Apparent Molar Isentropic Compressibility Research Articles

A study of enhancing the solubility of streptomycin sulphate in sorbitol using volumetric, acoustic and viscometric properties

The various molecular interactions present between streptomycin sulphate and sorbitol were evaluated using density (ρ), speed of sound (u) and viscosity (η) studies. All these studies have been obtained at different temperatures (300.15, 305.15, 310.15 ad 315.15) K and at 0.1 MPa pressure. The values obtained from these studies have been utilized to calculate the various thermodynamic parameters such as apparent molar volume (ΦV), apparent molar isentropic compression (ΦK), partial molar volume (ΦVo), partial molar isentropic compression (ΦKo), partial molar expansibility (ΦEo) of solute for SMS in various solutions of sorbitol. The data obtained from viscosity studies have been utilized to determine Falkenhagen coefficient (A), Jones- Dole coefficient (B), dB/dT and viscosity B-coefficient of transfer (Btr). A complete discernment into the physicochemical interactions present in the studied system have been redeemed through the scrutiny of above calculated parameters.

Structural elucidation of ternary mixtures of L‐valine/glycyl‐L‐valine and water + 1‐decyl‐3‐methylimidazolium bromide: Apparent molar properties at infinite dilution and expansivities

AbstractThis work comprises ternary systems of water + SAIL,1‐decyl‐3‐methylimidazolium bromide, and (S)‐2‐Amino‐3‐methylbutanoic acid generally identified as L‐valine/ (S)‐2‐(2‐Aminoacetamido)‐3‐methylbutanoic acid usually described as glycyl‐L‐valine, densities, and sound speed data have been computed at four operating temperatures, i.e., 288.15 to 318.15 K. Calculated density data have utilized for calculation of various thermodynamic parameters like Vϕ (apparent molar volume), (apparent molar volumes at infinite dilution), and calculated speed of sound statistics used to determine Kϕ,s (apparent molar isentropic compression), Ks (partial molar isentropic compression at infinite dilution). In our systems, the hydrophilic‐ionic interactions that are produced by co‐sphere overlap models are predominant. The Hepler's constant is used to analyze the solute's capacity to create or destroy solvent structures. The interaction parameter is computed using the McMillan‐Mayer theory. Understanding structure‐making, solvation characteristics, and numerous modifications in the ternary system of L‐valine/Glycyl‐L‐valine, water, and [C10MIm] [Br] is aided by a variety of thermodynamic factors.

Physiochemical study of 1-methyl imidazole trifluoro methane sulfonate ionic liquid in aqueous and aqueous amino acid solutions at different temperatures

The experimental density and speed of sound of 1-methyl imidazole trifluoro methane sulfonate ionic liquid in aqueous binary ([MIm][OTf]+H2O) solution and aqueous ternary ([MIm][OTf] + 0.05 mol.kg−1 aqueous glycine) solution are reported in the dilute concentration range (0.06 to 0.16 mol.kg−1) at the temperature between 288.15 and 318.15 K with 5K interval and at atmospheric pressure. These density (ρ) and speed of sound (u) data are utilized to derive various significant thermophysical parameters namely apparent molar volume of solute (Vϕ), isentropic compressibility of solution (κs) and apparent molar isentropic compressibility of solute (KS,ϕ). The limiting apparent molar volume (Vϕ0) and limiting apparent molar isentropic compressibility (KS,ϕ0) of [MIm][OTf] are estimated by extrapolation methods. By using Vϕ0and KS,ϕ0data of the studied binary and ternary systems, the values of transfer volumes i.e. volume changes due to transfer (ΔtrVϕ0)and transfer compressibility i.e. compressibility changes due to transfer(ΔtrKsϕ0) from aqueous to aqueous amino acid solution are estimated. The observed ΔtrVϕ0and ΔtrKsϕ0values are temperature dependent. The outcomes of this investigation are framed within the context of solute-solute and solute-solvent interactions.

