Aromatic Properties Research Articles

Helicene Aromaticity Deviates from the Clar Rule—On the Electronic Dissimilarity of Large Isomeric Fibonacenes

AbstractThis combined experimental and theoretical study illustrates the profound consequences of non‐planarity on the electronic properties of polycyclic arenes. Three isomeric [10]fibonacene tetraesters were synthesized through a robust and regiocontrolled Perkin/Mallory approach: a nearly planar [10]phenacene derivative, a moderately twisted [10]semicircle derivative, and a 3D non‐planar [10]helicene derivative. The photophysical properties of the 3D [10]helicene isomer were found to be dramatically different from the comparable ones of the [10]phenacene and [10]semicircle isomers. The aromatic properties of the [10]phenacene and [10]semicircle isomers conform well with their predictive Kekulé and Clar analyses, but the [10]helicene isomer deviates from these general topological rules, which appears to be a general phenomenon for [n]fibonacenes with n≥9.

Medicinal and Aromatic (Odoriferous) Properties of Pineapple (Minthostachys Mollis)

Objective: The purpose of the research is to provide relevant scientific information on the medicinal and aromatic properties of pineapple. Theoretical background: Based on the literature on the medicinal and aromatic properties of pineapple (Minthostachys mollis). Method: It was a research with quantitative approach, which consisted of a bibliographic search of articles, scientists and theses in the database such as Google Scholar, Sciencedirec, Elsevier, Scopus, Web of Science, Scielo, Redalyc, Doaj and Dialnet, second specialty, master's and doctoral theses, which were grouped and the bibliographic background was organized in a matrix according to the type of research, methodology and study participants (species). Results and conclusions: Research results that evaluate and demonstrate the medicinal, aromatic, antioxidant and essential oil properties of muña are shown. Originality/value: It shows the medicinal and aromatic properties of pineapple (Minthostachys mollis) for being a very powerful herb in the treatment of diseases to improve health. Its use in health is very beneficial, thanks to the properties it contains such as antibacterial and antitumor activity of the essential oil, as a natural medicine, insecticides, biological pest control, among other benefits.

The mechanism of low temperature enhances dough aromas during fermentation by Pichia kudriavzevii: Sugar and amino acid metabolism, acid utilization and alcohol production

In order to investigate the impact of low temperature on enhancing aromas in fermented dough by Pichia kudriavzevii CGMCC 17607 (EP), the study initially utilized gas chromatography to detect volatile organic compounds (VOCs), followed by analyzing basal metabolites derived from these VOCs. Metabolomics was employed to monitor metabolic changes during fermentation, while proteomics was used to examine protein expression related to these changes. Results indicated notable increases in VOCs such as 3-methyl-1-butanol and 2-phenylethanol. Essential metabolites exhibited decreases in sugars (e.g., sucrose, maltose), organic acids (e.g., lactic acid, acetic acid), and amino acids (e.g., leucine, histidine). Particularly, low temperature fermentation led to raised levels of NAD+, NADH, acyltransferases, and ATP, excluding pyruvic acid and glucose-6-phosphate dehydrogenase. These outcomes suggested that low temperature fermentation boosted acid utilization and alcohol production. Metabolomics and proteomics highlighted decreased glycolysis influencing energy metabolism. Moreover, metabolomics revealed elevated levels of flavor substances like octanoic acid and its derivatives with aromatic properties, as well as geranic acid with terpenoid aroma. Furthermore, key intermediates like chorismite and phenylpyruvic acid, along with the pivotal enzyme chorismate synthase, illustrated the biosynthesis pathway of shikimic acid instead of phenylalanine. In summary, at low temperature, EP showed weakened glycolysis, with sugars and amino acids metabolizing into desirable flavor substances like alcohols, which promoted acidity reduction and aroma enhancement of dough.

The Composition of Volatiles and the Role of Non-Traditional LOX on Target Metabolites in Virgin Olive Oil from Autochthonous Dalmatian Cultivars.

