Applications In Drug Delivery Systems Research Articles

Nanorobots mediated drug delivery for brain cancer active targeting and controllable therapeutics.

Brain cancer pose significant life-threats by destructively invading normal brain tissues, causing dysneuria, disability and death, and its therapeutics is limited by underdosage and toxicity lying in conventional drug delivery that relied on passive delivery. The application of nanorobots-based drug delivery systems is an emerging field that holds great potential for brain cancer active targeting and controllable treatment. The ability of nanorobots to encapsulate, transport, and supply therapies directly to the lesion site through blood-brain barriers makes it possible to deliver drugs to hard-to-reach areas. In order to improve the efficiency of drug delivery and problems such as precision and sustained release, nanorobots are effectively realized by converting other forms of energy into propulsion and motion, which are considered as high-efficiency methods for drug delivery. In this article, we described recent advances in the treatment of brain cancer with nanorobots mainly from three aspects: firstly, the development history and characteristics of nanorobots are reviewed; secondly, recent research progress of nanorobots in brain cancer is comprehensively investigated, like the driving mode and mechanism of nanorobots are described; thirdly, the potential translation of nanorobotics for brain diseases is discussed and the challenges and opportunities for future research are outlined.

Cysteine Conjugation: An Approach to Obtain Polymers with Enhanced Muco- and Tissue Adhesion

The modification of polymers towards increasing their biocompatibility gathers the attention of scientists worldwide. Several strategies are used in this field, among which chemical post-polymerization modification has recently been the most explored. Particular attention revolves around polymer-L-cysteine (Cys) conjugates. Cys, a natural amino acid, contains reactive thiol, amine, and carboxyl moieties, allowing hydrogen bond formation and improved tissue adhesion when conjugated to polymers. Conjugation of Cys and its derivatives to polymers has been examined mostly for hyaluronic acid, chitosan, alginate, polyesters, polyurethanes, poly(ethylene glycol), poly(acrylic acid), polycarbophil, and carboxymethyl cellulose. It was shown that the conjugation of Cys and its derivatives to polymers significantly increased their tissue adhesion, particularly mucoadhesion, stability at physiological pH, drug encapsulation efficiency, drug release, and drug permeation. Conjugates were also non-toxic toward various cell lines. These properties make Cys conjugation a promising strategy for advancing polymer applications in drug delivery systems and tissue engineering. This review aims to provide an overview of these features and to present the conjugation of Cys and its derivatives as a modern and promising approach for enhancing polymer tissue adhesion and its application in the medical field.

Cyclodextrins: Advances in Chemistry, Toxicology, and Multifaceted Applications

Cyclodextrins (CDs) have garnered significant attention in various scientific and industrial fields due to their unique ability to form inclusion complexes with a wide range of guest molecules. This review comprehensively explores the latest advancements in cyclodextrin chemistry, focusing on the synthesis and characterization of cyclodextrin derivatives and their inclusion complexes. This review examines the biological activities of cyclodextrins, highlighting their pharmacological properties and pharmacokinetics, and discussing their promising applications in drug delivery systems. Furthermore, the industrial utilization of cyclodextrins, including their role in nanomaterials and nanostructured coatings, as well as their potential in environmental remediation, are explored. The present research also addresses the critical aspect of toxicity, particularly concerning cyclodextrin inclusion complexes, providing an overview of the current understanding and safety considerations. Through a multidisciplinary approach, the aim is to present a complete view of cyclodextrins, underscoring their versatility and impact across various domains.

A stimulus responsive microneedle-based drug delivery system for cancer therapy.

The intricate nature of the tumor microenvironment (TME) results in the inefficient delivery of anticancer drugs within tumor tissues, significantly compromising the therapeutic effect of cancer treatment. To address this issue, transdermal drug delivery microneedles (MNs) with high mechanical strength have emerged. Such MNs penetrate the skin barrier, enabling efficient drug delivery to tumor tissues. This approach enhances drug bioavailability, while also mitigating concerns such as liver and kidney toxicity associated with intravenous and oral drug administration. Notably, stimulus responsive MNs designed for drug delivery have the capacity to respond to various biological signals and pathological changes. This adaptability enables them to exert therapeutic effects within the TME, exploiting biochemical variations and tailoring treatment strategies to suit tumor characteristics. The present review surveys recent advancements in responsive MN systems. This comprehensive analysis serves as a valuable reference for the prospective application of smart MN drug delivery systems in cancer therapy.

