway road that is nearby site 3 and the location of a cement factory that is nearby site 2. The potentially toxic elements of Cd, Pb, and As were non-detectable, and very low concentrations of Hg were observed in the range of 0.17 ± 0.01 to 1.82 ± 0.25 ppm in Artemisia herba-alba collected from all studied locations. High Cu concentrations (20.53 to 23.80 ppm) were detected in A. herba-alba collected from sites 1, 2, and 3 and were higher than the reported normal range of (4 to 15 ppm). On the other hand, the raw materials of all studied plants had low Ni, and Cr concentrations within the range of 0.38 (± 0.01) to 4.05 (± 0.16) ppm and 0.35 (± 0.01) to 2.82 (± 0.01) ppm, respectively. Cd and As were non-detectable in all water extracts of all studied plants. The highest Cu contents were observed in the water extracts of A. herba-alba collected from sites 2 and 3 at concentrations of 64.54 ± 6.41 ppm and 62.43 ± 1.85 ppm, respectively. ConclusionsThe heavy metal contamination in a panel of herbal samples was below the legal limit values, except for those plants harvested close to a highway with heavy traffic or a cement factory. This points to the necessity to selecting suitable locations to culture medicinal plants for therapeutic purposes. We recommend monitoring the herbal quality concerning heavy metal contamination on a routine basis to assure the safety of herbal products for the sake of patients in Jordan and elsewhere.

Algerian Artemisia herba-alba (Asso): Extract and Essential Oils Investigation

Background/Objective: Numerous studies have demonstrated the ethno-and pharmacological properties of various Artemisia species. However, this plant genus which grows abundantly and wildly in the ‘Tébessa’ Algerian region has not been investigated. This study focuses on the phytochemical characterization, biological activities evaluation with the antibacterial fraction identification of the aerial part aqueous extract (AE) and essential oil (EO) from Algerian Artemisia herba alba ( Aha) growing wild in the ‘Tebessa' region. Methods: Polyphenols, flavonoids, and condensed tannins were analyzed by spectrophotometer and the antimicrobial activity was determined by the gel diffusion followed by micro-dilution methods. The antioxidant effect was assayed using 2,2-diphenyl-1-picrilhidrazil (DPPH), total antioxidant capacity (TAC), and ferric reducing power (FRAP) tests. The cytotoxic and anti-leishmaniasis activities were experienced on Raw 264.7 cell line and on L. infantum and L. major promastigotes respectively. Thin-layer chromatography (TLC)/autobiography and gas chromatography-mass spectrometry (GC-MS) techniques were used to isolate and identify the antibacterial compounds. EO profile was determined by GC-MS analysis. Results: The extracts (AE and EO) demonstrated antioxidant activity, with the AE exhibiting the most pronounced levels. Both extracts showed antimicrobial activity against all the strains tested however; the EO effect was more effective, especially against the E. feacalis strain with a minimum inhibitory concentration (MIC) value of 0.0625 mg/mL. The antibacterial fraction exerted by AE towards E. feacalis was identified. AE and EO extracts showed antileishmanial activity and no toxic effect however, volatile extract was the most effective. EO profile revealed 19 identified compounds, led by camphor (51.14%), followed by 1,8 Cineole (19.30%), camphene (6.90%) and chrysanthenone (5.68%). Conclusion: As a result, the both extracts promise a high potential applications in agri-food, pharmaceutical, cosmetic sectors. This study aligns with Sustainable Development Goals (SDGs) 3, 12, and 15, emphasizing potential health benefits, the responsible use of natural resources, and biodiversity conservation.

Investigation of Antifungal Action of Fractions C17H31NO15 Isolated from Artemisia herba-alba extract versus Isolated Aspergillus niger from Zee maize.

