An anti-interference temperature sensor based on Mach-Zehnder interferometer (MZI) is proposed, which is formed by successively fusing a homemade Kagome Hollow-Core photonic crystal fiber (HC-PCF) with two no-core fibers and two single-mode fibers. Due to the anti-resonant reflection optical waveguide properties, the interference between hollow-core mode and glass mode is achieved in Kagome HC-PCF, which significantly simplifies the overall sensing architecture and maintains better stability of the sensing signal. Using Kagome HC-PCF length of 497 μm, the maximum temperature sensitivity of the proposed sensor is obtained as 38.39 pm/°C. Meanwhile, it exhibits a low sensitivity of 0.5041 pm/με to ambient stress variation, -0.28 nm/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> to curvature change and 9.35 nm/RIU to external refractive index change. This MZI temperature sensor has the advantages of compact structure, easy fabrication, low cost, small size, high sensitivity and anti-interference capability, which can be expected to be applied to temperature sensing in complex environments.