Architectonic Features Research Articles

Multimodal mapping of macaque monkey somatosensory cortex

The somatosensory cortex is a brain region responsible for receiving and processing sensory information from across the body and is structurally and functionally heterogeneous. Since the chemoarchitectonic segregation of the cerebral cortex can be revealed by transmitter receptor distribution patterns, by using a quantitative multireceptor architectonical analysis, we determined the number and extent of distinct areas of the macaque somatosensory cortex. We identified three architectonically distinct cortical entities within the primary somatosensory cortex (i.e., 3bm, 3bli, 3ble), four within the anterior parietal cortex (i.e., 3am, 3al, 1 and 2) and six subdivisions (i.e., S2l, S2m, PVl, PVm, PRl and PRm) within the lateral fissure. We provide an ultra-high resolution 3D atlas of macaque somatosensory areas in stereotaxic space, which integrates cyto- and receptor architectonic features of identified areas. Multivariate analyses of the receptor fingerprints revealed four clusters of identified areas based on the degree of (dis)similarity of their receptor architecture. Each of these clusters can be associated with distinct levels of somatosensory processing, further demonstrating that the functional segregation of cortical areas is underpinned by differences in their molecular organization.

A new map of the rat isocortex and proisocortex: cytoarchitecture and M2 receptor distribution patterns.

Neurotransmitters and their receptors are key molecules in information transfer between neurons, thus enabling inter-areal communication. Therefore, multimodal atlases integrating the brain's cyto- and receptor architecture constitute crucial tools to understand the relationship between its structural and functional segregation. Cholinergic muscarinic M2 receptors have been shown to be an evolutionarily conserved molecular marker of primary sensory areas in the mammalian brain. To complement existing rodent atlases, we applied a silver cell body staining and quantitative in vitro receptor autoradiographic visualization of M2 receptors to alternating sections throughout the entire brain of five adult male Wistar rats (three sectioned coronally, one horizontally, one sagittally). Histological sections and autoradiographs were scanned at a spatial resolution of 1µm and 20µm per pixel, respectively, and files were stored as 8 bit images. We used these high-resolution datasets to create an atlas of the entire rat brain, including the olfactory bulb, cerebellum and brainstem. We describe the cyto- and M2 receptor architectonic features of 48 distinct iso- and proisocortical areas across the rat forebrain and provide their mean M2 receptor density. The ensuing parcellation scheme, which is discussed in the framework of existing comprehensive atlasses, includes the novel subdivision of mediomedial secondary visual area Oc2MM into anterior (Oc2MMa) and posterior (Oc2MMp) parts, and of lateral visual area Oc2L into rostrolateral (Oc2Lr), intermediate dorsolateral (Oc2Lid), intermediate ventrolateral (Oc2Liv) and caudolateral (Oc2Lc) secondary visual areas. The M2 receptor densities and the comprehensive map of iso-and proisocortical areas constitute useful tools for future computational and neuroscientific studies.