Plants are harmed by parasitic organisms, and toxic poisons are created. Phytopathogenic fungi create toxins that can severely harm plants' basic physiological functioning. Investigation of antifungal impact of various fractions of methanol extract of Artemisia herba-alba to Aspergillus niger as a plant pathogen. Artemisia herba-alba extract was purified using column chromatography, giving various antifungal fractions tested versus A. niger. The 6th fraction give the highest inhibition zone with a diameter of 5.4 cm and MIC 125.02 ± 4.9 μg/ml, which was identified using Mass spectroscopy, 1HNMR, Elemental analysis as well as IR testing, revealing the chemical formula of the purified fraction. Ultrastructure alteration of treated A. niger was examined versus control using the transmission electron microscope. Purified fraction has tested versus normal cell line with minimal cytotoxicity. These results revealed the possibility of using Artemisia herba-alba methanol extract as a promising antifungal versus phytopathogenic fungi, especially A. niger after more verification of results.

Comparative study of different hexane extracts from Algerian Artemisia absinthium and Artemisia herba-alba: GC-MS profile, artemisinin content, and antioxidant properties

The genus Artemisia belongs to the Asteraceae family, known for its many pharmacological properties. This study focuses on the chemical characterization of two Algerian species: Artemisia absinthium (AA) and Artemisia herba-alba (AHA). Samples from eight different stations were subjected to four extraction procedures using hexane as solvent: maceration, reflux, Soxhlet, and ultrasound. After determining the yield, total phenolics were quantified in the 32 samples. In addition, the antioxidant activity of the extracts was evaluated by three tests (i.e. TAC, DPPH, and β-Carotene assays). The results showed that the reflux method was able to isolate low levels of phenols but presented a better antioxidant activity, compared to the other extraction protocols. Regarding the two plant species, A. absinthium revealed a higher antioxidant power. GC–MS analysis led us to identify a total of 68 chemical constituents from all hexane samples of the two species. Extracts were mainly dominated by fatty acids (FAs), monoterpenoids and sesquiterpenoids, without any significant variability based on the applied method. HPLC-DAD analysis proved that the highest content in artemisinin was present in A. absinthium extracts obtained by Soxhlet, with an amount estimated at 15.09 ± 0.62 µg per mg of plant material, followed by ultrasound extraction.

Integrating ADMET, enrichment analysis, and molecular docking approach to elucidate the mechanism of Artemisia herba alba for the treatment of inflammatory bowel disease-associated arthritis

ABSTRACT Inflammatory Bowel Disease-Associated Arthritis (IBD-associated arthritis) poses a significant challenge, intertwining the complexities of both inflammatory bowel disease (IBD) and arthritis, significantly compromising patient quality of life. While existing medications offer relief, these drugs often initiate adverse effects, necessitating the requirement for safer therapeutic alternatives. Artemisia herba-alba, a traditional medicinal plant known for its anti-inflammatory properties, emerges as a potential candidate. Our computational study focused on examining 20 bioactive compounds derived from A. herba-alba for potential treatment of IBD-associated arthritis. These compounds detected in A. herba-alba include camphor, alpha-thujone, eucalyptol, cis-chrysanthenyl acetate, vicenin-2, 4,5-di-O-caffeoylquinic acid, chlorogenic acid, hispidulin, isoschaftoside, isovitexin, patuletin-3-glucoside, vanillic acid, rutin, schaftoside, lopinavir, nelfinavir, quercetin, artemisinin, gallic acid, and cinnamic acid. Following rigorous analysis encompassing pharmacokinetics, toxicity profiles, and therapeutic targets, compounds with favorable, beneficial characteristics were identified. In addition, comparative analysis with disease-gene associations demonstrated the interconnectedness of inflammatory pathways across diseases. Molecular docking studies provided mechanistic insights indicating this natural plant components potential to modulate critical inflammatory pathways. Overall, our findings indicate that A. herba-alba-derived compounds may be considered as therapeutic agents for IBD-associated arthritis, warranting further experimental validation and clinical exploration.

