Artistic Strategies Research Articles

Injury Patterns in Krav Maga Training: A Cross-Sectional Study.

This cross-sectional study, conducted from July 2023 to January 2024, examines injury patterns and associated risk factors among Krav Maga athletes to develop tailored prevention strategies for this unique martial art. A survey of 109 participants revealed that 65 injuries were reported, with 59.6% caused by actions from another individual and 24.8% (27 cases) being self-inflicted. The most frequently injured areas were the lower limbs (42 participants, 38.5%), torso (19 participants, 17.4%), and upper limbs (19 participants, 17.4%). Sprains or ligament tears were the most common diagnosis, accounting for 35 cases (32.1%), followed by fractures in 24 cases (22%). Participants ranged in age from 10 to 65 years, with males (95 participants, 87.2%) experiencing more injuries than females. Significant disparities were noted in injury rates based on training intensity (p < 0.05). Recovery periods varied, with 21 participants (19.3%) reporting durations exceeding 30 days. These findings underscore specific injury patterns and risk factors in Krav Maga, highlighting the importance of tailored prevention strategies focusing on flexibility, strength, and proper techniques to reduce injury risks.

Artistic Strategies of Ecological Care Work: Marwa Arsanios, Cecylia Malik, and Diana Lelonek

Abstract In ecofeminist contemporary art, the role of women in patriarchal societies and the paradigm of wounded nature in need of care are closely connected. Referring to Maria Puig de la Bellacasa’s concepts of ecological care and soil time, I explore three artistic strategies by Marwa Arsanios, Cecylia Malik, and Diana Lelonek, dealing with seed conservation, protests against deforestation, and the collective harvesting of post-industrial landscapes. On the basis of these forms of women’s ecological care between mother, land cultivator, caregiver, and “maintenance provider,” it is worth asking which layers of the work are visible. How is the critique of the gendered division of labor expressed and does it go beyond the established narratives of the connection between woman, earth, and fertility

Cross-cultural Art Curation and Urban Space Revitalization

In the complex environment of globalization and digitalization in the 21st century, Bourriaud's "Relational Aesthetics" provides a theoretical basis for us, emphasizing that the value of works of art as a medium of social interaction lies in building relationships between audiences. Taking this as a starting point, the concept of generalized curation transcends the material boundaries of traditional curation. focus on the Lefebvre’s triadic concept of space production, which intergreate realities of landscapes and urban forms, and the conceptual, planned representation through designs. Additionally, it encompasses the symbolic dimensions that influence social identities toghther to illustrate the dynamic nature of spatial existence (Lefebvre, 2012, p81-84). These theoretical frameworks provide a solid theoretical basis for understanding how art curation promotes cross-cultural communication in the context of globalization and how it integrates with urban spatial revitalization. The parallel forum of "Broad Curation and Urban Public Art Power" under the theme of "Resonance · Breaking the waves" of the 2024 Hainan International Cultural and Creative Week, as a dialogue media platform that brings together global wisdom, provides a frontier exploration for the creative transformation of art curation concepts and urban public space. This paper aims to share the perception of the participants and explore the impact of the results of this forum on the field of news communication, especially the urban cultural narrative and public art communication strategy.

How the Historiosophy of Bunin’s Mature Works Was Shaped. Researches by Gaston Maspero in Zodiacal Light and Some Other Oeuvres

Purpose. Regarding Bunin’s texts’ principal dynamism and the writer’s resistance to the very idea of almost each of his works’ completeness, the author of the article attributes quotations from Maspero’s Ancient History of the Peoples of Orient revealing their alterations from early redactions of Bunin’s The Temple of the Sun to later ones. It is demonstrated how dramatic was the impact of these citations once used in order to form Bunin’s view on Egypt on «non-Egyptian» prosaic works of the 1910s.Results. The first result reached in the course of the analysis is the accurate attribution of obscure fragments as in fact borrowed from Maspero. Secondly, it was shown how Bunin treats his precursor’s text – creating his own associations, reducing and tightening initial passages. Thirdly, the paper demonstrates how descriptions and notions derived from the book of French historian have been transformed in their very nature: diverse facts and notions have become an integral poetic imagination inspirated by scenes of decline of the Ancient World. And finally, the article investigates some traces of Bunin’s «Egyptian text» in his mature prose works – exemplifying short stories The Chalise of Life and The Dust as most representative ones.Conclusion. The author concludes that Bunin’s intertextual poetics was specific in many respects. As it became clear in examples provided in the article, the text borrowed from another writer and «alienated» with inverted commas in fact, in its essence, was completely subordinated by Bunin to his general artistic strategy losing even slight tint of Bakhtinian «someone else’s word».