THE GENRE OF ARRANGEMENT OF UKRAINIAN FOLK MELODIES IN THE PIANO WORKS OF VASYL BEZKOROVAINYI

The article is devoted to the piano heritage of Vasyl Bezkorovainyi, a composer, conductor, music and public figure, pianist-accompanist, whose work and creativity are forgotten and little known in Ukrainian musical culture. He was an active figure in the musical life of Galicia, founding music schools, choirs, and orchestras. Subsequently, since 1948, he worked fruitfully to popularize Ukrainian music among the postwar Ukrainian emigration to the United States. The article briefly discusses the need to revive the artist’s multi-genre heritage, which has come down to us in manuscript form in more than 360 works. The article describes the way Vasyl Bezkorovainyi’s archive was returned to his homeland, preserved and organized by his daughter Neonila and brought to Ukraine by her husband Yevhen Stetskiv. At the initiative of the composer’s relatives, Natalia and Bohdan Bezkorovainy, 2 volumes of the composer’s piano works were published in 2020. Among the one hundred and sixteen piano opuses, a significant part is occupied by the genre of arrangements of folk songs and samples of the calendar and ritual cycle. The selected exemplary pieces demonstrate a wide range of genre interests of the artist, and the studied musical, expressive, architectonic features reveal the stylistic foundations of Vasyl Bezkorovainyi’s piano heritage. It is noted that the piano compositions have artistic and pedagogical value. On the example of the analysis of a number of arrangements of folk songs and calendar and ritual samples, it is demonstrated how nationally specific expressive means and traditional European harmonic turns of the romantic direction form the linguistic and stylistic phenomenon of the artist. It is noted that for the composer, when working on folk melodies, it is not simplicity or complexity that is important, but compliance with the spirit of the folk song, the need to leave its harmonic, intonational and metrical basis intact. In terms of formation, we note national models and methods of developing thematic material based on the variant principle, improvisation, and the regulatory nature of structural constructions. Most of the compositions are dominated by two- and three-part forms. In the palette of stylistic features and linguistic expressive means, we observe a synthesis of the harmonic, harmonic, metrical principles of European music and the peculiarities of Ukrainian folklore, with the dominance of the latter.

Delineating structural features of North Cameroon using the EIGEN6C4 high‐resolution global gravitational model

The Cretaceous basins of the West and Central African Rift System (WCARS) are characterized by sinistral strike–slip movements observed between the Benue and Arabian–Nubian microplates. These basins share a similar basin‐filling structure, history, and tectonic processes. They have attracted a significant interest in the study of their geodynamics and subsurface structure through geophysical exploration methods. Nevertheless, North Cameroon located in this microplate confluence has not yet been investigated in terms of identifying geological structures, such as lineaments and faults. To contribute to a better understanding of the northern Cameroon structural framework and its tectonic context, we investigate the lineaments in northern Cameroon by using the EIGEN‐6C4 gravitational model and a variety of recent processing techniques (Tilt derivative [TDR], Theta Map [TM], Horizontal tilt angle [TDX], and Edge Detector [ED]). Our results show that the lineaments are trending in ENE–WSW, NW–SE, NE–SW, and WNW–ESE directions. These directions are consistent with the Cretaceous Garoua Rift and granitoids of the Cameroon‐Chad line. The presented result clearly delineates continuous architectonic features of the structural edges of the Saharan Metacraton, the Cretaceous Garoua Rift, the Bibemi‐Léré granitoids, and the Adamawa faults.

Modeling the Sacred

Architecture and its attendant meanings are the subject of an exceptional group of ceramics produced by the Paracas (c. 800–200 BCE) of south coastal Peru. Masterfully executed in patterned detail, these designs encapsulate a moment in pictorial history that parallels innovation in building design and public acts of display. This essay considers how these architectonic features were pictured and demonstrates the significance of the forms. I examine specific features, such as the step and stepped pyramid, in the context of their architectural history. Modeling in portable objects is shown to be guided by design conventions that emphasize simultaneous, multidimensional perspectives. The objects’ value in ritual activity is also considered. Ideas about the built environment are discussed in relation to sacred geography. I propose a narrative for the interrelated ideas, motifs, and monuments that inform Paracas ceremonialism and sacred places.

Тhe coherence between the novel and short prose of alternative history: segmentation of the meta-genre as the internal architecture of the work

The article is devoted to the comparative analysis of the expression connections of architectonic components in short and novel prose. The purpose of this article is to to demonstrate in a comparative way the concepts of segmentation of the AI ​​meta-genre in T. Fermes' short prose, O. Menshova, V. Kozhelianko in comparison with the works of short prose, the paradigm of views on this concept in different historical and cultural milestones and their extrapolation in contemporary literature. The novelty of the article lies in the fact that Here, for the first time, chronotopic concepts in short prose of the meta-genre of alternative history are considered in comparison with novel prose AI. Research methods are a complex of comparative, descriptive, historical and literary approaches. Conclusions. Based on the study of the modern functioning of genealogy in extensive domestic and foreign literary and literary discourse, it is possible to develop potential of Russian comparative studies: avoiding the danger of falling into the trap of "literary timeless" theoretical analytical principles; in the course of the analysis, it was concluded that, by defining the genre marking of prose, should take into account not only the features of poetics in the context of the four-level structure of prose, but also the temporal the context of the work, its cultural background, literary area or direction. in which the writer analyzes mainly works, and aimed at recipients of a hidden conceptual and symbolic set of the analyzed alternative history meta-genre literature; there is a set of architectonic features of novel prose AI transferred to short form compositions, which is why the chronotope of the latter is subject to modification