Physicochemical studies of adenosine in the presence of aqueous caffeine and theophylline solutions, & sodium valproate with γ‐amino butyric acid in aqueous medium at T = (288.15–318.15) K and at p = 1 × 105 Pa

AbstractIn human body, drug‐neurotransmitter interactions have been the most significant process. Whereas, adverse reactions may be accompanied by unexpected interaction, which puts an individual in danger of life. Thus, the interactions between adenosine (ADN) and sodium valproate (SV) with caffeine (CAF), theophylline (TPY) and γ‐amino butyric acid (GABA) have been studied. Various properties like densities, ρ and speed of sound, u, have been used to calculate apparent molar volumes (V2,ϕ) and apparent molar isentropic compression (Ks,2,ϕ) for ADN and SV in aqueous (5, 10, 15 and 20 mmol kg−1) CAF, TPY and GABA solutions at T = (288.15–318.15) K and at pressure p = 1 × 105 Pa. The results of various interactions that occurred by mixing the solutions have been interpreted. Exothermicity is indicated by the negative values of standard molar enthalpy of transfer, ΔtrΔdilH0, obtained from the calorimetry. UV‐absorption and 1H NMR studies suggest that there is a dominance of solute‐cosolute interactions due to hyperchromic shift and shielding effect.

Thermo-acoustic properties of monosaccharides D(−)-ribose and D(+)-xylose in aqueous diammonium hydrogen phosphate solutions at different temperatures

The volumetric and acoustic properties are used for investigating the interactions of polyhydroxy solutes D(−)-ribose and D(+)-xylose in different concentrations of diammonium hydrogen phosphate (DAP) solutions. Densities and speeds of sound of D(−)-ribose and D(+)-xylose in aqueous diammonium hydrogen phosphate (DAP) solutions have been measured over a temperature range of (298.15–318.15) K and at experimental pressure p = 0.1 MPa. Different parameters viz apparent molar volumes, Vϕ, partial molar volumes, apparent molar isentropic compression, partial molar isentropic compression, partial molar volume of transfer and molar isentropic compression of transfer are obtained using experimental density and ultrasonic speed data. The calculated parameters are discussed in rapports of solute–solvent interactions in solutions indicated the presence of ion-ion, ion-polar, hydrophilic-hydrophilic and hydrophobic–hydrophobic interactions in these ternary solutions, which was also confirmed from obtained positive values of apparent molar volume and negative values of apparent molar isentropic compressibility. Pair (VAB, KAB) and triplet (VABB, KABB) interaction coefficients determined by means of McMillan-Mayer theory are used to acquire valuable information about the dominance of pairwise interactions in the studied mixtures.

Probing molecular interactions of an anti-epileptic drug, sodium valproate in aqueous MgCl2 solutions

Study of the physicochemical properties of anti-epileptic drugs in the presence of cosolutes in aqueous solutions has been a subject of interest of researchers because of their interaction with biological membranes to employ their effect. Such properties provide complete information regarding solute-solute and solute-solvent type interactions. As electrolytes are essential components of biological systems, therefore the study of drug-electrolyte chemistry is important to understand the mechanism of drug action at the molecular level and hence useful in drug design and development processes. Therefore, in the current report, the density and sound velocity of an anti-epileptic drug sodium valproate (SV) in aqueous and in aqueous solutions of an electrolyte viz. MgCl2 (mB = 0.024, 0.047, 0.070 mol kg−1) at different temperatures (288.15, 298.15, 308.15, and 318.15 K) and at a pressure of 0.101 MPa were measured along with 1H NMR spectroscopy. Various volumetric and acoustical parameters such as apparent molar volume (Vφ) and isentropic compressibility (Kφ) of the solute, apparent molar volume (Vφ°) and isentropic compressibility (Kφ°) of solute at infinite dilution, apparent molar expansibility (Eφ°) and their double derivatives (∂2Vφ°/∂T2)P, transfer volumes (∆trVφ°), hydration number (nH), acoustic impedance (Z), intermolecular free length (Lf), Wada's constant (W) and Rao's constant (R) were calculated from density and sound velocity data. The variation in all these parameters with cosolute concentration indicates the existence of hydrophilic/ionic-ionic interactions at lower concentrations but hydrophobic-ionic interactions at higher concentrations of MgCl2. The 1H NMR spectroscopic results also support the existence of hydrophobic-ionic interactions at higher concentrations of MgCl2. The decrease in electrostriction but increase in hydrophobic hydration of solute molecules has also been seen with rise in temperature.