Exploration of the Dissemination and Development of Guzheng Art in the New Era

With the development of the times and social changes, guzheng art, as an excellent traditional music culture in China, is facing new challenges of dissemination and development. The purpose of this paper is to analyse the communication status of guzheng art in the context of the new era, discuss the challenges and opportunities of its development, and propose strategies for innovation and development. Firstly, through the analysis of traditional and modern communication channels, it reveals the problems that exist in the communication process of guzheng art. Secondly, it discusses the impact of social change, cultural diversification and technological development on guzheng art, as well as the challenges and opportunities it faces. Then, the innovation and development strategies of guzheng art in the new era are proposed in terms of education promotion, work innovation, media communication and activity exchange. Then, through case analysis, it summarises the successful experiences of the dissemination and development of guzheng art at home and abroad, and discusses its inspiration for the development of guzheng art in China. Finally, this paper summarises the current situation and challenges of the dissemination and development of guzheng art in the new era, and looks forward to the future development trend of guzheng art.

The Interplay Between Art, Aesthetics and Politics in The Xyz Show

Artivism, a neologism of art and activism, has attracted the interest of scholars who have studied artivism in various popular art productions. The XYZ Show, the first animated Kenyan puppet comedy, has received fair attention; however, the nature of artivism in the show has not been consistently addressed. This study therefore interrogated The XYZ Show to determine how as a popular art production it engages art to ridicule various omissions and commissions of political leaders in Kenya. The interpretation is guided by Grace Musila’s model of reading popular art: Politics/Power/Agency, to corroborate the artistic aesthetics that make the show politically textured. The study is qualitative and it engages in textual analysis of purposively sampled episodes to explain the nature of artivism as depicted in the show. Videos of sampled episodes were watched and data was collected using structured observation checklists and analyzed using thematic content analysis. From the analysis of the data collected the study determined that The XYZ Show employs artistic strategies to speak truth to power. It uses allusion, allegory and imagery among other techniques to present events that are intelligible to the Kenyan audience with a view to satirizing government officials and the Kenyan political landscape. This article expects to add knowledge on the subject of popular art and artivism in Kenya

Rapid initiation of bictegravir/emtricitabine/tenofovir alafenamide as first-line therapy in HIV infection. A prospective study.

Rapid initiation of ART after HIV diagnosis is recommended for individual and public health benefits. However, certain clinical and ART-related considerations hinder immediate initiation of therapy. An open-label, single-arm, single-centre 48-week prospective clinical trial involving ART-naïve HIV-diagnosed adults who started bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) within a week from the first hospital visit, before the availability of baseline laboratory and genotype results. The primary aim was to determine the proportion of people with at least one condition that would hinder immediate initiation of any recommended ART regimen other than BIC/FTC/TAF. Clinicaltrials.gov: NCT04416906. We included 100 participants: 79% men, 64% from Latin America, median age 32 years. According to European AIDS Clinical Society (EACS) and US Department of Health and Human Services 2023 guidelines, 11% (95%CI 6; 19) of participants had at least one condition that made any ART different from BIC/FTC/TAF less appropriate for a rapid ART strategy. Seventy-nine percent of the people started BIC/FTC/TAF within the first 48 hours of their first hospital visit. There were 16 early discontinuations (11 lost to follow-up). By week 48, 92% (95%CI 86; 98) of the participants of the ITT population with observed data achieved viral suppression. Eight grade 3-4 adverse events (AEs), five serious AEs and six ART-related AEs were identified. Adherence remained high. BIC/FTC/TAF is an optimal treatment for rapid initiation of ART. However, additional strategies to improve retention in care must be implemented.

