Introduction: Vital tooth preparation necessitates the application of desensitizing agents due to hypersensitivity that arises out of trauma. Many desensitizing agents are currently available in the market. One must, however, note that such an application creates a barrier between the tooth cement interfaces that may alter retention. This study investigates the same. Aim: The aim of this study was to compare the effect of two desensitizing agents on crown retention using resinomer cement. Materials and Methods: Thirty-three extracted human maxillary first premolar teeth were selected for the study, which was prepared using a special assembly and divided into three groups, i.e., (R + U, R + G, and R) to compare the effect of GLUMA and ULTRASEAL on crown retention using resinomer cement significant. Conclusion: The application of GLUMA desensitizing agent to resinomer cement resulted in an increase in retention that was statistically significant. ULTRASEAL is ill-suited to combine with resinomer cement.
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