Approach For Breast Cancer Diagnosis Research Articles

Visualizing Transformers for Breast Histopathology By IJISRT

Detecting breast cancer early is crucial for improving patient survival rates. Using machine learning models to predict breast cancer holds promise for enhancing early detection methods. However, evaluating the effectiveness of these models remains challenging. Therefore, achieving high accuracy in cancer prediction is essential for improving treatment strategies and patient outcomes. By applying various machine learning algorithms to the Breast Cancer Wisconsin Diagnostic dataset, researchers aim to identify the most efficient approach for breast cancer diagnosis. They evaluate the performance of classifiers such as Random Forest, Naïve Bayes, Decision Tree (C4.5), KNN, SVM, and Logistic Regression, considering metrics like confusion matrix, accuracy, and precision. The assessment reveals that Random Forest outperforms other classifiers, achieving the highest accuracy rate of 97%. This study is conducted using the Anaconda environment, Python programming language, and Sci-Kit Learn library, ensuring replicability and accessibility of the findings. In summary, this study demonstrates the potential of machine learning algorithms for breast cancer prediction and highlights Random Forest as the most effective approach. Its findings contribute valuable insights to the field of breast cancer diagnosis and treatment.

Online sequential extreme learning machine approach for breast cancer diagnosis

Online sequential extreme learning machine approach for breast cancer diagnosis

Hybrid salp swarm and grey wolf optimizer algorithm based ensemble approach for breast cancer diagnosis

Hybrid salp swarm and grey wolf optimizer algorithm based ensemble approach for breast cancer diagnosis

Data Augmentation for Medical Image Classification based on Gaussian Laplacian Pyramid Blending with a Similarity Measure.

Breast cancer is a devastating disease that affects women worldwide, and computer-aided algorithms have shown potential in automating cancer diagnosis. Recently Generative Artificial Intelligence (GenAI) opens new possibilities for addressing the challenges of labeled data scarcity and accurate prediction in critical applications. However, a lack of diversity, as well as unrealistic and unreliable data, have a detrimental impact on performance. Therefore, this study proposes an augmentation scheme to address the scarcity of labeled data and data imbalance in medical datasets. This approach integrates the concepts of the Gaussian-Laplacian pyramid and pyramid blending with similarity measures. In order to maintain the structural properties of images and capture inter-variability of patient images of the same category similarity-metric-based intermixing has been introduced. It helps to maintain the overall quality and integrity of the dataset. Subsequently, deep learning approach with significant modification, that leverages transfer learning through the usage of concatenated pre-trained models is applied to classify breast cancer histopathological images. The effectiveness of the proposal, including the impact of data augmentation, is demonstrated through a detailed analysis of three different medical datasets, showing significant performance improvement over baseline models. The proposal has the potential to contribute to the development of more accurate and reliable approach for breast cancer diagnosis.

A Novel Fuzzy Relative-Position-Coding Transformer for Breast Cancer Diagnosis Using Ultrasonography.

Breast cancer is a leading cause of death in women worldwide, and early detection is crucial for successful treatment. Computer-aided diagnosis (CAD) systems have been developed to assist doctors in identifying breast cancer on ultrasound images. In this paper, we propose a novel fuzzy relative-position-coding (FRPC) Transformer to classify breast ultrasound (BUS) images for breast cancer diagnosis. The proposed FRPC Transformer utilizes the self-attention mechanism of Transformer networks combined with fuzzy relative-position-coding to capture global and local features of the BUS images. The performance of the proposed method is evaluated on one benchmark dataset and compared with those obtained by existing Transformer approaches using various metrics. The experimental outcomes distinctly establish the superiority of the proposed method in achieving elevated levels of accuracy, sensitivity, specificity, and F1 score (all at 90.52%), as well as a heightened area under the receiver operating characteristic (ROC) curve (0.91), surpassing those attained by the original Transformer model (at 89.54%, 89.54%, 89.54%, and 0.89, respectively). Overall, the proposed FRPC Transformer is a promising approach for breast cancer diagnosis. It has potential applications in clinical practice and can contribute to the early detection of breast cancer.

