Introduction: Main tendency in the modern liver surgery is application of parenchyma sparing segmentectomies and mesohepatectomies instead of hemihepatectomies and extended hepatectomies. These procedures are technically demanded and require perfect equipment. Clamp-crashing is the fastest tool of the liver parenchyma dissection, but it is accompanied with the highest blood loss. On the other hand, application of energy devices (radio frequency, harmonic scalpel or bipolar electro cautery) associates with adhesion of the active electrode to the liver tissue and its tearing off leads to more damage of the liver tissue. Materials and methods: We created a new instrument for the liver parenchyma separation, which integrates three principles: clamp-crashing, radio frequency ablation and irrigation. Carrying out 44 liver resections in 42 patients, among them: segmentectomies (16), bisegmentectomies (5), mesohepatectomies (5), hemihepatectomies (10), extended hemihepatectomies (4) and atypical resections (4), we compered blood loss and duration of the surgery applying three devices bipolar electro cautery (n = 19), harmonic scalpel (n = 7) and our instrument (n = 18). Results: Mean blood loss applying our instrument came to 627,04 ± 161,89 ml, applying harmonic scalpel – 1652,29 ± 624,50 ml (p = 0.008) and bipolar electro cautery – 811.01 ± 225,08 ml. Mean duration of the procedure came to 301,67 ± 26,08 min, 386,14 ± 40.40 min and 360,15 ± 29,31 min (p = 0.104) respectfully. Conclusion: Integration of three principles: clamp-crashing, radio frequency ablation and irrigation in one instrument for the liver parenchyma dissection enables to reach less blood loss then application of harmonic scalpel.