Aqueous Solutions Of Dextran Research Articles

Acoustical Analysis of Dextran+urea: Insights into Molecular Interactions

Introduction:: The aim of this study is to determine the acoustic parameters of polymer dextran with urea. Recent years have seen an increase in the use of ultrasonic research to describe the physiochemical and thermodynamic characteristics of liquid solutions at various temperatures and frequencies. The size of the pure component and the mixtures had an impact on various interactions, molecular mobility, and kinds of interaction. Which were studied using the acoustical and thermodynamic characteristics? To ascertain how the solvent urea interacts with the solute dextran at the molecular level. Materials and Method: Dextran (molecular weight of 70000) with 6(M)urea was used. The solution's density using a pycnometer, viscosity using an Ostwald viscometer, and ultrasonic velocity using an ultrasonic interferometer were examined. Results:: The physical properties of the medium are affected by the transmission of ultrasonic waves, which also teaches us about the physics of liquids and solutions. Understanding the interactions between the solutes and the solvent in the solution of dextran and urea, both the evaluated parameters were used, such as free volume, internal pressure, absorption coefficient, Rao's constant, and Wada's constant, as well as the observed values, such as ultrasonic velocity, density, and viscosity. Conclusion:: Based on the modification of these parameters with varied temperature and frequency, molecular mobility, different types of intermolecular interaction, and the strength of the bond between the solute (dextran 0.5%) and solvent (6(M) urea) are investigated. The findings have been explained in terms of a structural reorganisation in the aqueous dextran solution. At all the temperatures used for the investigation, the solute-solvent interactions are more significant. The change in the acoustic properties is small because the frequency variation causes the molecules to move swiftly and have little chance to interact. Investigating molecular interactions, including electrostriction, acceptor-donor association, dipole-dipole association, and hydrogen bonding, has used these properties. Understanding molecular interactions helps one to comprehend the core issues surrounding the mechanisms of chemical and biological catalysis and the routes of chemical reactions.

Development of food-grade xylanase encapsulation using electrospray dextran microparticles

With the rapid development of pre-mixed flour or pre-baked products, there is a huge market demand for food grade encapsulation of baking enzymes. In our work, a novel method for the food-grade electrospray encapsulation of enzymes was developed using dextran as a polymer matrix. The behavior of dextran in aqueous solution and its effects on electrospray were investigated, and their relationship function was determined. The electrospray properties of dextran were primarily determined by the critical concentration range required for particle formation as well as solution parameters. Subsequently, the encapsulation, characterization, and performance evaluation with respect to the Hmxyn xylanase, an enzyme from Halolactibacillus miurensis were studied. When Hmxyn xylanase was encapsulated with dextran using electrospray, both the dextran-based carrier and the electrospray method did not affect the activity of Hmxyn xylanase, with the encapsulation efficiency and activity recovery rate exceeding 90%. Fourier transform infrared spectra indicated that hydrogen bonding between dextran and xylanase was enhanced, favoring the formation of electrospray particles. In addition, the encapsulated xylanase was uniformly distributed in the dextran matrix and exhibited better thermal degradability and storage stability compared to the free enzymes. Herein, Hmxyn xylanase enzyme encapsulation at room temperature without an organic solvent involved provides a novel, facile, and safe-grade electrospray encapsulation technique that could be extended to more versatile food enzymes or biological additives.

ACOUSTIC AND THERMODYNAMICS STUDY OF AQUEOUS DEXTRAN: AN ULTRASONIC ANALYSIS

The acoustical investigation of molecular interaction has been performed from the measurement parameters of ultrasonic velocity (U), density (ρ) and viscosity (η) of aqueous dextran solution at different temperatures. The thermodynamic and other allied pa

Semi-Quantitative Evaluation of Asymmetricity of Dialysis Membrane Using Forward and Backward Ultrafiltration.

