Aroma Chemicals Research Articles

Contribution of polyvinylpolypyrrolidone (PVPP) treatment to the distribution of polyphenols and the evolution of esters and higher alcohols in Rosa roxburghii Tratt wine

Polyvinylpolypyrrolidone (PVPP) is commonly employed for fining in fruit wine brewing. This study aimed to investigate the impact of PVPP pretreatment on the formation of fermentation aroma and polyphenol distribution in Rosa roxburghii Tratt (RRT) wine. A significant effect of PVPP on polyphenol adsorption was observed, and polyphenol families or subfamilies such as flavanols and flavonols showed specific affinity for PVPP, decreasing by over 19 % and 30 %, respectively. Furthermore, it was the first time to demonstrate a significant enhancement in the ester content of the corresponding RRT wine after PVPP treatment, particularly in imparting sweet and fruity esters (increased by over 40 %). In contrast, the RRT wine treated with PVPP exhibited a significant reduction of over 20 % in the concentration of higher alcohols, particularly reflected in the green and chemical aromas. This indicates that PVPP treatment could promote the transformation of RRT wine aroma from green and chemical to sweet and fruity. Correlation analysis revealed a positive relationship between the concentration of higher alcohols and most phenolic compounds in RRT wine, while quercetin 3-glucoside, rutin, and polydatin were negatively correlated with esters that can impart fruit flavor and floral aroma to fruit wine. As a practical insight into fruit wine fermentation, PVPP fining before fermentation is more likely to alter the phenolic compositions of RRT wine, thereby influencing its aroma characteristics. Specifically, polyphenols associated with energy metabolism of yeast could have stimulated the formed fluxes of esters. The association between the formation of esters and higher alcohols with phenolic compounds will provide new information on the impact of clarification treatments on yeast-derived volatile metabolites in RRT wine and hold promise in improving the aroma of RRT wine by modulating polyphenol composition through pre-clarification.

Quantitative risk assessments of skin sensitization for 26 allergens in different consumer products in the Saudi market

Fragrance chemicals are ubiquitous in cosmetics; however, they have been linked to allergic contact dermatitis. Allergy prevention involves two main strategies. Firstly, consumers are protected by limiting the maximum concentration of fragrance in a given product to avoid inducing allergies. Secondly, consumers who are already sensitized are protected by having the presence of such fragrance communicated to them. In this study, a validated GC-MS method was employed to quantify 26 allergens in 108 products marketed in Saudi Arabia.Additionally, a quantitative risk assessment (QRA) was performed on the studied cosmetics to determine the risk of inducing allergies. The results indicated that most allergens were present at acceptable concentrations, while 19 products carried a risk of inducing allergies. Furthermore, Lilial and Lyral, two prohibited fragrances, were detected in 97 products. It should be emphasized that this is the first study conducted in Saudi Arabia to evaluate the safety of the well-known 26 fragrance allergens. Hence, this study can potentially serve as a regional standard for future research.

Dynamic Changes in Yeast Populations and Aroma Composition of ‘Beimei’ (Vitis vinifera × Vitis amurensis) during Spontaneous Fermentation

‘Beimei’ is a hybrid cultivar of Vitis vinifera and wild Vitis amurensis with fungus- and cold-resistant characteristics that is widely grown in many regions of China. However, studies on the yeast diversity and aroma compound composition of this cultivar remain scarce. Here, indigenous yeast diversity, aroma compound composition, and their dynamic changes during the spontaneous fermentation of ‘Beimei’ were investigated and monitored using high-throughput sequencing and gas chromatography-mass spectrometry. The result indicated that non-Saccharomyces yeasts were predominant at the initial stages of ‘Beimei’ spontaneous fermentation and then sharply decreased. Cladosporium herbarum and Hanseniaspora uvarum were identified as the dominant species of filamentous fungi and yeast, respectively, at the beginning and on the first day of fermentation, whereas unclassified_f_Saccharomycetacease was dominant throughout fermentation, starting from the third day until the end of fermentation. The main volatile aroma chemicals were esters and alcohols, which accumulated abundantly at the late stage of fermentation. Taken together, this study represents the first step in exploring untapped yeast species and aroma compounds, which is helpful for the screening of native yeasts from ‘Beimei’ and producing distinctive aroma wines.