Breast cancer diagnosis using hybrid AlexNet-ELM and chimp optimization algorithm evolved by Nelder-mead simplex approach

This study proposes a Hybrid AlexNet-Extreme Learning Machine (ELM) approach for breast cancer diagnosis using mammography images. Batch normalization is applied to improve AlexNet's performance, and the chimp optimization algorithm (ChOA) is utilized to avoid sub-optimal solutions in ELM. The Nelder-mead simplex (NEMS) technique is then employed to enhance the convergence behavior of ChOA. The study's main contributions are the proposed hybrid model and the application of ChOA and NEMS techniques to improve the performance of ELM. The proposed model is evaluated using the CBIS-DDSM dataset, with wiener and CALHE filters used as preprocessors. The effectiveness of the classification is examined using five optimization algorithms, and several metrics. The outcomes demonstrate that CALHE filter offered the best performance overall, and AlexNet-BN-ELM-CHOA-NEMS was the most accurate of the five models, with a sensitivity of 96.03 %, a specificity of 94.60 %, and an overall accuracy of 95.32 %. The findings demonstrate the effectiveness of the proposed model in breast cancer diagnosis.

A discrete equilibrium optimization algorithm for breast cancer diagnosis

Illness diagnosis is the essential step in designating a treatment. Nowadays, Technological advancements in medical equipment can produce many features to describe breast cancer disease with more comprehensive and discriminant data. Based on the patient’s medical data, several data-driven models are proposed for breast cancer diagnosis using learning techniques such as naive Bayes, neural networks, and SVM. However, the models generated are hardly understandable, so doctors cannot interpret them. This work aims to study breast cancer diagnosis using the associative classification technique. It generates interpretable diagnosis models. In this work, an associative classification approach for breast cancer diagnosis based on the Discrete Equilibrium Optimization Algorithm (DEOA) named Discrete Equilibrium Optimization Algorithm for Associative Classification (DEOA-AC) is proposed. DEOA-AC aims to generate accurate and interpretable diagnosis rules directly from datasets. Firstly, all features in the dataset that contains continuous values are discretized. Secondly, for each class, a new dataset is created from the original dataset and contains only the chosen class’s instances. Finally, the new proposed DEOA is called for each new dataset to generate an optimal rule set. The DEOA-AC approach is evaluated on five well-known and recently used breast cancer datasets and compared with two recently proposed and three classical breast cancer diagnosis algorithms. The comparison results show that the proposed approach can generate more accurate and interpretable diagnosis models for breast cancer than other algorithms.

SNSVM: SqueezeNet-Guided SVM for Breast Cancer Diagnosis.

Breast cancer is a major public health concern that affects women worldwide. It is a leading cause of cancer-related deaths among women, and early detection is crucial for successful treatment. Unfortunately, breast cancer can often go undetected until it has reached advanced stages, making it more difficult to treat. Therefore, there is a pressing need for accurate and efficient diagnostic tools to detect breast cancer at an early stage. The proposed approach utilizes SqueezeNet with fire modules and complex bypass to extract informative features from mammography images. The extracted features are then utilized to train a support vector machine (SVM) for mammography image classification. The SqueezeNet-guided SVM model, known as SNSVM, achieved promising results, with an accuracy of 94.10% and a sensitivity of 94.30%. A 10-fold cross-validation was performed to ensure the robustness of the results, and the mean and standard deviation of various performance indicators were calculated across multiple runs. This model also outperforms state-of-the-art models in all performance indicators, indicating its superior performance. This demonstrates the effectiveness of the proposed approach for breast cancer diagnosis using mammography images. The superior performance of the proposed model across all indicators makes it a promising tool for early breast cancer diagnosis. This may have significant implications for reducing breast cancer mortality rates.

