Moral responsibility is centered on the idea that, given some conditions, people deserve blame or credit, punishment or reward. At least according to traditional readings, moral responsibility presupposes free will, understood as the ability to choose independently of previous events. The achievements of neuroscience in recent decades make a very good case for the hypothesis that the mind is a material entity, a subset of the electrochemical activity of the brain. However, if the mind is a material entity, then it is subject to physical laws. According to some interpretations, this entails the affirmation of determinism and the denial of free will and moral responsibility. This article reviews some of those achievements and their likely impact on the attributions of moral responsibility. The first section presents evidence from lesion studies, imaging techniques and direct electrical stimulation of the brain and argues that the convergence of results from these methods supports the hypothesis that the mind is the activity of the brain. The next section concentrates on studies that are usually taken as directly threatening free will – Libet’s experiments and the apparent mental causation theory. The third section turns to the implications of these findings for moral responsibility, explaining determinism, epiphenomenalism, libertarianism, hard determinism and compatibilism. Finally, the last section defends that the requirement of free will as a precondition for moral responsibility should be replaced by the requirement of more naturalistic properties, such as behavioral flexibility, self-control and natural autonomy.Key words: moral responsibility, ethics, neuroscience, neuroethics, autonomy.