The lipoxygenase pathway has a significant influence on the composition of the volatile components of virgin olive oil (VOO). In this work, the influence of the maturity index (MI) on the activity of the lipoxygenase enzyme (LOX) in the fruits of the autochthonous Dalmatian olive cultivars Oblica, Levantinka and Lastovka was studied. The analysis of the primary oxidation products of linoleic acid in the studied cultivars showed that LOX synthesises a mixture of 9- and 13-hydroperoxides of octadecenoic acid in a ratio of about 1:2, which makes it a non-traditional plant LOX. By processing the fruits of MI~3, we obtained VOOs with the highest concentration of desirable C6 volatile compounds among the cultivars studied. We confirmed a positive correlation between MI, the enzyme activity LOX and the concentration of hexyl acetate and hexanol in cultivars Oblica and Lastovka, while no positive correlation with hexanol was observed in the cultivar Levantinka. A significant negative correlation was found between total phenolic compounds in VOO and LOX enzyme activity, followed by an increase in the MI of fruits. This article contributes to the selection of the optimal harvest time for the production of VOOs with the desired aromatic properties and to the knowledge of the varietal characteristics of VOOs.

Proteogenomic Characterization of Pseudomonas veronii SM-20 Growing on Phenanthrene as Only Carbon and Energy Source.

In this study, we conducted an extensive investigation of the biodegradation capabilities and stress response of the newly isolated strain Pseudomonas veronii SM-20 in order, to assess its potential for bioremediation of sites contaminated with polycyclic aromatic hydrocarbons (PAHs). Initially, phenotype microarray technology demonstrated the strain's proficiency in utilizing various carbon sources and its resistance to certain stressors. Genomic analysis has identified numerous genes involved in aromatic hydrocarbon metabolism. Biodegradation assay analyzed the depletion of phenanthrene (PHE) when it was added as a sole carbon and energy source. We found that P. veronii strain SM-20 degraded approximately 25% of PHE over a 30-day period, starting with an initial concentration of 600 µg/mL, while being utilized for growth. The degradation process involved PHE oxidation to an unstable arene oxide and 9,10-phenanthrenequinone, followed by ring-cleavage. Comparative proteomics provided a comprehensive understanding of how the entire proteome responded to PHE exposure, revealing the strain's adaptation in terms of aromatic metabolism, surface properties, and defense mechanism. In conclusion, our findings shed light on the promising attributes of P. veronii SM-20 and offer valuable insights for the use of P. veronii species in environmental restoration efforts targeting PAH-impacted sites.

On Neighborhood Eccentricity-Based Topological Indices with QSPR Analysis of PAHs Drugs

ABSTRACT This article examines newly introduced eccentricity topological descriptors that are used to analyze the structures of polycyclic aromatic hydrocarbons. The purpose is to identify structural components that have a significant impact on physicochemical properties. Regression analysis applies to find potential correlation between different drugs characteristics like bioavailability, toxicity and efficacy. The correlation between various polycyclic aromatic hydrocarbons physicochemical properties and the eccentric topological indices is then expressed through the construction of a significant linear regression model. The results show that topological indices and linear regression are useful in predicting significant characteristics of polycyclic aromatic hydrocarbons.

Highly Contorted Rigid Nitrogen-Rich Nanographene with Four Heptagons.

Nucleophilic substitution of 9,10-dichlorooctafluoroanthracene with 3,4-diethylpyrrole and subsequent Scholl reaction give the annularly fused decapyrrollyl anthracene. Single crystal X-ray analysis revealed a highly contorted geometry induced by a combination of adjacent heptagons, forming a unique 7-7-6-7-7 topology. The end-to-end twist angle along the acene moiety is 90°. Cyclic voltammetry studies reveal 6-electron oxidation waves. Density functional theory calculations provided further insights into the aromaticity and electronic properties of this highly twisted, nitrogen-rich nanographene. The structural rigidity and high racemization energy barrier have been studied theoretically and experimentally by VT-NMR.

Development and biochemical profile of Zingiber officinale under different population densities of Meloidogyne javanica

Ginger is a medicinal plant known for its aromatic, antioxidant, and pharmacological properties. This study aimed to examine the vegetative growth and biochemical profile of ginger exposed to Meloidogyne javanica at different initial inoculum levels. The experiment was conducted in a greenhouse using a completely randomized design. Treatments comprised 0, 2000, 4000, 6000, 8000, and 10,000 eggs of M. javanica and eight replications per treatment. At 70 days after inoculation, plants were harvested and evaluated for nematode parameters, vegetative growth, total phenolic compounds, gingerol content, antioxidant activity, and soluble sugars content. Total nematode number increased linearly as a function of initial inoculum level. The reproduction factor was greater than one (RF>1) in all treatments. Vegetative development, however, was not affected. The highest concentrations of total phenolics and gingerol were estimated to occur with initial inoculum levels of 4500 and 4000 eggs, respectively. Higher population levels (>6000 eggs) stimulated the production of soluble sugars in ginger rhizomes. Although increasing levels of M. javanica did not affect ginger vegetative development, it significantly altered biochemical parameters, such as total phenolic compounds, gingerol content, antioxidant activity, and soluble sugars content, proving that M. javanica influences the quality of ginger.