Volumetric-acoustic investigations of antihypertensive drug in aqueous acetaminophen system

Captopril is an antihypertensive drug used to lower the blood pressure in living organisms. In order to arbitrate and understand the synergy between antihypertensive drug viz., captopril and antipyretic drug acetaminophen in aqueous system, the density and sound velocity at different temperatures (293.15 to 318.15) K with temperature interval of 5 K were measured using Anton Paar density sound velocity meter (DSA5000M). The experimental measured data were further used to calculate volumetric and acoustic parameters such as apparent and partial molar volume, apparent and partial molar isentropic compressibility, partial molar expansibility, Hepler’s constant, compressibility hydration number, and intermolecular free length. Positive values of apparent molar volume (ϕv) and negative values of apparent and partial molar compressibility (ϕk and ϕko) of captopril in water and aqueous acetaminophen solution has been shown strong intermolecular interactions in solutions. Negative values of Hepler's constant indicate the structure breaking behavior of drug in water.

Toward an understanding of volumetric and isentropic compressibility behavior of imidazolium-based ionic liquids in aqueous polymer solutions

ABSTRACT A systematic experimental density and sound velocity measurement was carried out for imidazolium-based ionic liquids (ILs) in pure water and in aqueous solutions of 0.03 w/w of water-miscible polymers with different structures and molar masses at T= (288.15, 293.15, 298.15, 303.15 and 308.15) K and p = 84.5 kPa. The ILs under investigation are 1-butyl-3-methylimidazolium hydrogen sulphate ([C4mim][HSO4]) and 1-butyl-3-methylimidazolium bromide ([C4mim]Br). The effects of temperature, polymer type, and IL anion type on the various volumetric and compressibility properties, such as apparent molar volume, isentropic compressibility, apparent molar isentropic compressibility, and infinite dilution apparent molar properties for transfer of ILs from water to aqueous polymer solution were scrutinised. From the gathered results, ion-water interactions, ion-ion interactions at finite concentration, and water-structure breaking character for aqueous solutions of [C4mim][HSO4] are more considerable than aqueous solutions of [C4mim]Br. However, [C4mim]Br-polymer interactions are more favourable than interactions between [C4mim][HSO4] and the studied polymers.

Thymoquinone-Micellar Interactions: A physico-chemical investigation at molecular level

Thymoquinone (TQ) is considered the most-active component of the well-known essential oil of the black cumin/seeds (Nigella sativa L.), also known for its wide-spectrum anticancer and other pharmacological potentials since ancient times. Apart from its thermo- and photo-sensitive nature, TQ has also been reported to demonstrate strong hydrophobicity and low bioavailability. These physico-chemicals, properties hinder the development of a successful oral dosage formulation. Interaction of the pharmacologically active molecule with biological membranes is crucial step to manifest health-related effects. However, further insight into the biophysical interactions of “active” natural chemotherapeutics with cellular membranes can play a vital role in designing and developing new anti-cancer regimens. In this context pseudo-membrane models comprising ionic and non-ionic micelles offer a useful way to explore in vitro drug-membrane interactions at the molecular level. The present study focuses on the physicochemical interactions of a thymoquinone (TQ) with micelles of ionic (dodecyl trimethylammonium bromide, DTAB; and sodium dodecyl sulfate, SDS) and non-ionic (tween-80 and TX-100) surfactants at the molecular level in aqueous medium. Volumetric and acoustic parameters (apparent molar volume (ɸV), isentropic compressibility (Ks), apparent molar isentropic compressibility (ɸk), specific acoustic impedance (Z), relative association (RA), intermolecular free length (Lf)) are calculated from experimental data of density and sound velocity and interpreted in terms of solute/solvent–solute/solvent interactions using the co-sphere overlap model and the electrostriction effect. Further, UV spectroscopy and conductivity studies are used to predict the locus of TQ in the micelles, binding constant (Kb), partition coefficient (Kc), and free energy changes of TQ-micelle systems in the presence of surfactants. The results show that the binding and partitioning of TQ is more significant with TX-100 as compared with other ionic and non-ionic surfactants used.