Supplementation species effect on the phenolic content and biological bioactivities of the decocted green tea

Background: Green tea, produced from the leaves of Camellia sinensis, is the most widely consumed beverage in the world after water, and it is widely sold and popular owing to its flavor, and its health benefits. Spices have been used by consumers worldwide to improve flavors of food including tea. Phenolics are the most common phytochemical found in herbal teas and are beneficial in promoting health or preventing diseases. Aims: This study aims to investigate the impact of the addition of mint (Mentha piperita L.), cinnamon (Cinnamomum verum), star anise (Illicium verum), ginger (Zingiber officinale), white mugwort (Artemisia herba alba) and clove (Syzygium aromaticum) on green tea biological properties, and on consumers’ acceptance. Subjects and Methods: Different green tea blends were formulated with 10% of each proposed spice. Total phenolic and flavonoid contents of formulated blends were measured by Folin-Ciocalteu and aluminum chloride methods, respectively. The effect of these herbs supplementation on antioxidant activity of green tea was determined using three different methods, namely DPPH assay, ferric reducing antioxidant power (FRAP), and total antioxidant capacity (TAC). In vitro antibacterial activity was assessed by the disc-diffusion method. Consumers’ acceptance of tea blends was evaluated by a sensory hedonic analysis performed by 127 panelists. Results: The results revealed significant variability among tea blends in terms of both total polyphenols (from 591.951 to 1027.387 mg GAE/L) and flavonoids (from 140.78 to 279.329 mg QE/L). As regards the antioxidant activity, control (no supplemented) green tea exhibited the highest ferric reducing antioxidant power (RC0.5 = 27.25 mg AAE/g DE). Interestingly tea blends supplemented with white mugwort and ginger demonstrated the highest DPPH• scavenging effect with IC50 of about 3.37 and 3.38 mg AAE/g DE, respectively, while when supplemented with star anise, it showed the highest TAC (66.143 mg AAE/g DE). In the assessment of the antibacterial effect, control green tea showed the best efficacy, except for Listeria innocua which was particularly sensitive to samples flavored with star anise and clove. The sensory evaluation revealed that clove-flavored tea was the most preferred by the panelists (31.75%), closely followed by ginger green tea (30.95%), green tea and star anise flavored green tea (25.39%). Conclusion: The obtained results indicate that adding some species to green tea significantly enhance its phenolic content, boost its antioxidant capacity and improve its sensory properties. Keywords: Flavored green tea; polyphenols; antioxidant activity; antibacterial activity; sensory characteristic.

Native plant species growing on the abandoned Zaida lead/zinc mine site in Morocco: Phytoremediation potential for biomonitoring perspective.

This study aims to assess the level of metal contamination and the ecological risk index at the abandoned Zaida Pb/Zn mining site in eastern Morocco and identify native plant species found on the site that can be used in site rehabilitation through phytoremediation strategies. Samples from seven native and abundant plant species at the site, along with their rhizospheric soils, were collected and analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to determine the concentrations of various metal(loid)s, including As, Cu, Ni, Cd, Sb, Zn, and Pb. Indicators of soil pollution and ecological risks were also assessed, including the enrichment factor (EF), pollution index (PI), and ecological risk index (ERI). The Biological Accumulation Coefficient (BAC), Translocation Factor (TF), and Biological Concentration Factor (BCF) of plant samples were calculated. The results reveal polymetallic soil contamination, with notably higher concentrations of Pb, Cu and Zn, reaching respectively 5568 mg kg-1 DW, 152 mg kg-1 DW, and 148 mg kg-1 DW, indicating a significant potential ecological risk. The enrichment factor (EF) was also assessed for each metal(loid)s, and the results indicated that the metal contamination was of anthropogenic origin and linked to intensive mining activities in Zaida. These findings are supported by the pollution index (PI) ranging from 1.6 to 10.01, which reveals an extremely high metal(loid)s pollution level. None of the plant species exhibited a hyperaccumulation of metal(loid)s. However, Artemisia herba alba demonstrated a strong capacity to accumulate Pb in its aboveground parts, with a concentration of 468 mg kg-1 DW. Stipa tenacissima, Retama spherocarpa, and Astragalus armatus, showed a significant Pb accumulation in their roots reaching 280, 260, and 256 mg kg-1 DW.respectively. Based on BAC, TF, and BCF, Stipa tenacissima exhibited potential for Ni and Cd phytostabilization, as well as the ability for Zn phytoextraction. Additionally, Artemisia herba alba displayed the capability to phytoextract Cd and had a high propensity to translocate all the studied metal(loid)s. Astragalus armatus has the potential to be used in the phytostabilization of Zn and Ni, as well as for the phytoextraction of As and Sb. These native species from the Zaida site, although not hyperaccumulators, have the potential to contribute significantly to the phytoextraction or phytostabilization of potentially toxic elements (PTEs). Moreover, they can serve as vegetative cover to mitigate the erosion and dispersion of metal(loid)s.

