Integrating nanomaterials into membranes has revolutionized selective transport processes, offering enhanced properties and functionalities. Mixed-matrix membranes (MMMs) are nanocomposite membranes (NCMs) that incorporate inorganic nanoparticles (NPs) into organic polymeric matrices, augmenting mechanical strength, thermal stability, separation performance, and antifouling characteristics. Various synthesis methods, like phase inversion, layer-by-layer assembly, electrospinning, and surface modification, enable the production of tailored MMMs. A trade-off exists between selectivity and flux in pristine polymer membranes or plain inorganic ceramic/zeolite membranes. In contrast, in MMMs, NPs exert a profound influence on membrane performance, enhancing both permeability and selectivity simultaneously, besides exhibiting profound antibacterial efficacy. Membranes reported in this work find application in diverse separation processes, notably in niche membrane-based applications, by addressing challenges such as membrane fouling and degradation, low flux, and selectivity, besides poor rejection properties. This review comprehensively surveys recent advances in nanoparticle-integrated polymeric membranes across various fields of water purification, heavy metal removal, dye degradation, gaseous separation, pervaporation (PV), fuel cells (FC), and desalination. Efforts have been made to underscore the role of nanomaterials in advancing environmental remediation efforts and addressing drinking water quality concerns through interesting case studies reported in the literature.