A hybrid end-to-end learning approach for breast cancer diagnosis: convolutional recurrent network

In this study, mammography images are classified as normal, benign, and malignant using the Mammographic Image Analysis Society (MIAS) and INbreast datasets. After the preprocessing of each image, the processed images are given as input to two different end-to-end deep networks. The first network contains only a Convolutional Neural Network (CNN), while the second network is a hybrid structure that includes both the CNN and Bidirectional Long Short Term Memories (BiLSTM). The classification accuracy obtained using the first and second hybrid architectures is 97.60% and 98.56% for the MIAS dataset, respectively. In addition, experiments performed for the INbreast dataset at the study's end prove the proposed method's effectiveness. These results are comparable to those obtained in previous popular studies. The proposed study contributes to previous studies in terms of preprocessing steps, deep network design, and high diagnostic accuracy.

RNA interference: Promising approach for breast cancer diagnosis and treatment.

Today, cancer is one of the main health-related challenges, and in the meantime, breast cancer (BC) is one of the most common cancers among women, with an alarming number of incidences and deaths every year. For this reason, the discovery of novel and more effective approaches for the diagnosis, treatment, and monitoring of the disease are very important. In this regard, scientists are looking for diagnostic molecules to achieve the above-mentioned goals with higher accuracy and specificity. RNA interference(RNAi)is a posttranslational regulatory process mediated by microRNAintervention and small interfering RNAs. After transcription and edition, these two noncoding RNAs are integrated and activated with the RNA-induced silencing complex (RISC) and AGO2 to connect the target mRNA by their complementary sequence and suppress their translation, thus reducing the expression of their target genes. These two RNAi categories show different patterns in different BC types and stages compared to healthy cells, andhence, these molecules have high diagnostic, monitoring, and therapeutic potentials. This article aims to review the RNAi pathway and diagnostic and therapeutic potentials with a special focus on BC.

MLP-TLBO: Combining Multi-Layer Perceptron Neural Network and Teaching-Learning-Based Optimization for Breast Cancer Detection

Symptoms and types of breast cancer, like most other diseases, vary from person to person. This is while some infected people may not have any symptoms. Breast cancer is one of the common cancers among women, of course, some types of it also affect men. Basically, timely and early diagnosis before the progress of the disease can significantly provide treatment grounds. There are many approaches to breast cancer diagnosis. Classification of patients in terms of benign or malignant cancer using data mining techniques has attracted the attention of many researchers. Data mining can provide a medical assistant system with very low cost and high accuracy for early detection of breast cancer. In this regard, this study proposes a data mining-based method by a combining Multi-Layer Perceptron (MLP) neural network and an evolutionary approach for breast cancer diagnosis. We aim to tune MLP parameters using an evolutionary approach. Here, Teaching-Learning-Based Optimization (TLBO) is used as a new evolutionary approach. However, the capabilities of approaches such as Genetic Algorithm (GA), Particle Swarm Optimization (PSO) and Open-Source Development Model Algorithm (ODMA) are analyzed compared to TLBO. The proposed method named MLP-TLBO can simultaneously adjust all MLP parameters (i.e., effective features and their number, number of hidden layers, number of neurons in each hidden layer, and weights of links). To improve the classification process, MLP-TLBO develops an ensemble classification mechanism in which multiple MLPs simultaneously model the training data. The evaluation of the proposed method is done on the Wisconsin Breast Cancer Database. We use three common datasets from Wisconsin including WBCD, WDBC and WPBC for simulations. Based on the results, the proposed method has promising results and averages between 7% and 26% better performance compared to similar methods.