Xylopia aethiopica Attenuates Oxidative Stress and Hepatorenal Damage in Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Abstract Objectives Xylopia aethiopica (XAE), commonly known as African pepper or Ethiopian pepper, is a plant native to West Africa and known for its aromatic and medicinal properties. It was used to investigate the antioxidative, antihepatotoxic, and antinephrotoxic potentials of XAE in benign prostatic hyperplasia (BPH) in Wister albino rats. Methods The proximate, and vitamin composition, oxidative stress indicators, and indices of kidney and hepatic functions were performed by standard methods. Results The proximate composition of the XAE leaf showed varied concentrations of Mg, Ca, Na, Zn, Se, and Cl, as well as vitamins A, E, B3, D, C, K, B2, and Bi. The activities of catalase glutathione, superoxide dismutase, malondialdehyde levels, K, Na, Cl−, urea, uric acid, and creatinine in the kidney were increased in testosterone propionate (Tp)-induced BPH compared with the control groups. Total protein levels significantly decreased in Tp-induced BPH compared with XAE-treated groups increased on XAE treatment. The aspartate transaminase, alanine aminotransferase, and alkaline phosphatase activities were not significantly different in Tp-induced BPH, XAE, and normal controls. Conclusion The study revealed that XAE can be used in the management of oxidative stress and hepatorenal damage in BPH condition.

Impact of semolina-barley mixture on the volatolomic profile of dough and pasta: characterization by a multivariate chemometric approach.

Barley flour, known to be rich in various phytochemicals, has been demonstrated to improve the technological and nutritional properties of pasta; however, its volatile profile, on which its aromatic properties depend, also plays an important role in the acceptance of barley-enriched pasta. In the present work, volatile organic compounds (VOCs) of semolina doughs enriched with different percentages of barley and of the related pasta were characterized by solid phase micro-extraction (HS-SPME) coupled to gas-chromatography/mass spectrometry (GC-MS), and evaluated using a multivariate statistical approach, including principal component analysis (PCA), cluster heatmaps, Pearson's and Spearman's correlations, and partial least squares correlation (PLSC). The effects of single raw materials, and their interactions, were studied to establish their importance in the volatile profile of the samples, and the correlation between the dough VOCs and the processed product VOCs was assessed. The presence of barley flour markedly affected the volatile profile in comparison with the dough obtained with only durum wheat. For alcohols, esters, terpenes, and some aldehydes there was a clear correlation with the percentage of barley. For some of the VOCs, on the other hand, a strong dependence on the ingredients interaction effect due to the mixing stage has been demonstrated. The heatmaps allowed a good graphical visualization of the relationship between molecules and barley percentage, offering the possibility to select the best one according to the desired volatolomic footprint. Pasta with 40% of barley was demonstrated to give pasta with the most complex volatile profile. © 2024 Society of Chemical Industry.

Chromosome-level genome assembly provides insights into the genome evolution and functional importance of the phenylpropanoid–flavonoid pathway in Thymus mongolicus