Development and Evaluation of Bioconverted Milk with Anti-Microbial Effect against Periodontal Pathogens and α-Glucosidase Inhibitory Activity.

To decrease periodontal pathogens and increase the number of beneficial bacteria, probiotics and bioactive compounds made via microbial bioconversion are recently used. In addition, the interest regarding probiotics-mediated bioconversion with popular medicinal plants is increasing. Artemisia herba-alba, a type of wormwood, has recently been attention as a medicinal plant due to its various bioactive compounds. Therefore, we developed bioconverted milk containing A. herba-alba that effectively inhibited periodontal pathogens and α-glucosidase. To select the appropriate lactic acid bacteria for the probiotic candidate strain, 74 strains of lactic acid bacteria were screened. Among them, Lactiplantibacillus plantarum SMFM2016-RK was chosen as the probiotic due to its beneficial characteristics such as high acid and bile tolerance, antioxidant activity, and α-glucosidase inhibition. Based on the minimal bactericidal concentration against three periodontal pathogens, the following appropriate concentrations of Artemisia herba-alba extract were added to milk: 5 mg/mL of A. herba-alba ethanol extract and 25 mg/mL of A. herba-alba hot-water extract. Four bioconverted milks (BM), BM1, BM2, BM3, and BM4, were produced by combining L. plantarum SMFM2016-RK alone, L. plantarum SMFM2016-RK and ethanol extract, L. plantarum SMFM2016-RK and hot-water extract, and L. plantarum SMFM2016-RK with both extracts. As a result of antimicrobial activity, BM3 inhibited the growth of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis the most, and BM4 suppressed the growth of Fusobacterium nucleatum the most. In addition, bioconverted milk containing A. herba-alba (BM2, BM3, and BM4) inhibited α-glucosidase more effectively than BM1. The whole genome of L. plantarum SMFM2016-RK was obtained, and 3135 CDS, 67 tRNA, and 16 RNA were predicted. The genome annotation of L. plantarum SMFM2016-RK revealed 11 CDS related to proteolysis and amino acid metabolism and 2 CDS of phenolic acid-metabolizing enzymes. In conclusion, A. herba-alba-added milk bioconverted by L. plantarum SMFM2016-RK displayed both the growth inhibitory effect on periodontal pathogens and the α-glucosidase inhibitory activity; thus, it necessitates to evaluate the effects on the alleviation of periodontal diseases and glycemic control through future animal experiments.

Effect of Essential oil and Extracts of Artemisia Herba – Alba Plant Against Some E Pathogenic Bacteria

Artemisia Herba – Alba is the one of the most important genus of Asteraceae family. It has numerous values because of medicine properties. Artemisia Herba – Alba has numerous application in traditional medicine from ancient times. In this research, antimicrobial effects of leaf aqueous, alcoholic extracts and essential oil of Artemisia Herba – Alba against Staphylococcus aureus PTCC 1431 and Escherichia coli PTCC 1399 were studied, using agar disc diffusion method. Methanol and ethanol extracts obtained from leaves of A. Herba – Alba exhibited antimicrobial activity against test microorganisms. In addition Artemisia herba-alba essential oil was inhibitory effects against all studied pathogenic bacteria. The results showed that essential oil of Artemisia herba-alba had the most inhibition diameter zone in Staphylococcus aureusthan E.coli (25-17mm successively). Therefore in this research we showed that the positive gram bacteria are more sensitive than negative gram bacteria. our results indicate the possibility of using essential oil in the treatment of bacterial infections, and the results of this study was encouraging, despite the need for clinical studies to determine of the real effectiveness and potential toxic effects in vivo

