Apocrine Sweat Gland Carcinoma Research Articles

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma.

Cutaneous apocrine carcinoma is an extreme rare malignancy derived from a sweat gland. Histologically sweat gland cancers resemble metastatic mammary apocrine carcinomas, but the genetic landscape remains poorly understood. Here, we report a rare metastatic case with a PALB2 aberration identified previously as a familial susceptibility gene for breast cancer in the Finnish population. As PALB2 exhibits functions in the BRCA1/2-RAD51-dependent homologous DNA recombination repair pathway, we sought to use ex vivo functional screening to explore sensitivity of the tumor cells to therapeutic targeting of DNA repair. Drug screening suggested sensitivity of the PALB2 deficient cells to BET-bromodomain inhibition, and modest sensitivity to DNA-PKi, ATRi, WEE1i and PARPi. A phenotypic RNAi screen of 300 DNA repair genes was undertaken to assess DNA repair targeting in more detail. Core members of the HR and MMEJ pathways were identified to be essential for viability of the cells. RNAi inhibition of RAD52-dependent HR on the other hand potentiated the efficacy of a novel BETi ODM-207. Together these results describe the first ever CAC case with a BRCAness genetic background, evaluate combinatorial DNA repair targeting, and provide a data resource for further analyses of DNA repair targeting in PALB2 deficient cancers.

外科的切除を実施した犬のアポクリン汗腺癌5例の臨床および病理学的特徴

犬のアポクリン汗腺癌5症例の臨床および病理学的特徴を検討した。いずれも12歳以上の高齢犬に発生した単発腫瘍で、腫瘍細胞の表皮浸潤による潰瘍をともなっていた。全例で腺様構造、線維増生、間質浸潤がみられ、2例では硬癌の組織学的特徴も認められた。全例とも拡大切除によって局所制御はできたが、硬癌の特徴がみられた1例（前肢の指間腫瘍）は術後3ヶ月目に浅頸リンパ節転移が認められた。硬癌の別の1例（肘の固着腫瘍）には脈管浸潤があり、術後6ヶ月目に皮膚の転移巣が広がって死亡した。もっとも分裂指数が高かった1例（陰部横の腫瘍）は術後7ヶ月目に多臓器転移で死亡し、残りの2例は追跡中に転移は認められなかった。犬のアポクリン汗腺癌では拡大切除が局所制御に有効であるが、組織学的に硬癌の浸潤像、高分裂指数、脈管浸潤がみられる例では転移する可能性を考慮すべきと思われた。

Metastatic apocrine sweat gland adenocarcinoma in a terrier dog

This report describes the clinical and pathological aspects of an apocrine sweat gland carcinoma with distant metastasis in an aged dog. A 7-year-old male terrier dog was referred to small animal hospital of Shahid Bahonar University of Kerman with a 5.5×3.5 centimeter pedunculated mass on its head near left auricular region which had been progressively growing since three months ago. The radiography showed no local and distant metastasis. Surgical excision and histological evaluation was done. Histologically, the mass was composed of epithelial cells arranged in glandular and solid patterns. The morphologic findings suggested either a primary or metastatic apocrine-gland carcinoma. Immunohistochemically, the tumor cells were intensely positive for cytokeratin 7 and 20 and negative for S100 protein. On the basis of histopathological and clinical findings, the tumor was diagnosed as a malignant apocrine gland tumor, arising from apocrine sweat glands of the skin. Local tumor recurrence with anorexia and weight loss was reported by the owner nine month later. Severe submandibular and prescapular lymphadenomegaly was noted in clinical examination. Several large pulmonary nodules were noted in chest radiographs resembling mediastinal lymph node metastasis. Second surgery and chemotherapy was rejected by the owner due to grave prognosis of the patient. The animal was died 45 days later due to respiratory complications. Tumors of apocrine sweat glands are relatively uncommon in dogs whereas apocrine gland adenocarcinoma with distant metastasis is extremely rare.

Fine-needle aspiration cytology of the canine apocrine sweat gland carcinoma

Tumors of apocrine sweat glands are uncommon in comparison to tumors of sebaceous glands in dogs. Animals older than 8 years of age are most likely to develop these tumors. The authors report a case of apocrine sweat gland carcinoma in a 2-year-old crossbred dog that was diagnosed by fine-needle aspiration cytology. The technique was shown to be helpful for the correct diagnosis and treatment approach. However, despite being time consuming, the histopathological study remains the method of choice for accurate classification of the disease.

Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: A diagnostic dilemma on fine‐needle aspiration cytology

Carcinoma arising in the apocrine sweat glands is rare and there are few reports describing the cytological features of this neoplasm. We describe the cytological features of a histologically confirmed apocrine carcinoma occurring in a 55-year-old man who presented with an ulcerated mass in the right axilla. Fine-needle aspiration cytology revealed features of a signet ring adenocarcinoma. The significance of this infrequently encountered neoplasm lies in its potential for diagnostic confusion with more common lesions containing signet ring cells. In an axillary mass lesion, cytological features along with clinical correlation are essential to distinguish primary apocrine carcinoma from mammary neoplasms with signet ring cells and other metastatic adenocarcinomas.

Metastatic sweat gland adenocarcinoma: A clinico-pathological dilemma

BackgroundSweat gland adenocarcinoma is a rare malignancy with high metastatic potential seen more commonly in later years of life. Scalp is the most common site of occurrence and it usually spreads to lymph nodes. Liver, lung and bones are the distant sites of metastasis with fatal results. The differentiation between apocrine and eccrine metastatic sweat gland carcinoma is often difficult. The criteria's are inadequate to be of any practical utility.Case ReportTwo cases of metastatic sweat gland adenocarcinoma (one of eccrine and the other one of apocrine origin) are being reported on account of the rarity and different outcome.ConclusionSweat gland carcinomas are rare cancers with a poor prognosis often presenting as histological surprises. Surgery in the form of wide local excision and lymph node dissection is the mainstay of treatment. Chemotherapy and/or radiotherapy has limited role.

Malignant apocrine sweat gland carcinoma of the caruncle

A 34-year-old male presented with a mass in the medial aspect of the orbit. Histological examination demonstrated a malignant apocrine sweat gland carcinoma, which we consider to be most likely derived from the caruncle. We describe the clinical, radiological and histological features, with management options and a review of the relevant literature regarding sweat gland carcinomas.

Malignant apocrine sweat gland carcinoma of the caruncle

A 34-year-old male presented with a mass in the medial aspect of the orbit. Histological examination demonstrated a malignant apocrine sweat gland carcinoma, which we consider to be most likely derived from the caruncle. We describe the clinical, radiological and histological features, with management options and a review of the relevant literature regarding sweat gland carcinomas.

えきか部原発アポクリン癌の１例 転移巣における擦過細胞診

An 83-year-old male was diagnosed with apocrine sweat gland carcinoma in the right axillary region. After the first operation, a metastatic lesion near the primary site was noticed and a second operation was performed. Cytological examination showed tumor clusters arranged in papillary or sheet-like pattern. Some of the tumor cells had abundant eosinophilic cytoplasm with Orange G-stained coarse granules and were positive for GCDFP-15 and B 72.3 immunohistochemically.In conclusion, cytological features of the metastatic lesion retain the characteristic cytological appearance of apocrine sweat glands, which enabled a diagnosis of carcinoma of apocrine sweat gland origin.

APOCRINE SWEAT GLAND CARCINOMA.

SUMMARY.— A case of apocrine sweat gland carcinoma in a man aged 78 is presented. The patient died of widespread huematogenous metastases. Enzyme histochemical findings were important for the final identification of the tumour.

Apocrine adenoma of the anus.

