The transformative impact of generative AI, extending beyond traditional AI, raises numerous concerns including the replacement of human roles and AI misuse in an array of industries. This article introduces blockchain technology as a complementary technological safeguard to address some of these challenges. We emphasize blockchain’s role in promoting transparency, verifiability, and decentralization in AI development and usage, thereby offering potential solutions for four distinct challenges: (1) AI toxicity, biases, hallucinations, (2) AI interest misalignment, (3) AI as a black box, and (4) AI misuse. This article proposes ways to ensure responsible and transparent AI usage through the integration of blockchain. We position the convergence of AI and blockchain as a means to manage AI’s societal impact and unlock its benefits—contingent upon collaborative efforts among various stakeholders such as businesses, developers, and regulatory bodies. We contribute to the discourse on ethical AI usage and the potential of blockchain to enhance AI’s reliability and accountability for organizations.