Interaction study of L-phenylalanine/glycyl-L-phenylalanine in water-soluble 1-decyl-3-methylimidazolium bromide ([C10mim]Br) ionic liquid: thermodynamic/physicochemical approaches

AbstractRecent times have witnessed notable progress in augmenting the effectiveness of pharmaceutical actions, leading to the creation of novel drug formulations and delivery technologies. A complete understanding of the molecular-level interactions between drug molecules and biological membranes is necessary to achieve optimal design in these processes. Comprehensive understanding of these interactions can be gained through thermodynamic research, which helps pharmaceutical professionals make well-informed decisions about which manufacturing compounds are most suited for a certain application. Because ionic liquids can interact with biological membranes and exert their effects on them, studying ionic liquids in combination with co-solvents in aqueous settings is important for many kinds of research. Using an Anton Paar DSA 5000 M apparatus, the densities, and speed of sound in a liquid mixture comprising L-phenylalanine and glycyl-L-phenylalanine within an aqueous 1-decyl-3-methylimidazolium bromide ([C10mim]Br), the ionic solution was measured. This was done across temperature ranges of 288.15 K, 298.15 K, 308.15 K, and 318.15 K and experimental pressure of p = 0.1 MPa with concentrations of “0.000, 0.005, 0.030, and 0.050 mol kg–1”. From the experimental results, various acoustic and physicochemical properties were derived, including apparent molar properties, partial compression, isentropic compression, and transfer properties. These computations provided insights into intermolecular interactions within the combination of 1-decyl-3-methylimidazolium bromide, water, L-phenylalanine, and glycyl-L-phenylalanine. The mixture’s characteristics were explored through pair and triplet coefficients, taking into account empirical constants and expansibilities, thereby delving into solute–solvent, hydrophilic-hydrophilic, dipole–dipole, and ion-hydrophilic interactions. Graphical Abstract

Thermodynamic characterization of aqueous solutions of NaCl, KCl, MgCl2 and CaCl2: volumetric, acoustic, viscometric and computational analysis

The volumetric and acoustic properties of alkali and alkaline earth metal salts are ubiquitous in numerous biological and non-biological processes and accurate formulation of their thermophysical properties is a fundamental prerequisite for complete exploration of their diverse applications. To meet this purpose, in this investigation, we herewith report the systematic data of densities ρ, speed of sound u and viscosity η of aqueous binary solutions of the prominent alkali and alkaline earth metal salts viz. NaCl, KCl, MgCl2, and CaCl2 at seven different temperatures T = (288.15–318.15 K) and ambient pressure over the wide concentration range of (0.002–1) mol∙kg−1.These experimental data have been further employed to obtain some important thermodynamic parameters, viz, the apparent molar volume of solute Vϕ, limiting apparent molar volume of solute Vϕ0, isentropic compressibility of solution κS, apparent molar isentropic compression of the solute KS,ϕ, limiting apparent molar isentropic compression of solute KS,ϕ0 and apparent molar expansibility Eϕ0. Further, the coefficient of thermal expansion α*, the second-order derivative of limiting apparent molar volume ∂2Vϕ0/∂T2, Jones-Dole equation viscosity A, B, D coefficients, temperature derivative of B coefficient i.e. dB/dT, activation parameters for viscous flow and hydration number nH have also been computed. The results obtained have been used to elucidate different interactions taking place in the aqueous electrolytic solutions. To corroborate the experimental results, quantum chemical calculations were performed using density functional theory (DFT) by Gaussian software package. The calculations included an analysis of molecular orbitals, with particular emphasis on the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO).