CancerVolume 7, Issue 2 p. 367-372 ArticleFree Access Apocrine adenoma of the anus H. A. Teloh M.D., H. A. Teloh M.D. Departments of Pathology, Evanston Hospital Association, Evanston, and Northwestern University Medical School, Chicago, IllinoisSearch for more papers by this author H. A. Teloh M.D., H. A. Teloh M.D. Departments of Pathology, Evanston Hospital Association, Evanston, and Northwestern University Medical School, Chicago, IllinoisSearch for more papers by this author First published: March 1954 https://doi.org/10.1002/1097-0142(195403)7:2<367::AID-CNCR2820070222>3.0.CO;2-UCitations: 11AboutReferencesRelatedInformationPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessClose modalShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Danforth, W. C.: Hydradenoma vulvae. Am. J. Obst. & Gynec. 45: 329– 331; disc. 331-333, 1943. 2 Gates, O.; Warren, S., and Warvi, W. N.: Tumors of sweat glands. Am. J. Path. 19: 591– 631, 1943. 3 Hartz, P. H.: Adenomyoepithelioma of sweat gland; report of case. Am. J. Clin. Path. 16: 385– 390, 1946. 4 Lacy, G. R.: Hydradenoma and hydradenoid car cinoma of the vulva. Am. J. Obst. & Gynec. 51: 268– 271, 1946. 5 Leitner, M. J.: Adenoma of the ceruminous glands; report of a case. Am. J. Clin: Path. 22: 466– 471, 1952. 6 Lever, W. F.: Pathogenesis of benign tumors of cutaneous appendages and of basal cell epithelioma. I. Benign tumors of the cutaneous appendages. Arch. Dermat. & Syph. 57: 679– 708, 1948. 7 McDonald, J. R.: Apocrine sweat gland carcinoma of the vulva. Am. J. Clin. Path. 11: 890– 897, 1941. 8 Novak, E., and Stevenson, R. R.: Sweat gland tumors of the vulva, benign (hidradenoma) and malignant (adenocarcinoma). Am. J. Obst. & Gynec. 50: 641– 659, 1945. 9 Sheldon, W. H.: The myoepithelium in sweat gland tumors; distribution, histology, embryology and function. Arch. Path. 31: 326– 337, 1941. Citing Literature Volume7, Issue2March 1954Pages 367-372 ReferencesRelatedInformation RecommendedIntra‐oral sebaceous gland adenomaBruce N. Epker DDS, Fred A. Henny DDS, CancerA quantitative ultrastructural study of the pleomorphic adenoma (mixed tumor) of human minor salivary glandsDerrick M. Chisholm BDS, PhD, John P. Waterhouse MD, BDS, Eugenia Kraucunas DDS, James J. Sciubba DMD, PhD, CancerGlycosaminoglycan‐synthetic activity of pleomorphic adenoma, adenoid cystic carcinoma and nonneoplastic tubuloacinar cells of the salivary glandJun Takeuchi, Mitsuko Sobue, Masahiko Yoshida, Emiko Sato, CancerCarcinoma of the breast. Histologic and clinical features of apocrine tumorsWilliam J. Frable MD, Saul Kay MD, CancerBasal cell adenoma of the parotid gland. Case report with ultrastructural observationsMario A. Luna MD, Bruce Mackay MD, PhD, Cancer

Malignant Disease in the Undescended Testis

Primary apocrine sweat gland carcinoma (PASGC) is an extremely rare neoplasia whose management and treatment are still evolving. The only curative therapy is wide local excision. Many patients have metastasis at the time of the diagnosis, mainly because this neoplasm has been misdiagnosed as some benign skin lesions.We herein report a case of a 72-year-old-man with PASGC affecting the axilla and regional lymph nodes that underwent surgical resection and lymphadenectomy at our Institution. This is the first case reported in Brazil.Our observation suggests just a MRI as necessary to study tumoral limits and lymph nodes and a full surgical excision with free margins is decisive for success.Despite the PASGC be a rare cancer and require expensive tests, knowledge of this disease is critical to reduce costs in medical services without availability of investment.

Apocrine Sweat Gland Carcinoma of the Vulva

Apocrine Sweat Gland Carcinoma of the Vulva

The Relationship of Malignant Amelanotic Melanoma (Naevocarcinoma) to Extramammary Paget's Disease

Ever since Sir James Paget first described the disease of the nipple named after him and remarked that he had seen a lesion clinically resembling it on the glans penis, followed by cancer, reputed cases of extramammary Paget's disease have been sporadically reported and their nature discussed. The debate has been ancillary to the related question of the nature of Paget's disease, which is still not completely settled, although the great majority of writers now accept it as a malignant neoplasm and not a dyskeratosis which may only secondarily become neoplastic. In a recent very excellent analysis of 57 reported cases of extramammary Paget's disease to which he added one more, Weiner rejected 32, accepted 16 (including his own) without qualification, and thought 10 more were probably acceptable but had insufficient data to be sure. The accepted cases were all either in the axilla, on the vulva, or on the penis and scrotum. Moreover, many of them were associated with underlying glandular carcinomas or had some relationship with sweat or sebaceous glands. Weiner pointed out that the apocrine glands, which have a genetic relationship with the mammary glands, are found only in these regions, and he felt it proper to conclude that extramammary Paget's disease does exist and that it is an intradermal metastasis from an underlying carcinoma of the apocrine sweat glands. After studying all of the case reports analyzed by Weiner and a few more which he failed to include, the writer is persuaded that his conclusions are well taken and that he has settled the question: Extramammary Paget's disease does occur, and it consists of peculiar skin lesions which are clinically and microscopically similar to Paget's disease of the nipple, are associated usually with an underlying apocrine sweat gland carcinoma, and are quite possibly secondary to it.