Application Of Hyperbaric Oxygen Therapy Research Articles

Penerapan Terapi Hiperbarik Oksigen Terhadap Penyembuhan Luka Pada Pasien Ulkus Kaki Diabetik: Studi Literatur

Background: Diabetic foot ulcers are advanced complications experienced by people with diabetes mellitus that have a negative impact and must be treated immediately. One method that can be done to overcome the incidence of diabetic foot ulcers is hyperbaric oxygen therapy. This therapy is known to facilitate wound healing by improving wound tissue perfusion, increasing fibroblast replication and collagen production and increasing phagocytic ability. Purpose: The purpose of this study was to determine the application of hyperbaric oxygen therapy to wound healing in diabetic foot ulcer patients. Methods: The method used in this writing is literature review, with secondary data obtained from previous research with empirical studies of the last 10 years, data sources are accessed through the google scholar database, by taking journals that are relevant to the research topic. Results: This study shows that the results that have been carried out on the administration of hyperbaric oxygen therapy to diabetic foot ulcers, show the ability to heal wounds in a fast time and more effective results. Conclusion: Based on the results of literature review research by collecting several journals, it is concluded that the management of hyperbaric oxygen therapy in diabetic foot ulcer patients is more effective, cost-effective, and increases the prevalence of wound healing.

Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta-analysis.

Hyperbaric oxygen therapy (HBOT) has been used in patients with diabetic foot ulcers (DFU) for many years, but its clinical efficacy is still controversial. Therefore, this study explored the efficacy of HBOT applied to DFU by means of meta-analysis. PubMed, Cochrane Library, Embase, CNKI and Wanfang databases were searched, from database inception to October 2023, and published randomised controlled trials (RCTs) of HBOT in DFU were collected. Two investigators independently screened the collected literature, extracted relevant data and assessed the quality of the literature. Review Manager 5.4 software was applied for data analysis. Twenty-nine RCTs with 1764 patients were included. According to the combined results, when compared with conventional treatment, HBOT significantly increased the complete healing rate of DFUs (46.76% vs. 24.46%, odds ratio [OR]: 2.83, 95% CI: 2.29-3.51, p < 0.00001) and decreased the amputation rate (26.03% vs. 45.00%, OR: 0.41, 95% CI: 0.18-0.95, p = 0.04), but the incidence of adverse events was significantly higher in patients (17.37% vs. 8.27%, OR: 2.49, 95% CI: 1.35-4.57, p = 0.003), whereas there was no significant difference in the mortality (6.96% vs. 12.71%, OR: 0.52, 95% CI: 0.21-1.28, p = 0.16). Our results suggest that HBOT is effective in increasing the complete healing rate and decreasing the amputation rate in patients with DFUs, but increases the incidence of adverse events, while it has no significant effect on mortality.

Application of HBOT with Minimally Invasive Guided Surgery to Heal chronic Brooker 4 Diabetic Ulcer

Foot ulcers are a frequent precursor for a significant number of amputations in the diabetic population. This study presents a 71-year-old man with diabetes with a foot ulcer connected to a sinus fistula to a joint in his great toe. The patient was treated with a Minimally Invasive Image Guided (MIIGS) guided Interphalangeal Joint (IPJ) fusion with Hyperbaric Oxygen Therapy (HBOT) and injection of biologics with successful closure of the ulcer and resolution of surrounding cellulitis. Key points of study The patient had poorly controlled diabetes and severe foot ulcers, resulting in 2 amputated toes on the right foot Patient had 6 months of dressings and debridement’s and had been booked for amputation An IPJ fusion preceded and followed by HBOT sessions were successful in healing the ulcers and saving the remaining toe This approach shows promise as an alternative to amputation for diabetic foot ulcers, potentially reducing costs and improving patient outcomes This study suggests that a combination of MIIGS and HBOT can revolutionize treatment for diabetic foot ulcers. This approach offers a limb-saving alternative to amputation along with reducing the healthcare costs to the health industry and patients.