Applications and Developments of Gene Therapy Drug Delivery Systems for Neurological Disorders

AbstractNeurological diseases (NDs) such as Alzheimer's disease, Parkinson's disease, ischemic strokes, spinal cord injuries, and other similar conditions that continue to pose a substantial health and economic burden on a global scale. It is crucial to tackle the difficulties provided by current medications due to the adverse effects and its immunological reactions to develop improved treatments for neurodegenerative illnesses. Gene therapy is currently being extensively used in preclinical and clinical studies for various diseases because of its ability to enhance the delivery and effectiveness of treatments. Various gene delivery techniques, including messenger RNA, small interfering RNA, antisense oligonucleotides, microRNA, CRISPR/Cas9 system, and plasmid DNA, have been created to address these difficulties. The goal of this study is to provide a clear overview of the pathophysiological underpinnings of NDs illnesses while also illuminating recent developments in gene delivery vector technologies. It goes over the main classifications of these vectors, their individual benefits and drawbacks, and their specific applications in the delivery of gene therapy.

Application of the Nirmala Index in Nanotechnology: Optimizing Molecular Structures for Advanced Nanomaterials

Abstract Chemical graph theory has played a key role in advancing our understanding of molecular structure by producing degree-based topological indices that forecast crucial physical and chemical properties. In this paper we attempt to investigate this recently defined Nirmala index as an invariant from different topological angles and applications on multiple molecular graph structures such as triangular, double, and alternate quadrilateral snake structures. This index offers a more profound comprehension of the connections between molecular structures and attributes. The next generation of ground breaking developments in nanotechnology, where the creation of devices and functional nanomaterials hinges on molecular interaction at the nanoscale, may also be greatly influenced by this index. These indices have potential applications in drug delivery systems and in molecular structure optimization related to nanotechnological fields like nanophotonics and nanoelectronics. Consequently, the Nirmala index will pave the way for the development of more sophisticated tools for the production of high-performing nanoscale materials.

Preparation and Characterization of Cellulose/Silk Fibroin Composite Microparticles for Drug-Controlled Release Applications.

Microparticles derived from biomaterials are becoming increasingly popular for application in drug delivery systems. In this study, the water-in-oil (W/O) emulsification-diffusion method was used to create cellulose (C), silk fibroin (SF), and C/SF composite microparticles. We then observed the morphology of all obtained microparticles using scanning electron microscopy (SEM), evaluated their functional groups using attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), and conducted thermogravimetric analysis using a thermogravimetric analyzer (TGA). SEM micrographs indicated that the native SF microparticles have the highest spherical shape with smooth surfaces. With blue dextran, the C microparticle was smaller than the native microparticle, while the drug-loaded SF microparticles were larger than the native microparticle. The morphological surfaces of the C/SF composite microparticles were varied in shape and surface depending on the C/SF ratio used. The spherical shape of the C/SF composite microparticle increased as the SF content increased. Furthermore, the size of the drug-loaded C/SF composite microparticles increased when the SF content gradually increased. The significant functional groups in the C and SF structures were identified based on the ATR-FTIR data, and a suggestion was made regarding the interaction between the functional groups of each polymer. When compared to both native polymers, the C/SF composite microparticles exhibit improved thermal stability. XRD patterns indicated that all prepared particles have crystalline structures and are directly affected by the released profile. The C/SF composite microparticle at a 1:3 ratio had the lowest drug release content, whereas the hydrophilicity of the C microparticle affected the highest drug release content. As a result, one crucial factor affecting the medication released from the microparticle is its structure stability. According to the obtained results, C, SF, and C/SF composite microparticles show promise as delivery systems for drugs with controlled release.