A Combined Deep CNN: LSTM with a Random Forest Approach for Breast Cancer Diagnosis

The most predominant kind of disease that is normal among ladies is breast cancer. It is one of the significant reasons among ladies, regardless of huge endeavors to stay away from it through screening developers. An automatic detection system for disease helps doctors to identify and provide accurate results, thereby minimizing the death rate. Computer-aided diagnosis (CAD) has minimum intervention of humans and produces more accurate results than humans. It will be a difficult and long task that depends on the expertise of pathologists. Deep learning methods proved to give better outcomes when correlated with ML and extricate the best highlights of the images. The main objective of this paper is to propose a deep learning technique in combination with a convolution neural network (CNN) and long short-term memory (LSTM) with a random forest algorithm to diagnose breast cancer. Here, CNN is used for feature extraction, and LSTM is used for extracted feature detection. The experimental results show that the proposed system accomplishes 100% of accuracy, a sensitivity of 99%, recall of 99%, and an F1-score of 98% compared to other traditional models. As the system achieved correct results, it can help doctors to investigate breast cancer easily.

A Transfer Representation Learning Approach for Breast Cancer Diagnosis from Mammograms using EfficientNet Models

Breast cancer is a deadly disease that affects the lives of millions of women throughout the world. Over time, the number of cases of breast cancer has increased. Preventing this disease is difficult and remains unidentified, but the survival percentage can be improved if diagnosed early. The progress of computer-assisted diagnosis (CAD) of breast cancer has seen a lot of improvements thanks to advances in deep learning. With the notable advancement of deep neural networks, diagnostic capabilities are nearing a human expert's. In this paper, we used EfficientNet to classify mammograms. This model is introduced with the new concept of model scaling called compound scaling. Compound scaling is the strategy which scales the model by adding more layers to extend the receptive field along with more channels to catch the detailed features of larger input. We also compare the performance of various variants of EfficientNet over CBIS-DDSM mammogram datasets. We used the optimum fine-tuning procedure to represent the importance of transfer learning (TL) during training.

Salivary biomarkers in breast cancer diagnosis: A systematic review and diagnostic meta-analysis.

BackgroundSalivary diagnostics and their utility as a nonaggressive approach for breast cancer diagnosis have been extensively studied in recent years. This meta‐analysis assesses the diagnostic value of salivary biomarkers in differentiating between patients with breast cancer and controls.MethodsWe conducted a meta‐analysis and systematic review of studies related to salivary diagnostics published in PubMed, EMBASE, Scopus, Ovid, Science Direct, Web of Science (WOS), and Google Scholar. The articles were chosen utilizing inclusion and exclusion criteria, as well as assessing their quality. Specificity and sensitivity, along with negative and positive likelihood ratios (NLR and PLR) and diagnostic odds ratio (DOR), were calculated based on random‐ or fixed‐effects model. Area under the curve (AUC) and summary receiver‐operating characteristic (SROC) were plotted and evaluated, and Fagan's Nomogram was evaluated for clinical utility.ResultsOur systematic review and meta‐analysis included 14 papers containing 121 study units with 8639 adult subjects (4149 breast cancer patients and 4490 controls without cancer). The pooled specificity and sensitivity were 0.727 (95% CI: 0.713–0.740) and 0.717 (95% CI: 0.703–0.730), respectively. The pooled NLR and PLR were 0.396 (95% CI: 0.364–0.432) and 2.597 (95% CI: 2.389–2.824), respectively. The pooled DOR was 7.837 (95% CI: 6.624–9.277), with the AUC equal to 0.801. The Fagan's nomogram showed post‐test probabilities of 28% and 72% for negative and positive outcomes, respectively. We also conducted subgroup analyses to determine specificity, sensitivity, DOR, PLR, and NLR based on the mean age of patients (≤52 or >52 years old), saliva type (stimulated and unstimulated saliva), biomarker measurement method (mass spectrometry [MS] and non‐MS measurement methods), sample size (≤55 or >55), biomarker type (proteomics, metabolomics, transcriptomics and proteomics, and reagent‐free biophotonic), and nations.ConclusionSaliva, as a noninvasive biomarker, has the potential to accurately differentiate breast cancer patients from healthy controls.