Iatrogenic gas embolism in a juvenile loggerhead sea turtle (Caretta caretta)

A mild pneumocoelom was diagnosed by computed tomography in a stranded juvenile loggerhead sea turtle (Caretta caretta). After gas extraction by ultrasound-guided puncture, the animal did not improve and was subjected to hyperbaric oxygen therapy (HBOT). After HBOT, the turtle developed marked subcutaneous emphysema and was found dead the following morning. Gross lesions included a distended right atrium with numerous gas bubbles within the epicardium, gas bubbles in the hepatic, gastric and mesenteric veins, a small gas-filled bulla in the left lung and diffuse haemorrhages in the encephalon. Histological lesions included gas-like emboli in the lumen of the right atrium with myocardial necrosis, gas-like emboli in the lumina of intestinal, pulmonary and renal blood vessels and severe meningeal haemorrhages. From a forensic pathology perspective, the subcutaneous emphysema of immediate onset after HBOT and the greater severity of the histological lesions in blood vessels, heart, lung and brain differentiate this case from other cases of gas embolism in turtles due to incidental capture. Two factors contributed to this outcome: the existence of a probably unresolved pneumocoelom and the application of HBOT without an initial diagnosis that accurately indicated its use. Therefore, as in human medicine, the use of HBOT in sea turtles with lung lesions and pneumocoelom is discouraged. This is the first description of an iatrogenic gas embolism in a sea turtle.

EFFECTS OF HYPERBARIC OXYGEN THERAPY ON INTESTINAL ISCHEMIA-REPERFUSION AND ITS MECHANISM.

Ischemia can cause reversible or irreversible cell or tissue damage, and reperfusion after ischemia not only has no therapeutic effect but also aggravates cell damage. Notably, gut tissue is highly susceptible to ischemia-reperfusion (IR) injury under many adverse health conditions. Intestinal IR (IIR) is an important pathophysiological process in critical clinical diseases. Therefore, it is necessary to identify better therapeutic methods for relieving intestinal ischemia and hypoxia. Hyperbaric oxygenation refers to the intermittent inhalation of 100% oxygen in an environment greater than 1 atm pressure, which can better increase the oxygen level in the tissue and change the inflammatory pathway. Currently, it can have a positive effect on hypoxia and ischemic diseases. Related studies have suggested that hyperbaric oxygen can significantly reduce ischemia-hypoxic injury to the brain, spinal cord, kidney, and myocardium. This article reviews the pathogenesis of IR and the current treatment measures, and further points out that hyperbaric oxygen has a better effect in IR. We found that not only improved hypoxia but also regulated IR induced injury in a certain way. From the perspective of clinical application, these changes and the application of hyperbaric oxygen therapy have important implications for treatment, especially IIR.

Application of Hyperbaric Oxygen Therapy in Chronic Distal Tibial Osteomyelitis in Severe Extremity Trauma

The purpose of this case study is to present the utility of using hyperbaric oxygen therapy (HBOT) as a tool to treat septic arthritis and tibial distal osteomyelitis. A 28-year-old female patient presented with septic arthritis and tibial distal osteomyelitis following an open complex ankle fracture due to a motor vehicle accident (MVA). The patient had internal fixation surgery, flap surgery and the debridement’s for infection. Osteomyelitis remains a troubling disorder to treat with catastrophic repercussion for the infected limb. The patient underwent 50 total HBOT sessions at 100 kPa using the integrant Hyperbaric mono chamber. This case study proves the viability of HBOT as an important adjunctive treatment for septic arthritis and osteomyelitis. It also shows that osteomyelitis can be reclaimed without necessity to remove it.

Application of HBOT and Wolf Grafting in Chronic Diabetic Foot Ulcer

Diabetic foot ulcers are a serious complication of poorly controlled diabetes, often leading to amputations. This study presents a 60-year-old man with diabetes and severe foot ulcers who opted for a Wolfe skin graft with Hyperbaric Oxygen Therapy (HBOT) instead of amputation. Key points of study 1. The patient had poorly controlled diabetes and severe foot ulcers, resulting in 2 amputated toes. 2. Further amputations were anticipated for a chronic Wagner 3 diabetic ulcer. (Wagner, et. al., Foot and Ankle international) 3. A Wolfe skin graft limited debridement and minimally invasive surgery followed by HBOT sessions were successful in healing the ulcers and saving the toe. 4. This approach shows promise as an alternative to amputation for diabetic foot ulcers, potentially reducing costs and improving patient outcomes. Overall, this study suggests that Wolfe skin grafting combined with HBOT can be a viable alternative to amputation for treating diabetic foot ulcers. This approach may offer cost savings and improved quality of life for the patient by preserving limbs.

Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects.

The hypoxia pathway not only regulates the organism to adapt to the special environment, such as short-term hypoxia in the plateau under normal physiological conditions, but also plays an important role in the occurrence and development of various diseases such as cancer, cardiovascular diseases, osteoporosis. Bone, as a special organ of the body, is in a relatively low oxygen environment, in which the expression of hypoxia-inducible factor (HIF)-related molecules maintains the necessary conditions for bone development. Osteoporosis disease with iron overload endangers individuals, families and society, and bone homeostasis disorder is linked to some extent with hypoxia pathway abnormality, so it is urgent to clarify the hypoxia pathway in osteoporosis to guide clinical medication efficiently. Based on this background, using the keywords "hypoxia/HIF, osteoporosis, osteoblasts, osteoclasts, osteocytes, iron/iron metabolism", a matching search was carried out through the Pubmed and Web Of Science databases, then the papers related to this review were screened, summarized and sorted. This review summarizes the relationship and regulation between the hypoxia pathway and osteoporosis (also including osteoblasts, osteoclasts, osteocytes) by arranging the references on the latest research progress, introduces briefly the application of hyperbaric oxygen therapy in osteoporosis symptoms (mechanical stimulation induces skeletal response to hypoxic signal activation), hypoxic-related drugs used in iron accumulation/osteoporosis model study, and also puts forward the prospects of future research.

The Efficacy of Hyperbaric Oxygen Therapy in Traumatic Brain Injury Patients: Literature Review and Clinical Guidelines

Introduction: The application of hyperbaric oxygen therapy for patients with both acute and chronic traumatic brain injury has been suggested for over five decades. In the past decade, the design and quality of studies were more detailed and thorough leading to an improved unerstanding of the uses of HBOT and the profiles of the patients who can benefit the most. Objectives: Perform a comprehensive literature review of hyperbaric oxygen therapy application for the treatment of patients with both acute, subacute and chronic traumatic brain injury. Methods: Extensive literature search from 1969 to April 2023 was performed on April 1st 2023 within the following databases: Cochrane Library, PubMed, Google Scholar, and Web of Science, including humans clinical data, in articles providing information on the type of treatment and clinical outcomes. Articles were first categorized into acute-subacute traumatic brain inury and chronic traumatic brain injury and further classified into low, medium or high level quality. Results: There was high level evidence including nine randomized controlled trials, one meta-analysis and two prospective study evaluating the clinical effects of hyperbaric oxygen therapy in patients suffering from traumatic brain injuries in the acute and subacute settings. Mortality was significantly reduced in all studies that used it as an endpoint, while favorable functional outcomes in survivors showed mixed results. In chronic severe traumatic brain injury, there is low to moderate evidence including two uncontrolled prospective studies, two cohort studies and eight case reports suggesting improved outcomes. In chronic mild traumatic brain injury, there is high level evidence including seven randomized controlled trials, and six prospective studies suggesting significant improvement in cognitive function, symptoms and quality of life. Conclusions: Hyperbaric oxygen therapy may be recommended in acute moderate-severe traumatic brain injury patients (Type 2a recommendation, level A evidence). However, further studies are needed to both evaluate outcomes and to determine the optimal treatment protocols for the different types of injuries (Type 1 recommendation, level A evidence). Hyperbaric oxygen threrapy should be recommended in chronic traumatic brain injury for a selected group of patients suffering from prolonged post-concussion syndrome who have clear evidence of metabolic dysfunctional brain regions as determined by neuroimaging (Type 2a recommendation, level B-R evidence). Patients should be properly evaluated by standardized cognitive tests and functional brain imaging (Type 1 recommendation, level B-R evidence).

The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter?