CYCLIZATION IN OLEKSA STEFANOVYCH’S POETRY

The article analyses the peculiarities of cyclization in Oleksa Stefanovych’s (1899—1970) poetry. Based on the theoretical definitions of a lyrical cycle (cycle of poems, sequence of poems) formulated in the works of Rolf Fieguth, Mikhail Darvin, Larisa Liapina, Ronald Vroon, Leonid Yanitskii, et al., the research outlines the main compositional, stylistic, thematic, and functional traits of Stefanovych’s lyrical cycles and demonstrates the evolution of certain key images in them. The material for analysis is taken from the collection of Stefanovych’s poetry published posthumously in Toronto (“Zibrani Tvory” / “Collected Works”, 1975).
 The special attention is paid to his apocalyptic cycle “Kintsesvitnie” (“The World’s End”) that demonstrates the whole complex of architectonic and stylistic features inherent to a cycle of poems, particularly the presence of the ‘cyclic subject’ defined by R. Fieguth as “the subject of all creative, especially compositional, acts which are the basis of this poetic cycle” [13, 19].
 The composition of “Kintsesvitnie” is based on the combination of the chronological and the plot development principles allowing to encompass Stefanovych’s creative work as a whole. The poems from various periods are selected and arranged so that they form a clear cyclic structure with steady imagery and a distinct thematic echo between its beginning and its end. Their dating reflects the consistency of the poet’s catastrophic worldview declared by the cycle’s title. It also demonstrates the evolution of its key metaphors (an evil bird, a thunderstorm, a trumpet) that arise in Stefanovych’s early works as visual or acoustic images and gradually evolve into the apocalyptic symbols of “Kintsesvitnie”.

“THE SONG REMAINS THE SAME”: MYKOLA KHVYLOVYІ’S NON-CLASSIC SHORT STORIES AND THE CANONIC WRITER’S STYLE

The paper analyzes Mykola Khvylovyi’s selected ‘non-classic’ small pieces of prose (“A Happy Secretary”, “The Last Day”). The writer was found to have resorted to a set of literary means and techniques that had previously proven effective in baring his views on the issues of the time. These include various types of stylistic repetition, antithesis, and irony as a way of criticizing ideological differences. A renewed emphasis is placed on the relevance of the colour blue in the writer’s works as one of the means of creating a stylistic contrast between the explicit context and the overtones that lie beneath it. The texts under study centre on the fate of the new Soviet man, diligent, industrious, and submissive, capable of a personal life but doomed to failure because of certain irrevocable obligations. The writer exemplifies the existential dilemmas his characters face by reinforcing the ironic aspects of the discourse. Narratological and architectonic features of the stories have been studied. The various types of chronotope have been distinguished – the everyday life, the socio-historical, and the road chronotope. The holistic view on the problem under study is due to a combination of cultural-historical, semantic-stylistic, comparative-typological, and descriptive-analytical methods. The findings are to prove useful to all those involved in: the study of the Ukrainian writer’s signature world-view; the issue of personality both in Khvylovyi’s fiction and some Ukrainian prose writers of the 20-30s of the twentieth century; the analysis of the Ukrainian literature of the first half of the twentieth century development; the studies on the perception of Khvylovyi’s works by literary critics and scholars; for experts in artistic anthropology and narratological analysis of Khvylovyi’s written works. It will also be relevant in pursuing the studies of both the writer’s late fiction and his mature pieces of work; studying the texts of the latter phase with regard to intertextual interaction (for instance, the short story The Inspector-General, 1929).

