Objective Pandemics have been shown to affect both physical and mental health, with healthcare workers (HCWs) bearing a particularly heavy burden. During the COVID-19 pandemic, HCWs faced a high volume of cases, extended work hours, and heightened pandemic-related stressors, which placed them at increased risk for mental health issues. This study examines the effects of COVID-19-related anxiety on HCWs’ mental health, specifically exploring the roles of compassion fatigue (comprising burnout and secondary traumatic stress) as potential mediators in this relationship. Method A sample of 104 HCWs completed an online survey measuring their demographic characteristics (such as gender, age, length of service, marital status, and education), levels of COVID-19 anxiety, compassion fatigue, and mental health outcomes. Path analysis and bootstrapping procedures were used to analyze the data. Results Results indicated that COVID-19 anxiety was positively associated with compassion fatigue, defined as the emotional strain of caring for others, which includes both burnout (emotional exhaustion from work) and secondary traumatic stress (stress from exposure to others’ trauma). Compassion fatigue, particularly secondary traumatic stress, mediated the relationship between COVID-19 anxiety and various mental health indicators, including symptoms of anxiety, depression, and psychological distress. Both COVID-19 anxiety and compassion fatigue were significant predictors of these mental health outcomes. Conclusions These findings suggest that COVID-19 anxiety alone does not fully explain mental health outcomes among HCWs, as compassion fatigue, specifically secondary traumatic stress, plays a substantial role. Recognizing the complex interplay of pandemic-related stressors and compassion fatigue may guide interventions to better support HCWs’ mental health.
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