Fragrance Contact Allergy - A Review Focusing on Patch Testing.

Fragrance materials are widely used in various types of products in daily life and many of them can be contact sensitizers. Contact allergy to fragrances has been reported to be common worldwide. Unlike other groups of contact allergens such as metals and preservatives, fragrance materials in consumer products can be present as single fragrance chemicals or in the form of mixtures known as natural complex substances. Due to the complexity of the fragrance materials and the high number of fragrance substances known to cause contact sensitization, selecting suitable materials for patch testing is challenging. Emerging fragrance markers have been additionally introduced in different baseline series for screening to enhance the rate of fragrance contact allergy detection. Moreover, there have been continual updates on basic knowledge, clinical perspectives, sources of exposure, and regulations on the use of fragrance materials. Avoiding pitfalls while performing patch testing with fragrance test materials is also crucial and should not be overlooked. Therefore, this review aims to update knowledge to provide a high-quality holistic approach to fragrance contact allergy diagnosis and management.

Fragrance chemicals in nail salons: Personal inhalation exposures and potential sources

The indoor air of nail salons is full of volatile organic compounds (VOCs), many of which have fragrances. Little is known about the fragrance chemicals in nail salons, as fragrance ingredients are not required on nail product labels and are considered trade secrets. This study aimed to identify fragrance chemicals and their potential sources and exposures in nail salons. Indoor air samples were collected in seven nail salons in the Greater Boston Area between November 2016 and June 2017. Personal samples were also collected from ten nail salon workers during their work shifts. Follow-up area sampling was performed in two salons one year after the initial visits. All air samples were collected using thermal desorption (TD) tubes and analyzed on a TD-gas chromatography/mass spectrometry (GC/MS) system targeting 55 fragrance chemicals. Eighteen compounds were detected in air samples, including terpenes, alcohols, carbonyls, ethers, and esters. The concentrations displayed limited spatial variation within a salon but moderate variation over time. The highest median personal inhalation concentrations were benzaldehyde (36.4 μg/m3), 2-ethylhexanol (30.0 μg/m3), d-limonene (16.6 μg/m3), and 2-butoxyethanol (12.6 μg/m3). Highest personal levels were reached by maximum concentrations of 2-butoxyethanol (<1611 μg/m3)), d-limonene (<413 μg/m3), and methyl salicylate (<113.5 μg/m3). Personal concentrations of most compounds were highly correlated with area concentrations (Spearman correlations = 0.69−0.92). Fragrance concentrations from area and personal air samples did not correlate significantly with the ventilation rate. Cleaning agents, personal care products, and nail products were identified as important possible emission sources. This study reveals a subset of fragrance chemicals in nail salons’ indoor air and calls for future research on a full spectrum of these chemicals, their health effects among nail salon workers, and ways to reduce these exposures.

Versatile Application of Polymeric Gel Using Gelatin Polymer

Fragrance chemicals have been utilized to refresh the air and hide smells since antiquity. Electric air fresheners have a 30% market share, sprays, including aerosol air fresheners, have a 27% market share, car air fresheners have a 16% market share, gel air fresheners have a 9% market share, candle air fresheners and wax melts have a 7% market share, liquid air fresheners have a 6% market share, and others. According to research studies, 34.7% of the population in the United States experienced health concerns such as migraine headaches and respiratory difficulties after being exposed to fragranced items. As a result, there are various studies that show that fragmented items might have harmful health impacts on the general population.Given that air, fresheners have been linked to undesirable negative health impacts, the motivation for developing a greener and healthier method of synthesis of gel air fresheners. The gel air fresheners in this work were created utilizing a simple and green sol-gel reaction that included natural biodegradable polymer gelatin and mogra essence, as well as silver nanoparticles and ampicillin drug for antibacterial gel. In any case, the gel air freshener made from mogra essence is safer for human health than commercially available ones. According to the findings of this investigation, there should be future improvements in stability.Weanalyze the property of the gel from different analysis methods like SEM, TGA, FTIR, and XRD.