Interactional behaviour of analgesic drugs in aqueous solution of caffeine at different temperatures using multi-technique approach

Drug combination therapies have been a promising strategy to overcome drug resistance. However, unexpected drug–drug interaction may cause adverse reactions, which puts patients in danger. Keeping this in mind, the interactions between pain killers, paracetamol (PCM), and ibuprofen sodium with caffeine (CAF) have been studied. Apparent molar volumes ( V2,ϕ) and apparent molar isentropic compression ( Ks,2,ϕ) for analgesic drugs in aqueous (1, 2, 5, and 10 mmol·kg−1) CAF solutions have been determined from measured densities, ρ, and speeds of sound, u, respectively, at T = 288.15–318.15 K and at pressure p = 101.3 kPa. The results have also been interpreted in terms of various interactions occurring in the mixed solution. Calorimetrically determined negative values of ΔtrΔdil H0 indicate the exothermicity and thus the occurrence of energetically more favorable process. The hyperchromic shift (UV absorption) in the spectra of PCM in aqueous solution of CAF suggests the dominance of solute–cosolute interactions through the hydrophobic–hydrophobic/hydrophilic groups (1H NMR) of PCM + CAF system.

Thermodynamic and physicochemical characteristics of 2-butoxyethanol/2-phenoxyethanol in aqueous maltitol solutions

In this study, interactions occurring among solute and solvent in aqueous solutions containing maltitol and 2-butoxyethanol (2-BE) and 2-phenoxyethanol (2-PhE) as a solute were studied (Viz volumetric, acoustic and spectroscopic study). Density, ρ, and speed of sound,s, of 2-BE and 2-PhE in aqueous solutions of maltitol with concentrations (0.01, 0.02, and 0.03) mol∙kg-1 were measured at various temperatures ranging from 288.15 K to 308.15 K at 0.1 MPa.The data was used to calculate acoustic and thermodynamic parameters, such as the apparent molar volume (Vϕ), apparent molar isentropic compression (Kϕ,s), partial molar volume (Vϕ0) and partial molar isentropic compression at infinite dilution (Kϕ,s0). This analysis helped us understand the solvation behaviour of maltitol, which is a key component in sugar-free products. Additionally, the co-sphere overlap model was used to examine several intermolecular interactions in the ternary systems. We investigated the partial molar expansibilities (Eϕ0) and their first-order derivatives ∂Eϕ0/∂Tp to examine the solute's structure-making and structure-breaking properties. Finally, we also carried out spectroscopic studies for both binary and ternary mixtures. The observed molar properties indicate the presence of significant interactions between the solute and solvent components within the ternary mixture. This is further supported by the positive values of partial molar expansibility. Moreover, the partial molar properties of the mixture strongly imply the occurrence of hydrogen bond formation.

Influence of anion structure on volumetric properties of dilute binary systems containing carboxylate functioned trihexylammonium ionic liquids in toluene / dodecane

We are actively involved in synthesis of hydrophobic ionic liquids, their volumetric behaviour in various solvents of different polarity and their application in metal ions extraction from water. In continuation of previous work, we are presenting new protic ionic liquids (PILs) containing Trihexylammonium cation and carboxylate anions namely Trihexylammonium propionate [THA][Pro] and Trihexylammonium pentanoate [THA] [Pent]. The simultaneous measurements of densities, ρ along with speeds of sound, u for binary systems of [THA][Pro] and [THA][Pent] in toluene and in dodecane were collected. The measurements were carried out in dilute concentrations range of PILs, at 0.1 MPa and different temperatures from 293.15 K to 328.15 K. The experimental values of densities, ρ and speeds of sound, u, were utilized to obtain calculated values of apparent molar properties: Vϕ (apparent molar volume) and Ks,ϕ (apparent molar isentropic compressibility). It is observed that the apparent molar properties of investigated systems are quite sensitive to variation in temperature, solvent and anion’s structure of PILs. The values of Vϕ and Ks,ϕ increases with each increment in studied temperature and when toluene was replaced by dodecane as a solvent in the system. The each addition of –CH2 group in anion chain of PILs leading to increase Vϕ whereas decrease with concentration of PILs in the binary system. The limiting values of apparent molar volume, Vϕ∞ and apparent molar isentropic compressibility, Kϕ∞ were also reported. The strength of interactions between PIL-PIL and PIL-solvent in studied binary systems was explained by Sk and Sv parameters. The PILs + dodecane systems exhibit greater interaction between PILs and solvent than binary systems of PIL + toluene.

