Applications Of Carbon Dots Research Articles

Advances in the study of the biological activity of polysaccharide-based carbon dots: A review.

Carbon dots have attracted worldwide interest due to their customizable nature, luminescent properties, and exceptional biocompatibility. In particular, biomass-derived carbon dots have attracted attention for their environmentally friendly and cost-effective synthesis. Recent research looks into how polysaccharides can be used to make carbon dots. Using them as starting materials for nanomaterials has benefits in terms of structure, morphology, and doping elements. Although research has extensively examined the optical properties of carbon dots, their potential biological applications have not been thoroughly investigated. This review mainly summarises the cytotoxicity and biological functions of polysaccharide-based carbon dots (e.g. agar, alginate, cellulose, carrageenan, chitosan, chitosan, starch, gelatin, etc.), such as antioxidant, antibacterial and anti-tumor functions, highlighting the different scenarios of the methods of preparation of carbon dots. The applications of carbon dots in food, biomedical sciences, soil fertilization, and power generation are highlighted by reviewing the low toxicity of carbon dots with safety and biocompatibility in human contact. Finally, the importance and challenges of polysaccharide-based carbon dots and the prospects and research directions of polysaccharide-based carbon dots are explained by comparing them with other nanomaterials.

Ratiometric Fluorescent pH Sensing with Carbon Dots: Fluorescence Mapping across pH Levels for Potential Underwater Applications.

Ocean acidification has become a major climate change concern requiring continuous observation. Additionally, in the industry, pH surveillance is of great importance. Consequently, there is a pressing demand to develop robust and inexpensive pH sensors. Ratiometric fluorescence pH sensing stands out as a promising concept. The application of carbon dots in fluorescent sensing presents a compelling avenue for the advancement of pH-sensing solutions. This potential is underpinned by the affordability of carbon dots, their straightforward manufacturing process, low toxicity, and minimal susceptibility to photobleaching. Thus, investigating novel carbon dots is essential to identify optimal pH-sensitive candidates. In this study, five carbon dots were synthesized through a simple solvothermal treatment, and their fluorescence was examined as a function of pH within the range of 5-9, across an excitation range of 200-550 nm and an emission range of 250-750 nm. The resulting optical features showed that all five carbon dots exhibited pH sensitivity in both the UV and visible regions. One type of carbon dot, synthesized from m-phenylenediamine, displayed ratiometric properties at four excitation wavelengths, with the best results observed when excited in the visible spectrum at 475 nm. Indeed, these carbon dots exhibited good linearity over pH values of 6-9 in aqueous Carmody buffer solution by calculating the ratio of the green emission band at 525 nm to the orange one at 630 nm (I525nm/I630nm), demonstrating highly suitable properties for ratiometric sensing.

Cellulose Nanorods Modified with Polyethylenimine and Carbon Dots for Applications as Piezoelectric and Fluorescent Materials

Cellulose Nanorods Modified with Polyethylenimine and Carbon Dots for Applications as Piezoelectric and Fluorescent Materials

Application of Carbon Dots as Antibacterial Agents: A Mini Review

Application of Carbon Dots as Antibacterial Agents: A Mini Review

Carbon Dots an Integrative Nanostructure for Fluorescent Bio-imaging, Targeted Delivery of Medication and Phototherapy in Malignancy: A Review

Background: Silent onset and metastasis in tissues make cancer the most devastating illness globally. Monitoring the growth of the tumour and delivering drugs to specific tissues are some of the major issues associated with treatment. However, with an improved understanding of tumour microenvironments and advancements in nanocarriers of drugs, novel nano-targeting pathways that can be utilised by nanocarriers have been developed. Carbon Dots, with their tiny size and outstanding physicochemical features, are an emerging category of carbon nanostructures that have attracted a lot of curiosity. Objective: Multitudinous attempts and extensive studies have been undertaken by many researchers regarding the synthesis of Carbon Dots and their applications in various fields. These studies have explained that the synthesised Carbon Dots have versatile surface functionalities, high luminescence, and excellent biocompatibility. This article focuses on recent developments in synthesis approaches, carbon precursors used, and applications of Carbon Dots, specifically within the biomedical field, with a particular focus on cancer. Results: Carbon dots synthesised from a variety of precursors can act as prominent candidates for bioimaging and drug carriers and are used in cancer phototherapy. In this article, Carbon Dots are summarised based on their bright luminescent properties, distinct structure, drug loading capacity, and near-infrared (NIR) emission. Conclusion: Carbon dots, employed as tumour theranostics, can serve as an alternative to synthetic fluorescent dyes. They fulfil the role of bioimaging agents and facilitate the precise delivery of drugs to cancer cells. Additionally, they exhibit excellence as phototherapeutic agents, featuring high nearinfrared (NIR) emission and minimal side effects.