Stroke has become a significant cause of death and disability globally. Along with the transition of the world's aging population, the incidence of acute ischemic stroke is increasing year by year. Even with effective treatment modalities, patients are not guaranteed to have a good prognosis. The treatment model combining intravenous thrombolysis/endovascular therapy and neuroprotection is gradually being recognized. After the clinical translation of pharmacological neuroprotective agents failed, non-pharmacological physical neuroprotective agents have rekindled hope. We performed a literature review using the National Center for Biotechnology Information (NCBI) PubMed database for studies that focused on the application of hyperbaric oxygen therapy in acute ischemic stroke. In this review, we present the history and mechanisms of hyperbaric oxygen therapy, focusing on the current status, outcomes, current challenges, perspective, safety, and complications of the application of hyperbaric oxygen in animal experiments and human clinical trials. Hyperbaric oxygen therapy, a non-pharmacological treatment, can improve the oxygenation level at the ischemic lesions in increased dissolved oxygen and oxygen diffusion radius to achieve salvage of neurological function, giving a new meaning to acute ischemic stroke.

Clinical application of hyperbaric oxygen therapy in China: A 2020 baseline survey

Objectives: This is the first nationwide survey to obtain baseline information on the clinical application of hyperbaric oxygen (HBO2) therapy in China. The findings provide a reference for future management and policy formulation research. Methods: This questionnaire-based survey was implemented using an online survey tool. The survey assessed six aspects related to HBO2 practice: characteristics of institutions, departments/units, chambers, practitioners, treatment capacity, and scientific research. Results: Subjects were 1,924 institutions (2,699 HBO2 chambers and 11,266 practitioners) from 31 provinces, municipalities, and autonomous regions in mainland China. The findings showed that most institutions (86.9%) were public hospitals and 70.0% of chambers were air pressurized. The numbers of newly built HBO2 departments/units and chambers have gradually increased over the last five decades. We found that 70.8% of HBO2 departments/units were independent, most non-independent HBO2 units were affiliated to rehabilitation departments, and 88.1% of institutions had 24-hour emergency treatment capacity. Most institutions (44.5%) had 1,001 to 5,000 annual therapy sessions. In 2019, three conditions most frequently treated across the institutions were cerebrovascular diseases, carbon monoxide poisoning, and central nervous system injury. We identified the following shortcomings: shortage of doctors and (particularly) technicians; imbalances in emergency capacity, treatment facilities, and staff composition among institutions of different classifications; and little high-quality scientific research. Conclusions: Chinese HBO2 therapy is flourishing. With the growth in emergency capacity, Chinese HBO2 and rehabilitation medicine are developing in a coordinated way. However, several shortcomings require addressing in future work.

Uloga hiperbarične oksigenoterapije u lečenju progresivne infekcije stopala kod pacijenta obolelog od diabetes mellitus-a de novo - prikaz slučaja

Introduction: Hyperbaric oxygen therapy (HBOT) is a therapeutic and diagnostic method wherein the patient breathes 100% oxygen gas at a pressure of more than one atmosphere absolute (ATA) in a hyperbaric chamber. Diabetes mellitus is a heterogenous group of metabolic disorders which manifest as elevated blood glucose levels resulting from either insufficient insulin secretion or an abnormality in insulin action. Diabetic foot is the most common chronic complication of diabetes mellitus. Case report: We present the case of a fifty-three-year-old patient referred to our hospital for the purpose of receiving hyperbaric oxygen therapy due to wet gangrene and phlegmon of the right foot. The patient was newly diagnosed with diabetes. He was hospitalized at a tertiary healthcare institution where his wound was surgically treated. Appropriate antibiotic, antiaggregation, and insulin therapy was introduced for the purpose of achieving the best possible degree of glucoregulation. An X-ray of the right foot was performed verifying the presence of soft tissue gas. Due to the local finding on the foot, the progression and the propagation of the infection proximally, with the presence of gas, hyperbaric oxygen therapy was introduced immediately, according to the emergency protocol, for the purpose of saving the limb. After 30 hyperbaric oxygen therapy sessions, the local finding was significantly improved, and the limb was no longer in danger. Conclusion: Any abnormality in the continuity of the skin, immunity, and vascularization may be considered a risk factor for the development of phlegmon in patients with diabetes. Diabetic foot is the consequence of neuroischemic changes, which occasionally become complicated with further infection. According to the Tenth European Consensus Conference on Hyperbaric Medicine recommendations, indications for the application of hyperbaric oxygen therapy are classified according to the strength of evidence, and there is a high level of consensus for the above-described pathology. With this case presentation we wanted to demonstrate that it is possible to resolve severe infections in diabetic foot through the application of hyperbaric oxygen therapy, with the implementation of a multidisciplinary approach.