Performance of the dialysis membrane is strongly dependent upon the physicochemical structure of the membrane. The objective of this study is to devise a new in vitro evaluation technique to quantify the physicochemical structures of the membrane. Three commercial dialyzers with cellulose triacetate (CTA), asymmetric CTA (termed ATA®), and polyether sulfone (PES) membranes (Nipro Co., Osaka, Japan) were employed for investigation. Forward and backward ultrafiltration experiments were performed separately with aqueous vitamin B12 (MW 1355), α-chymotrypsin (MW 25,000), albumin (MW 66,000) and dextran solutions, introducing the test solution inside or outside the hollow fiber (HF), respectively. Sieving coefficients (s.c.) for these solutes were measured under the test solution flow rate of 200 mL/min and the ultrafiltration rate of 10 mL/min at 310 K, according to the guidelines provided by Japanese academic societies. We defined the ratio of s.c. in the backward ultrafiltration to that in the forward ultrafiltration and termed it the index for asymmetricity (IA). The IA values were unity for vitamin B12 and α-chymotrypsin in all three of the dialyzers. The IA values for albumin, however, were 1.0 in CTA, 1.9 in ATA®, and 3.9 in PES membranes, respectively, which corresponded well with the fact that CTA is homogeneous, whereas ATA® and PES are asymmetrical in structure. Moreover, the asymmetricity of ATA® and PES may be different by twofold. This fact was verified in continuous basis by employing dextran solution before and after being fouled with albumin. These findings may contribute to the development of a novel membrane for improved success of dialysis therapy.

Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration.

Spray freeze drying (SFD) is an ice templating method used to produce highly porous particles with complex pore architectures governed by ice nucleation and growth. SFD particles have been advanced as drug carrier systems, but the quantitative description of the morphology formation in the SFD process is still challenging. Here, the pore space dimensions of SFD particles prepared from aqueous dextran solutions of varying molecular weights (40-200 kDa) and concentrations (5-20%) are analyzed using scanning electron microscopy. Coexisting morphologies composed of cellular and dendritic motifs are obtained, which are attributed to variations in the ice growth mechanism determined by the SFD system and modulation of these mechanisms by given precursor solution properties leading to changes in their pore dimensions. Particles with low-aspect ratio cellular pores showing variation of around 0.5-1 μm in diameter with precursor composition but roughly constant with particle diameter are ascribed to a rapid growth regime with high nucleation site density. Image analysis suggests that the pore volume decreases with dextran solid content. Dendritic pores (≈2-20 μm in diameter) with often a central cellular region are identified with surface nucleation and growth followed by a slower growth regime, leading to the overall dendrite surface area scaling approximately linearly with the particle diameter. The dendrite lamellar spacing depends on the concentration according to an inverse power law but is not significantly influenced by molecular weight. Particles with highly elongated cellular pores without lamellar formation show intermediate pore dimensions between the above two limiting morphological types. Analysis of variance and post hoc tests indicate that dextran concentration is the most significant factor in affecting the pore dimensions. The SFD dextran particles herein described could find use in pulmonary drug delivery due to their high porosity and biocompatibility of the matrix material.

Analysis of the physical and chemical properties of natural polysaccharides and the effect of dispersed glauconite mineral on them

The object of research is natural polysaccharides. One of the problems is the high cost and not always environmental friendliness of foreign analogues of these substances. Therefore, the methods of purification of polydisperse systems with the help of dispersed minerals, in particular separated dispersed mineral glauconite, purified and enriched up to 60 % of the initial content, are proposed. The study used aqueous solutions of dextran and pectin, which added glauconite in the amount of 0.3 to 0.9 % by weight of the solution, heated to 60 ºC and kept for 10 minutes. Using glauconite in the amount of 0.3 % by weight of the solution gave high quality indicators. Thus, the dependence of the viscosity of polysaccharides dextran and pectin on the concentration of the introduced mineral was studied. The lowest value of viscosity is observed when adding 0.3 % glauconite to the mass of the solution, with increasing concentration, the viscosity increases. The process of interaction of dextran molecules with the surface of glauconite is due to the fact that the proposed method of studying the viscosity has a feature that connects neighboring mineral particles through the dextran bridge and the formation of a stable gel structure. These structures are manifested in the form of partial groups of glauconite. This provides the ability to obtain such an indicator as adsorption. The mechanism of interaction of dextran with glauconite is confirmed by the dependence of the amount of dextran adsorbed on the surface of the mineral. Thus, at low concentrations of glauconite – up to 0.3 % adsorption of dextran on the surface increases, and with increasing concentration of glauconite – greatly decreases. This is crucial for the technological parameters of the mineral when using it in preparation processes, in comparison with similar adsorbents of unnatural origin. This will provide the benefits of glauconite over the use in the food industry and the regulation of the physicochemical properties of industrial polydisperse solutions as inexpensive additives of natural origin (stabilizers, thickeners, etc.) that are harmless to human health.