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Hydrogels are known for their high water retention capacity and biocompatibility and have become essential materials in tissue engineering and drug delivery systems. This review explores recent advancements in hydrogel technology, focusing on innovative types such as self-healing, tough, smart, and hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited for applications in dynamic biomedical environments. Tough hydrogels are designed with enhanced mechanical properties, enabling their use in load-bearing applications such as cartilage regeneration. Smart hydrogels respond to external stimuli, including changes in pH, temperature, and electromagnetic fields, making them ideal for controlled drug release tailored to specific medical needs. Hybrid hydrogels, made from both natural and synthetic polymers, combine bioactivity and mechanical resilience, which is particularly valuable in engineering complex tissues. Despite these innovations, challenges such as optimizing biocompatibility, adjusting degradation rates, and scaling up production remain. This review provides an in-depth analysis of these emerging hydrogel technologies, highlighting their transformative potential in both tissue engineering and drug delivery while outlining future directions for their development in biomedical applications.

Synthesis of Nanoparticles for Drug Delivery in Korea

Purpose: The aim of the study was to assess the synthesis of nanoparticles for drug delivery in Korea. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The study indicated that the synthesis of nanoparticles for drug delivery has emerged as a promising strategy to enhance the efficacy and precision of therapeutic interventions. Nanoparticles offer several advantages, such as improved bioavailability, targeted delivery, and controlled release of drugs. Various methods are employed in their synthesis, including chemical reduction, sol-gel processes, and biological methods using natural organisms. These nanoparticles can be engineered to carry a wide range of drugs, including chemotherapeutics, antibiotics, and vaccines. Their small size allows them to navigate biological barriers and deliver drugs directly to specific tissues or cells, reducing side effects and improving treatment outcomes. However, challenges such as scalability, toxicity, and regulatory hurdles remain, necessitating further research to optimize their clinical applications. Implications to Theory, Practice and Policy: Brownian motion theory, nanoscale phenomena theory, thermodynamic theory of nanoparticle stability may be used to anchor future studies on the synthesis of nanoparticles for drug delivery in Korea. Practitioners in the field should prioritize the enhancement of synthesis techniques and the focus on biocompatibility and safety to improve the practical applications of nanoparticle drug delivery systems. To ensure the safe and effective use of nanoparticles in drug delivery, policymakers must establish clear guidelines and regulations governing their application.

Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound.

Chronic wounds are characterized by long-term inflammation, including diabetic ulcers, traumatic ulcers, etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics are the main clinical treatment method for chronic wound infections. However, the overuse of antibiotics may accelerate the emergence of drug-resistant bacteria, which poses a significant threat to human health. Therefore, there is an urgent need to develop new therapeutic strategies for bacterial infections. Nanozyme-based antimicrobial therapy (NABT) is an emerging antimicrobial strategy with broad-spectrum activity and low drug resistance compared to traditional antibiotics. NABT has shown great potential as an emerging antimicrobial strategy by catalyzing the generation of reactive oxygen species (ROS) with its enzyme-like catalytic properties, producing a powerful bactericidal effect without developing drug resistance. Nanozyme-based cascade antimicrobial technology offers a new approach to infection control, effectively improving antimicrobial efficacy by activating cascades against bacterial cell membranes and intracellular DNA while minimizing potential side effects. However, it is worth noting that this technology is still in the early stages of research. This article comprehensively reviews wound classification, current methods for the treatment of wound infection, different types of nanozymes, the application of nanozyme cascade reaction technology in antimicrobial therapy, and future challenges and prospects.

The Design Features, Quality by Design Approach, Characterization, Therapeutic Applications, and Clinical Considerations of Transdermal Drug Delivery Systems—A Comprehensive Review

Transdermal drug delivery systems (TDDSs) are designed to administer a consistent and effective dose of an active pharmaceutical ingredient (API) through the patient’s skin. These pharmaceutical preparations are self-contained, discrete dosage forms designed to be placed topically on intact skin to release the active component at a controlled rate by penetrating the skin barriers. The API provides the continuous and prolonged administration of a substance at a consistent rate. TDDSs, or transdermal drug delivery systems, have gained significant attention as a non-invasive method of administering APIs to vulnerable patient populations, such as pediatric and geriatric patients. This approach is considered easy to administer and helps overcome the bioavailability issues associated with conventional drug delivery, which can be hindered by poor absorption and metabolism. A TDDS has various advantages compared to conventional methods of drug administration. It is less intrusive, more patient-friendly, and can circumvent first pass metabolism, as well as the corrosive acidic environment of the stomach, that happens when drugs are taken orally. Various approaches have been developed to enhance the transdermal permeability of different medicinal compounds. Recent improvements in TDDSs have enabled the accurate administration of APIs to their target sites by enhancing their penetration through the stratum corneum (SC), hence boosting the bioavailability of drugs throughout the body. Popular physical penetration augmentation methods covered in this review article include thermophoresis, iontophoresis, magnetophoresis, sonophoresis, needle-free injections, and microneedles. This review seeks to provide a concise overview of several methods employed in the production of TDDSs, as well as their evaluation, therapeutic uses, clinical considerations, and the current advancements intended to enhance the transdermal administration of drugs. These advancements have resulted in the development of intelligent, biodegradable, and highly efficient TDDSs.