Seed Germination and Plant Growth in Ocimum Variety by Physical Treatment Methods

Ocimum one of the largest family of Lamiaceae,it comprised about 150 species distributed all over tropical and subtropical region of world. The essential components of family is eugenol found which is used for cosmetic product, culinary uses,food and drug industry. sweet basil or Indian basil, is an industrially important source of essential oil, oil painting and aroma chemicals. the present study entitled “Germination and growth responses in Ocimum specie’s to seed pretreatments ” has been accepted with the ideal of homogenizing pretreatment of seeds for enhanced germination and growth plants. The main objective of studies is to carried physical treatment of seeds were vanquished to various physical treatments analogous as scarification( using sandpaper), water soaking( overnight), hot water( 25℃) treatment for 5 min to study their effect on seed germination to obtain maximum germination percentage and growth of seedlings. In this study there are four specie’sof Ocimum, Ocimum tenuiflorum L., Ocimum basilicum L., Ocimum grattisum L., Ociumum thrysiflorum L. selected for seed pretreatment and evaluation of pretreatment seeds. Study area analysis taken different measurements were germination percentage, survival percentage, Mean germination time, shoot length,root length, seedlings height, Allometric index observed. The highest germination percentage and height also lowest rate and height calculate by using formula.

Plant Resource Use and Pattern of Usage by the Naturalized Orchid Bee (Euglossa dilemma: Hymenoptera: Apidae) in Florida.

The Neotropical orchid bee Euglossa dilemma was found to be naturalized in southern Florida in 2003, and, by 2022, it had colonized the southern half of Florida. Observations of the bee's collection of plant resources, primarily flowers, were made from 2003 through to 2022 to document its plant usage and understand the patterns of its plant usage. The bee utilized 259 plant taxa, 237 species, and 22 horticultural forms, in 156 genera and 56 families in 263 total uses. Of 247 taxa of flowers, 120 were visited primarily for nectar, 46 for both nectar and pollen, 60 for pollen, including 42 buzz-pollinated flowers, 15 for fragrance chemicals for the males, and 5 for resin rewards by females for nesting. Fragrance chemicals were also collected by males from the leaves of 12 plant species. These extensive resource use data allowed the following predictions to be made. (1) The bee's presence in Florida, distant from its native region of Mexico and Central America and the geographical ranges of other orchid bees, would result the usage of many new taxa of plants. True, half, 74/148 (50%), of the genera and one third, 16/51(31%), of the plant families of the plants with flowers used by the bee were not previously recorded as being utilized by Euglossine bees. (2) Like other naturalized bees, it would use relatively more plants from its native range or congeners of these plants. True, 113/148 (76%) of genera with species bearing collected floral rewards are native or congeners with species native to the bee's native range. (3) Given the bee's long tongue, ability to buzz pollen from poricidal anthers, and ability to collect and use specialized rewards, it would disproportionately use plants with protected or highly specialized floral rewards. True, 180/247 (72%) utilized species bear rewards which were protected and unavailable to, or of no interest to, most other flower visitors.

Aroma Chemicals Identification by Sophisticated Technique and Their Role Against Pathogens

Citrus fruits and their essential oils play a vital role in every aspect of human life. Essential oils derived from citrus peel are rich in polyphenols and act as secondary metabolites to treat various diseases and they can be used as insecticide or pesticide. These citrus oil derivatives are much popular in flavour and fragrance industry and FMCG sector. In present research work five variants of citrus fruits; C. aurantium (Narinja), C. hystrix (Gondhoajlebu), C. limon (Lemon), C. limetta (Mosambi) and Citrus reticulata Blanco (Nagur Orange) were selected from different regions of India; Telangana, Andhra Pradesh, Kolkata and Maharashtra. The collected samples were further studied using SPME-GCMS analysis to identify the specific molecules which are not in common. Most identified moleculesthrough GCMS analysis are Limonene, Alpha pinene, Myrcene, Delta-carene, Sabinene etc. Each molecule has a significant aroma and used in many Flavour &amp;amp; Fragrance industry. The chemical molecules identified in Narinja (C. aurantium) citrus fruit are specific and not identified in any of the selected fruits they areBicyclogermacrene, Isopiperitenone, Alpha eudesmol, Beta eudesmol. Antimicrobial activity of five essential oilsreports Narinja oil has potent activity on E. coli, Staphylococcus aureus and Bacillus followed by lemon oil and orange oil on E. coli and Bacillus, Mosambion Bacillus and Gondhorajlebu on E. coli. This data reveals that there aresome specific molecules in C. aurantiumto be considered for further research for their medicinal aspects, as mosquito repellent or in F&amp;amp;F industry.

Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic Cannabis.

Cannabis sativa L. produces a wide variety of volatile secondary metabolites that contribute to its unique aroma. The major volatile constituents include monoterpenes, sesquiterpenes, and their oxygenated derivates. In particular, the compounds ß-myrcene, D-(+)-limonene, ß-caryophyllene, and terpinolene are often found in greatest amounts, which has led to their use in chemotaxonomic classification schemes and legal Cannabis sativa L. product labeling. While these compounds contribute to the characteristic aroma of Cannabis sativa L. and may help differentiate varieties on a broad level, their importance in producing specific aromas is not well understood. Here, we show that across Cannabis sativa L. varieties with divergent aromas, terpene expression remains remarkably similar, indicating their benign contribution to these unique, specific scents. Instead, we found that many minor, nonterpenoid compounds correlate strongly with nonprototypical sweet or savory aromas produced by Cannabis sativa L. Coupling sensory studies to our chemical analysis, we derive correlations between groups of compounds, or in some cases, individual compounds, that produce many of these diverse scents. In particular, we identified a new class of volatile sulfur compounds (VSCs) containing the 3-mercaptohexyl functional group responsible for the distinct citrus aromas in certain varieties and skatole (3-methylindole) as the key source of the chemical aroma in others. Our results provide not only a rich understanding of the chemistry of Cannabis sativa L. but also highlight how the importance of terpenes in the context of the aroma of Cannabis sativa L. has been overemphasized.

Fragrance in dermocosmetic emulsions: From microstructure to skin application.

Fragrance is added to almost all dermocosmetic emulsions, as it has been found to be a key driver in consumer choice and contributes to the perception of product performance. Fragrance is a complex mixture of odorant chemicals at different concentrations. When incorporated into a formulation, the individual fragrance chemicals partition between the emulsion phases depending on their physicochemical properties, which can impact the structure, stability, texture and odour of the final product. On the other hand, it is well known in the food industry how the composition and structure of food emulsion matrices influence the release of aroma chemicals. Fragranced dermocosmetic emulsions have been studied to a lesser extent but it is interesting to apply findings from the food domain since emulsion structure, composition and aroma compounds share common features. This review aims to give an overview of the literature dealing with the interactions between fragrance and dermocosmetic emulsions. The effects of fragrance on emulsion microstructure, stability and texture are highlighted and discussed. The effects of composition and structure of emulsion on the release of fragrance molecules are also presented. Finally, the interactions between skin and fragranced emulsions are addressed.

Oil-in-water (O/W) nanoemulsion loaded with biotransformation product containing limonene and α-terpineol stabilized with Tween®20: Formation and physicochemical stability along with time

Aroma chemicals are essential in the food industry as they are added to numerous food products to enhance sensory experience. However, preserving the shelf-life and maintaining the physicochemical stability of these additives is a challenging task for food processors. Encapsulation techniques can help overcome these challenges by facilitating incorporation, increasing loading capacity and enabling controlled release of flavor oils. This study specifically focused on encapsulating a biotransformation product comprising a blend of alpha-terpineol (α-TOH), limonene (LIM), and soybean oil, obtained through bioconversion of limonene in a submerged liquid fermentation media using Sphingobium sp. as a biocatalyst. By using Tween®20 as a surfactant, an oil-in-water nanoemulsion system was used as encapsulation strategy to extend the shelf life of these sensitive flavor oils. Subsequently, the nanoemulsified samples were subjected to varying temperatures (5 °C, 25 °C, and 50 °C) for up to 600 days. The physical stability of the samples we assessed by measuring mean droplet diameter and turbidity, while chemical stability was analyzed using gas chromatography (GC). Findings revealed that physical stability was maintained for up to 600 days at 5 °C and 25 °C. Conversely, the nanoemulsion broke down on the 120th day when exposed to 50 °C. Furthermore, it was found that the chemical stability was temperature-dependent, with losses of LIM and α-TOH increasing as the storage temperature rose. In conclusion, this study emphasizes the critical role of encapsulation techniques in prolonging the shelf life of sensitive compounds such as aroma chemicals.

