ABSTRACTThe introduction of Industry 4.0, to improve Internet of Things (IoT) standards, has sparked the creation of 5G, or highly sophisticated wireless networks. There are several barriers standing in the way of 5G green communication systems satisfying the expectations for faster networks, more user capacity, lower resource consumption, and cost‐effectiveness. 5G standards implementation would speed up data transmission and increase the reliability of connected devices for Industry 4.0 applications. The demand for intelligent healthcare systems has increased globally as a result of the introduction of the novel COVID‐19. Designing 5G communication systems presents research problems such as optimizing resource usage, managing mobility, ensuring cost‐efficiency, managing interference, and maximizing spectral efficiency. The fast advancement of artificial intelligence (AI) in several domains yields improved performance in contrast to traditional methods. Hence, including AI in 5G standards would enhance performance by catering to diverse end‐user applications. Initially, we provide an overview of concepts such as Industry 4.0, the 5G standard, and recent developments in the sphere of wireless communications in the future. The goal is to use 5G technology to look at current research problems. We present a new architecture for Industry 4.0 and 5G‐compliant smart healthcare systems. We develop and run the proposed model to investigate the current 5G methods using the Network Simulator (NS2). The results of the simulation show that 5G resource management and interference management approaches already in use face challenges including performance trade‐offs.