SPIRITUAL THEMES AND POETIC STYLE COMPARATIVE ANALYSIS IN YASAWI AND BLAKE’S WORKS

This article is a comparative analysis of the works of AhmedYasawi, a representative of the Kazakh literary tradition, and William Blake, a great poet of the English Romantic school. The study aims to identify common spiritual themes and artistic strategies in the works of these two poets, as well as to search forpossible interrelations in their poetic styles. Both poets address deep spiritual issues such as love, mysticism, and the meaning of human existence. The analysis identifies unique traits and similar motifs in Yasawi and Blake's work, demonstrating how they use artistic techniques to express their philosophical beliefs.The article helpsreaders a deep dive into the world of Yasawi and Blake's poetry, revealing the common themes and symbols that permeate their works. Not only are the texts themselves analyzed, but also the context in which they were created, reflecting the influence of cultural, religious, and philosophical factors on their work.The study intends not only to broaden our understanding of Yasawi's and Blake's poetry, but also to emphasize the universality of the themes addressed by the literature of different cultural traditions. It invites readers to immerse themselves in a world of mysticism, love, and spiritual quest, providing new keys to interpreting the works of these outstanding poets. Methodological approaches such as textual analysis, comparative analysis, semiotic analysis, literary review and critical theory were used throughout the study.The comparative analysis of the works is a relevant study that enriches cultural dialog andreveals the deep spiritual aspects of their works that are relevant to the contemporary global context.The study of these authors works has practical value for a deeper understanding of cultural and spiritual contexts, as well as theoretical value by providing a basis for a broader discussion of the influence of literature on intercultural dialog.

Research on The Innovative Development of Digital Media Art in The Era of Artificial Intelligence

From desktop design to virtual imaging, digital media art has jumped beyond the "screen" and undergone tremendous changes in the past few decades. Its application fields have also shifted from the initial graphic design and film and television special effects to display design, military, geography and other fields. Digital media art brings novel audio-visual experiences and provides convenience in life. Human activities are closely connected with digital media. Digital media art relies on digital media technology to artistically display creativity, which has a profound impact and is crucial to the development and growth of cultural and creative industries. In order to explore the characteristics and future development of digital media art, this article uses interdisciplinary research methods, comparative research methods, literature research methods, etc. to understand the relationship between digital media technology and artificial intelligence, from the perspectives of technology, communication, and art Let’s observe the current performance of digital media art as it becomes more and more intelligent, find out the problems and solutions hidden under the wave of intelligence, and explore the innovative development strategies of digital media art.

Strategies of Displacement in Artists’ Periodicals from the 1970s: &lt;i&gt;Neon de Suro&lt;/i&gt;, &lt;i&gt;Schmuck&lt;/i&gt;, &lt;i&gt;Commonpress&lt;/i&gt;, and &lt;i&gt;La Città di Riga&lt;/i&gt;

During the 1960s and 1970s, artists&amp;rsquo; periodicals flourished as a new artistic medium. Strikingly, artists behind these alternative publications often claimed a peripheral position, assuming a geographical anchorage far from the capitals and main artistic centres. This paper addresses how the notion of periphery manifests itself in four European artists&amp;rsquo; periodicals published during the 1970s. It will focus on their distribution strategies, their ideological positioning, the works they disseminated, and the artists&amp;rsquo; writings and statements they featured. First, the analysis of three European alternative periodicals &amp;mdash; Neon de Suro (Spain, 1975&amp;ndash;82), Schmuck Magazine (England, 1972&amp;ndash;76), and Commonpress (Poland, 1977&amp;ndash;91) &amp;mdash; will highlight how a peripheral position far from the capitals and the main artistic poles could become a strength, even a real editorial strategy. Such preoccupations were not, however, reserved for artists outside the official art scene: the question of periphery also found its place, albeit in different ways, in more institutionalized periodicals. This will be evident in the case of the Italian periodical La Citt&amp;agrave; di Riga (1976&amp;ndash;77), the focus of the second part of this paper, which negotiated the idea of centre and periphery right from its name. Through the case studies of these four periodicals and the analysis of coeval theoretical contributions, this paper aims to shape an elastic notion of the relationship between centre and periphery, at the same&amp;nbsp;time derived from and applicable to the experimental editorial strategies of artists&amp;rsquo; periodicals from the 1970s.

The pedagogical–artistic strategies of community music facilitators as an inspiration for formal music education: A single case study

In this article, we elaborate on the pedagogical–artistic strategies of a community music project and how they may inspire formal music educational practices. To do so, we draw on findings from a study on the pedagogical–artistic strategies of the musicians–coaches of The Ostend Street Orchestra (TOSO), a community music project that started as an artistic response towards the commotion around a group of homeless people in the coastal town of Ostend, Belgium. The pedagogical–artistic strategies adopted by the TOSO coaches foster the emergence of an educational approach that may have the potential to enrich music educational practices by creating a learning environment that is more democratic and inclusive. Data collection included in-depth semi-structured interviews with the TOSO coaches in 2017 and 2021, as well as video-stimulated recall. The interview data were analysed using thematic analysis. Seven themes emerged from our analysis: embodied interaction, co-coaching, re-thinking musical parameters, personal musical skills, collaboration, collective experiential learning and inclusion. We present the framework and rationale of the study, describe the pedagogical–artistic strategies of the coaches, and discuss the results. In conclusion, we briefly consider possibilities for further research and music teacher education.