Physicochemical studies of propylene and hexylene glycols in methanol solutions of hexachlorophene at different temperatures

The current study investigates the molecular interactions of glycol molecules (propylene (PG) and hexylene (HG) glycols) in hexachlorophene solutions at different temperatures and experimental pressure 0.1 MPa by merging acoustic and thermodynamic processes. The density and speed of sound of liquid mixtures are measured using an Anton Paar DSA 5000 M. These experimental values are used to calculate a variety of thermodynamic and acoustic parameters. The apparent molar volume (Vϕ), partial molar volume (Vϕ0), apparent molar isentropic compression (Kϕ,s), and partial molar isentropic compression (Kϕ,s0) are calculated with the help of experimentally determined density and speed of sound, as well as the partial molar expansibility (Eϕ0) is also calculated. The apparent molar parameters show the existence of strong interactions between solute and solvent in the ternary mixture, and it is also supported by the positive partial molar expansibility data, whereas the partial molar parameters indicate the hydrogen bonding formation in the mixture.

Volumetric-acoustic study of Disodium Ethylenediaminetetraacetic acid with Propylene and Hexylene glycol at different temperatures

The present study shows the molecular interactions at constant pressure of 0.1 megapascals (MPa) and a range of temperatures from (288.15, 298.15, 308.15, 318.15 K) in aqueous solution of Disodium EDTA in (0.01, 0.02, 0.03) mol.kg-1 along with Propylene glycol and Hexylene glycol. Speed of sound and density data is determined using Anton Paar DSA 5000 M. Various thermo-acoustic parameters are calculated using the obtained data. Experimental density values determined apparent Molar Volume (Vϕ), Partial Molar Volume (Vϕ°) as well as Partial Molar Volume of Transfer (ΔVϕ°) along with Partial Molar Expansibility (Eϕ°) and thermal expansion coefficient (α). While speed of sound determined the Apparent Molar Isentropic Compression (Kϕ,S), Partial Molar Isentropic Compression (Kϕ,S°) as well as Partial Molar Isentropic Compression of Transfer (ΔKϕ.S°). Pair and Triplet Coefficients along with Empirical constants have also been estimated. FTIR spectroscopic research had been carried out in the binary mixture. From propylene through hexylene glycols, these factors provide data related to significant interactions between solute and solvent.

Viscometric, ultrasonic and FTIR approach of streptomycin sulphate in the aqueous medium of K3Cit and Na3Cit at various temperatures: A Drug-Drug intermolecular interaction study

The effect of electrolyte on antibiotic drug streptomycin sulfate has been investigated at five temperatures (298.15–318.15) K and 0.1 MPa atmospheric pressure. The influence of concentrations and temperatures on the viscometric and ultrasonic properties of K3Cit and Na3Cit with water has been studied. The experimentally obtained data of ultrasonic speed (u) and viscosity (η) of the solutions have been used to evaluate different parameters at the studied temperatures. A, called the Falkenhagen coefficient, and B, is the Jones-Dole coefficient, transfer viscosity B-Coefficient, ΔtrB, at various temperatures (298.15–318.15) K were assessed by viscosity data. The ultrasonic data and the parameter for instance apparent molar isentropic compressibility,Kϕ,S, limiting apparent molar isentropic compressibility,Kϕ,S0, and limiting apparent molar isentropic compressibility of transfer, ΔtrKϕ,S0 have been analysed to study the presence of molecular interactions at different temperatures. The spectroscopic data have been used to know the existence of Hydrogen-bonding and other types of solute and solvent interactions in the solution. All these parameters have been taken to observe the different forces of attraction, association, dissociation, and structure-making/breaking properties of the drug streptomycin sulphate in the K3Cit + Water and Na3Cit + Water solutions at said temperatures.