Bacterial Cellulose: A Multifunctional Platform for Biomedical Applications

Bacterial cellulose (BC), a biopolymer synthesized by various bacterial species, has emerged as a promising material for biomedical applications due to its unique properties, including high purity, biocompatibility, mechanical strength, and structural similarity to the extracellular matrix. This review explores the advancements in BC research over the last decade, focusing on its applications in tissue engineering, wound healing, and drug delivery systems. While BC offers numerous benefits, challenges such as large-scale production, structural modification, however regulatory approval hinder its broader clinical use. Recent studies have introduced innovative solutions, such as using agro-industrial waste to lower production costs and combining BC with other materials to enhance its bioactivity. As research progresses, BC has the potential to revolutionize the field of biomedicine, offering sustainable, versatile, and effective solutions for a wide range of medical applications.

Exploring Applications of Flexible Vesicular Systems as Transdermal Drug Delivery.

Deformable lipidic-nano carriers are a category of advanced liposomal formulations. Deformable lipidic-nano carriers have a specific character to transform by rearranging the lipidic backbone to squeeze themself through a pore opening ten times smaller than their diameter when exposed to a variable condition like hydration gradient as these have potentially been used as a non-invasive delivery system to transdermally migrate various therapeutic agents for over three decades. Despite their vast application in transdermal drug delivery system, non-uniformity to express their chemical nature still exist and authors use various terms synonymously and interchangeably with each other. The present study delineates the terminologies used to express different derived deformable vesicular carriers to harmonize the terminological use. It also includes the effectiveness of deformable nanocarriers like Transferosomes, Ethosomes, Menthosomes, Invasomes, and Glycerosomes in skin conditions like basal cell carcinoma, fungal and viral infections, and hyperpigmentation disorders, along with others. Various review and research articles were selected from the 'Pubmed' database. The keywords like Transferosomes, Flexi-vesicular system, ultra-deformable vesicles, and nano-vesicular systems were used to extract the data. The data was reviewed and compiled to categorically classify different flexible vesicular systems. The composition of the different vesicular systems is identified and a report of various pathological conditions where the use of flexible lipid nanocarrier systems was implemented is compiled. The review also offers suggestive approaches where the applicability of these systems can be explored further.

A three-dimensional unsteady flow of Casson nanofluid with suspension of microorganisms with variable thermal conductivity: A modified Fourier theory approach

The study of nanofluids is important due to valuable applications in drug delivery systems, thermal processes, solar management systems, microfluidic devices, extrusion phenomenon, chemical processes etc. The objective of current analysis is to investigates the enhanced thermal performances of magnetized Casson nanofluid with suspension of microorganisms. An unsteady periodically oscillating flow due to bidirectional moving porous surface have been considered. The analysis is subject to assumptions of variable thermal conductivity. The modelled problem is based on implementation of modified Fourier theories. The Buongiorno nanofluid model is used to predicts the significance of Brownian motion and thermophoresis effects. Chemical reaction species are also attributed. For solution methodology, homotopy analysis scheme is implemented. The convergence region is specified. The physical impact of problem is visualized. The significant applications of parameters have been focused. The claimed results offer significance in cooling systems, chemical reactions, air conditioning, solar thermal systems, automotive radiators, heat exchangers in power plants etc.