Ethnopharmacological survey of medicinal plants used in traditional treatment of respiratory system disorders in the Southeast region of Morocco

The use of medicinal plants in primary healthcare in Africa, especially among populations in developing countries, is a common practice. To identify the most commonly used medicinal plants in traditional medicine for treating common respiratory disorders, an ethnobotanical survey was conducted in the Draa Tafilalet region, South-Eastern Morocco, involving 235 herbalists and sellers of medicinal plants from three provinces (Errachidia, Tinghir, and Zagora). Ethnobotanical data were evaluated using use value (UV), frequency of citation (FC), relative frequency of citation (RFC), and family importance value (FIV). The survey identified a total of 76 species belonging to 39 families, with the most represented being Lamiaceae, Apiaceae, and Asteraceae, followed by Fabaceae. As for the most commonly used species against respiratory disorders, they include Origanum vulgare L. (UV = 0.413), Artemisia herba-alba (UV = 0.370), Foeniculum vulgare (UV = 0.357), Thymus vulgaris (UV = 0.332), Lavandula dentata (UV = 0.319), Matricaria chamomilla (UV = 0.311), Nigella sativa (UV = 0.302), Allium sativum L. (UV = 0.298), Eucalyptus globulus (UV = 0.289), and Plantago major L. (UV= 0.281). Decoction (48.68%) and infusion (47.37%) are the most recommended preparation methods by herbalists for remedies. Leaves are the most prescribed part, while the majority of plants are exclusively administered orally (92.11%). This ethnobotanical survey holds the potential to aid scientists and researchers in identifying plants that treat common respiratory disorders, potentially invaluable for the development of novel drugs.

Evaluation of Some Medicinal Plant Crude Extracts (Aqueous, Ethanol, and Acetone) Against Several Pathogenic Bacteria

Abstract Background: The Terminalia chebula fruit extract possesses various biological properties such as anti-cancer, anti-inflammatory, antioxidant, and protoparasite. Objective: This study aimed to detect the active compounds in the aqueous, ethyl alcoholic, and acetone extracts of the seeds of Terminalia chebula, Pimpinella anisum, and Artemisia herba-alba against the bacterial species that will be isolated from bacterial skin infections. Materials and Methods: A total of 120 pathological isolates were isolated from patients with bacterial skin infections; aqueous, alcoholic, and acetone extracts were prepared; the efficiency of these plant extracts against bacterial species was evaluated; and the minimum inhibitory concentration (MIC) was determined. Results: A total of 100 bacterial isolates were obtained out of 120 samples, which included 42 isolates of Staphylococcus aureus and 33 isolates of Klebsiella pneumoniae and 25 of Pseudomonas aeruginosa. The alcoholic extract of the seeds of the Terminalia chebula plant was the best plant extract in inhibiting the isolated bacterial species. Conclusions: The Iraqi environment is rich in medicinal plants such as Terminalia chebula, Pimpinella anisum, and Artemisia herba-alba. Conclusion: It was also found that the alcoholic extracts of the seeds of the Terminalia chebula showed an inhibitory effect on the growth of bacteria species under study, and all studied plants contain most of the active compounds.

Seriphidium herba-alba (Asso): A comprehensive study of essential oils, extracts, and their antimicrobial properties.