Evaluation of the eco-compatibility of polyamidoamines by means of seed germination test

The eco-compatibility of the glycine-derived polyamidoamine M-GLY, chosen as the benchmark for water-soluble polyamidoamines, was investigated by means of the seed germination test using watercress seeds. The percent germinated seeds and their root elongation were measured, and the corresponding germination index (GI) calculated for each set of data obtained by incubating the seeds with M-GLY aqueous solutions with concentration in the range 0.156 – 5.0 mg mL−1. The results obtained with M-GLY were compared with those obtained with 0.1% potassium dichromate and distilled water, as positive and negative blanks, and aqueous solutions of dextran, chosen as reference biocompatible polymer, having the same concentrations of M-GLY. M-GLY solutions with concentrations 5.0 and 2.5 mg mL−1 aged 98 days in water and, finally, α,ω-glycine- and α,ω-acrylamide-end-terminated M-GLY oligomers with different chain length were also tested. None of the M-GLY and aged M-GLY solutions inhibited germination and root elongation of watercress seeds as revealed by the GI values invariably higher than 1. In some cases, GI >> 1, suggesting a fertilizing effect. As for the differently end-functionalized M-GLY oligomers, they inhibited the root elongation at the maximum concentration tested, i.e. 5.0 mg mL−1. In most conditions the M-GLY oligomers exhibited GI ≥ 1 and in some instances GI ≥ 1.2, suggesting a fertilizing effect.

Temperature-dependence of riboflavin phosphorescence in cryosolvents

The molecular mobility of amorphous excipients is important for the stability of biomaterials during preservation, facilitating matrix formulation and product design. Phosphorescence spectroscopy is a sensitive optical method to study molecular mobility. However, there is a need to expand the pool of probes available for analysis since molecules differ in sensitivity. This research explored the feasibility and limitations of using riboflavin as a phosphorescent probe for monitoring matrix molecular mobility. Phosphorescence decays of riboflavin in four amorphous cryosolvents (aqueous solutions of glycerol, ethanol, sucrose, and dextran) were collected at 77 K to capture its natural phosphorescence lifetime (estimated at 170 ms). Decays were also collected during ballistic heating to assess the sensitivity of riboflavin towards changes in matrix molecular mobility. Riboflavin exhibited good sensitivity towards matrix secondary relaxations in the glass, indicating that riboflavin has excellent potential as an edible phosphorescent probe for molecular mobility in food and pharmaceutical products.

Optical properties of dextran-stabilized silicon nanoparticles in aqueous medium

Silicon nanoparticles (Si-NPs) with initial sizes of the order of 100 nm were prepared by femtosecond laserablation-fragmentation of microcrystalline silicon in water followed by drying and resuspending in wateror in aqueous solutions of dextran. The prepared aqueous suspensions of Si-NPs without dextran and withdextran coating were investigated by means of the scanning electron microscopy, dynamic light scatteringand optical absorption spectroscopy in the spectral range from 250 to 800 nm. The optical absorption ofuncoated Si-NPs in an aqueous medium with different pH-level varied from 4 to 8 was found to decreasewith time because of a process of the dissolution of those NPs in water. The dissolution rate dependednonmonotonically on the solution acidity (pH level) and the corresponding times were in the range from 50to 180 hours. The addition of dextran into the solution was found to significantly decrease the dissolutionrate of Si-NPs to 300 hours because of the coating of NPs with a polymer shell. The obtained results canbe useful to develop new biomedical technologies involving Si-NPs as stabilized theranostics (therapy anddiagnostics) agents. Key words: nanoparticles, dextran, biopolymer, optics, absorbance.

Utilization of xanthan to stabilize water in water emulsions and modulate their viscosity

Water in water emulsions were prepared by mixing aqueous solutions of dextran and poly(ethylene oxide) at three volume fractions. The xanthan was added to the emulsions up to 0.5 wt%. The stability of the emulsions was probed by measuring the time dependence of the transmission profiles at different centrifugal forces. At lower concentrations, xanthan partitioned to the dextran phase and strong shear-thinning was observed at higher concentrations. At lower concentrations, destabilization was caused by a combination of coalescence and creaming or sedimentation. Above 0.1 wt%, xanthan strongly increased the viscosity of the emulsions and stabilized them under gravity for at least one week. The time evolution of the emulsion microstructure was observed using confocal scanning laser microscopy. The effect of shear on the microstructure was investigated using a specific rheo-optical device. It showed the formation of thin strands that broke up into small drops after stopping the flow.