From waste to wonder: Developing engineered nanomaterials for multifaceted applications

The escalating generation of industrial and consumer waste poses a significant environmental challenge, necessitating innovative approaches to waste management and resource utilization. One promising solution lies in the transformation of waste materials into engineered nanomaterials (ENMs), which hold immense potential for a diverse range of applications. This review explores the development of ENMs from waste, highlighting their multifaceted uses in environmental remediation, energy storage, medical applications, and advanced manufacturing. The process of converting waste into ENMs involves sophisticated techniques such as chemical vapour deposition, sol-gel synthesis, and hydrothermal methods, which enable the creation of materials with precise structural and functional properties at the nanoscale. By utilizing waste as a raw material, this approach not only addresses waste disposal issues but also provides a sustainable and cost-effective source of high-value nanomaterials. ENMs derived from waste exhibit unique properties, including high surface area, tunable porosity, and enhanced reactivity, making them suitable for environmental applications such as pollutant adsorption, water purification, and air filtration. In the energy sector, these nanomaterials contribute to the development of advanced batteries, supercapacitors, and fuel cells, enhancing energy storage and conversion efficiency. The biomedical field benefits from waste-derived ENMs through their application in drug delivery systems, diagnostic tools, and tissue engineering. The biocompatibility and functional versatility of these materials enable targeted therapeutic interventions and innovative medical solutions. Furthermore, in advanced manufacturing, ENMs improve the performance and durability of materials used in electronics, coatings, and composites, fostering the development of next-generation products with superior properties. The integration of waste-derived ENMs into various industries represents a paradigm shift towards a circular economy, where waste is not merely a byproduct but a valuable resource. This approach aligns with global sustainability goals, promoting resource efficiency, reducing environmental impact, and driving technological advancements. In conclusion, the development of engineered nanomaterials from waste exemplifies the transformative potential of nanotechnology in addressing critical environmental and industrial challenges. By harnessing waste as a resource, this innovative approach paves the way for multifaceted applications that contribute to environmental sustainability, technological progress, and economic growth. Further research and development in this field will continue to expand the possibilities and impact of waste-derived ENMs in various sectors.

Nanostructured lipid carrier formulation for delivering poorly water-soluble ITF3756 HDAC inhibitor

Histone deacetylases (HDACs) are enzymes that play crucial roles in cellular processes by hydrolyzing acetyl-L-lysine side chains in core histones, thereby regulating gene expression and maintaining homeostasis. Histone deacetylase inhibitors (HDACi) have emerged as promising agents, particularly in cancer treatment, due to their ability to induce cytotoxic and pro-apoptotic effects. Selective HDAC6 inhibitors, such as ITF3756, have shown low off-target toxicity and promising pharmacological activities, but their poor water solubility limits their application in nanoparticulate drug delivery systems. Here, we optimized a nanostructured lipid carrier (NLC) formulation for delivering ITF3756 using the design of experiments (DOE) and response surface methodology (RSM). An interaction between the factor surfactant and formulation volume was observed, thus demonstrating that the surfactant concentration impacts the NLC size. It can be speculated that the higher the amount of the drug in the formulation, the lower the polydispersion index (PDI), thus resulting in more stable nanostructures. The optimized ITF3756-NLC demonstrated a size of 51.1 ± 0.3 nm, 8.85 ± 4.71 mV charge, and high entrapment efficiency (EE%), maintaining stability for 60 days. Moreover, ITF3756-NLC enhanced α-tubulin acetylation in melanoma, lung, and brain cancer cell lines, indicating retained or improved bioactivity. The ITF3756-NLC formulation offers a viable approach for enhancing the bioavailability and therapeutic efficacy of HDAC6 inhibitors, demonstrating potential for clinical applications in cancer immunotherapy.

Comprehensive Evaluation of Process Parameters in the Green Synthesis of Iron Oxide Nanoparticles Using Moringa olifera extract.