Seriphidium herba-alba (Asso), a plant celebrated for its therapeutic qualities, is widely used in traditional medicinal practices throughout the Middle East and North Africa. In a detailed study of Seriphidium herba-alba (Asso), essential oils and extracts were analyzed for their chemical composition and antimicrobial properties. The essential oil, characterized using mass spectrometry and retention index methods, revealed a complex blend of 52 compounds, with santolina alcohol, α-thujone, β-thujone, and chrysanthenone as major constituents. Extraction yields varied significantly, depending on the plant part and method used; notably, methanol soaking of aerial parts yielded the most extract at 17.75%. The antimicrobial analysis showed that the extracts had selective antibacterial activity, particularly against Staphylococcus aureus, and broad-spectrum antifungal activity against organisms such as Candida albicans and Aspergillus spp. The methanol-soaked extract demonstrated the strongest antimicrobial properties, indicating its potential as a natural antimicrobial source. This study not only underscores the therapeutic potential of Seriphidium herba-alba (Asso) in pharmaceutical applications but also sets a foundation for future research focused on isolating specific bioactive compounds and in vivo testing.

Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo.

Arthritis is a debilitating condition impacting the quality of life for millions worldwide, characterized by pain and inflammation. Understanding the mechanisms of arthritis and developing effective treatments are crucial. This study investigated the hydroethanolic extract of Artemisia herba-alba for its protective potential against arthritis hallmarks, oxidative stress, and lipid peroxidation in vitro. It also assessed its in vivo anti-arthritic activity. The phytochemical analysis identified various compounds within the extract, with high concentrations of polyphenols and flavonoids. These compounds are associated with numerous health benefits, making A. herba-alba a potential source of valuable phytochemicals. A. herba-alba demonstrated a notable effect in body weight loss, paw edema, and arthritic severity. Histopathological examination revealed structural improvements in bone and muscle tissues, emphasizing its therapeutic potential in managing chronic arthritis. Furthermore, while these findings are promising, further studies are necessary to delve deeper into the mechanisms underlying the observed hematological changes and to gain a more comprehensive understanding of the in vivo results. This research sets the stage for continued exploration, ultimately aiming to unlock the full potential of A. herba-alba in addressing chronic arthritis and enhancing the lives of those affected by this condition.

Ethnobotanical Study of an Asteraceae Artemisia Herba Alba (Asso.) in Chott El Gharbi (Western Algeria)

Abstract The objective of this work is to identify the therapeutic uses of medicinal plants in the Chott El Gharbi region through ethnobotanical surveys carried out on a local population who have used phytotherapy for a long time in a way transmitted from generation to generation. The investigation was carried out in the two communes of Chott El Gharbi. Among the botanical families of the species most used in herbal therapy, Lamiaceae and Asteraceae. The best-known species in various treatments is Artemisia herba alba (Asso.). The leaves represent the most used parts of plants and the decoction represents the most frequent method of preparation.

Impact of Aqueous Extract Artemisia Herba-Alba Leaves as a Green Inhibitor against Acid Activation of 2024 Aluminum Alloy

This work is part of the development of new bio-sourced corrosion inhibitors from an abundant resource that can replace conventional synthetic inhibitors that are harmful to both human health and the environment. The corrosion inhibition performance of an aqueous extract of Artemisia herba-alba on the corrosion of 2024 aluminum alloy in a 1 M hydrochloric acid solution is investigated by weight loss method, electrochemical (linear polarization, potentiodynamic polarization, and electrochemical impedance spectroscopy) and SEM techniques. The extract shows excellent corrosion-inhibiting properties on aluminium alloy with a maximum inhibition efficiency of 93% at 0.6 g/L. The adsorption of the natural extract obeys the extended Langmuir isotherm equation adsorption model for multicomponent systems. Temperature studies show that the efficiency of the extract decreases with increasing temperature and that the corrosion activation energies increase in the presence of the extract. Liquid chromatography/high resolution mass spectrometry is used to identify the chemical constituents of the natural extract, and the most abundant phytochemicals for each subclass of metabolite are investigated using density functional theory (DFT) calculations. This study paves the way for further development of a plant that is particularly abundant in the desert regions of North Africa and has until now been used mainly for food for livestock and for pharmaceutical applications.