Biomechanical Response After Corneal Cross-linking With Riboflavin Dissolved in Dextran Solution Versus Hydroxypropyl Methylcellulose.

To evaluate corneal stiffening in porcine eyes induced by corneal cross-linking (CXL) using riboflavin dissolved in either aqueous dextran or hydroxypropyl methylcellulose (HPMC) solution. Fifty-one porcine corneas were divided into three groups of 17 each. After deepithelialization, the first (Dresden) group was treated for 30 minutes with 0.1% riboflavin (riboflavin-5-monophosphate in 0.9% NaCl) dissolved in hypertonic 20% dextran and the second (HPMC) group for 30 minutes with isotonic solution containing 0.1% riboflavin and 1.1% HPMC. Thereafter, corneas of both groups were irradiated using 5.4 J/cm2 (irradiance of 9 mW/cm2 for 10 minutes; 10*9). After CXL, all corneas were kept in an isotonic 16% dextran bath for 2 hours to obtain an equal hydration state. The third group served as the control group. Stress-strain measurements were performed on 5-mm-wide strips. Corneal thickness was monitored throughout the entire course of the experiments. The required stress for a 10% strain was increased by 83% in the Dresden group and 35% in the HPMC group compared to the control group. Resultant Young's modulus (at 10% strain) was 2.53 ± 0.73, 1.87 ± 0.50, and 1.47 ± 0.44 Pa for the Dresden, HPMC, and control groups, respectively. The differences between the Dresden and HPMC groups (P = .006), the Dresden and control groups (P < .001), and the HPMC and control groups (P = .014) were statistically significant. Pachymetry measurements showed a significantly increased corneal thickness after application of HPMC compared with the Dresden group (P = .002) and control group (P = .041). The biomechanical stiffening of the cornea by CXL can be achieved using dextran- and HPMC-based riboflavin solutions in porcine corneas with an application time of 30 minutes. Dextran-based riboflavin solutions seem to induce a slightly stronger biomechanical response in this setting. HPMC solutions induce less thinning than dextran solutions. [J Refract Surg. 2021;37(9):631-635.].

Effect of hydrophobicity and molar mass on the capacity of chitosan and κ-carrageenan to stabilize water in water emulsions

A range of commercial chitosan samples with different molar masses and degrees of acetylation was tested for their capacity to stabilize water in water (W/W) emulsions formed by mixing aqueous solutions of dextran and poly (ethylene oxide). To further understand the effect of the acetylation degree, commercial samples were acetylated and deacetylated to different degrees. The effect of pH and chitosan concentration on the stability was investigated. The lowest investigated degree of acetylation (6%) was sufficient to inhibit coalescence, but higher degrees that were studied (up to 50%) led to faster stabilization resulting in smaller stable dispersed droplets that did not sediment for at least one week. The effect of hydrophobic acetyl units on the stability was confirmed for κ-carrageenan that could stabilize the W/W emulsion only after acetylation. For chitosan it was shown that the molar mass should be above a critical value independent of the degree of acetylation.

Stabilizing Aqueous Three-Dimensional Printed Constructs Using Chitosan-Cellulose Nanocrystal Assemblies.

The assembly and binding of nanoparticles at the interfaces of aqueous two-phase systems enable the three-dimensional (3D) printing of all-aqueous naturally occurring materials. When a dispersion of cellulose nanocrystals (CNCs) in an aqueous solution of polyethylene glycol (PEG) is brought into contact with chitosan dissolved in an aqueous solution of dextran, the CNCs and chitosan diffuse to the interface between the two immiscible aqueous solutions, electrostatically interact, and form a solid, membranous layer sufficiently rapidly to 3D print tubules of one liquid in the other. The diameter, length, spatial arrangement, and stability of the printed tubules can be broadly controlled. Adsorption and directional diffusion of ionic species across the membranous layer make heavy metal ion removal possible. The results present a platform for fabricating and developing all-aqueous compartmentalized systems where function can be independently coupled to the inherent functionality of the nanoparticles or ligands.