Apparent molar volume, compressibility, and spectroscopic studies of ionic surfactants in aqueous solutions of antibiotic gemifloxacin

This work aims to explore the interactions between a wide-spectrum bactericidal drug, gemifloxacin (GMF), and micelles of cationic (dodecyltrimethylammonium bromide, DTAB) and anionic (sodium dodecyl sulfate, SDS) surfactants at the molecular level under physiological conditions (using a phosphate buffer, pH 7.4). Various physical parameters are calculated from volumetric and acoustic data. These include apparent molar volume (), apparent molar isentropic compressibility (), isentropic compressibility (), specific acoustic impedance (Z), relative association (RA), intermolecular free length (Lf ) and sound velocity number (U). The obtained quantities are interpreted regarding of solute-solute and solute-solvent interactions employing the cosphere overlap model and electrostriction effect. Further, normal and differential UV-visible spectroscopy is employed to predict GMF locus in ionic micelles and to find the binding constant (Kb ) and partition coefficient (Kc ) along with the corresponding free energy changes of GMF-ionic micelle systems. The results demonstrate that the binding and partitioning of GMF with SDS is more significant than DTAB.

Impact of diphenhydramine hydrochloride on an aqueous solution of imidazolium based surface-active ionic liquids at different temperatures: Physicochemical, thermodynamic and transport studies

In order to embrace the synergy between drug diphenhydramine hydrochloride (DPH) and ionic liquids 1-decyl-3-methylimidazolium bromide [C10mim][Br] and 1-dodecyl-3-methylimidazolium bromide [C12mim][Br] in aqueous media, we investigated the thermodynamics and transport properties of binary and ternary system. The calculation of quantities such as apparent molar volume (Vϕ), limiting apparent molar volume (Vοϕ), apparent molar isentropic compressibility (Kϕ) and limiting apparent molar isentropic compressibility (Kοϕ) of DPH in aqueous solution of ionic liquids from the volumetric and acoustic data help us to explore the solute–solute as well as solute–solvent interaction existing in the ternary systems. The apparent molar expansivity (Eoϕ), Hepler's constant (∂Eoϕ/∂T)P have been further determined to assist the interpretations earned from the volumetric and acoustic analysis. In addition, using the Jones–Dole equation, viscosity B-coefficients and temperature derivative of B-coefficients (dB/dT) have been determined. By using co-sphere overlap model of ternary mixtures we have studied the different types of interaction prevailing in the DPH and aqueous ionic liquids solution. The dominance of ionic-hydrophilic and hydrophilic-hydrophilic interactions in the ternary system is indicated by the positive and increasing ΔtrVϕ0 and ΔtrKοΦ values with increasing ILs concentration. Finally, the structure making nature of the DPH in aqueous ionic liquid solution is confirmed by the Hepler’s constant and viscosity B- coefficients.

Thermophysical Properties of Acetaminophen in Aqueous Solutions of Protic Ionic Liquids Based on Ethanolamine at T = 288.15–318.15 K

Protic ionic liquids (PILs), a novel category of inexpensive and sustainable solvents, have been employed to solve industrial and medicine solubility problems. Using a combination of ultrasonic, volumetric, and electrical conductivity methods at 288.15–318.15 K and a pressure of ≈87.1 kPa, researchers investigated the thermophysical properties of acetaminophen (ACP) in water and aqueous solutions of three protic ionic liquids (PILs), which are composed of the cations 2-hydroxyethylammonium, bis(2-hydroxyethyl)ammonium, and tris(2-hydroxyethyl)ammonium as well as the anion lactate. Study of intermolecular interactions using the thermophysical properties is very important because it provides a deep insight into the forces that are functional in the liquid mixtures. For the medication acetaminophen in water and aqueous PIL solutions, thermophysical parameters including apparent molar volume and apparent molar isentropic compressibility are examined in the current work. The findings showed that interactions between acetaminophen and PILs predominated in the systems under study and that these interactions increased as the PIL concentrations rose. The positive transfer results have been interpreted using the cosphere overlap model.