Artists invoke urban food security: Nature-based solutions when everything is imaginable

Art is an amorphous field of operations that continuously sheds revered traditions and adds unprecedented innovations. It is, therefore, primed to offer original solutions to entrenched problems, such as those associated with urban foodways. Assessing the significance of the novel forms of expression that artistic license often entails entering uncharted cultural territories, then surveying the new terrains for the insights they contain. The five contemporary artists who are featured in this essay affirm this observation. The artworks they produced bypassed traditional still lifes and rural landscapes. Instead, they interrogated the particularities of current urban foodways.I treated these artworks to two concurrent paths of inquiry. One involved assessing the content of the artists’ urban food anxiteies and solutions. The other involved relating this content to the unconventional art strategies they employed to convey their creative food-generating initiatives. Methodology, therefore, constitutes an essential component of their creative practices. Their innovative strategies offer pragmatic solutions regarding urban food dilemmas that far exceed the cultural arena of art.For example, although all five artists live amid urban abundance, their focus zeroed in on food insecurity. Their artworks not only expose potential shortages and citizen vulnerabilities; they also propose security-bolstering solutions. Significantly, those solutions are not vested in broad-scale systems of production and distribution. Instead, the responsibility is entrusted to individual citizens. Their artworks introduce schemes for gaining food security that are both modest and innovative. They are modest because they are scaled to individuals, neighborhoods, and communities. They are innovative because these domestically scaled initiatives offer novel nature-based urban food solutions. For this reason, the artworks discussed on the following pages could contribute to future NBS urban food approaches. Some seem suitable for scaling up. Others demonstrate the need to relax regulations that inhibit experimentation. A few might bolster broad-scale institutional policies designed to facilitate independent food production. All replace stress with confidence.

Glass-Blowing-Inspired Upcycling of Thermosetting Polymer to Neuron-Like Hierarchical Carbon for Microwave Absorption and Conversion.

Upgrading thermosetting polymer waste and harvesting unwanted electromagnetic energy are of great significance in solving environmental pollution and energy shortage problems. Herein, inspired by the glass-blowing art, a spontaneous, controllable, and scalable strategy is proposed to prepare hollow carbon materials by inner blowing and outside blocking. Specifically, hierarchically neuron-like hollow carbon materials (HCMSs) with various sizes are fabricated from melamine-formaldehyde sponge (MS) waste. Benefiting from the synergistic of the hollow "cell body" and the connected "protrusions" networks, HCMSs reveal superior electromagnetic absorption performance with a strong reflection loss of -54.9dB, electromagnetic-heat conversion ability with a high conversion efficiency of 34.4%, and efficient energy storage performance in supercapacitor. Furthermore, a multifunctional device integrating electromagnetic-heat-electrical energy conversion is designed, and its feasibility is proved by experiments and theoretical calculations. The integrated device reveals an output voltage of 34.5mV and a maximum output power of 0.89 µW with electromagnetic radiation for 60s. This work provides a novel solution to recycle polymer waste, electromagnetic energy, and unwanted thermal energy.

Exploring the experiences of dancers who have achieved peak performance: on-stage, pre-stage, and post-stage

The aim of this study is to identify and classify the different attributes that contribute to peak performance among professional dancers, and to understand how these attributes change over time. We conducted an analysis using inductive content analysis on open-ended survey data collected from 42 formally trained professional dancers. Additionally, we analyzed interview data from seven professional dancers who demonstrated outstanding achievements in the field among the survey participants. The main themes that emerged were related to various temporal events of peak performance experience: pre-stage, on-stage, and post-stage. During the on-stage, peak performance was perceived by both internal and external factors. During the pre-stage, emphasis was placed on technical, cognitive, and artistic strategies during practice, whereas just before going on the stage, attention shifted to psychological and physical strategies. During the post-stage, dancers reported immediate changes in their psychological and physical states following the peak performance experience, and thereafter, the peak performance experience was noted to influence psychological, technical, and cognitive aspects. These findings provide valuable insights into the key characteristics that emerge throughout a series of peak performance experiences and are consistent with previous research.