Древние ритуальные объекты Окинского плоскогорья (Восточный Саян)

Sacral beliefs took one of the most important spheres in the life of ancient societies. The evidence of such beliefs can be recognized in stone constructions used for various ritual activities and differentiated by architectonic features depending on their functionality. Some of such constructions were found on the territory of the Oka region (Buryat Republic). One part of them has a four-angled, circular, or ring-shaped form and a diameter up to 2 m; the other had circular burial mound-like or flat configuration with a diameter of 3–6 m. The first excavations of the large stone mounds of the circular form were carried out in 1870 P.A. Rovinskiy near the Oka guard fort (archeological site Oka, locality 1 and 2). The researcher characterized excavated constructions as cenotaphs or sacrificial places. In 2020 A.V. Kharinskiy excavated other two large stone mounds at the Shasnur-3 archeological site. Based on materials from excavations reinforced with ethnographical data, we can regard circular mounds with the 3–6 m diameter in the Mountain Oka region as cenotaphs. One of the small ring-shaped stone settings was investigated by V.I. Tashak at the Zun Nomto-Gol-1 archeological site. Taking into consideration the ethnographical data, the setting from Nomto-Gol-1 as other stone settings with a diameter up to 2 m can be characterized as ancient sacrificial places devoted to the spirits — hosts of the local landscapes. Key words: ancient ritual objects, burial grounds, Eastern Sayan, Oka plateau

High-resolution mapping and digital atlas of subcortical regions in the macaque monkey based on matched MAP-MRI and histology

Subcortical nuclei and other deep brain structures are known to play an important role in the regulation of the central and peripheral nervous systems. It can be difficult to identify and delineate many of these nuclei and their finer subdivisions in conventional MRI due to their small size, buried location, and often subtle contrast compared to neighboring tissue. To address this problem, we applied a multi-modal approach in ex vivo non-human primate (NHP) brain that includes high-resolution mean apparent propagator (MAP)-MRI and five different histological stains imaged with high-resolution microscopy in the brain of the same subject. By registering these high-dimensional MRI data to high-resolution histology data, we can map the location, boundaries, subdivisions, and micro-architectural features of subcortical gray matter regions in the macaque monkey brain. At high spatial resolution, diffusion MRI in general, and MAP-MRI in particular, can distinguish a large number of deep brain structures, including the larger and smaller white matter fiber tracts as well as architectonic features within various nuclei. Correlation with histology from the same brain enables a thorough validation of the structures identified with MAP-MRI. Moreover, anatomical details that are evident in images of MAP-MRI parameters are not visible in conventional T1-weighted images. We also derived subcortical template “SC21” from segmented MRI slices in three-dimensions and registered this volume to a previously published anatomical template with cortical parcellation (Reveley et al., 2017; Saleem and Logothetis, 2012), thereby integrating the 3D segmentation of both cortical and subcortical regions into the same volume. This newly updated three-dimensional D99 digital brain atlas (V2.0) is intended for use as a reference standard for macaque neuroanatomical, functional, and connectional imaging studies, involving both cortical and subcortical targets. The SC21 and D99 digital templates are available as volumes and surfaces in standard NIFTI and GIFTI formats.

The Search of St. Peter’s Memory ad catacumbas in the Cemeterial Area ad Duos Lauros in Rome

The purpose of our study is to research Peter’s memory ad catacumbas. According to the Depositio Martyrum—a document of the late Emperor Constantine period—there was no memory of the first St. Peter’s Basilica on the Vatican Hill. We start with a critical analysis on the Roman Basilica attributed to Emperor Constantine in Liber Pontificalis, then we deepen the search of Peter’s memory in the catacombs of the Sts. Marcellinus and Peter (ad Duos Lauros), also known as Tor Pignattara. Indeed, the basilica and mausoleum built in this cemeterial area are the only buildings attributable, with certainty, to Emperor Constantine, who wished to be buried in the mausoleum, close to an apostle. Besides some striking archeological finds on Peter’s memory already discovered near a particular cubicle in these catacombs, a geometrical and mathematical study of the unusual architectonic characteristics of the basilica and mausoleum of Tor Pignattara shows that the buildings were part of a single architectonic plan, very likely designed for coding data useful to locate Peter’s burial site unambiguously, in the area of the cubicle mentioned.

