This study investigates the impact of the COVID-19 pandemic and the Ever Given ship blockage on the air quality in Suez Canal region. Nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), and aerosol optical depth (AOD) were studied, and data were obtained from satellite instruments. The study compared monthly average data for 2020, 2021, and 2022 with a baseline period of 2017–2019 to investigate the pandemic’s effect. The study also analyzed the corresponding period of the canal blockage to identify its impact on air pollution levels. The pandemic had a significant role in decreasing NO2 by 2.5 × 1014 molecule/cm2 and SO2 by 0.05 DU due to reduced car traffic and industrial activities. A reduction in AOD by 20% and CO concentration in the range from 3.5% to 4.7% was reported in early 2020. During the blockage, NO2 and SO2 levels decreased by 14.4% and 66.0%, respectively, while CO and AOD index increased by 12.68% and 51.0%, respectively. The study concludes that the containment measures during the pandemic had a positive impact on the environment, which shows how the reduction in the anthropogenic activities, especially industrial and transportation activities, have improved the air quality. Thus, stricter actions are needed to protect the environment; for example, the transition towards the using of electric vehicle is necessary, which is part of Egypt’s strategy to transition towards a green economy. The government should also adopt a policy to trade carbon emissions reduction certificates to help reduce air pollution.