Comprehensive treatment of aroma chemicals industrial effluent with substantial COD content by a novel PVP/polyamide composite hydrophilized RO membrane

A hydrophilized polyvinyl pyrrolidone/polyamide composite high rejection reverse osmosis (HPA-HR RO) membrane was used for the treatment of aroma chemicals containing effluent coming as multiple effect evaporators (MEE) condensate at UK Aromatics Pvt. Ltd., Boisar, Maharashtra. The unique membrane has an active composite layer of polyamide prepared by interfacial polymerization of high diamine (3%) and acid chloride (0.2%) monomer concentrations, which is further coated with polyvinyl pyrrolidone (PVP) to enhance hydrophilicity and chemical inertness. The plant provides removal of total dissolved solids (TDS) from 2500 to 3500 ppm in the feed to a value of 50–100 ppm in the permeate water indicating a rejection of more than 95% of the dissolved solids, with a high water recovery of 80% in permeate. Similarly, complete rejection of color was observed from dark brown to colorless (transparent), whereas the COD content was brought down from 3000 to 5000 mg/L in the MEE condensate to around 1000 mg/L indicating removal of 60 % to 80% depending upon the pressure applied to overcome the high osmotic pressure of the effluent. Physicochemical interactions between the PVP and polyamide skin layers of the composite membrane make the separating barrier durable and highly hydrophilic. Water would have greater sorption due to high affinity with the membrane and higher diffusion coefficient from its smaller size, while the less polar esters that constitute most of the COD would have low interaction and their larger molecular sizes make them less diffusive. The recovered permeate water has been reused in various internal industrial applications like cooling towers, cleaning, etc. at UK Aromatics.

Common fragrance chemicals activate dendritic cells in coculture with keratinocytes.

Fragrances are important contact allergens; however, investigation of their skin sensitization potency has been challenging in new approach methods (NAMs). Many fragrance chemicals are susceptible to autoxidation or can be metabolized by enzymes constitutively expressed in skin keratinocytes. Strong sensitizers can be formed in both of these processes. Further, keratinocytes can modulate the dendritic cell (DC) activation and maturation potential, a key event in the acquisition of contact allergy. To evaluate the 2D coculture model consisting of keratinocytes and DCs using different weak to moderate sensitizing fragrance chemicals. Further, to investigate fragrances and related oxidation products in the in vitro model and compare to in vivo data. Chemicals were tested in the coculture activation test (COCAT), consisting of HaCaT keratinocytes and THP-1 cells. THP-1 cell surface expression of costimulatory and adhesion molecules (CD86 and CD54) collected after 24 h incubation with the chemicals was analysed using flow cytometry. Twenty-four molecules were tested positive, three were negative (n = 27). Four pairs were evaluated, with aldehydes showing a 6- to 13-fold stronger responses compared to their corresponding alcohols. Results provide insight into the activation of DC in their natural environment of keratinocytes. α,β-Unsaturated alcohols were classified as weaker sensitizers compared to their corresponding aldehydes. In sum, testing of fragrances retrieved results in good agreement with in vivo data.

BASF will expand aroma chemicals

BASF will expand aroma chemicals

BASF will expand aroma chemicals in China and Germany

BASF will expand aroma chemicals in China and Germany

Do Synthetic Fragrances in Personal Care and Household Products Impact Indoor Air Quality and Pose Health Risks?

