The conventional heat transfer fluid like water has limited potential to meet the needs of practical thermal applications. The current analysis is based on the comparative examination of the different heat transfer nanofluids (aqueous Al2O3, MgO, GO nanofluids) incorporated in the set-up of pyramid solar still, and their influence on the solar still performance was evaluated. The thermo physical properties of the prepared nano-suspensions were evaluated and studied. Dispersing nano-sized particles in the conventional heat transfer fluids (base fluid) significantly augments the thermo physical properties of the latter. This augmentation attained in the thermo physical properties depends upon the concentration of nanoparticles in the base fluid. Suspending Al2O3 nanoparticles in water at 1.0 wt% concentration results in the maximum increment of about 1%, 2%, 3%, and 4% in the thermal conductivity, specific heat, dynamic viscosity, and density relative to that of water and suspending MgO nanoparticles in water at 1.0 wt% concentration results in the maximum increment of about 1%, 2%, 3% and 4% in the thermal conductivity, dynamic viscosity, specific heat and density relative to that of water. Utilizing 1.0 wt% Al2O3 mono-nanofluid as the heat transfer fluid in the set-up results in the maximum increment of about 38.52% in the distilled water yield relative to that attained using water. Utilizing 1.0 wt% MgO mono-nanofluid as heat transfer fluid in the set-up results in a maximum increment of about 48.91% in the distilled water yield relative to that attained using water. In this present study, the thermophysical properties of Al2O3, MgO, and GO with water were investigated experimentally.