The Internet of Things-enabled Smart Healthcare System (IoT-SHS) is a networked infrastructure of intelligent wearables, software applications, health systems, and services that continuously monitors and transmits patient-sensitive data using an open wireless channel. The conventional security mechanisms are unsuitable for detecting attacks in the dynamic IoT-SHS context due to resource limitations and heterogeneity in low-cost healthcare devices. Deep Learning (DL) solutions for Intrusion Detection System (IDS) and softwarization of the network has the potential to achieve secure network services in the IoT-SHS environment. Motivated by the aforementioned discussion, we propose an intelligent softwarized IDS for protecting the critical infrastructure of the IoT-SHS ecosystem. Specifically, the DL-based IDS is designed using a hybrid cuda Long Short-Term Memory Deep Neural Network (cuLSTM-DNN) algorithm to assist network administrators in efficient decision-making for the generated intrusions. To further bolster the system’s resilience, we suggest a deployment architecture for the proposed CUDA-powered IDS using OpenStack Tacker in a real SDN environment, ensuring that virtual machines can directly utilize the host’s NVIDIA GPU, thereby streamlining and enhancing the network’s operational efficiency. The experimental results using the CICDDoS2019 dataset confirm the effectiveness of the proposed framework over some baseline and recent state-of-the-art techniques.