Sensing a Twenty-First-Century Commons in the Theater: Relationality in a Climate of Distrust and Destruction

Abstract Conceptualizations of a “commons” have recently been gaining traction in theorizations of specific locations, gatherings, and activism in and beyond the arts. A theater-based commons that adopts a planetary and relational approach to selfhood, interaction, and future survival on Planet Earth tends to focus on breaking with social, political, economic, and aesthetic hierarchies. I will first introduce how notions of relationality have been integrated in theorizations of solidarity, humanitarian action, and a commons. Then, I will discuss these theorizations within the contexts of theater as communication and action that involves both theater-makers and audience members as actants. Finally, I intend to show how these conceptualizations can be meaningfully applied to unraveling the artistic strategies of a broad array of plays associated with the biannual theater festival Climate Change Theatre Action, which has been taking place before and after the United Nations Conference of the Parties climate conferences since 2015. The examples from the corpus of 250 five-minute plays are to illustrate the intervention of climate-change theater in potentially insurgent commons-based engagement and thinking which tries to avoid virtue signaling and other self-promoting forms of supposed solidarity.

Protection and dissemination strategies of ethnic minority art in the context of digital age

This paper discusses the profound impact of the digital age on the protection and dissemination of ethnic minority art. In the context of globalization and technological innovation, traditional art forms are in urgent need of digital transformation in terms of survival, innovation and sharing. This paper aims to develop effective conservation and communication strategies to explore how digital technologies are reshaping art creation, preservation and dissemination patterns, how to balance the original presentation of art with public acceptance, and how to stimulate young people’s interest in and responsibility for inheritance of minority art through digital means. This study not only helps to enrich the theoretical framework of cultural diversity and promote cross-cultural exchange and understanding, but also provides strategic direction for ethnic policymakers and cultural workers to ensure that ethnic minority arts are properly protected and widely disseminated in the digital process, thereby enhancing their global impact. Through literature review and empirical research, this paper hopes to reveal how to innovatively apply the power of science and technology to achieve sustainable development and global sharing of minority art.

Future-making through eventing human-machine listening

Reverb-Resonate: Sounding the Affective Frequencies of Migration operates at the intersection of art, science, and technology to articulate an emotional landscape of migration and exile. Rooted in the methodology of research-creation (RC) and grounded in the interdisciplinary field of Art, Science, and Technology Studies (ASTS), the project transcends conventional disciplinary boundaries to offer speculative possibilities through human-machine listening. Drawing on the body is an already augmented site, the project makes audible physiological sensors that capture micro-level intricacies responsible for stress regulation. Listening, is, thus, foregrounded as the core public engagement strategy, creating a layered sound collage that interweaves somatic registers of recorded breathing samples and physiological sensor values with machine listening to recreate new forms of sound. Engagement with ASTS is, hence, in the form of a method that traverses transforming sensor application, generating technicized sound and composing an acoustic experience capable of affective engagement. Through machine learning—a subfield of artificial intelligence—the notion of ‘machine listening’ extends beyond human hearing limitations, introducing non-normative structures to challenge and expand habitual forms of human listening. Reverb-Resonate, hence, leverages artistic strategies and techno-augmentations to address the crisis of imagination that hinders opening up to realities far from the familiar and the personal to imagine ‘what could be’ as a way of future-making. It underscores the critical edge of RC and ASTS in addressing complex critical issues, proposing a speculative space where the human-machine hybrid puts forth a socio-technical assemblage of listening to understand 'otherly' experiences. The project, thus, advances a critical inquiry into the mediation and augmentation of listening to imagine new possibilities for embodied engagement with unfamiliar emotional spaces and experiences.

Evaluating Hepatotoxicity: A Comparative Analysis of New Generation versus Historical Antiretroviral Agents.

(1) Background: Since the advent of zidovudine in 1987, antiretroviral therapy has undergone significant evolution, marked by the introduction of 34 antiretroviral drugs and 24 fixed-dose combinations. Despite these advances, hepatotoxicity remains a formidable challenge, influencing morbidity, mortality, and treatment adherence in HIV-infected patients. This study aims to compare the hepatotoxic effects of latest-generation antiretroviral medications with those of older-generation therapies, assessing their long-term impact on liver health in HIV patients. (2) Methods: This retrospective study analyzed data from 304 HIV patients treated with either latest-generation or older-generation antiretroviral drugs over four years. Patients were monitored for hepatotoxicity through liver function tests at diagnosis, six months, and one-year post-treatment initiation. (3) Results: Initial and six-month liver function tests showed no significant differences between the two groups. However, at one-year post-treatment, patients on latest-generation antiretrovirals exhibited significant improvements in ALT, AST, and ALP levels, suggesting a better safety profile regarding hepatotoxicity. Additionally, a significantly lower incidence of splenomegaly was observed in patients treated with newer medications. (4) Conclusions: The findings suggest that the latest-generation antiretroviral medications may offer a safer profile in terms of hepatotoxicity compared to older therapies, with potential benefits for long-term liver health. This study underscores the importance of continuous monitoring and further research to optimize ART strategies, ensuring improved patient outcomes and quality of life for individuals living with HIV.