Assessment of the stability of water in water emulsions using analytical centrifugation

Water in water (W/W) emulsions were prepared by mixing aqueous dextran and polyethylene oxide (PEO) solutions. Addition of different amounts of the polysaccharide chitosan inhibited coalescence of dispersed droplets of the dextran phase in the continuous PEO phase to different extents depending on the concentration and pH. Transmission profiles were measured during centrifugation and analysed. It is shown that the evolution of the transmission profile is determined by the relative rates of coalescence and sedimentation of the droplets. The rate of coalescence of the sedimented droplets into a continuous dextran phase depends on the resistance of the protective chitosan layer to compression by centrifugation. It is concluded that the efficacy of stabilization of W/W emulsions can rapidly be quantitatively assessed, but it is difficult to deduce the behaviour under gravity from that observed during centrifugation.

Optical Properties of Hyperosmotic Agents for Immersion Clearing of Tissues in Terahertz Spectroscopy

We measured the transmission spectra of the most common hyperosmotic agents, such as pure glycerol, propylene glycol (PG), dimethyl sulfoxide (DMSO), polyethylene glycol (PEG) with molecular weights of 200, 300, 400, and 600 Da, their aqueous solutions, and aqueous solutions of sucrose, glucose, fructose, and dextran 40 and 70. The experiments were carried out using a THz pulsed spectrometer with an evacuated measuring compartment to eliminate the effect of water vapor on spectral measurements. We reconstructed the dielectric characteristics of hyperosmotic agents in the spectral range from 0.1 to 2.5 THz and plotted a dependence of the amplitude absorption coefficient on the concentration of the considered agents at a frequency of 0.5 THz. The results are useful for selecting optimal agents for immersion optical clearing in the THz range.

Preparation of dextran cryogels for separation processes of binary dye and pesticide mixtures from aqueous solutions

AbstractWe present mechanically strong macroporous, squeezable dextran cryogels as a column filling material for the removal and separation of binary organic dye and pesticide mixtures from aquatic medium. Dextran cryogels were prepared from aqueous solutions of dextran of various molecular weights (MWs) in the presence of 20 to 50 mol% divinyl sulfone (DVS) as a cross‐linker at −18°C. The cryogels have interconnected irregular pores of 100 μm in sizes, and exhibit 69‐84% reversible squeezability without damaging the 3D dextran network. Their total open pore volumes (6.3‐10 mL g−1), weight swelling ratios in water (1380%‐2200%), and mechanical parameters could easily be adjusted by both DVS mol% and MW of dextran. Dextran cryogel with the highest modulus (3.8 ± 0.5 MPa), compressive stress (8 ± 2 MPa) and plateau stress (0.46 ± 0.04 MPa) was obtained at 50 mol% DVS using dextran with a MW of 15 to 25 kg·mol−1. Dextran cryogels are hydrolysable at pH = 1 and 9 but stable at 7.4 independent on both the degree of cross‐linking and MW of dextran. At below 50 mol% DVS, they are blood compatible and possess slight thrombogenic effect with blood clotting index value of 98% ± 5%. They are also capable to separate binary dye and pesticide mixtures from aqueous solutions via ionic interactions.

Development of hydroxyl and carboxylic acid functionalized CNTs–polysulphone nanocomposite fouling-resistant ultrafiltration membranes for oil–water separation

Fouling-resistant composite ultrafiltration (UF) membranes of hydroxyl functionalized multi-walled carbon nanotubes (MCNTs) ( $$_{\mathrm {{OH}}}\text {CNT}$$ )/polysulphone (PSF)/polyvinylpyrrolidone (PVP) and carboxylic acid functionalized MCNTs ( $$_{\mathrm {{COOH}}}\hbox {CNT}$$ )/PSF/PVP in weight ratios of 0.7/86.1/13.2 and 1.3/85.5/13.2 were prepared by phase inversion process from dimethylformamide solution. These membranes were characterized by infrared, scanning electron microscopy, atomic force microscopy, differential scanning calorimetry and water contact angle measurements. The molecular weight cut off values of these membranes were measured by permeating aqueous solutions of different molecular weight PEGs and dextrans. Among the fabricated UF membranes, $$_{\mathrm {{COOH}}}\text {C}_{{{1.3}}}\text {PS}_{{{85.5}}}\text {PV}_{{{13.2}}}$$ composite membrane showed a lower average contact angle ( $$62^{\circ }$$ ). The $$_{\mathrm {{COOH}}}\text {C}_{{{0.7}}}\text {PS}_{{{86.1}}}\text {PV}_{{{13.2}}}$$ membrane exhibited higher flux (99 $$\hbox {l}~\hbox {m}^{-2}~\hbox {h}^{-1}$$ ) than all the fabricated membranes (62–78 $$\hbox {l}~\hbox {m}^{-2}~\hbox {h}^{-1}$$ ) at 2 bar pressure. The flux recovery ratio values for bovine serum albumin feed solution were in the range of 63–72% for $$_{\mathrm {{COOH}}}\hbox {CNTs}$$ containing membranes and 53–64% for $$_{\mathrm {{OH}}}\text {CNTs}$$ membranes, whereas PSF/PVP blend membrane exhibited 45% at 2 bar applied pressure. The membranes containing 0.7 and 1.3 wt% carboxylic acid functionalized MCNTs showed 100% oil rejection when tested with an oil–water emulsion containing 1000 ppm lube oil. Conversely, membranes containing hydroxyl functionalized MCNTs showed relatively lower oil rejection (86–90%), whereas the PSF/PVP membrane showed 86% oil rejection.

