Appearance Of Nephritis Research Articles

Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor

BackgroundImmune checkpoint inhibitors have become the first line therapy in melanoma treatment and their use is extending to other malignancies. However, we are still learning about immune side effects produced by these drugs and their severity especially in patients with history of inflammatory diseases.Case presentationWe present two cases of metastatic melanoma treated with nivolumab and pembrolizumab (anti PD-1). Both patients developed acute interstitial nephritis during immune checkpoint therapy. We emphasize the causal association between immune checkpoint inhibitors and the nephritis. The timing of drug administration and appearance of nephritis is suggestive of a causal relation between the checkpoint inhibitor therapy and this adverse event.ConclusionsAlthough uncommon, some side effects from checkpoint inhibitors can be severe and may need to be addressed with immunosuppression. Given the increasing frequency of immunotherapy use, awareness should be raised in regards to immune side effects and their appropriate management.

Renal manifestations of Henoch–Schönlein purpura in a 6-month prospective study of 223 children

ObjectiveTo assess the risk factors for developing Henoch–Schönlein purpura nephritis (HSN) and to determine the time period when renal involvement is unlikely after the initial disease onset.DesignA prospective study of...

Appearance of nephritis associated with type 57 streptococcal impetigo in North America.

Four cases of acute glomerulonephritis associated with M-Type 57 streptococcus occurred at the Red Lake Indian Reservation during the summer of 1969. Prospective studies point to the skin as the initial site of infection in these patients. Two patients and four siblings were under continuous observation for more than a month before and after development of nephritis. In all patients with nephritis throat cultures were negative for Group A streptococci, and no pharyngitis preceded onset. In four of the six children from the nephritis family, the M-57 strain was isolated from normal skin sites before development of skin lesions. In all cases, appearance of the strain on the normal skin preceded recovery from the upper respiratory tract. In two patients with renal disease the nephritogenic strain reappeared on normal skin after antibiotic therapy, followed by recurrence of skin lesions due to Type 57 in one patient.

馬杉腎炎に及ぼす下垂体, 副腎皮質ホルモンの影響

With pituitary-adrenocortical hormon (DOCA, Cortisone and ACTH) administed to rabbits with Masugi-nephritis, a study was made of the influence of these hormones on the appearance of nephritis from the view points of variation of blood pressure, albuminuria, a decrease of the complement and the variation of serum protein accompanied by a histological survey.(1) When DOCA was given, variation of blood pressure, the appearance of albuminuria and a decrease of the complement were found at the earlier stage than a control case.It was also considered that the appearance of nephritis and severity of the disease were accelerated, on the basis of serum protein and from a histological view point.(2) In case of Cortisone and ACTH, as to variation of blood presure, the apperance of albuminuria and a decrease of the complement, changes were not so remarkable as in a control case. In that respect Cortisone and ACTH did not seem to check the appearance of nephritis.Although it was interesting that some qualitative variation had developed in Masugi-nephritis, pathological changes in the glomerulus had been mitigated especially following the administration of Cortisone. Still, a nephrotic pattern was indicated in serum protein of each case as mentioned above.