Multimodal 3D atlas of the macaque monkey motor and premotor cortex

In the present study we reevaluated the parcellation scheme of the macaque frontal agranular cortex by implementing quantitative cytoarchitectonic and multireceptor analyses, with the purpose to integrate and reconcile the discrepancies between previously published maps of this region.We applied an observer-independent and statistically testable approach to determine the position of cytoarchitectonic borders. Analysis of the regional and laminar distribution patterns of 13 different transmitter receptors confirmed the position of cytoarchitectonically identified borders. Receptor densities were extracted from each area and visualized as its “receptor fingerprint”. Hierarchical and principal components analyses were conducted to detect clusters of areas according to the degree of (dis)similarity of their fingerprints. Finally, functional connectivity pattern of each identified area was analyzed with areas of prefrontal, cingulate, somatosensory and lateral parietal cortex and the results were depicted as “connectivity fingerprints” and seed-to-vertex connectivity maps.We identified 16 cyto- and receptor architectonically distinct areas, including novel subdivisions of the primary motor area 4 (i.e. 4a, 4p, 4m) and of premotor areas F4 (i.e. F4s, F4d, F4v), F5 (i.e. F5s, F5d, F5v) and F7 (i.e. F7d, F7i, F7s). Multivariate analyses of receptor fingerprints revealed three clusters, which first segregated the subdivisions of area 4 with F4d and F4s from the remaining premotor areas, then separated ventrolateral from dorsolateral and medial premotor areas. The functional connectivity analysis revealed that medial and dorsolateral premotor and motor areas show stronger functional connectivity with areas involved in visual processing, whereas 4p and ventrolateral premotor areas presented a stronger functional connectivity with areas involved in somatomotor responses.For the first time, we provide a 3D atlas integrating cyto- and multi-receptor architectonic features of the macaque motor and premotor cortex. This atlas constitutes a valuable resource for the analysis of functional experiments carried out with non-human primates, for modeling approaches with realistic synaptic dynamics, as well as to provide insights into how brain functions have developed by changes in the underlying microstructure and encoding strategies during evolution.

Age-related changes in the lower third of the face considering anatomical and physiological aspects and morphotypes of skin aging

All areas and tissues of the face will go through age-related changes; however, aging occurs at a faster rate in the lower third of the face than in other areas. This study presents the anatomical and physiological aspects of age-related changes in all areas and tissues of the face, mainly in the lower third, such as the skin, subcutaneous fat, muscular-aponeurotic system, deep layers of adipose tissue, and bone structures of the face. Involutional changes were differentiated by taking into account the constitutional and architectonic features of the face. Heterochronous and heterotopic characteristics of age-related changes, cutaneous, and treatment components of facial aging were identified. The most commonly used visual scales to assess cosmetic effects and determine chronological aging included global aesthetic improvement scale, Glogau scale, Fitzpatrick wrinkle classification, and Merz visual 5-point aging scale. According to the classification of age-related changes proposed by Kolgunenko, five morphotypes of aging are distinguished: tired, wrinkled, deformation, mixed, and muscular. Understanding the pathogenesis of involutional changes in the lower third of the face in patients with different morphotypes of aging allows for an objective and individualized choice of optimal therapy methods.