BackgroundThymus mongolicus (family Lamiaceae) is a Thyme subshrub with strong aroma and remarkable environmental adaptability. Limited genomic information limits the use of this plant.ResultsChromosome-level 605.2 Mb genome of T. mongolicus was generated, with 96.28% anchored to 12 pseudochromosomes. The repetitive sequences were dominant, accounting for 70.98%, and 32,593 protein-coding genes were predicted. Synteny analysis revealed that Lamiaceae species generally underwent two rounds of whole genome duplication; moreover, species-specific genome duplication was identified. A recent LTR retrotransposon burst and tandem duplication might play important roles in the formation of the Thymus genome. Using comparative genomic analysis, phylogenetic tree of seven Lamiaceae species was constructed, which revealed that Thyme plants evolved recently in the family. Under the phylogenetic framework, we performed functional enrichment analysis of the genes on nodes that contained the most gene duplication events (> 50% support) and of relevant significant expanded gene families. These genes were highly associated with environmental adaptation and biosynthesis of secondary metabolites. Combined transcriptome and metabolome analyses revealed that Peroxidases, Hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferases, and 4-coumarate-CoA ligases genes were the essential regulators of the phenylpropanoid–flavonoid pathway. Their catalytic products (e.g., apigenin, naringenin chalcone, and several apigenin-related compounds) might be responsible for the environmental tolerance and aromatic properties of T. mongolicus.ConclusionThis study enhanced the understanding of the genomic evolution of T. mongolicus, enabling further exploration of its unique traits and applications, and contributed to the understanding of Lamiaceae genomics and evolutionary biology.

A Candidate for Health Promotion, Disease Prevention and Treatment, Common Rue (Ruta graveolens L.), an Important Medicinal plant in Traditional Medicine.

Ruta graveolens L. belongs to Rutaceae; it is a semi-wood perennial or a small evergreen sub-shrub, which is native to Southern Europe, West of Asia and Northern Africa. The goal of this manuscript was to outline the most notable traditional and modern advantages and pharmaceutical benefits of common rue. The manuscript covers review articles, randomized control experiments, analytical studies and observations, which have been gathered from different sources such as Google Scholar, Scopus, Science Direct and PubMed. A review of the literature was carried out using the keywords rutin, Ruta graveolens L., rue, common rune, coumarin, natural products and pharmaceutical benefits. Rue contains quinoline alkaloids, such as graveoline and graveolinine, acridone alkaloids, such as furacridone and gravacridone, the furanoquinoline dictamnine, coumaris, such as gravelliferone, isorutarin, rutacultin, rutaretin, and suberenone, and the furanocoumarins 5-methoxypsoralen (bergapten) and 8-methoxypsoralen (xanthotoxine). Most of its aromatic and medicinal properties are from its rutin, and essential oil. It has been used in folk medicines as a stimulant, anti-inflammatory and analgesic properties, anti-androgenic activity, anti-hyperglycemic effects, anti-hyperlipidemic effects, xanthine oxidase inhibition activity, anticancer properties. According to pharmacological and phytochemical advantages, pennyroyal shows its importance as a medicinal plant in both modern medicinal science and traditional medicine.

Theoretical Studies on the Relationship between Aromaticity and Electron Transport Properties of Analogous [10]-Annulene Derivatives

In the overall aromaticity of a molecular system, the magnitude of [Formula: see text]-aromaticity influences the degree of bond length averaging in the molecular geometry, while the magnitude of [Formula: see text]-aromaticity reflects the strength of [Formula: see text]-electron delocalization, subsequently affecting the electronic transport properties of the entire molecular system. Simultaneously, the aromaticity type of a molecular system is primarily determined by the symmetry of the innermost [Formula: see text] molecular orbitals. In this study, we conducted computational simulations of the aromaticity and electronic transport properties of compounds, including C8H8Cu2 with [Formula: see text]–[Formula: see text] delocalization effects and C12H8 with [Formula: see text]–[Formula: see text] delocalization effects, along with their Li derivatives. Based on calculated NICS values, ring current directions, molecular structural configurations and the symmetry of the innermost [Formula: see text] molecular orbitals, we clarified the aromaticity types of the molecular systems. Combined with the analysis of molecular electrical conductivity properties, we gained insights into the fundamental attributes of Li-bridge bonds in Li derivatives and the factors influencing electronic transport pathways. Consequently, we established a relationship between the aromaticity of molecular systems and their electronic transport properties. To a certain extent, a novel criterion for evaluating molecular aromaticity is proposed from the perspective of single-molecule electronics.

BIBLIOGRAPHIC REVIEW OF THE APPLICATION OF CINNAMALDEHYDE AS A DRUG IN DENTISTRY

Cinnamon (Cinnamomum sp) has been used as a spice for millennia, offering nutritional, aromatic, and pharmaceutical properties. The essential oil from cinnamon bark predominantly contains cinnamaldehyde, which exhibits applications as an antioxidant, anti-inflammatory, antimicrobial, and wound-healing agent. These characteristics have drawn the interest of the pharmaceutical industry, seeking to identify alternative uses of this compound for the treatment of oral diseases. In light of this, the present study aims to conduct a literature review, justifying the potential presented by cinnamon essential oil, specifically cinnamaldehyde, for the synthesis of new pharmaceuticals intended for dental use.