This study investigates the green synthesis of iron oxide nanoparticles using Moringa olifera ethanolic extract and evaluates the impact of various process parameters on their physicochemical characteristics. The parameters examined include synthesis time, temperature, pH, stirring speed (RPM), and the ratio of extract to iron precursors. The findings reveal that a lower proportion of the extract increases the entrapment efficiency of the nanoparticles. Specifically, batch ME3 (3:1 ratio) produced the smallest nanoparticles at 117.8 nm, with a drug release of 75.54% and the highest entrapment efficiency at 60.28%. Extending the synthesis time to three hours in batch TM3 resulted in a drug release of 74.23% and a particle size of 116.3 nm. Batch TEM1, synthesized at 70°C, showed the highest entrapment efficiency and a favorable drug release profile of 71.09%, with the smallest particle size of 105.24 nm, suggesting that higher synthesis temperatures favor smaller particle sizes. Adjusting the pH to 10 in batch PM3 achieved a drug release efficiency of 76.02%. Batch RM5, synthesized with a stirring speed of 750 RPM, demonstrated a particle size of 95.7 nm and a drug release of 78.26%, indicating that higher stirring rates produce smaller nanoparticles and enhance drug release. These results highlight the significance of optimizing synthesis conditions to produce nanoparticles with desired properties. The use of M. olifera extract as a sustainable reducing and stabilizing agent presents an environmentally friendly approach to nanotechnology. This method has potential applications in drug delivery systems and various other industries, emphasizing the importance of green synthesis in creating sustainable and efficient nanomaterials.

Preparation of Baicalin Liposomes Using Microfluidic Technology and Evaluation of Their Antitumor Activity by a Zebrafish Model.

Baicalin (BCL), a well-known flavonoid molecule, has numerous therapeutic applications. However, its low water solubility and bioavailability limit its applicability. Microfluidics is a new method for liposome preparation that provides efficient and rapid control of the process, improving the stability and controllability. This study used microfluidic techniques to create baicalin liposomes (BCL-LPs), first screening for optimal total flow rates (TFR) and flow rate ratios (FRR), and then optimizing the phospholipid concentration, phospholipid-to-cholesterol ratio, and Tween-80 concentration using univariate and response surface methodology approaches. The study found that the ideal phospholipid content was 9.5%, the phospholipid-to-cholesterol ratio was 9:1 (w:w), and the Tween-80 concentration was 15%. BCL-LPs achieved 95.323% ± 0.481% encapsulation efficiency under the optimum circumstances. Characterization indicated that the BCL-LPs were spherical and uniform in size, with a mean diameter of 62.32 nm ± 0.42, a polydispersity index of 0.092 ± 0.009, and a zeta potential of -25.000 mV ± 0.216. In vitro experiments found that BCL-LPs had a better slow-release effect and stability than the BCL monomer. In zebrafish bioassays, BCL-LPs performed better than BCL monomer in terms of biological activity and bioavailability. The established method provided a feasible medicine delivery platform for BCL and could apply for the transport and encapsulation of more natural compounds, expanding the applications of drug delivery systems in healthcare and cancer therapies.

Engineered metal nanoparticles for precision drug delivery: Pioneering the future of medicine: Mini review

AbstractMetal nanoparticles (NPs) have emerged as crucial components in precision drug delivery, presenting innovative opportunities to significantly enhance therapeutic efficacy and targeting accuracy. This review investigates recent developments in the engineering of metal NPs, emphasizing their distinctive properties and novel applications in drug delivery systems. A comprehensive analysis is performed on gold, silver, iron, and zinc oxide NPs, emphasizing their exceptional physicochemical properties and enhanced drug‐loading capacities. These features collectively enable the development and implementation of targeted and controlled drug delivery systems, indicating a new era of advanced therapeutic approaches. This review article accomplishes this by reflecting on the transformative potential of metal NPs, envisioning heightened efficacy, minimized side effects, and improved patient outcomes within the dynamic landscape of drug delivery platforms.

A Descriptive Review on the Potential Use of Diatom Biosilica as a Powerful Functional Biomaterial: A Natural Drug Delivery System.

Although various chemically synthesized materials are essential in medicine, food, and agriculture, they can exert unexpected side effects on the environment and human health by releasing certain toxic chemicals. Therefore, eco-friendly and biocompatible biomaterials based on natural resources are being actively explored. Recently, biosilica derived from diatoms has attracted attention in various biomedical fields, including drug delivery systems (DDS), due to its uniform porous nano-pattern, hierarchical structure, and abundant silanol functional groups. Importantly, the structural characteristics of diatom biosilica improve the solubility of poorly soluble substances and enable sustained release of loaded drugs. Additionally, diatom biosilica predominantly comprises SiO2, has high biocompatibility, and can easily hybridize with other DDS platforms, including hydrogels and cationic DDS, owing to its strong negative charge and abundant silanol groups. This review explores the potential applications of various diatom biosilica-based DDS in various biomedical fields, with a particular focus on hybrid DDS utilizing them.