This paper describes an experimental investigation of flow control for the wake around a wall-mounted cube using horizontal control holes (HCHs) of different diameters drilled from the center of the front surface to the rear surface of the cube. The cube has side lengths of D = 50 mm, and HCHs with diameters of d = 10, 12, and 14 mm are considered. The instantaneous velocity fields are measured at a Reynolds number of 7800 based on time-resolved particle image velocimetry in a water tunnel. The HCHs suppress the recirculation zone, turbulence intensity, and Reynolds stress, and these control effects gradually increase with the hole diameter. The issuing flow from the large-diameter HCH completely obstructs the development of the downwash flow to the bottom wall and decomposes the near-wake arch-type vortex into a double arch-type structure. As the hole diameter increases, the dominant frequency of the spectrum in the HCH wake increases. Proper orthogonal decomposition analysis indicates that the large-scale spanwise vortices are suppressed by HCH. In the dynamic evolution process of the cube wake, the HCH issuing flow hinders the interaction of shear flow on both sides, and the issuing vortices attract the spanwise vortices and accelerate their shedding.