Relevance. Properly selected personal oral hygiene products play a crucial role in minimizing the risk of hard tissue and periodontal diseases while also preventing their development. Consequently, there is a need for research to assess the effectiveness of various oral hygiene products and their combinations.The objective of our study was to compare the clinical efficacy of a mouthwash and an irrigant in patients with fixed or removable orthodontic appliances.Materials and methods. The study comprised 60 patients aged 20 to 29, all without medical conditions. Participants were evenly divided into two groups, each consisting of 30 individuals. The first group utilized Asepta Fresh mouthwash (Werteks Ltd, Russian Federation), while the second group used both a mouthwash and irrigant from the this brand.Results. The study observed quantitative changes in the following indices: Lange’s API, Silness – Loe, Green – Vermillion (OHI-S), and Ulitovsky – Orekhova’s HI ORTHO (Hygiene Index ORTHOdontic). Throughout the study, based on the alterations in these indices, both groups showed an improvement in oral hygiene. However, it is noteworthy that the positive trends were more pronounced in the second group.Conclusion. The use of liquid products such as Asepta Fresh (Werteks Ltd, Russian Federation) in personal oral hygiene practices proves to be a sufficiently effective method for cleaning approximal tooth surfaces. This effectiveness is substantiated by the positive changes observed in oral hygiene measured by the aforementioned indices. Hence, it may be recommended as an auxiliary method for controlling oral hygiene in orthodontics with fixed appliances.