Cultural and Aesthetic Dynamics of Photography as a Form of Contemporary Art

Art-photography is a form of contemporary art that marked itself in the early 1960s. Its historical evolution has not been sufficiently studied. At the same time, it provides an opportunity to identify and understand the logic of the internal development of art-photography and its relationship with the external cultural context. The cultural and aesthetic dynamics of art-photography is associated with three historical stages: early, mature and late postmodernism (meta modernism) and the corresponding forms of contemporary art. The first stage (1960—1970) saw the realization by contemporary artists of the conceptual possibilities of photography. It was mainly the photographic documentation of process-action forms of contemporary art. The same period saw the birth and formation of the main artistic strategies and creative methodologies of art-photography: adherence to documentaries, the use of staging (directing), the introduction of seriality (typology), the combination of word and image. The second stage (1980s — 1990s) of art-photography functioning is characterized by further development and enrichment of established artistic tendencies and the emergence of new practices in which photographic material expands its subject matter and claims the role of a text that problematizes (thematizes) the represented reality. The development of art-photography at the third stage (2000s to the present) is determined by two main factors: the processes of digitalization and oscillation of contemporary culture and art, which leads to the transformation of the “mode of truth” of the photographic image and the strengthening of the importance of the aesthetics of the individual photographic frame. At the level of practice, this is expressed in the creation of photographic pictures where reality and fantasy images merge into a single whole and become indistinguishable. This effect was reinforced by printing photographs of enormous size and exhibiting them in museum spaces and galleries. Nowadays, art-photography, while remaining a form of contemporary art, seeks to go beyond it and acquire signs of aesthetic self-sufficiency.

Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies.

In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed to compare the metabolome and lipidome of INSTI and NNRTI-based regimens. The 2000HIV study includes asymptomatic PLHIV (n = 1646) on long-term cART, separated into a discovery cohort with 730 INSTI and 617 NNRTI users, and a validation cohort encompassing 209 INSTI and 90 NNRTI users. Baseline plasma samples from INSTI and NNRTI users were compared using mass spectrometry-based untargeted metabolomic (n = 500) analysis. Perturbed metabolic pathways were identified using MetaboAnalyst software. Subsequently, nuclear magnetic resonance spectroscopy was used for targeted lipoprotein and lipid (n = 141) analysis. Metabolome homogeneity was observed between the different types of INSTI and NNRTI. In contrast, higher and lower levels of 59 and 45 metabolites, respectively, were found in the INSTI group compared to NNRTI users, of which 77.9% (81/104) had consistent directionality in the validation cohort. Annotated metabolites belonged mainly to 'lipid and lipid-like molecules', 'organic acids and derivatives' and 'organoheterocyclic compounds'. In pathway analysis, perturbed 'vitamin B1 (thiamin) metabolism', 'de novo fatty acid biosynthesis', 'bile acid biosynthesis' and 'pentose phosphate pathway' were detected, among others. Lipoprotein and lipid levels in NNRTIs were heterogeneous and could not be compared as a group. INSTIs compared to individual NNRTI types showed that HDL cholesterol was lower in INSTIs compared to nevirapine but higher in INSTIs compared to doravirine. In addition, LDL size was lower in INSTIs and nevirapine compared to doravirine. NNRTIs show more heterogeneous cardiometabolic effects than INSTIs, which hampers the comparison between these two classes of drugs. Targeted lipoproteomic and lipid NMR spectroscopy showed that INSTI use was associated with a more unfavorable lipid profile compared to nevirapine, which was shifted to a more favorable profile for INSTI when substituting nevirapine for doravirine, with evidently higher fold changes. The cardiovascular disease risk profile seems more favorable in INSTIs compared to NNRTIs in untargeted metabolomic analysis using mass-spectrometry.