BACKGROUND: The subject of the study is the technological process of protective spraying of agricultural crops using a combined method against perennial weeds in sites in the field using two pneumohydraulic devices with slot atomizers as part of an improved small-sized boom sprayer. AIM: Development of a technical mean for exterminating sites of perennial root shoot weeds with pests and diseases in them. METHODS: The developed pneumohydraulic devices were used for an improved mounted boom sprayer of plants to treat sites of perennial weeds in the field. Chemical spraying with combined use of the traditional method and the developed pneumohydraulic devices with axial fans and 12 V electric motors, ensuring the distribution of droplet liquid on the treatment surface with two sprayers over 4 meters, is able to reduce the amount of the applied chemicals compared to the conventional technology and to reduce the pesticide load on crop plants by local destruction of sites of weeds, pests and diseases. Based on the developed methods, the results of spraying the surface with a drop liquid with a known dispersion using slot sprayers and controlled liquid pressures with a dial gauge during experiments were obtained. SCIENTIFIC NOVELTY: For the first time, a combined method and technical mean of achieving the research aim have been proposed for the destruction of sites of perennial weeds in the field and the diseases and pests of agricultural crops spread in them. RESULTS: When using a mounted sprayer with two containers for working fluids of combined herbicide solutions or for an insecticide solution in one of the containers and installation of the improved pneumohydraulic devices on the edges of the boom with a conventional arrangement of slot atomizers, it is possible to meet agrotechnical requirements for the use of herbicides, insecticides and fungicides. The simultaneous impact of large drops of herbicides on weeds and the penetration of small drops into plants will destroy sites of rhizome and root weeds with pests and diseases to ensure favorable conditions for the production of agricultural crops. CONCLUSION: A combined method and the technical mean of chemical treatment of perennial weeds with pests and diseases to create favorable conditions for the production of cultivated plants has been experimentally substantiated. Compliance with the conditions is ensured by equipping the mounted sprayer with two containers, pumps for supplying liquid through hoses to slot atomizers, and installing pneumohydraulic liquid nozzles at the edges of the boom. Working liquid sprayers ensure spraying width of more than 4 m, taking into account the size of a site, as well as spraying inaccessible areas using conventional technical means. The efficiency of the developed combined protective spraying of agricultural crops against perennial weeds and pests by the technical mean of its implementation lies in the savings of expensive herbicides and insecticides up to 70% in the later stages of their growing season (as they grow over the field area) compared to the forced continuous application of the herbicide over the entire field area.