THE VARIANT ANATOMY OF THE CELIAC TRUNK AND ITS BRANCHES IN ADULT MEN AND WOMEN WITH VARIOUS BODY SHAPE

In connection with the rapid development of endovascular surgery and the increasing number of minimally invasive surgeries there is a need for a detailed study of variants of the architectonic and topographic and anatomical characteristics of extraorganic blood vessels. The purpose of the study was to study the variant anatomy of the celiac trunk and its branches in adult men and women with different shapes of body. The analysis of 2300 computer tomograms of the abdominal aorta and its unpaired branches of adult men and women in age 25-75 years with a different body type was made. According to the value of the Pinier index, were dedicated asthenic, normosthenic and hypersthenic forms of the physique. It is established that the cases of a typical classic variant of celiac trunk trifurcation in men is observed only in 35% of cases, and in women – in 41.2%, with an atypical variant of its division was observed significantly more often (in 65 and 58,8%, respectively). It is shown that regardless of gender and the shape of the body at Pinier index in all studied groups, the incidence of typical branching of the celiac trunk varies from 32.1 to 49.4%, and the frequency of atypical variant is an average of 62.1%. Among atypical variants of division of the celiac trunk quadrifurcation occurs more often. Thus, the frequency of most of the variants of the celiac trunk showed significant differences depending on gender and body type. Knowledge of variant anatomy of the celiac trunk will be may significantly increase the quality of preoperative diagnosis in surgery on the celiac trunk and its branches, and exclude iatrogenic damage of these vessels.

Nuevas evidencias de sitios arqueológicos Tehuelche/Aonikenk-Mapuche (siglo XX) en Santa Cruz, Patagonia (Argentina)

The process of occupation of Santa Cruz province by the Argentinean State towards the end of the 19th century and during the early 20th Century, involved its division in small units (estancias) and promoted the settlement of groups of European descent focused on sheep breeding. At the same time, specific areas (“reservations”) were created with the intention of constraining indigenous families. Here, we present archaeological evidence of four sites occupied during the 20th Century by families of Tehuelche/Aonikenk-Mapuche origin. The analysis focuses on architectonic features and glass scrapers. Two sites are located inside the former “reservation” area of Lago Viedma (“Cerro Indice”), while the other two are placed nearby former “reservations”. This evidence broadens the variability of archaeological contexts from Patagonia historical times and advances in the visualization of indigenous people.

Illustrations of the 1925-edition Yingzao fashi 營造法式: Jørn Utzon’s aesthetic confirmation and inspiration for the Sydney Opera House design (1958–1966)

ABSTRACTIn his 1958 study trip to China, Danish architect Jørn Utzon (1918–2008) acquired two copies of the 1925-edition Yingzao fashi (Chinese Building Standards), first published in 1103 AD. Utzon’s own Yingzao fashi meticulously documented the imperial building practice in feudal China with numerous illustrations. The monograph later became one of the most important sources for Utzon to study the design, structure, construction and decoration of Chinese monuments during his enduring interest in Chinese building culture. However, the precise role of Utzon’s ideas and ideals inspired by the Yingzao fashi in the Opera House design still remains largely unexplored. By surveying the primary sources in The Utzon Archives, the State Library of New South Wales and the architectural collection of Utzon’s family, as well as interviewing his staff and colleagues, the authors argue the Yingzao fashi delivered an important impact both on the aesthetic ideal and architectonic characteristics of Utzon’s Opera House design. This presents that illustrations of Utzon’s Yingzao fashi served not only as a conceptual means to initiate his design but also as practical implements for him and his team to solve the problems of design, production and construction, before their forced resignation in 1966.

Neuron density fundamentally relates to architecture and connectivity of the primate cerebral cortex

Studies of structural brain connectivity have revealed many intriguing features of complex cortical networks. To advance integrative theories of cortical organization, an understanding is required of how connectivity interrelates with other aspects of brain structure. Recent studies have suggested that interareal connectivity may be related to a variety of macroscopic as well as microscopic architectonic features of cortical areas. However, it is unclear how these features are inter-dependent and which of them most strongly and fundamentally relate to structural corticocortical connectivity. Here, we systematically investigated the relation of a range of microscopic and macroscopic architectonic features of cortical organization, namely layer III pyramidal cell soma cross section, dendritic synapse count, dendritic synapse density and dendritic tree size as well as area neuron density, to multiple properties of cortical connectivity, using a comprehensive, up-to-date structural connectome of the primate brain. Importantly, relationships were investigated by multi-variate analyses to account for the interrelations of features. Of all considered factors, the classical architectonic parameter of neuron density most strongly and consistently related to essential features of cortical connectivity (existence and laminar patterns of projections, area degree), and in conjoint analyses largely abolished effects of cellular morphological features. These results confirm neuron density as a central architectonic indicator of the primate cerebral cortex that is closely related to essential aspects of brain connectivity and is also highly indicative of further features of the architectonic organization of cortical areas, such as the considered cellular morphological measures. Our findings integrate several aspects of cortical micro- and macroscopic organization, with implications for cortical development and function.