The Intersection of Nanotechnology and Urban Agriculture: Applications of Carbon Dots

Amidst the ongoing urbanization process, the significance of urban agriculture has garnered increasing attention. With the expansion of urban population, the urban landscape broadens, and agriculture becomes more commercialized, the...

Fluorometric Sensing of Metal Ions by Carbon Nano Dots - A Review

abstract: Contamination from heavy metal ions is a rising problem. It has direct and indirect impacts on human health, the environment, and aquatic life. Thus, detecting trace amounts of these elements presents significant challenges. It is important to develop effective, affordable, accurate, fast sensing monitoring systems. A new field of sensing techniques has emerged with the discovery of bio-compatible fluorescent carbon nanodots. Although the study of heavy metal ion detection using carbon nanodots and fluorometric sensing techniques is relatively new and developing, it holds great potential for aiding scientists in the development of environmentally friendly sensing systems. This article focuses on the utilization of carbon nanodots in fluorescencebased detection of metal ions in various media. The ability to emit fluorescence across the entire visible spectrum under UV and visible light excitation offers fluorescent quenching or fluorescent enhancement phenomena in the presence of trace amount of metal ions. The present work discusses different fluorometric sensing phenomena, its mechanism and applications of carbon dots on it. It covers the recent progress in carbon-nano dots for bio-based synthesis, physical properties, and application in heavy metal sensing.

Properties, synthesis, and applications of carbon dots: A review

Properties, synthesis, and applications of carbon dots: A review

Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal of In Vitro and In Vivo Studies.

In recent decades, several studies demonstrating various applications of carbon dots (C-dots), including metal sensing, bioimaging, pH sensing, and antimicrobial activities, have been published. Recent developments have shifted this trend toward biomedical applications that target various biomarkers relevant to chronic diseases. However, relevant developments and research results regarding the anti-inflammatory properties of C-dots against inflammation-associated diseases have not been systematically reviewed. Hence, this review discusses the anti-inflammatory effects of C-dots in in vivo and in vitro models of LPS-induced inflammation, gout, cartilage tissue engineering, drug-induced inflammation, spinal cord injury, wound healing, liver diseases, stomach cancer, gastric ulcers, acute kidney and lung injury, psoriasis, fever or hypothermia, and bone tissue regeneration. The compiled studies demonstrate the promising potential of C-dots as anti-inflammatory agents for the development of new drugs.

Synthetic Methods and Applications of Carbon Nanodots

In the recent decade, carbon dots have drawn immense attention and prompted intense investigation. The latest form of nanocarbon, the carbon nanodot, is attracting intensive research efforts, similar to its earlier analogues, namely, fullerene, carbon nanotube, and graphene. One outstanding feature that distinguishes carbon nanodots from other known forms of carbon materials is its water solubility owing to extensive surface functionalization (the presence of polar surface functional groups). These carbonaceous quantum dots, or carbon nanodots, have several advantages over traditional semiconductor-based quantum dots. They possess outstanding photoluminescence, fluorescence, biocompatibility, biosensing and bioimaging, photostability, feedstock sustainability, extensive surface functionalization and bio-conjugation, excellent colloidal stability, eco-friendly synthesis (from organic matter such as glucose, coffee, tea, and grass to biomass waste-derived sources), low toxicity, and cost-effectiveness. Recent advances in the synthesis and characterization of carbon dots have been received and new insight is provided. Presently known applications of carbon dots in the fields of bioimaging, drug delivery, sensing, and diagnosis were highlighted and future applications of these astounding materials are speculated.

Synthesis, Characterization, and Applications of Carbon Dots: A Review

Synthesis, Characterization, and Applications of Carbon Dots: A Review

The application of carbon dots in tumor immunotherapy: Researches and prospects

AbstractSince the rapid development of nanomedicine in oncotherapy, multiple nanomaterials are adopted to regulate the immune system in cancer individuals. Tumor immunotherapy enhances the immune function of patients to achieve the purpose of killing tumor cells by utilizing the organism immune mechanism. As emerging inorganic carbon nanoparticles, carbon dots (CDs) have been found as photosensitizers, vaccines, immunoadjuvants, and so on for cancer treatment due to their unique structure and property, such as effective platforms for drug delivery, immunomodulation, and phototherapy. In this review, we mainly discuss the recent application of CDs in tumor immunotherapy and the prospects of CDs in the field of immune medicine. By assessing the achievements and challenges of CDs in tumor immunotherapy, our review would provide mechanistic insights into the evolution of future nanomedicine.