A novel machine learning approach for breast cancer diagnosis

Breast cancer disease is a major public health problem among women worldwide. This article proposes an expert system for the diagnosis of breast cancer disease based on an evolutionary algorithm known as Differential Evolution (DE) of a Radial-Based Function Kernel Extreme Learning Machines (RBF-KELM). In the structure of the RBF-KELM, there are two adjustable parameters of the RBF-kernel which are the penalty parameter C and the RBF-kernel's parameter (σ). These parameters play a major role in the efficiency of RBF-KELM. In this study, the optimal values of these parameters have been obtained using a differential evolution (DE) algorithm. To validate the effectiveness of the suggested approach, DE-RBF-KELM was examined on the two datasets: The Mammographic Image Analysis Society (MIAS) and the wisconsin breast cancer database (WBCD) and the results were satisfactory compared to conventional approaches.

An effective approach for breast cancer diagnosis based on routine blood analysis features.

Breast cancer is a widespread disease and one of the primary causes of cancer mortality among women all over the world. Computer-aided methods are used to assist medical doctors to make early diagnosis of the disease. The aim of this study is to build an effective prediction model for breast cancer diagnosis based on anthropometric data and parameters collected through routine blood analysis. The proposed approach innovatively exploits principal component analysis (PCA) technique cascaded by median filtering so as to transform original features into a form of containing less distractive noise not to cause overfitting. Since a generalized regression neural network (GRNN) model is adopted to classify patterns of the transformed features, the computational load imposed in the training of artificial neural network model is kept minimized thanks to the non-iterative nature of GRNN training. The proposed method has been devised and tested on the recent Breast Cancer Coimbra Dataset (BCCD) that contains 9 clinical features measured for each of 116 subjects. Outperforming all of the existing studies on BCCD, our method achieved a mean accuracy rate of 0.9773. Experimental results evidence that this study achieves the best prediction performance ever reported on this dataset. The fact that our proposed approach has accomplished such a boosted performance of breast cancer diagnosis based on routine blood analysis features offers a great potential to be used in a widespread manner to detect the disease in its inception phase. Graphical abstract.

Tuning to Optimize SVM Approach for Breast Cancer Diagnosis with Blood Analysis Data

As one of the most prevalent cancers among women worldwide, breast cancer has attracted the most attention by researchers. It has been verified that an accurate and early detection of breast cancer can increase the chances for the patients to take the right treatment plan and survive for a long time. This paper intents the scope of the biomarker that can be used to predict the breast cancer from the routine Blood Analysis Data. Support vector machine (SVM) has already made an important contribution to the field of cancer classification. However, different kernel function configurations and their parameters will significantly affect the performance of SVM classifier. To improve the classification accuracy of SVM classifier for breast cancer diagnosis, this paper proposed a novel cancer classification algorithm based on optimizes the relevant parameters of SVM classifier through an intelligent algorithm using Grid Search Algorithm These parameters are: Gaussian radial basis function (GRBF) kernel parameter g and C penalty parameter of SVM classifier. Our experiment showed that SVM parameter optimization using grid search always finds near optimal parameter combination within the given ranges to evaluate the performance of the proposed model, Breast Cancer Coimbra Dataset used taken from UCI library. In this dataset age, body mass index (BMI), glucose, insulin, homeostasis model assessment (HOMA), leptin, adiponectin, resistin and chemokine monocyte chemoattractant protein 1 (MCP1) attributes were used. The performance of the proposed method is compared with that of other methods on this data sets. The obtained results show the improvement over state of-the-art algorithms with improved performance parameters e.g. disease prediction accuracy, sensitivity and better F1 score etc.. Funding Statement: The authors stated that this research received no external funding. Declaration of Interests: The authors declare no conflict of interest. Ethics Approval Statement: Not required.