Hanging droplets from liquid surfaces

Natural and man-made robotic systems use the interfacial tension between two fluids to support dense objects on liquid surfaces. Here, we show that coacervate-encased droplets of an aqueous polymer solution can be hung from the surface of a less dense aqueous polymer solution using surface tension. The forces acting on and the shapes of the hanging droplets can be controlled. Sacs with homogeneous and heterogeneous surfaces are hung from the surface and, by capillary forces, form well-ordered arrays. Locomotion and rotation can be achieved by embedding magnetic microparticles within the assemblies. Direct contact of the droplet with air enables in situ manipulation and compartmentalized cascading chemical reactions with selective transport. Applications including functional microreactors, motors, and biomimetic robots are evident.

SYNTHESIS AND CRYSTALLOCHEMICAL PROPERTIES OF Ce-SUBSTITUTED NANOPARTICLES OF MANGANITE (La,Sr)MnO3

Serious of Ce-substituted lanthanum-strontium man-ganites La0.7–xSr0.3CexMnO3 (x = 0–0.2) nanoparticles were synthesized by sol-gel method with further heat treatment of precursors at 800 °C. Crystallographic properties of obtained nanoparticles were investiga-ted by X-ray diffraction method. According to XRD data, it was established that the substitution of lan-thanum ions by cerium in the crystalline structure and formation of single-phased nanoparticles occurs only up to 5 % mol. of Ce regardless of the heating temperature. Linear decreasing the cell volume of nanoparticles in this concentration range of Ce satis-fies the Vegard law and indicates on the formation of a continuous series of solid solutions with the dis-torted perovskite up to 5 % of Ce. At higher concen-trations of Ce there are additional peaks on the XRD patterns, which point on the formation of an addi-tional phase of CeO2. According to TEM studies, it was calculated that the average size of was 30–40 nm. To estimate heating efficiency of synthesized nanoparticles in the alternating magnetic field, mag-netic fluids based on the synthesized nanoparticles and aqueous dextran solution were prepared. It was shown that they effectively heated up to controlled temperatures in an alternating magnetic field, and their heating efficiency was directly proportional to the increase of the concentration of cerium. Accor-ding to the results of the complex studies, it was shown the possibility to synthesize single-phase Ce-substituted nanoparticles of manganite with a pe-rovskite structure. It was established that cerium does not significantly influence on the change of magnetic properties of such nanoparticles and they are promising for further investigations as the in-ducers of magnetic hyperthermia, as well as for the biological tests.

Intermolecular Interaction of Aqueous Dextran with Urea

In this paper, the authors have given information regarding intermolecular interactions of aqueous dextran solution in urea. The behavior of dextran in urea has been examined by the help of ultrasonic interferometer working at frequency 5MHz at different temperatures ranging from 303 K to 323 K in 5K interval. Ultrasonic speed, density, viscosity measurements have been used for the evaluation of thermodynamic parameters like Gibb’s free energy (ΔG) as well as acoustical parameters are acoustic impedance (Z), isentropic compressibility (β), intermolecular free length (Lf) and relaxation time (τ), etc. The results have been used to throw light on the nature of the interaction among solute and solvent, interpreted in the light of structural rearrangement occurs in the aqueous dextran and urea solution.