Architectonic Quality of Industrial Log Architecture in the Scope of Tectonics – Learning from Architectural Competitions

Abstract Log is a highly topical building material. Despite the current potential of log, large-scale log buildings of high architectonic quality are rare. By increasing understanding of the architectonic quality of industrial log building, the quality of future log buildings can be enhanced. Our research data is based on the outcomes of two recent architectural competitions and interviews related to these. Methodology combines semi-structured interviews with research by design. The results describe, in the scope of tectonics, architectonic features that are essential for architectonic quality of a log building and are revealing of log structures, acknowledging the preconditions of log in the design, and making secondary design solutions characteristic for log. The results are coherent with ideals of tectonic theory.

Drawing Glasgow School of Art: the graphics of reconstruction

The Glasgow School of Art has a long history of the cultivation of the art of drawing. Many types of drawing have been taught and practiced within the institution since its establishment in 1845. Mackintosh's Glasgow School of Art building, completed between 1897 and 1909, can be seen as one great outcome of that design-through-tradition. The building not only sheltered and thus enabled a further cultivation of the art of drawing, but became itself a model for the practices of that drawing tradition. There is a strong body of work, much of it by teachers and students of the Mackintosh School of Architecture, which has focussed on the building and explored through drawing the architectonic features and significance of the structure. This work has been useful as a teaching and critical aid but also as a contribution to the art and discipline of architecture. In the wake of the first 2014 fire, which destroyed part of the building, this body of work suddenly became of use as a design tool rather than simply an exploratory or critical tool, as the institution sought to reproduce exactly what had been lost. The most recent 2018 fire wreaked a destruction much more comprehensive across the whole building. Accordingly, we are forced to completely review the relationship of that drawing heritage to the building. That is to say, the building largely no longer exists, and the drawings take on a life of their own in a way not previously attached to them. The school may, however, be rebuilt, recreated ‘as was’ at some point in the future, potentially instigating yet another type of relationship between the existing drawing work and a new ‘Mackintosh’ building.

Architectonic characteristics of the visual thalamus and superior colliculus in titi monkeys.

Titi monkeys are arboreal, diurnal New World monkeys whose ancestors were the first surviving branch of the New World radiation. In the current study, we use cytoarchitectonic and immunohistochemical characteristics to compare titi monkey subcortical structures associated with visual processing with those of other well-studied primates. Our goal was to appreciate features that are similar across all New World monkeys, and primates in general, versus those features that are unique to titi monkeys and other primate taxa. We examined tissue stained for Nissl substance, cytochrome oxidase (CO), acetylcholinesterase (AChE), calbindin (Cb), parvalbumin (Pv), and vesicular glutamate transporter 2 (VGLUT2) to characterize the superior colliculus, lateral geniculate nucleus, and visual pulvinar. This is the first study to characterize VGLUT2 in multiple subcortical structures of any New World monkey. Our results from tissue processed for VGLUT2, in combination with other histological stains, revealed distinct features of subcortical structures that are similar to other primates, but also some features that are slightly modified compared to other New World monkeys and other primates. These included subdivisions of the inferior pulvinar, sublamina within the stratum griseum superficiale (SGS) of the superior colliculus, and specific koniocellular layers within the lateral geniculate nucleus. Compared to other New World primates, many features of the subcortical structures that we examined in titi monkeys were most similar to those in owl monkeys and marmosets, with the lateral geniculate nucleus consisting of two main parvocellular layers and two magnocellular layers separated by interlaminar zones or koniocellular layers.