Fragrance compounds (synthetic fragrances or natural essential oils) comprise formulations of specific combinations of individual materials or mixtures. Natural or synthetic scents are core constituents of personal care and household products (PCHPs) that impart attractiveness to the olfactory perception and disguise the unpleasant odor of the formula components of PCHPs. Fragrance chemicals have beneficial properties that allow their use in aromatherapy. However, because fragrances and formula constituents of PCHPs are volatile organic compounds (VOCs), vulnerable populations are exposed daily to variable indoor concentrations of these chemicals. Fragrance molecules may trigger various acute and chronic pathological conditions because of repetitive human exposure to indoor environments at home and workplaces. The negative impact of fragrance chemicals on human health includes cutaneous, respiratory, and systemic effects (e.g., headaches, asthma attacks, breathing difficulties, cardiovascular and neurological problems) and distress in workplaces. Pathologies related to synthetic perfumes are associated with allergic reactions (e.g., cutaneous and pulmonary hypersensitivity) and potentially with the perturbation of the endocrine-immune-neural axis. The present review aims to critically call attention to odorant VOCs, particularly synthetic fragrances and associated formula components of PCHPs, potentially impacting indoor air quality and negatively affecting human health.

IFF to divest aroma chemical business

International Flavors & Fragrances will sell its flavor specialty ingredients business to Exponent, a UK-based private equity firm, for $220 million. The business makes more than 1,000 synthetic aroma chemicals and natural extracts used in flavors. It has about $100 million in annual sales and operates plants in the UK, the US, and China. Exponent notes that it is already an investor in two other food businesses: Quorn Foods, a maker of meat alternatives, and Meadow Foods, a dairy ingredients firm.

Genome-wide investigation of Cytochrome P450 superfamily of Aquilaria agallocha: Association with terpenoids and phenylpropanoids biosynthesis

Agarwood is a dark resinous wood, produced when Aquilaria tree responds to wounding and microbial infection resulting in the accumulation of fragrant metabolites. Sesquiterpenoids and 2-(2-phenylethyl) chromones are the major phytochemicals in agarwood and Cytochrome P450s (CYPs) are one of the important enzymes in the biosynthesis of these fragrant chemicals. Thus, understanding the repertoire of CYP superfamily in Aquilaria can not only give insights into the fundamentals of agarwood formation, but can also provide a tool for the overproduction of the aroma chemicals. Therefore, current study was designed to investigate CYPs of an agarwood producing plant, Aquilaria agallocha. We identified 136 CYP genes from A. agallocha genome (AaCYPs) and classified them into 8 clans and 38 families. The promoter regions had stress and hormone-related cis-regulatory elements which indicate their participation in the stress response. Duplication and synteny analysis revealed segmental and tandem duplicated and evolutionary related CYP members in other plants. Potential members involved in the biosynthesis of sesquiterpenoids and phenylpropanoids were identified and found to be upregulated in methyl jasmonate-induced callus and infected Aquilaria trees by real-time quantitative PCR analyses. This study highlights the possible involvement of AaCYPs in agarwood resin development and their complex regulation during stress exposure.

Understanding the Environmental Distribution and Potential Health Risks of Pollutants from Deodorant Products: A Review

Deodorants are frequently used personal care products; however, questions have been raised concerning their possible toxicity to cause air and water pollution, and their potential impact on human health. The degree to which deodorant ingredients, such as fragrance chemicals, antibacterial compounds, aluminium compounds, and preservatives, are toxic depends on their chemical composition. Many of these chemicals have been connected to adverse health effects, such as skin rashes, allergic reactions, endocrine disruption, and respiratory problems. Understanding these chemicals’ toxicity is crucial for determining any potential risks to human health. Spray formulations have the potential to release volatile organic compounds into the air, such as propellants and fragrance chemicals, which can be harmful to human respiratory health and lead to indoor and outdoor air pollution. Improper disposal and wastewater treatment can lead to the contamination of water bodies, potentially impacting aquatic ecosystems and human water supplies. This review provides an overview of the toxicity of deodorant ingredients in various formulations, including sprays, roll-ons, and sticks. The partition coefficients Log Kaw (air-water partition coefficient), Log Koa (airorganic carbon partition coefficient), and Log Kow (octanol-water partition coefficient), values of deodorant ingredients were summarized for assessing their potential for long-range transport, persistence in the environment, and bioaccumulation in organisms.