A data-driven principal component analysis-support vector machine approach for breast cancer diagnosis: Comparison and application

In recent years, with the development of artificial intelligence, data-driven methodologies have been widely studied in fault diagnosis and detection, since an increasing number of complexities of modern complex systems make the mechanism model information difficult to obtain. Especially in people’s health monitoring, it is very difficult to achieve the mechanism model. The existing challenges, such as huge amount of data, high data dimension, large noise interference, and so forth, make the applications of data-driven approaches more suitable. For the sake of solving the problems above, we present principal component analysis-support vector machine (PCA-SVM) method with different kernels to reduce data dimension, and two sets of breast-cancer data are utilized to verify the method. Additionally, support vector machine-recursive feature elimination (SVM-RFE), the original SVM with different kernels, PCA and modified PCA (MPCA) methods are also applied to diagnose malignant cancer in comparison with PCA-SVM. In experiments, PCA-SVM via radial basis function (RBF) kernel shows better performance than other methods, with the two breast cancer datasets obtained from the University of Wisconsin Hospital. Finally, PCA-SVM in this study uses only six principal components and obtains better accuracy (97.19%) than most of the previous studies.

A Novel Score Fusion Approach for Breast Cancer Diagnosis

Meme kanseri tüm dünyada yaygın bir hastalık olması sebebiyle hastalığın erken teşhisi, hastaların bu hastalıktan tamamen kurtulabilmeleri açısından kritik öneme sahiptir. Hastalığın teşhisini kolaylaştırmak için tıp doktorları bilgisayar destekli uzman sistemlerden yararlanabilmektedir. Bu çalışmada meme kanseri veri örneklerini iyi huylu veya kötü huylu sınıflarına ayırmak için genel regresyon sinir ağı (Generalized Regression Neural Network-GRNN) ve ileri beslemeli sinir ağı (Feed Forward Neural Network-FFNN) temelli bir skor füzyon yöntemi önerilmiştir. Önerilen yöntem Wisconsin Teşhis Meme Kanseri (Wisconsin Diagnostic Breast Cancer-WDBC) veri seti üzerinde test edilmiştir. Bu iki temel ağın ve önerilen yöntemin kullanışlılığı incelenmiş ve performans sonuçları karşılaştırmalı olarak sunulmuştur. Önerilen yöntem sınıflandırma doğruluğu bakımından literatürde WDBC veri setini kullanarak yapılan mevcut çalışmalar ile kıyaslanmıştır. Elde edilen deneysel sonuçlar önerilen yöntemin, meme kanseri teşhisi için umut vadettiğini ve tıp uzmanlarının hastalığa ilişkin karar vermelerinde yardımcı bir araç olarak kullanılabileceğini göstermektedir.

Machine Learning Classification Techniques for Breast Cancer Diagnosis

Breast cancer is one of the most widely spread disease and the second leading cause of cancer death among women. Breast cancer starts when malignant lumps which are cancerous begin to grow from the breast cells. Doctors may wrongly diagnose benign tumor (which is non-cancerous) as malignant tumor. There is need for a computer aided detection (CAD) systems which uses machine learning approach to provide accurate diagnosis of breast cancer. These CAD systems can aid in detecting breast cancer at an early stage. When, breast cancer is detected early enough, the survival rate increases because better treatment can be provided. This paper aims at investigating Support Vector Machine (using radial basis kernel), Artificial Neural Networks and Naïve Bayes using the Wisconsin Diagnostic Breast Cancer (WDBC) Dataset. The focus of this paper is to integrate these machine learning techniques with feature selection/feature extraction methods and compare their performances to identify the most suitable approach. The goal is combining the advantages of dimensionality reduction and machine learning. This paper proposed a hybrid approach for breast cancer diagnosis by reducing the high dimensionality of features using linear discriminant analysis (LDA), and then applying the new reduced feature dataset to Support Vector Machine. The proposed approach obtained an accuracy of 98.82%, sensitivity of 98.41%, specificity of 99.07% and area under the receiver operating characteristic curve of 0.9994.