Background. This study systematizes the principles of using polymer composite materials in bridge structure design, outlining the fundamental principles for calculating load-bearing structures of bridge spans featuring these materials. Aim. The goal is to enhance the strength and durability of bridge spans during construction and maintenance, while optimizing costs through the use of polymer composite materials. Materials and Methods. The research employs a modern approach to bridge structure design, utilizing mathematical statistics for experimental data analysis and numerical methods for calculating bridge structures using nonlinear deformation models of anisotropic materials. Results. Developed principles for designing bridge spans with polymer composite elements include methods for strengthening and reinforcing concrete bridge structures. These methods account for operational factors such as long-term constant and temporary loads, low and elevated temperatures, as well as methods for designing all-composite spans pedestrian and road bridges Conclusion. The principles of designing bridge spans with elements made of polymer composite materials have been introduced into the practice of transport construction in the Russian Federation. The technical and economic efficiency of using polymer composite materials in bridge structures of transport infrastructure has been confirmed.