CRISPR/Cas9-mediated enhancement of semi-dwarf glutinous traits in elite Xiangdaowan rice (Oryza sativa L.): targeting SD1 and Wx genes for yield and quality improvement.

In rice cultivation, the traits of semi-dwarfism and glutinous texture are pivotal for optimizing yield potential and grain quality, respectively. Xiangdaowan (XDW) rice, renowned for its exceptional aromatic properties, has faced challenges due to its tall stature and high amylose content, resulting in poor lodging resistance and suboptimal culinary attributes. To address these issues, we employed CRISPR/Cas9 technology to precisely edit the SD1 and Wx genes in XDW rice, leading to the development of stable genetically homozygous lines with desired semi-dwarf and glutinous characteristics. The sd1-wx mutant lines exhibited reduced gibberellin content, plant height, and amylose content, while maintaining hardly changed germination rate and other key agronomic traits. Importantly, our study demonstrated that exogenous GA3 application effectively promoted growth by compensating for the deficiency of endogenous gibberellin. Based on this, a semi-dwarf glutinous elite rice (Oryza sativa L.) Lines was developed without too much effect on most agronomic traits. Furthermore, a comparative transcriptome analysis unveiled that differentially expressed genes (DEGs) were primarily associated with the anchored component of the membrane, hydrogen peroxide catabolic process, peroxidase activity, terpene synthase activity, and apoplast. Additionally, terpene synthase genes involved in catalyzing the biosynthesis of diterpenoids to gibberellins were enriched and significantly down-regulated. This comprehensive study provides an efficient method for simultaneously enhancing rice plant height and quality, paving the way for the development of lodging-resistant and high-quality rice varieties.

Co-inoculation of Meyerozyma guilliermondii and Saccharomyces cerevisiae reduced alcohol content and improved flavor profiles of red pitaya (Hylocereus polyrhizus) wine

Abstract Red pitaya (Hylocereus polyrhizus) is cultivated in tropical and subtropical regions worldwide. Red pitaya is rich in nutritional and medicinal ingredients. Oenological yeasts play vital roles in wine fermentation by metabolizing a variety of aromatic compounds that affect the flavor and sensory properties of wine. In this study, we examined the influence of Meyerozyma guilliermondii on the physicochemical parameters, sensory properties, and aroma chemical composition of red pitaya wine co-inoculated with Saccharomyces cerevisiae. The results showed that mixed inoculation of M. guilliermondii and S. cerevisiae reduced the alcohol content of red pitaya wine. Moreover, using M. guilliermondii and S. cerevisiae as fermentation starters increased the content of volatile alcohols, aldehydes, ketones, and other compounds, as well as the types of alcohols, aldehydes, and ketones. In addition, M. guilliermondii did not affect the sensory characteristics of the red pitaya wine. Therefore, co-inoculation of M. guilliermondii and S. cerevisiae was helpful in enhancing the richness and complexity and improving the aromatic flavor properties of red pitaya wine. The results obtained in this study could serve as a reference for the production of red pitaya wine and other fruit wines.

Assessment of Morphological Diversity and Vegetative Growth Parameters of Fifteen Betel Vine Varieties Cultivated Along the Odisha Coast