Carbon Dot Emission Enhancement in Covalent Complexes with Plasmonic Metal Nanoparticles.

Carbon dots can be used for the fabrication of colloidal multi-purpose complexes for sensing and bio-visualization due to their easy and scalable synthesis, control of their spectral responses over a wide spectral range, and possibility of surface functionalization to meet the application task. Here, we developed a chemical protocol of colloidal complex formation via covalent bonding between carbon dots and plasmonic metal nanoparticles in order to influence and improve their fluorescence. We demonstrate how interactions between carbon dots and metal nanoparticles in the formed complexes, and thus their optical responses, depend on the type of bonds between particles, the architecture of the complexes, and the degree of overlapping of absorption and emission of carbon dots with the plasmon resonance of metals. For the most optimized architecture, emission enhancement reaching up to 5.4- and 4.9-fold for complexes with silver and gold nanoparticles has been achieved, respectively. Our study expands the toolkit of functional materials based on carbon dots for applications in photonics and biomedicine to photonics.

Applications of Carbon Dots (CDs) in Drug Delivery

The star of the carbon nanomaterials industry is now carbon dots (C-Dots). C-Dots are a potential tool because of their applications in imaging, environmental, catalytic, biological, and energy fields thanks to their numerous distinctive physicochemical and photochemical characteristics. C-Dots have received plenty of research attention and have shown remarkable application growth to date. Green biomass or sustainable raw materials may be used to create C-Dots since they are economical, cost-effective, and most significantly, they encourage waste reduction. However, there is still a problem that must be solved regarding the production of high-quality C-Dots from biomass waste. Chemotherapy is currently recognized as the most successful way of cancer treatment, although it is known to induce severe side effects in patients due to its non-discriminatory harmful impact on both normal and tumor cells. The fundamental issue in cancer and other complicated disorders of chemotherapy is understanding drug distribution throughout organs and designing a site-specific drug delivery method that targets cancer cells. Therefore, it is of crucial importance to create advanced routes for the targeted and traceable administration of anti-cancer drugs. C-Dots can be produced using top-down or bottom-up approaches, with the latter method being more frequently employed for high-volume and low-cost syntheses. In this comprehensive review article, we mainly discuss the structure of CDs, classification of CDs, their properties, limitations, source of CDs, fabrication techniques, and characterization techniques. More significantly, we bring readers update on the most recent trends of CDs development in health care.

Recent advances in carbon dots: synthesis and applications in bone tissue engineering.

Bone tissue engineering (BTE), based on the perfect combination of seed cells, scaffold materials and growth factors, has shown unparalleled potential in the treatment of bone defects and related diseases. As the site of cell attachment, proliferation and differentiation, scaffolds composed of biomaterials play a crucial role in BTE. Over the past years, carbon dots (CDs), a new type of carbon-based nanomaterial, have attracted extensive research attention due to their good biocompatibility, unique optical properties, and abundant functional groups. This paper reviews recent research progress in the use of CDs in the field of BTE. Firstly, different preparation methods of CDs are summarized. Then, the properties and categories of CDs applied in BTE are described in detail. Subsequently, the applications of CDs in BTE, including osteogenesis, fluorescence tracing, phototherapy and antibacterial activity, are presented. Finally, the challenges and future perspectives of CDs in BTE are briefly discussed to give a comprehensive picture of CDs. This review provides a theoretical basis and advanced design strategies for the application of CDs in BTE.

Applications of Carbon Dots in Electrochemical Energy Storage

As one kind of carbon nanomaterials, since their discovery at the beginning of the century, carbon dots (CDs) have been attracting extensive attention in sensing, bioimaging, catalysis, organic light-emitting diodes, etc. due to their rich and diverse physical and chemical properties. Although the precise structures of CDs need to be further analyzed and elaborated, it is confirmed that there are many functional groups on the surfaces including amino, hydroxyl, carboxyl and thiol, depending on the precursors and preparation processes used. The crystalline/amorphous conjugated graphite-like sp2 domains and segments inside the CDs provide good electrical conductivity and photoelectric conversion capability. The applications of CDs in electrochemical energy storage have been carried out extensively and become a hot topic in recent years. In this review, the recent progress about the applications of CDs in typical electrochemical energy storage devices including supercapacitors, lithium-ion batteries, sodium-ion batteries and potassium-ion batteries is outlined and summarized. The relationships between material structures and device performances are mainly analyzed. Finally, it is anticipated that the development of CDs can continuously boost the study of high-efficiency energy storage devices profoundly.

