Emptying processes are operations frequently required in hydraulic installations by water utilities. These processes can result in drops to sub-atmospheric pressure pulses, which may lead to pipeline collapse depending on soil characteristics and the stiffness of a pipe class. One-dimensional mathematical models and 3D computational fluid dynamics (CFD) simulations have been employed to analyse the behaviour of the air–water interface during these events. The numerical resolution of these models is challenging, as 1D models necessitate solving a system of algebraic differential equations. At the same time, 3D CFD simulations can take months to complete depending on the characteristics of the pipeline. This presents a mathematical approach for directly solving air–water interactions in emptying processes involving entrapped air, providing a predictive tool for water utilities. The proposed mathematical approach enables water utilities to predict emptying operations in water pipelines without needing 2D/3D CFD simulations or the resolution of a differential algebraic equations system (1D model). A practical application is demonstrated in a case study of a 350 m long pipe with an internal diameter of 350 mm, investigating the influence of air pocket size, friction factor, polytropic coefficient, pipe diameter, resistance coefficient, and pipe slope. The mathematical approach is validated using an experimental facility that is 7.36 m long, comparing it with 1D mathematical models and 3D CFD simulations. The results confirm that the derived mathematical expression effectively predicts emptying operations in single water installations.