Possible Applications of Hyperbaric Oxygen Therapy-Narrative Review

Abstract Hyperbaric oxygen therapy is a method supporting the treatment of many diseases. Oxygen therapy treatments are conducted in hyperbaric chambers, in which patients breathe pure, 100% oxygen with higher than atmospheric pressure. This allows to increase the amount of oxygen supplied to all cells of the body many times over. The treatment with hyperbaric oxygen therapy enables the patient to recover faster and be fully active, and also reduces the costs of standard treatment. The aim of the study was to summarize the possible applications of hyperbaric oxygen therapy. The available literature in the PUBMED database was reviewed in September 2022 with the use of the phrases ‘hyperbaric oxygen therapy’, ‘therapeutic applications’. The indications for therapy in a hyperbaric chamber are all kinds of diseases, both acute and chronic. The method supports the nourishment and regeneration of cells and tissues of the organism, and also slows down the aging process. However, due to the possible side effects of such therapy, patients should be qualified for its use after a careful analysis of their clinical condition and coexisting diseases. To sum up: hyperbaric oxygen therapy is most often used in the treatment of skin diseases and injuries, burns, and peripheral vascular diseases.

Application of Hyperbaric Oxygen Therapy in the Skin Diseases Treatment

The hyperbaric oxygen therapy (HBOT) involves the use of 100% pure oxygen in conditions of increased pressure, exceeding atmospheric pressure. This allows the supply of several times more oxygen to internal organs and blood serum than when using standard pressure. HBOT has proven to support the treatment of autoimmune skin diseases, complications of metabolic diseases and burns, as confirmed by clinical studies. In addition, this therapy can also be used to improve the physiological condition of the skin after cosmetology procedures. The aim of this work is to review information on the therapeutic effects of hyperbaric oxygen therapy in the treatment of skin diseases, especially atopic dermatitis, psoriasis, diabetic foot, second degree burns and complications after cosmetic procedures. The review was based on the works published in the last twenty years (1999-2019), available in the following databases: PubMed, GoogleSchoolar, PEDro. The use of HBOT is becoming more common in the treatment of skin complications of diabetes, as well as burn wounds. It is estimated that HBOT reduces the risk of foot ulcers and amputation in diabetic foot syndrome. In addition, HBOT promotes faster healing of burn wounds, also with the use of allogenic skin grafts. By increasing the level of reactive oxygen species (ROS), hyperbaric oxygen therapy significantly supports the treatment of psoriasis and atopic dermatitis. Despite this, the exact mechanisms of hyperbaric oxygen are still poorly understood, and the use of HBOT in the treatment of skin diseases has not yet been included in treatment protocols.

Hyperbaric Oxygen Therapy for Carbon Monoxide Poisoning can Lead a Perfect Result: A Case Report

Carbon monoxide poisoning (COP) is a common emergency worldwide, especially in the wintertime. It is known to cause serious morbidities, resulting in high mortality risk. COP is also reported to result in neurological complications for which hyperbaric oxygen therapy is likely to offer some benefits, which certainly makes it one of the potential treatment modalities. Here, Case in the paper is of a 64-year-old female patient with carbon monoxide poisoning. Her neurological symptoms nearly disappeared after the application of hyperbaric oxygen therapy (HBOT) and conventional medical treatment. Our case guides for the key role of HBOT in the treatment process of a 64-year-old female patient with COP. Our clinical experience revealed that hyperbaric oxygen therapy could successfully reverse the symptoms of delayed neurological findings caused by COP, a serious and preventable health problem.

Non-invasive physical therapy as salvage measure for ischemic skin flap: A literature review.

This review focuses on the available evidence regarding the molecular mechanisms and treatment potential of several non-surgical physical therapies for managing flap ischemia to propose a non-invasive, economical, and simple treatment to improve flap survival. A review of the literature was conducted on the topics of various non-invasive methods for the treatment of ischemic necrosis of the distal end of the flap between 1988 and 2019. A total of 52 published studies were reviewed on the applications of hyperbaric oxygen therapy, electrical stimulation therapy, heat stress pretreatment, phototherapy, and vibration therapy to manage skin flap necrosis. The underlying molecular mechanisms of these physical therapies on revitalizing the dying skin flaps were discussed and preliminary clinical uses of these therapies to salvage the necrotic skin flaps were pooled and summarized for clarifying the safety and feasibility of these methods. Various physical therapy regimens have been ushered to manage necrotic development in cutaneous flaps. With the refinement of these new technologies and enhancement of related basic science research on vascular revitalization, the prevention and treatment of flap ischemia will enter a new era.

