The article describes the main threats to electronic document management systems. The importance of the electronic document management system for organizational processes of enterprises and information security is considered. Particular importance is the use of electronic document management systems for the efficiency and speed of performing organizational functions. The article analyzes the aspects of information security when using electronic document management systems in practice and the effectiveness of implementation to ensure information security in comparison with traditional paper document management. The importance of the Information Security Strategy until 2025, approved by the Cabinet of Ministers of Ukraine, is emphasized. Attention is focused on the advantages of using the stages of implementing the cybersecurity model in electronic document management systems to protect information and data. It also discusses best practices for secure document storage and sharing that promote an integrated approach to various aspects of document management security to protect confidential information from potential cyber threats. The criteria for choosing a high-quality electronic document management system, for ensuring information security and countering cyber attacks are quite important. In particular, attention is focused on modern antivirus technologies that allow detecting almost all known viruses by comparing the code of a suspicious file with samples stored in the antivirus database. Therefore, for organizations seeking to use the latest technologies, information security is essential in electronic document management systems to increase the level of cybersecurity.