Betel vine (Piper betle) is a tropical evergreen plant renowned for its cultural and medicinal significance. With origins in Southeast Asia, its heart-shaped leaves, vibrant colors and aromatic properties contribute to its widespread cultivation. The study investigates the morphological diversity and vegetative growth parameters of fifteen betel vine varieties cultivated along the Odisha coast, with a focus on vine elongation, leaf dimensions, internodal length, leaf area, weight of fresh leaves, number of adventitious root production and the number of leaves per meter of vine. The results revealed significant variation among the varieties. Notably, vine elongation ranged from 39.5 to 68.8 cm/month, with the Golabandha varieties showing the highest rate. Leaf length varied from 8.84 to 20.24 cm, and the Chandrakana varieties displayed the longest leaves. Leaf breadth ranged from 4.46 to 15.3 cm, with the widest leaves found in Chandrakana varieties. Internodal length varied from 3.06 to 6.46 cm, with Gunthuni having the lowest internodes. Leaf area ranged from 38.04 to 177.37 cm2, with Chandrakana exhibiting the largest leaf area. Weight of fresh leaves varied significantly, with Chandrakana and Ralaba varieties having the highest and lowest weights, respectively. Cluster analysis grouped varieties based on their morphological characteristics, revealing distinct clusters related to leaf dimensions and growth parameters. Understanding the morphological diversity of betel vine varieties is crucial for identifying the superior varieties for sustainable cultivation and ensuring the quality of this culturally and economically significant crop.

Advances for Triangular and Sandwich-Shaped All-Metal Aromatics.

Much experimental work has been contributed to all-metal σ, π and δ-aromaticity among transition metals, semimetallics and other metals in the past two decades. Before our focused investigations on the properties of triangular and sandwich-shaped all-metal aromatics, A. I. Boldyrev presented general discussions on the concepts of all-metal σ-aromaticity and σ-antiaromaticity for metallo-clusters. Schleyer illustrated that Nucleus-Independent Chemical Shifts (NICS) were among the most authoritative criteria for aromaticity. Ugalde discussed the earlier developments of all-metal aromatic compounds with all possible shapes. Besides the theoretical predictions, many stable all-metal aromatic trinuclear clusters have been isolated as the metallic analogues of either the σ-aromatic molecule's [H3]+ ion or the π-aromatic molecule's [C3H3]+ ion. Different from Hoffman's opinion on all-metal aromaticity, triangular all-metal aromatics were found to hold great potential in applications in coordination chemistry, catalysis, and material science. Triangular all-metal aromatics, which were theoretically proved to conform to the Hückel (4n + 2) rule and possess the smallest aromatic ring, could also play roles as stable ligands during the formation of all-metal sandwiches. The triangular and sandwich-shaped all-metal aromatics have not yet been specifically summarized despite their diversity of existence, puissant developments and various interesting applications. These findings are different from the public opinion that all-metal aromatics would be limited to further applications due to their overstated difficulties in synthesis and uncertain stabilities. Our review will specifically focus on the summarization of theoretical predictions, feasible syntheses and isolations, and multiple applications of triangular and sandwich shaped all-metal aromatics. The appropriateness and necessities of this review will emphasize and disseminate their importance and applications forcefully and in a timely manner.

Database of 4 Million Medicinal Chemistry-Relevant Ring Systems.

Central ring systems are the most important part of bioactive molecules. They determine molecule shape, keep substituents in their proper positions, and also influence global molecular properties. In the present study, a database of 4 million medicinal chemistry-relevant ring systems has been created, not by crude random enumeration but by applying a set of rules derived by analyzing rings present in bioactive molecules. The aromatic properties and tautomer stability of generated rings have also been considered to ensure that the rings in the database are stable and chemically reasonable. 99.2% of these rings are novel and not included in molecules in the ChEMBL or PubChem databases. This large database of ring systems has been created with the goal to provide support for bioisosteric design and scaffold hopping as well as to be used in generative chemistry applications. The complete set of created rings is available for download in the SMILES format from https://peter-ertl.com/molecular/data/.

Aromatic and magnetic properties in a series of heavy rare earth-doped Ge6 cluster anions.

A series of pentagonal bipyramidal anionic germanium clusters doped with heavy rare earth elements, (RE = Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu), have been identified at the PBE0/def2-TZVP level using density functional theory (DFT). Our findings reveal that the centrally doped pentagonal ring structure demonstrates enhanced stability and heightened aromaticity due to its uniform bonding characteristics and a larger charge transfer region. Through natural population analysis and spin density diagrams, we observed a monotonic decrease in the magnetic moment from Gd to Yb. This is attributed to the decreasing number of unpaired electrons in the 4f orbitals of the heavy rare earth atoms. Interestingly, the system doped with Er atoms showed lower stability and anti-aromaticity, likely due to the involvement of the 4f orbitals in bonding. Conversely, the systems doped with Gd and Tb atoms stood out for their high magnetism and stability, making them potential building blocks for rare earth-doped semiconductor materials.