Carbon nanomaterials for drug delivery and tissue engineering.

Carbon nanomaterials are some of the state-of-the-art materials used in drug-delivery and tissue-engineering research. Compared with traditional materials, carbon nanomaterials have the advantages of large specific surface areas and unique properties and are more suitable for use in drug delivery and tissue engineering after modification. Their characteristics, such as high drug loading and tissue loading, good biocompatibility, good targeting and long duration of action, indicate their great development potential for biomedical applications. In this paper, the synthesis and application of carbon dots (CDs), carbon nanotubes (CNTs) and graphene in drug delivery and tissue engineering are reviewed in detail. In this review, we discuss the current research focus and existing problems of carbon nanomaterials in order to provide a reference for the safe and effective application of carbon nanomaterials in drug delivery and tissue engineering.

Research advances on the application of carbon dots in wound treatment

Chronic and infectious wound healing has always been an issue of concern in clinical and scientific research, in which bacterial infection and oxidative damage are the key factors hindering wound healing. Carbon dots, as a new material, has attracted much attention because of its unique physical and chemical properties and good biological safety. In recent years, the researches on the antibacterial property, antioxidant, and photoluminescence properties of carbon dots are more and more extensive and carbon dots have great potential in the treatment of chronic and infectious wounds. This paper reviews the research progress of carbon dots in three aspects: antibacterial, anti-oxidation and monitoring of wound infection are reviewed, and further discusses its specific mechanism, potential research direction, and application prospect.

Application of Carbon Dots as Corrosion Inhibitor: A Systematic Literature Review

Corrosion is spontaneity and unavoidable reactions which cause degradation in the quality of the materials. Most industries have been harmed by the corrosion of manufacturing equipment. Several methods can be applied to control this problem. The use of corrosion inhibitors is an effective and practical way to decrease metal deterioration significantly. Many commercial inorganic and organic compounds are effective inhibitors, but most of them are not completely safe and relatively expensive. Carbon dots and their derivatives are potential compounds for resolving corrosion reactions on metal surfaces. Carbon dots can be synthesized from various natural sources to be more environmentally friendly. This systematic review aims to summarize the concept of corrosion, types of carbon dots-based corrosion inhibitor and their effectiveness on various metals, inhibition mechanism, surface analysis of the protected metals, kinetics, thermodynamics, and quantum computational chemistry studies. This review also presents the significance and the prospects of carbon dots-based corrosion inhibitors.

Trophic transfer and environmental safety of carbon dots from microalgae to Daphnia

The application of carbon dots (CDs), a novel carbon nanomaterial, is extensive, leading to inevitable CD pollution. However, studies on their environmental fate and related risks to aquatic ecosystems are limited. Here, the trophic transfer of CDs from Chlorella pyrenoidosa to Daphnia magna and their toxic effects on the two organisms were analyzed. 14C-labelling was used to quantify and evaluate the fate of CDs. The results showed that the radioactivity of CDs in water was >80 % of the initial radioactivity, and that water extractable residues were dominant in organisms, with only 3 % or less recovered from the mineralization product 14CO2. The distribution of radioactivity illustrated how the exposure routes changed the fate of CDs in aquatic environments. CD aggregates were found in algal cells and Daphnia intestinal tract, indicating the cellular uptake of CDs in these aquatic organisms. Wall-membrane detachment, cell collapse, and rupture were observed in the ultrastructural investigations of microalgae, whereas pneumatosis cystoides intestinalis was observed in the ultrastructural investigations of D. magna. CD exposure affected the growth and chlorophyll content of C. pyrenoidosa as well as the feeding behavior, oxidative stress system, digestive system, and symbiotic bacteria of D. magna. The toxicity of CDs is also affected by the route of exposure. These findings suggest that dietary exposure to CDs was more likely to cause environmental risk and adverse effects than aqueous exposure, and the environmental risks associated with CDs should not be underestimated.