Application Of Electrostimulation Research Articles

Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.

Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments. Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel compositesis reported. A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions. These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability. This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.

Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites

AbstractEutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water‐free environments. Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported. A fluorescent glutamic acid‐derived low‐molecular‐weight gelator (LMWG) was found to self‐assemble into nanofibrillar networks in deep eutectic solvents (DES)/poly(3,4‐ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions. These dynamic materials displayed excellent injectability and self‐healing properties, high ionic conductivity (up to 10−2 S cm−1), good biocompatibility, and fluorescence imaging ability. This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.

Electrical therapies act on the Ca2+/CaM signaling pathway to enhance bone regeneration with bioactive glass [S53P4] and allogeneic grafts

This study aimed to investigate the application of low-intensity electrostimulation (ES) and electromagnetic stimulation (EM) associated with bioactive glass (BG) or allogeneic grafts (BB) in bone regeneration. A cell viability test on osteoblasts (UMR-106) was performed in the presence of BB and BG grafts associated with ES (10μA/5min) and EM (500 Hz/2min). Critical defects (25 mm2 ) in calvaria were generated in male Wistar rats, and bone regeneration was evaluated on the 30th, 60th, and 120th days after surgery. Cell proliferation increased with the application of ES in both grafts and after EM with BG. Bone remodeling was more effective using the allogeneic graft in both therapies, with increased angiogenesis, osteoblast proliferation, and OPN expression in the BB + EM group. A higher number of osteoblasts and osteoclasts, and an increase in bone sialoprotein, Runx-2, and Opn gene expression were found in the BB + ES group. The BG graft associated with EM therapy had an increased proliferation of osteoblasts and increased expression of Runx-2 and Opn. Groups that had BG and ES therapy had increased numbers of osteoblasts, osteoclasts, and increased OPN expression. The expression of voltage-gated calcium channels increased in groups with ES, while calmodulin expression increased in therapies without grafting. ES and EM therapies favored the repair of bone defects upon grafting by improving angiogenesis, osteogenic gene expression, and tissue reorganization. Despite activating different pathways, both therapies increased the intracellular concentrations of calmodulin, leading to cell proliferation and bone regeneration.

Improve of dysphagia with electrostimulation after a stroke

Patients who have suffered a stroke may have dysphagia in more than 30% of cases. When the alteration is located in the bulbar area, since the neural control of swallowing is located at the bulbar level, where the centers responsible for processing the afferent sensory signals and programming the motor deglutory sequence are located this percentage increases. The goal of treatment is to obtain secure and sufficient oral intake for adequate hydration and nutrition. Treatment techniques are designed to change the physiology of swallowing. Neuromuscular electrical stimulation can also be performed as studies have shown that this treatment appears to help people with moderate dysphagia. Clinical observation: we present the case of a 44-year-old woman who suffered laterobulbar ischemic Ictus. The physical exam, showed dysarthria, facial paresis and limb dysmetry without motor deficit and severe alteration of swallowing. Fibroendoscopic studies were performed and oral diet was contraindicated thus enteral nutrition was required from the time of admission. Speech therapy plus the application of electrostimulation was initiated. After 4 months of treatment, enteral nutrition was removed and the patient was able to change to a complete oral diet. Patients who are diagnosed of a bulbar stroke have a high percentage of swallowing dysfunction. Swallowing therapy with electrical stimulation may help clinical improvement of dysphagia.

PEDOT-CNT Composite Microelectrodes for Recording and Electrostimulation Applications: Fabrication, Morphology, and Electrical Properties.

Composites of carbon nanotubes and poly(3,4-ethylenedioxythiophene, PEDOT) and layers of PEDOT are deposited onto microelectrodes by electropolymerization of ethylenedioxythiophene in the presence of a suspension of carbon nanotubes and polystyrene sulfonate. Analysis by FIB and SEM demonstrates that CNT–PEDOT composites exhibit a porous morphology whereas PEDOT layers are more compact. Accordingly, capacitance and charge injection capacity of the composite material exceed those of pure PEDOT layers. In vitro cell culture experiments reveal excellent biocompatibility and adhesion of both PEDOT and PEDOT–CNT electrodes. Signals recorded from heart muscle cells demonstrate the high S/N ratio achievable with these electrodes. Long-term pulsing experiments confirm stability of charge injection capacity. In conclusion, a robust fabrication procedure for composite PEDOT–CNT electrodes is demonstrated and results show that these electrodes are well suited for stimulation and recording in cardiac and neurophysiological research.

Application of electrostimulation in the treatment of pain syndrome in diseases of the peripheral nervous system

Diseases of the peripheral nervous system account for almost half of the neurological morbidity of the adult population. One of the leading clinical signs of peripheral nervous system disorders is pain. With all the commonplace simplicity of the concept "pain", the scientific definition of this specific feeling is associated with significant difficulties of epistemological nature. One of the essential moments of correct understanding and estimation of pain phenomenon is its division into primary and secondary, which is based on the classification suggested by Gode in 1881, which distinguishes protopathic and epicritic pain, that is identical to division of pain into acute and chronic.

Applications of Electrostimulation in Physical Conditioning

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Applications of Electrostimulation in Physical Conditioning: A Review

Applications of Electrostimulation in Physical Conditioning: A Review