Research on the Possibility of Treating Streptococcal Infections with Hyperbaric Oxygenation

Abstract The aim of the study was to determine the effect of the application of hyperbaric oxygen therapy on the course of an infection with group A type T-3 hemolytic β streptococcus. Experiments were carried out on Porton white mice and in vitro blood plates. General and local infections with streptococci were induced in animals. The infected animals were treated with hyperbaric oxygenation. The lethal effect of infection was significantly inhibited using hyperbaric oxygenation on the first and second day following the infection.

Clinical utility of hyperbaric oxygen therapy in dentistry.

This fuller impact of the use of hyperbaric oxygen therapy within dentistry is taking greater notice with newer research findings. There are new advancements in research regarding postradiotherapy cases, osteonecrosis of the jaw, osteomyelitis, periodontal disease, and dental implants. Hyperbaric oxygen therapy can even be used in conjunction with other procedures such as bone grafting. Although the research and clinical utility has come a long way, there are several complications to be mindful of during the application of hyperbaric oxygen therapy.

Might hyperbaric oxygen therapy (HBOT) reduce renal injury in diabetic people with diabetes mellitus? From preclinical models to human metabolomics.

Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure in the western world. Current treatment of diabetic kidney disease relies on nutritional management and drug therapies to achieve metabolic control. Here, we discuss the potential application of hyperbaric oxygen therapy (HBOT) for the treatment of diabetic kidney disease (DKD), a treatment which requires patients to breathe in 100% oxygen at elevated ambient pressures. HBOT has traditionally been used to diabetic foot ulcers (DFU) refractory to conventional medical treatments. Successful clinic responses seen in the DFU provide the underlying therapeutic rationale for testing HBOT in the setting of DKD. Both the DFU and DKD have microvascular endothelial disease as a common underlying pathologic feature. Supporting evidence for HBOT of DKD comes from previous animal studies and from our preliminary prospective clinical trial reported here. We report urinary metabolomic data obtained from patients undergoing HBOT for DFU, before and after exposure to 6weeks of HBOT. The preliminary data support the concept that HBOT can reduce biomarkers of renal injury, oxidant stress, and mitochondrial dysfunction in patients receiving HBOT for DFU. Further studies are needed to confirm these initial findings and correlate them with simultaneous measures of renal function. HBOT is a safe and effective treatment for DFU and could also be for individuals with DKD.

Beneficial Effect of Hyperbaric Oxygen Therapy on an Open Abdominal Laparostomy Wound

Hyperbaric oxygen therapy (HBOT) is the exposure to 100% oxygen at pressures greater than atmospheric pressure. Currently there are several approved applications, and indications for the use of HBOT are increasing. HBOT has been successfully used as adjunctive therapy for wound healing. A 50-year-old female presented at the surgical emergency department with bile-stained discharge from the port site of a laparoscopic cholecystectomy performed 4 days previously. Exploratory laparotomy revealed two perforations in the ileum and edema of the bowel. An ileostomy was constructed, but the abdomen was not closed because of the edematous bowel, and a Bogota bag was placed over the bowel to cover the laparostomy. The abdominal wound was extensive, with exposed loops of bowel. When the wound failed to heal, HBOT was first given on the 10th post-operative day (POD). She had a total of 4 sessions of HBOT with 100% oxygen under 2.5 atmospheres absolute pressure for 60 minutes on PODs 10, 12, 14 and 16. Healthy granulation tissue started appearing over the bowel and wound edges, and impressive wound healing occurred with only 4 60-minute sessions of HBOT. The patient was discharged on POD 20. The application of HBOT for cases of burst abdomen has not been previously documented. This is the first report of its beneficial effect in a single case with an extensive open laparostomy wound. Further studies need to be conducted in order to confirm the therapeutic effect of HBOT on open abdominal wounds.